EKS-MYL-00033

Eukaryotic Protein Kinase & Protein Phosphatase Database

Tag

Content

EKPD ID

EKS-MYL-00033

Classification

Group/Family	Score	E-Value	Start	End	Domain Length
TK/Jak	339.7	1.3E-101	705	978	274

Status

Unreviewed

Ensembl Protein

ENSMLUP00000006103

UniProt Accession

G1P7K0;

Protein Name

Tyrosine-protein kinase

Protein Synonyms/Alias

Gene Name

JAK3

Gene Synonyms/Alias

JAK3;

Ensembl Information

Ensembl Gene ID	Ensembl Protein ID	Ensembl Transcript ID
ENSMLUG00000006664	ENSMLUP00000006103	ENSMLUT00000006685

Organism

Myotis lucifugus

Functional Description

Protein Length

987

Protein Sequence
(FASTA)

FYFPNWFGLE TCHRFGLRKD LASAILDLPV LEYLFAQHRN DLVSGRLPVG LSLKEQGECL 60

SLAVLDLARM ACEQAQQPED LLKTVSYKTC LPPGLRDLIQ GLSFVTRRRI RRRVRQALLR 120

VATCQADRHS LMAKYIMDLE RLDLARATET FLVGLPGSAG GQEAKGLLRV AGGSGIAWSP 180

GTQEVFQPFC DFPEIVDISI KQAPRVGPAG EHRLVTITRT DNQILEAEFP GLPASLSFVA 240

LVDGYFRLTT DSQHYFCKEV APPRLLEEVA QQCQGPITLD FAINKLKTGG SLPGSYVLRR 300

SPQDFDSFLL TVCVQTPLGP DYKGCLIRCD PTGTFSLAGL GRPHSSLREL LAACWDGGLH 360

VDGVALNLTF CCTPRPKEKS NLIVVRRSCS PPTSSPVQPH SGCQLSQMTF HKIAADSLEW 420

CENLGHGSFT KIYRGCRHET VDGEPRETEV LLKVLDAKHK HCMESFLEAA SLMSQVSYQH 480

LVLLHGVCMA GDSIMVQEFV RLGALDTYLR KCGHLVPASW KLQVIKQLAY ALNYLVSAPL 540

PAPSSILRGG VGGVEGGLCC MDRSLARVPG WRAKHMYGLR DDLCLYPEAN GEPATGWETS 600

IREGGGMPIS TLEPAKKLQF YEDRQQLPAP KWMELALLIQ QCMAYEPGHR PSFRAVIRDL 660

NNLITSDYEL LSDPTPGALA PHDGLWNGAQ LYACQDPTIF EERHLKYISQ LGKGNFGSVE 720

LCRYDPLGDN TGALVAVKQL QHSGPDQQRD FQREIQILKA LHSDFIVKYR GVSYGPGRQS 780

LRLVMEYLPS GCLRDFLQRH RARLDAGRLL LYASQICKGM EYLGSRRCVH RDLAARNILV 840

ENETHVKIAD FGLAKLLPLD KDYYVVREPG QSPIFWYAPE SLSDNIFSRQ SDVWSFGVVL 900

YELFTYSDKS CSPSAEFLRM MGCERDVPAL CRLLDLLAEG QRLPAPPACP GEVHELMKLC 960

WAPSPQDRPS FSTLGPQLEA LWSGSRG 987

Nucleotide Sequence
(FASTA)

TTTTACTTCC CCAACTGGTT TGGGCTAGAG ACGTGTCACC GCTTTGGGCT TCGGAAGGAC 60

TTGGCCAGCG CCATCCTTGA CCTGCCAGTC CTGGAATACC TATTTGCTCA GCACCGCAAT 120

GACCTGGTGA GTGGCCGCCT TCCGGTGGGC CTCAGCCTCA AGGAGCAGGG CGAATGTCTC 180

AGCCTGGCTG TGCTGGACTT GGCCCGGATG GCCTGTGAGC AGGCCCAGCA GCCGGAGGAT 240

CTGCTGAAGA CCGTCAGCTA CAAGACCTGC CTGCCCCCGG GCCTGCGCGA CCTGATCCAG 300

GGCCTGAGCT TCGTTACGCG GAGGCGCATC CGGAGGAGGG TGCGCCAGGC CCTGCTCCGC 360

GTGGCCACCT GCCAGGCTGA CAGACACTCA CTCATGGCCA AGTACATCAT GGACCTGGAG 420

AGGCTGGACC TGGCGAGGGC CACGGAGACC TTCCTCGTGG GCCTCCCCGG GTCGGCTGGG 480

GGTCAAGAGG CGAAGGGACT GCTCCGCGTG GCCGGTGGTA GCGGCATCGC CTGGAGTCCA 540

GGAACACAGG AGGTCTTCCA GCCTTTCTGC GACTTCCCAG AAATCGTGGA CATCAGCATC 600

AAGCAGGCCC CGCGCGTTGG CCCAGCTGGG GAGCATCGCC TGGTCACCAT CACCAGGACA 660

GACAACCAGA TCCTGGAGGC TGAGTTCCCG GGGCTGCCAG CCTCCTTGTC CTTCGTGGCG 720

CTCGTGGACG GCTACTTCCG ACTGACCACG GACTCCCAGC ACTACTTCTG CAAGGAGGTG 780

GCGCCGCCGC GGCTGCTGGA GGAGGTGGCC CAGCAGTGCC AAGGCCCCAT CACCCTGGAT 840

TTTGCCATCA ACAAGCTCAA GACTGGAGGA TCCCTCCCTG GCTCCTACGT TCTCCGCCGC 900

AGCCCCCAGG ATTTCGACAG CTTCCTCCTC ACTGTGTGTG TCCAGACCCC GCTGGGCCCC 960

GATTACAAGG GCTGCCTCAT CCGGTGCGAC CCCACAGGAA CCTTCTCCCT GGCTGGCCTT 1020

GGCCGACCCC ATAGCAGTCT CCGAGAGCTC CTGGCGGCCT GCTGGGACGG TGGTCTGCAT 1080

GTAGACGGGG TTGCTCTGAA CCTCACCTTC TGCTGCACCC CTAGGCCCAA AGAAAAGTCC 1140

AACCTGATTG TGGTCCGGAG AAGTTGCAGT CCACCCACAT CATCCCCTGT TCAGCCCCAC 1200

TCGGGATGCC AGCTGAGTCA GATGACATTT CACAAGATCG CCGCTGACAG CCTGGAGTGG 1260

TGTGAGAACC TGGGTCATGG ATCCTTCACC AAGATTTACC GGGGCTGTCG CCACGAGACT 1320

GTGGATGGGG AGCCTCGGGA GACGGAGGTG CTGCTCAAAG TGTTGGATGC TAAGCATAAG 1380

CACTGCATGG AGTCATTCCT GGAAGCAGCG AGTTTGATGA GCCAAGTGTC GTACCAGCAT 1440

CTCGTGTTGC TTCATGGCGT GTGCATGGCC GGAGACAGCA TCATGGTGCA GGAGTTTGTA 1500

CGCCTGGGAG CACTGGACAC ATACCTGCGC AAGTGTGGCC ATTTGGTGCC CGCCAGCTGG 1560

AAGCTTCAGG TGATCAAACA GCTGGCCTAT GCTCTCAACT ATCTGGTGAG TGCTCCTCTG 1620

CCTGCTCCGT CCTCCATTCT CAGAGGGGGG GTGGGGGGGG TTGAGGGTGG GCTCTGTTGT 1680

ATGGATCGCA GTTTGGCAAG GGTGCCAGGA TGGAGGGCAA AGCATATGTA CGGGCTCAGA 1740

GATGACCTTT GTCTTTATCC TGAAGCCAAT GGGGAGCCAG CCACAGGGTG GGAGACCAGT 1800

ATTCGAGAAG GGGGGGGGAT GCCCATCAGC ACCCTGGAGC CCGCCAAGAA GCTCCAGTTT 1860

TATGAGGACC GGCAGCAGCT GCCTGCCCCT AAGTGGATGG AGCTGGCCCT GCTGATCCAA 1920

CAGTGCATGG CCTATGAGCC AGGCCACAGG CCCTCCTTTC GCGCTGTCAT CCGTGACCTG 1980

AACAACCTCA TTACATCAGA TTATGAGCTC CTCTCGGACC CCACACCTGG TGCCCTGGCG 2040

CCCCATGACG GGCTGTGGAA TGGCGCCCAG CTCTACGCCT GCCAGGACCC TACCATCTTT 2100

GAGGAGAGAC ACCTCAAGTA CATCTCACAG CTAGGCAAGG GCAACTTTGG CAGCGTGGAA 2160

CTGTGCCGCT ACGACCCCCT GGGAGACAAC ACGGGCGCCC TGGTGGCTGT GAAGCAGCTG 2220

CAGCACAGCG GGCCAGACCA GCAGAGGGAC TTCCAGCGGG AGATCCAGAT CCTCAAAGCC 2280

CTGCACAGCG ACTTCATTGT CAAGTACCGC GGCGTCAGCT ATGGCCCAGG CCGCCAGAGC 2340

CTGCGGCTGG TCATGGAGTA CCTGCCCAGC GGCTGCCTGC GCGACTTCCT GCAGCGGCAC 2400

CGGGCGCGCC TCGATGCTGG CCGCCTGCTC CTCTACGCCT CGCAGATCTG CAAGGGCATG 2460

GAGTACCTGG GCTCCCGCCG CTGTGTGCAC CGCGACCTGG CAGCGCGGAA CATCCTGGTG 2520

GAGAATGAGA CGCACGTCAA GATCGCTGAC TTCGGCCTTG CCAAGCTGCT ACCGCTGGAC 2580

AAAGACTATT ACGTTGTCCG GGAACCGGGC CAAAGCCCCA TCTTCTGGTA CGCCCCGGAG 2640

TCCCTCTCGG ACAACATCTT CTCACGCCAG TCAGATGTCT GGAGCTTTGG GGTTGTTCTG 2700

TACGAGCTGT TCACCTACAG CGACAAGAGC TGCAGCCCCT CCGCTGAGTT CCTGCGGATG 2760

ATGGGATGTG AGCGAGATGT CCCGGCTCTC TGCCGCCTCC TGGACCTGCT GGCCGAGGGC 2820

CAGAGGCTGC CTGCACCTCC AGCCTGCCCT GGCGAGGTTC ATGAGCTCAT GAAGCTGTGC 2880

TGGGCTCCTA GCCCACAAGA CCGGCCATCC TTCAGCACCC TGGGCCCCCA GCTGGAGGCG 2940

CTGTGGAGTG GAAGTCGGGG GTAG 2964

Domain Profile

S: 1     lkqiesLgkgtftkvfevredaegdsteeevalkvLkesgedisrdfkreaeilsqlshe  60

         lk+i++Lgkg+f++v+++r+d+ gd+t++ va+k+L++sg+d++rdf+re++il++l+++

Q: 705   LKYISQLGKGNFGSVELCRYDPLGDNTGALVAVKQLQHSGPDQQRDFQREIQILKALHSD  764

         799*********************************************************

S: 61    hivklkgvcvaegen..rlVmeyvesGsLdiyLrkkkealslsslldvakqlakameYLe  118

         +ivk++gv++ +g++  rlVmey++sG+L+++L++++++l++ +ll +a+q++k+meYL+

Q: 765   FIVKYRGVSYGPGRQslRLVMEYLPSGCLRDFLQRHRARLDAGRLLLYASQICKGMEYLG  824

         ************************************************************

S: 119   dkklvhrdvaarnvLveresnegtppfvklsdpglakavnqd.eYylvreerdsripwla  177

         ++++vhrd+aarn+Lve+e +      vk++d+glak+++ d +Yy+vre+++s+i+w+a

Q: 825   SRRCVHRDLAARNILVENETH------VKIADFGLAKLLPLDkDYYVVREPGQSPIFWYA  878

         *********************......*********************************

S: 178   peclseaknlstasdvWsFgvtlyellt.cskgesp....lrsesle.......rklell  225

         pe+ls++  +s++sdvWsFgv+lyel+t  +k++sp    lr++++e       r+l ll

Q: 879   PESLSDNI-FSRQSDVWSFGVVLYELFTySDKSCSPsaefLRMMGCErdvpalcRLLDLL  937

         ********.*******************999*****************************

S: 226   eekerlpkpk.cpaelaelmtnclsyepsqrpsFrailedl  265

          e++rlp+p+ cp e++elm+ c++ +p++rpsF+++  +l

Q: 938   AEGQRLPAPPaCPGEVHELMKLCWAPSPQDRPSFSTLGPQL  978

         ************************************98776

Domain Sequence
(FASTA)

LKYISQLGKG NFGSVELCRY DPLGDNTGAL VAVKQLQHSG PDQQRDFQRE IQILKALHSD 60

FIVKYRGVSY GPGRQSLRLV MEYLPSGCLR DFLQRHRARL DAGRLLLYAS QICKGMEYLG 120

SRRCVHRDLA ARNILVENET HVKIADFGLA KLLPLDKDYY VVREPGQSPI FWYAPESLSD 180

NIFSRQSDVW SFGVVLYELF TYSDKSCSPS AEFLRMMGCE RDVPALCRLL DLLAEGQRLP 240

APPACPGEVH ELMKLCWAPS PQDRPSFSTL GPQL 274

Keyword

ATP-binding; Complete proteome; Kinase; Nucleotide-binding; Phosphoprotein; Reference proteome; SH2 domain; Transferase; Tyrosine-protein kinase.

Sequence Source

Ensembl

Orthology

Ortholog group

Ailuropoda melanoleuca"; ?>Bos taurus"; ?>Canis familiaris"; ?>Cavia porcellus"; ?>Equus caballus"; ?>Felis catus"; ?>Gorilla gorilla"; ?>Homo sapiens"; ?>Ictidomys tridecemlineatus"; ?>Loxodonta africana"; ?>Macaca mulatta"; ?>Monodelphis domestica"; ?>Mus musculus"; ?>Mustela putorius furo"; ?>Nomascus leucogenys"; ?>Ornithorhynchus anatinus"; ?>Otolemur garnettii"; ?>Pan troglodytes"; ?>Pongo abelii"; ?>Pteropus vampyrus"; ?>Rattus norvegicus"; ?>Sarcophilus harrisii"; ?>Sus scrofa"; ?>

Gene Ontology

GO:0005856	; C:cytoskeleton
GO:0016020	; C:membrane
GO:0005524	; F:ATP binding
GO:0004715	; F:non-membrane spanning protein tyrosine kinase activity
GO:0007243	; P:intracellular protein kinase cascade

KEGG

InterPros

IPR000299	; FERM_domain.
IPR011009	; Kinase-like_dom.
IPR000719	; Prot_kinase_cat_dom.
IPR017441	; Protein_kinase_ATP_BS.
IPR001245	; Ser-Thr/Tyr_kinase_cat_dom.
IPR000980	; SH2.
IPR008266	; Tyr_kinase_AS.
IPR020635	; Tyr_kinase_cat_dom.
IPR016251	; Tyr_kinase_non-rcpt_Jak/Tyk2.
IPR020775	; Tyr_kinase_non-rcpt_Jak3.

Pfam

PF07714

; Pkinase_Tyr; 3.

SMARTs

SM00252	; SH2; 1.
SM00219	; TyrKc; 1.

Prosites

PS50057	; FERM_3; 1.
PS00107	; PROTEIN_KINASE_ATP; 1.
PS50011	; PROTEIN_KINASE_DOM; 1.
PS00109	; PROTEIN_KINASE_TYR; 1.

Prints

PR01823	; JANUSKINASE.
PR01826	; JANUSKINASE3.
PR00109	; TYRKINASE.

Created Date

20-Feb-2013