EKS-MYL-00244

Eukaryotic Protein Kinase & Protein Phosphatase Database

Tag

Content

EKPD ID

EKS-MYL-00244

Classification

Group/Family	Score	E-Value	Start	End	Domain Length
CAMK/CAMKL	332.5	1.5E-99	60	311	252

Status

Unreviewed

Ensembl Protein

ENSMLUP00000006306

UniProt Accession

G1P831;

Protein Name

Protein Synonyms/Alias

Gene Name

NUAK1

Gene Synonyms/Alias

NUAK1;

Ensembl Information

Ensembl Gene ID	Ensembl Protein ID	Ensembl Transcript ID
ENSMLUG00000006906	ENSMLUP00000006306	ENSMLUT00000006902

Organism

Myotis lucifugus

Functional Description

Protein Length

666

Protein Sequence
(FASTA)

MEGAAAPRPE TAPTWGRGRQ VSPPEAVAGA TAAPAAAAPE PRKPHGVKRH HHKHNLKHRY 60

ELQETLGKGT YGKVKRATER FSGRVVAIKS IRKDKIKDEQ DMVHIRREIE IMSSLNHPHI 120

ISIYEVFENK DKIVIIMEYA SKGELYDFIS ERRRLSERET RHFFRQIVSA VHYCHKNGVV 180

HRDLKLENIL LDDNCNIKIA DFGLSNLYQK DKFLQTFCGS PLYASPEIVN GRPYRGPEVD 240

SWALGVLLYT LVYGTMPFDG FDHKNLIRQI SSGEYREPTQ PSDARGLIRW MLMVNPDRRA 300

TIEDIANHWW VNWGYKSSVC DCDALPNSES PLLARIIDWH HRSTGLQAEA EAKMKNLTKP 360

GASEVMLERQ RSLKKSKKEN DFAQSGQDSV PESPSKLSSK RPKGILKKRS NSEHRSHSTG 420

FIEGVVSPAL PPAFKMEQDL CRTGVPLPSS PEAEVPGKLS PKQAATMPKK GILKKTQQRE 480

SGYYSSPERS ESSELLDSND GMGSSIPSPS PPDTARVTVH SLSCRRKGIL KHSSKYSAGT 540

MDPALASPEM PTLESLLEPS VSSEGLSRSY SRPSSIISDD SVLSSDSFDL LDLQENRPAR 600

QRIRSCVSAE NFLQIQDFEG LQNRPRPQYP KRYRNRLGDS SFSLLTDMDD VTQVYKKALE 660

ICNKLN 666

Nucleotide Sequence
(FASTA)

ATGGAGGGGG CCGCTGCGCC GCGGCCCGAG ACGGCCCCGA CTTGGGGCCG GGGGCGCCAG 60

GTTTCTCCCC CGGAGGCGGT GGCGGGGGCG ACCGCAGCCC CGGCAGCGGC GGCCCCGGAG 120

CCCAGGAAGC CGCACGGGGT GAAGCGGCAT CACCACAAGC ACAACTTGAA GCACCGCTAC 180

GAGCTGCAGG AGACGCTGGG CAAAGGCACC TACGGCAAAG TCAAGAGGGC CACCGAGAGG 240

TTCTCGGGCC GAGTGGTTGC TATAAAATCC ATTCGTAAGG ACAAAATTAA GGATGAACAA 300

GACATGGTTC ACATCAGACG AGAGATTGAG ATTATGTCAT CCCTCAACCA TCCTCATATC 360

ATCAGTATTT ATGAAGTGTT TGAGAACAAA GATAAGATTG TGATCATCAT GGAATACGCC 420

AGCAAAGGGG AGCTGTATGA TTTCATCAGC GAGCGGAGAC GCCTCAGCGA GAGGGAGACC 480

AGGCACTTCT TCCGGCAGAT CGTCTCCGCC GTTCACTATT GTCACAAGAA CGGTGTGGTC 540

CACCGGGACT TGAAGCTGGA AAATATACTG CTCGATGACA ACTGCAATAT TAAGATTGCT 600

GACTTTGGGC TTTCCAACCT GTACCAGAAG GACAAGTTCT TGCAAACGTT TTGTGGGAGC 660

CCACTCTATG CGTCTCCTGA AATTGTCAAT GGGAGGCCTT ACCGAGGGCC AGAGGTGGAC 720

AGCTGGGCCC TGGGCGTGTT GCTTTACACC CTGGTTTATG GAACAATGCC CTTCGATGGT 780

TTCGATCACA AAAACCTCAT TCGGCAGATC AGCAGCGGAG AGTACCGGGA GCCCACGCAG 840

CCCTCAGATG CTCGAGGACT CATCCGGTGG ATGCTGATGG TGAACCCCGA TCGCCGGGCC 900

ACCATCGAGG ACATCGCCAA CCACTGGTGG GTGAACTGGG GCTACAAGAG CAGCGTCTGT 960

GACTGCGATG CCCTCCCCAA CTCCGAGTCG CCGCTCCTGG CCCGGATTAT CGACTGGCAC 1020

CACCGGTCCA CGGGGCTGCA GGCCGAGGCG GAAGCCAAAA TGAAGAACCT GACGAAGCCG 1080

GGGGCCTCGG AGGTCATGCT GGAGCGGCAG CGGTCGCTGA AGAAGTCCAA GAAAGAGAAC 1140

GACTTTGCCC AGTCCGGCCA GGACTCGGTG CCCGAGAGTC CATCCAAACT GAGCTCCAAG 1200

AGACCCAAAG GGATCCTGAA GAAGCGAAGC AACAGCGAGC ATCGCTCTCA CAGCACCGGC 1260

TTCATCGAAG GCGTCGTCAG TCCTGCCTTA CCCCCTGCTT TCAAGATGGA GCAGGACCTG 1320

TGCCGGACTG GCGTGCCCCT CCCGAGCTCC CCCGAGGCAG AGGTGCCAGG TAAACTCAGC 1380

CCCAAGCAGG CGGCCACCAT GCCCAAGAAA GGCATCTTGA AAAAGACGCA GCAGAGGGAA 1440

TCGGGTTACT ACTCCTCCCC GGAGCGCAGC GAGTCCTCGG AGCTGTTGGA CAGCAACGAT 1500

GGGATGGGCA GCAGCATCCC GTCCCCCAGC CCCCCGGACA CAGCCAGGGT GACTGTCCAC 1560

AGCCTGTCCT GCCGCAGGAA GGGCATCTTG AAACACAGCA GCAAGTACTC CGCAGGCACC 1620

ATGGACCCGG CCCTCGCCAG CCCCGAAATG CCCACACTGG AATCCTTGCT GGAGCCCAGC 1680

GTCTCCTCCG AGGGCCTCTC CCGGAGCTAC AGCCGGCCTT CCAGCATCAT CAGTGATGAC 1740

AGTGTCCTGT CCAGCGACTC CTTTGACTTG CTGGATTTGC AGGAGAATCG CCCCGCCCGC 1800

CAGCGCATCC GCAGCTGTGT CTCGGCGGAA AACTTCCTCC AGATCCAGGA CTTTGAGGGG 1860

CTCCAGAACC GGCCCCGGCC TCAGTACCCG AAGCGGTACC GGAACCGGCT GGGAGACAGC 1920

AGCTTCTCCC TCCTCACGGA CATGGATGAC GTGACTCAGG TCTACAAGAA AGCGCTGGAG 1980

ATCTGCAACA AACTCAACTA G 2001

Domain Profile

S: 1     ykllktlGegsfgkVklakhketkekvavKiikkkkl.seeslekikrEieilkklkhpn  59

         y+l++tlG+g++gkVk a+++  ++ va+K i+k+k+ +e+ + +i+rEiei+++l+hp+

Q: 60    YELQETLGKGTYGKVKRATERFSGRVVAIKSIRKDKIkDEQDMVHIRREIEIMSSLNHPH  119

         99**********************************95667788****************

S: 60    iikllevietkkklylvleyasggeLfdyieekgrlkekearklfkqlvsavkYlhskgi  119

         ii+++ev+e+k+k+++++eyas+geL+d i+e++rl+e+e+r++f+q+vsav+Y+h++g+

Q: 120   IISIYEVFENKDKIVIIMEYASKGELYDFISERRRLSERETRHFFRQIVSAVHYCHKNGV  179

         ************************************************************

S: 120   vHrDlKpeNllldkkenikiaDFGlanlfkegklletfcGsppYaaPellkgkkYegpkv  179

         vHrDlK+eN+lld++ nikiaDFGl+nl++++k l+tfcGsp Ya+Pe+++g++Y+gp+v

Q: 180   VHRDLKLENILLDDNCNIKIADFGLSNLYQKDKFLQTFCGSPLYASPEIVNGRPYRGPEV  239

         ************************************************************

S: 180   DvWslGvvLyalvtgklPfdeenlkellekilkgkleipkklskelesLlrklLvvdpek  239

         D W+lGv+Ly+lv+g++Pfd+ + k+l ++i++g+++ p++  ++++ L+r +L+v+p++

Q: 240   DSWALGVLLYTLVYGTMPFDGFDHKNLIRQISSGEYREPTQ-PSDARGLIRWMLMVNPDR  298

         ***************************************99.7789**************

S: 240   Ratieeilkhewl  252

         Ratie+i +h w+

Q: 299   RATIEDIANHWWV  311

         ************6

Domain Sequence
(FASTA)

YELQETLGKG TYGKVKRATE RFSGRVVAIK SIRKDKIKDE QDMVHIRREI EIMSSLNHPH 60

IISIYEVFEN KDKIVIIMEY ASKGELYDFI SERRRLSERE TRHFFRQIVS AVHYCHKNGV 120

VHRDLKLENI LLDDNCNIKI ADFGLSNLYQ KDKFLQTFCG SPLYASPEIV NGRPYRGPEV 180

DSWALGVLLY TLVYGTMPFD GFDHKNLIRQ ISSGEYREPT QPSDARGLIR WMLMVNPDRR 240

ATIEDIANHW WV 252

Keyword

ATP-binding; Complete proteome; Nucleotide-binding; Reference proteome.

Sequence Source

Ensembl

Orthology

Ortholog group

Ailuropoda melanoleuca"; ?>Anolis carolinensis"; ?>Bos taurus"; ?>Caenorhabditis elegans"; ?>Callithrix jacchus"; ?>Canis familiaris"; ?>Cavia porcellus"; ?>Ciona intestinalis"; ?>Ciona savignyi"; ?>Danio rerio"; ?>Dipodomys ordii"; ?>Drosophila melanogaster"; ?>Equus caballus"; ?>Felis catus"; ?>Gadus morhua"; ?>Gallus gallus"; ?>Gasterosteus aculeatus"; ?>Gorilla gorilla"; ?>Homo sapiens"; ?>Ictidomys tridecemlineatus"; ?>Latimeria chalumnae"; ?>Loxodonta africana"; ?>Macaca mulatta"; ?>Meleagris gallopavo"; ?>Monodelphis domestica"; ?>Mus musculus"; ?>Mustela putorius furo"; ?>Nomascus leucogenys"; ?>Ochotona princeps"; ?>Oreochromis niloticus"; ?>Ornithorhynchus anatinus"; ?>Oryctolagus cuniculus"; ?>Oryzias latipes"; ?>Otolemur garnettii"; ?>Pan troglodytes"; ?>Pelodiscus sinensis"; ?>Pongo abelii"; ?>Procavia capensis"; ?>Pteropus vampyrus"; ?>Rattus norvegicus"; ?>Sarcophilus harrisii"; ?>Sus scrofa"; ?>Taeniopygia guttata"; ?>Takifugu rubripes"; ?>Tetraodon nigroviridis"; ?>Tursiops truncatus"; ?>Xenopus tropicalis"; ?>Xiphophorus maculatus"; ?>

Gene Ontology

GO:0005524	; F:ATP binding
GO:0004674	; F:protein serine/threonine kinase activity

KEGG

InterPros

IPR011009	; Kinase-like_dom.
IPR000719	; Prot_kinase_cat_dom.
IPR017441	; Protein_kinase_ATP_BS.
IPR002290	; Ser/Thr_dual-sp_kinase_dom.
IPR008271	; Ser/Thr_kinase_AS.

Pfam

PF00069

; Pkinase; 1.

SMARTs

SM00220

; S_TKc; 1.

Prosites

PS00107	; PROTEIN_KINASE_ATP; 1.
PS50011	; PROTEIN_KINASE_DOM; 1.
PS00108	; PROTEIN_KINASE_ST; 1.

Prints

Created Date

20-Feb-2013