EKS-MYL-00396
Eukaryotic Protein Kinase & Protein Phosphatase Database
TagContent
EKPD IDEKS-MYL-00396
Classification
Group/FamilyScoreE-ValueStartEndDomain Length
TK/PDGFR612.03.4E-184592949358
StatusUnreviewed
Ensembl ProteinENSMLUP00000006167
UniProt AccessionG1P7Q7;
Protein NameTyrosine-protein kinase receptor
Protein Synonyms/Alias
Gene NamePDGFRA
Gene Synonyms/Alias PDGFRA;
Ensembl Information
Ensembl Gene IDEnsembl Protein IDEnsembl Transcript ID
ENSMLUG00000006741ENSMLUP00000006167ENSMLUT00000006755
OrganismMyotis lucifugus
Functional Description
Protein Length1088
Protein Sequence
(FASTA)
MGTSHLALLV LGCLLAGPSL ILCQLSLPSI LPNENEKVVQ LNSSFSLRCF GESEVTWQYP 60
MSDEDPNVRI RNEENNSGLF VTVLEVANAS AAHTGLYTCY YNHTQSEENE IEGSHIYIYV 120
PDPDVVFVPL GMTDYLVIVE NDDFAIIPCR TTDPQTPVTL LSSDGVVLAD YDSRQGFNGT 180
FSGGPYVCEA IVRGKKFHSI PFNIYSVKAT SELDLELEAP KTVYMAGETI VLTCIVLNNE 240
VVDFQWTYPG EVKNKGVVML EEIKDPSIKL VHTLMVPKAT VKDSGDYECI ARLATREVKE 300
MKKVTIAVHE KGFIEIQPGF SQLEAVNLHE VKHFVVDVQA YPPPRISWLK DNLTLIENLT 360
EITTDIEKVQ EIRYRSRLKL IRAKEEDSGH YTIVVQNEDD MKSYTFELLT QVPASILDLV 420
DDHHGSTGGQ TVRCTAAGTP LPEIEWMICK DIKKCNNETS WAILANNISN IVTEVYRQDR 480
SRVEGRVTFA KVEETIAVRC LAKNLLGVEN RELKLVAPTL RSELTVAAAV LVLLVIVIIS 540
LIVLVVIWKQ KPRYEIRWRV IESISPDGHE YIYVDPMQLP YDSRWEFPRD GLVLGRILGS 600
GAFGKVVEGT AYGLSRSQPV MKVAVKMLKP TARSSEKQAL MSELKIMTHL GPHLNIVNLL 660
GACTKSGPIY IITEYCFYGD LVNYLHKNRD SFLSHHPEKP KKELDIFGLN PTDESTRSYV 720
VLSFENNGDY MDMKQADTTQ YVPMLERKEV SKYSDIQRSL YDRPASYKKK SMLDSEVKNL 780
LSDDNAEGLT LLDLLSFTYQ VARGMEFLAS KNCVHRDLAA RNVLLAQGKI VKICDFGLAR 840
DIMHDSNYVS KGSTFLPVKW MAPESIFDNL YTTLSDVWSY GILLWEIFSL GGTPYPGMMV 900
DSTFYNKIKS GYRMAKPDHA TSEIYEIMVK CWNSEPEKRP SFYHLREIVE NLLPGQYKKS 960
YEKIHLDFLK SDHPAVARMR VDADNAYIGV TYKNEEDKLK DWEGGLDEQR LSADSGYIIP 1020
LPDIDPIPEE EDLGKRNRHS SQTSEESAIE TGSSSSTFIK REDETIEDID MMDDIGIDSS 1080
DLVEDSFL 1088
Nucleotide Sequence
(FASTA)
ATGGGGACTT CCCATCTGGC ACTCCTGGTC CTAGGCTGTC TCCTCGCAGG GCCGAGCCTA 60
ATCCTCTGCC AGCTTTCACT ACCCTCTATC CTCCCAAACG AAAATGAAAA GGTTGTGCAG 120
CTGAATTCAT CCTTTTCTCT GAGATGCTTT GGGGAGAGTG AAGTGACCTG GCAGTACCCC 180
ATGTCTGACG AGGACCCCAA TGTGAGGATC AGAAACGAGG AGAACAACAG TGGCCTTTTT 240
GTGACGGTGC TGGAAGTGGC CAACGCCTCG GCGGCTCACA CGGGGTTGTA CACTTGCTAT 300
TACAACCACA CGCAGTCAGA AGAGAACGAG ATTGAAGGCA GTCACATTTA CATCTACGTG 360
CCAGACCCAG ATGTAGTCTT CGTGCCTCTG GGAATGACAG ACTATTTAGT CATTGTGGAG 420
AACGACGATT TTGCCATCAT ACCTTGTCGC ACGACTGACC CTCAGACTCC GGTGACCTTG 480
CTCAGCAGTG ACGGGGTGGT CCTCGCTGAC TATGACAGCC GGCAGGGCTT CAACGGGACC 540
TTCTCGGGTG GGCCCTATGT GTGCGAGGCC ATCGTCAGGG GGAAGAAGTT CCACTCCATC 600
CCATTTAACA TTTATTCTGT CAAAGCAACA TCAGAACTCG ATCTAGAATT GGAAGCCCCG 660
AAAACTGTCT ACATGGCAGG GGAAACCATT GTGCTCACCT GCATCGTCTT GAACAACGAG 720
GTGGTTGACT TTCAGTGGAC TTACCCTGGA GAAGTGAAAA ACAAAGGCGT CGTAATGCTG 780
GAGGAAATCA AGGACCCATC CATCAAACTG GTGCACACCC TGATGGTCCC CAAGGCCACG 840
GTGAAAGACA GTGGAGATTA CGAATGTATC GCCCGCCTGG CCACCAGGGA GGTCAAAGAG 900
ATGAAGAAAG TCACCATTGC TGTCCACGAG AAAGGGTTCA TTGAAATCCA GCCCGGCTTC 960
AGCCAGCTGG AAGCTGTCAA CCTGCATGAA GTCAAACATT TTGTGGTGGA CGTGCAGGCC 1020
TACCCGCCGC CCAGGATATC CTGGCTGAAG GACAACCTGA CTCTGATCGA AAACCTCACC 1080
GAGATCACCA CCGACATAGA AAAGGTCCAG GAGATCAGGT ACCGAAGTAG ATTAAAGCTG 1140
ATCCGTGCTA AGGAGGAAGA CAGTGGCCAT TACACTATTG TCGTTCAAAA TGAAGACGAC 1200
ATGAAGAGCT ACACTTTTGA ACTCTTAACT CAAGTTCCCG CATCTATTCT GGACTTGGTC 1260
GACGACCACC ATGGCTCCAC GGGGGGACAG ACCGTGAGAT GCACAGCTGC AGGGACACCT 1320
CTTCCTGAAA TTGAGTGGAT GATTTGCAAG GATATTAAGA AATGTAATAA TGAGACTTCA 1380
TGGGCGATTT TGGCCAACAA CATCTCAAAC ATCGTCACGG AGGTCTACCG CCAGGACAGG 1440
AGTAGGGTGG AGGGCCGGGT GACGTTCGCC AAAGTGGAGG AGACCATTGC GGTTCGATGT 1500
CTGGCTAAGA ATCTCCTTGG TGTTGAGAAC CGAGAGCTGA AGCTGGTGGC TCCCACTCTG 1560
CGTTCTGAGC TCACGGTGGC AGCCGCAGTC CTGGTGCTAT TGGTGATTGT GATCATCTCA 1620
CTGATTGTCC TGGTTGTCAT TTGGAAACAG AAACCAAGGT ATGAAATTCG CTGGAGGGTC 1680
ATTGAATCAA TCAGCCCCGA TGGACACGAA TATATTTATG TGGACCCGAT GCAGCTGCCT 1740
TATGACTCGA GATGGGAGTT TCCAAGAGAC GGACTAGTGC TGGGTCGTAT ACTGGGATCT 1800
GGTGCGTTTG GGAAGGTTGT TGAAGGAACT GCCTACGGAT TAAGCCGGTC CCAACCGGTC 1860
ATGAAAGTAG CAGTGAAGAT GCTTAAACCC ACAGCCAGAT CCAGTGAAAA ACAAGCCCTC 1920
ATGTCTGAAC TGAAGATAAT GACCCACCTG GGGCCGCATT TAAACATTGT CAACCTGTTG 1980
GGCGCCTGTA CCAAGTCAGG CCCCATTTAC ATCATCACTG AATACTGCTT TTATGGGGAT 2040
TTGGTCAACT ACTTACATAA GAATAGGGAC AGCTTCCTGA GCCACCACCC AGAGAAGCCA 2100
AAGAAAGAGC TGGACATCTT TGGATTAAAT CCTACCGATG AAAGCACACG GAGTTATGTT 2160
GTTTTATCTT TTGAAAACAA TGGTGACTAC ATGGACATGA AGCAAGCTGA CACCACACAG 2220
TATGTCCCCA TGCTGGAAAG GAAAGAGGTT TCTAAATACT CGGACATCCA GAGGTCGCTG 2280
TATGACCGCC CAGCCTCATA CAAGAAGAAG TCTATGTTAG ACTCAGAAGT CAAAAACCTC 2340
CTTTCGGATG ATAACGCAGA AGGCCTGACT TTGTTGGATT TGTTGAGCTT CACCTATCAA 2400
GTTGCTCGAG GAATGGAGTT TTTGGCTTCA AAGAATTGTG TCCACCGGGA CCTGGCCGCT 2460
CGCAACGTCC TCCTGGCACA AGGGAAAATC GTGAAGATCT GCGACTTTGG CCTGGCCAGA 2520
GACATCATGC ATGACTCGAA CTACGTATCG AAAGGCAGCA CCTTCCTCCC TGTGAAGTGG 2580
ATGGCTCCTG AGAGCATCTT CGACAACCTC TACACCACGC TGAGCGACGT CTGGTCTTAC 2640
GGCATTCTGC TCTGGGAGAT CTTTTCCCTG GGTGGCACAC CCTACCCTGG CATGATGGTT 2700
GATTCTACTT TCTACAATAA GATCAAGAGT GGGTACCGGA TGGCCAAGCC TGACCATGCC 2760
ACCAGTGAAA TCTACGAGAT CATGGTGAAG TGCTGGAACA GTGAGCCGGA GAAGAGACCC 2820
TCCTTTTACC ACCTGAGAGA GATTGTGGAG AACCTGCTGC CTGGACAGTA TAAAAAGAGT 2880
TATGAAAAGA TTCACCTGGA TTTCCTGAAG AGCGACCATC CTGCTGTGGC GCGCATGCGA 2940
GTGGATGCTG ACAACGCCTA CATTGGCGTC ACCTACAAAA ACGAGGAGGA CAAGCTGAAG 3000
GACTGGGAGG GTGGCCTGGA CGAGCAGAGG CTGAGCGCTG ACAGCGGCTA CATCATCCCT 3060
CTGCCTGACA TCGACCCCAT TCCTGAGGAG GAAGACCTGG GCAAGAGGAA CAGACACAGC 3120
TCGCAGACCT CTGAAGAGAG TGCCATTGAG ACAGGTTCCA GCAGCTCCAC CTTCATCAAG 3180
AGAGAGGACG AGACCATTGA GGACATCGAC ATGATGGATG ACATTGGCAT AGACTCCTCA 3240
GACCTGGTGG AGGACAGCTT CCTTTAA 3267
Domain Profile
S: 1     lelGkvlGsGafGkvveatayGlsksdavlkvavkmlkstarssekealmselkilshlG  60
         l+lG++lGsGafGkvve+tayGls+s++v+kvavkmlk+tarssek+almselki++hlG
Q: 592   LVLGRILGSGAFGKVVEGTAYGLSRSQPVMKVAVKMLKPTARSSEKQALMSELKIMTHLG  651
         78**********************************************************
S: 61    ehenivnllGactkgGpiyviteyccyGdllnylrrkresflkkslekkkekeeeldska  120
         +h+nivnllGactk+Gpiy+iteyc+yGdl+nyl+++r+sfl+++ ek   +++eld+++
Q: 652   PHLNIVNLLGACTKSGPIYIITEYCFYGDLVNYLHKNRDSFLSHHPEK---PKKELDIFG  708
         *********************************************999...9999*****
S: 121   l.ladkslrsksslssesseeyvdlkkd................vsdvssskadklasek  163
         l ++d+s+rs++ ls+e++++y+d+k++                +sd+++s +d++as+k
Q: 709   LnPTDESTRSYVVLSFENNGDYMDMKQAdttqyvpmlerkevskYSDIQRSLYDRPASYK  768
         *9*************************9********************************
S: 164   kksalerevkaaleeedsevleledllsfsyqvakGmeflaskncvhrdlaarnvllteG  223
         kks+l++evk+ l++++ e+l+l dllsf+yqva+Gmeflaskncvhrdlaarnvll++G
Q: 769   KKSMLDSEVKNLLSDDNAEGLTLLDLLSFTYQVARGMEFLASKNCVHRDLAARNVLLAQG  828
         ************************************************************
S: 224   kvvkicdfGlardimkdsnyvvkGnarlpvkwmapesifdslytvksdvwsyGillweif  283
         k+vkicdfGlardim+dsnyv+kG+++lpvkwmapesifd+lyt+ sdvwsyGillweif
Q: 829   KIVKICDFGLARDIMHDSNYVSKGSTFLPVKWMAPESIFDNLYTTLSDVWSYGILLWEIF  888
         ************************************************************
S: 284   slGstpypgllvdskfyklikeGyrmaqpayateeiyeimqkcweaepekrpsfkqlvel  343
         slG+tpypg++vds+fy++ik+Gyrma+p++at+eiyeim+kcw++epekrpsf++l e+
Q: 889   SLGGTPYPGMMVDSTFYNKIKSGYRMAKPDHATSEIYEIMVKCWNSEPEKRPSFYHLREI  948
         ********************************************************9887
S: 344   l  344
         +
Q: 949   V  949
         5
Domain Sequence
(FASTA)
LVLGRILGSG AFGKVVEGTA YGLSRSQPVM KVAVKMLKPT ARSSEKQALM SELKIMTHLG 60
PHLNIVNLLG ACTKSGPIYI ITEYCFYGDL VNYLHKNRDS FLSHHPEKPK KELDIFGLNP 120
TDESTRSYVV LSFENNGDYM DMKQADTTQY VPMLERKEVS KYSDIQRSLY DRPASYKKKS 180
MLDSEVKNLL SDDNAEGLTL LDLLSFTYQV ARGMEFLASK NCVHRDLAAR NVLLAQGKIV 240
KICDFGLARD IMHDSNYVSK GSTFLPVKWM APESIFDNLY TTLSDVWSYG ILLWEIFSLG 300
GTPYPGMMVD STFYNKIKSG YRMAKPDHAT SEIYEIMVKC WNSEPEKRPS FYHLREIV 358
KeywordATP-binding; Complete proteome; Disulfide bond; Immunoglobulin domain; Kinase; Membrane; Nucleotide-binding; Phosphoprotein; Receptor; Reference proteome; Repeat; Transferase; Transmembrane; Transmembrane helix; Tyrosine-protein kinase.
Sequence SourceEnsembl
Orthology
Ortholog group
Ailuropoda melanoleuca"; ?>Anolis carolinensis"; ?>Bos taurus"; ?>Callithrix jacchus"; ?>Canis familiaris"; ?>Cavia porcellus"; ?>Equus caballus"; ?>Felis catus"; ?>Gallus gallus"; ?>Gasterosteus aculeatus"; ?>Gorilla gorilla"; ?>Homo sapiens"; ?>Ictidomys tridecemlineatus"; ?>Latimeria chalumnae"; ?>Loxodonta africana"; ?>Macaca mulatta"; ?>Meleagris gallopavo"; ?>Monodelphis domestica"; ?>Mus musculus"; ?>Mustela putorius furo"; ?>Nomascus leucogenys"; ?>Ochotona princeps"; ?>Oreochromis niloticus"; ?>Ornithorhynchus anatinus"; ?>Oryctolagus cuniculus"; ?>Oryzias latipes"; ?>Otolemur garnettii"; ?>Pan troglodytes"; ?>Pelodiscus sinensis"; ?>Pongo abelii"; ?>Rattus norvegicus"; ?>Sarcophilus harrisii"; ?>Taeniopygia guttata"; ?>Takifugu rubripes"; ?>Tetraodon nigroviridis"; ?>Tursiops truncatus"; ?>Xenopus tropicalis"; ?>
EKS-AIM-00373
EKS-ANC-00388
EKS-BOT-00401
EKS-CAJ-00405
EKS-CAF-00401
EKS-CAP-00430
EKS-EQC-00393
EKS-FEC-00385
EKS-GAG-00339
EKS-GAA-00490
EKS-GOG-00393
EKS-HOS-00407
EKS-ICT-00380
EKS-LAC-00417
EKS-LOA-00410
EKS-MAM-00400
EKS-MEG-00333
EKS-MOD-00390
EKS-MUM-00433
EKS-MUP-00395
EKS-NOL-00366
EKS-OCP-00085
EKS-ORN-00512
EKS-ORA-00350
EKS-ORC-00376
EKS-ORL-00470
EKS-OTG-00403
EKS-PAT-00380
EKS-PES-00356
EKS-POA-00392
EKS-RAN-00416
EKS-SAH-00370
EKS-TAG-00476
EKS-TAR-00508
EKS-TEN-00509
EKS-TUT-00117
EKS-XET-00512
Gene Ontology
GO:0005887; C:integral to plasma membrane
GO:0005524; F:ATP binding
GO:0005021; F:vascular endothelial growth factor-activated receptor activity
GO:0048010; P:vascular endothelial growth factor receptor signaling pathway
GO:0038084; P:vascular endothelial growth factor signaling pathway
KEGG
InterPros
IPR007110; Ig-like.
IPR013783; Ig-like_fold.
IPR013098; Ig_I-set.
IPR003599; Ig_sub.
IPR011009; Kinase-like_dom.
IPR000719; Prot_kinase_cat_dom.
IPR017441; Protein_kinase_ATP_BS.
IPR001245; Ser-Thr/Tyr_kinase_cat_dom.
IPR008266; Tyr_kinase_AS.
IPR020635; Tyr_kinase_cat_dom.
IPR016243; Tyr_kinase_CSF1/PDGF_rcpt.
IPR001824; Tyr_kinase_rcpt_3_CS.
IPR009134; Tyr_kinase_VEGFR_rcpt_N.
Pfam
PF07679; I-set; 1.
PF07714; Pkinase_Tyr; 1.
SMARTs
SM00409; IG; 3.
SM00219; TyrKc; 1.
Prosites
PS50835; IG_LIKE; 2.
PS00107; PROTEIN_KINASE_ATP; 1.
PS50011; PROTEIN_KINASE_DOM; 1.
PS00109; PROTEIN_KINASE_TYR; 1.
PS00240; RECEPTOR_TYR_KIN_III; 1.
Prints
PR01832; VEGFRECEPTOR.
Created Date20-Feb-2013