EKS-MYL-00179

Eukaryotic Protein Kinase & Protein Phosphatase Database

Tag

Content

EKPD ID

EKS-MYL-00179

Classification

Group/Family	Score	E-Value	Start	End	Domain Length
AGC/PKC	471.8	6.3E-142	271	531	261

Status

Unreviewed

Ensembl Protein

ENSMLUP00000006464

UniProt Accession

G1P8G3;

Protein Name

Protein Synonyms/Alias

Gene Name

PRKCE

Gene Synonyms/Alias

PRKCE;

Ensembl Information

Ensembl Gene ID	Ensembl Protein ID	Ensembl Transcript ID
ENSMLUG00000007061	ENSMLUP00000006464	ENSMLUT00000007078

Organism

Myotis lucifugus

Functional Description

Protein Length

600

Protein Sequence
(FASTA)

APKDNEERVF RERMRPRKRQ GAVRRRVHQV NGHKFMATYL RQPTYCSHCR DFIWGVIGKQ 60

GYQCQVCTCV VHKRCHELII TKCAGLKKQE TPDEVGSQRF SVNMPHKFSI HNYKVPTFCD 120

HCGSLLWGLL RQGLQCKVCK MNVHRRCETN VAPNCGVDAR GIAKVLADLG VTPDKITNSG 180

QRRKKLLAGA ESPQPASGGS PSEEDRSKSA PTSPCDQELK ELENNIRKAL SFDNRGEEHR 240

AAGSTDGQLA SPGENGEVRQ GQTKRLGLDE FNFIKVLGKG SFGKVMLAEL KGKDEVYAVK 300

VLKKDVILQD DDVDCTMTEK RILALARKHP YLTQLYCCFQ TKDRLFFVME YVNGGDLMFQ 360

IQRSRKFDEP RSRFYAAEVT SALMFLHQHG VIYRDLKLDN ILLDAEGHCK LADFGMCKEG 420

ILNGVTTTTF CGTPDYIAPE ILQELEYGPS VDWWALGVLM YEMMAGQPPF EADNEDDLFE 480

SILHDDVLYP VWLSKEAVSI LKAFMTKNPH KRLGCVAAQN GEDAIKQHPF FKEIDWVLLE 540

QKKIKPPFKP RIKTKRDVNN FDQDFTREEP VLTLVDEAIV KQINQEEFKG FSYFGEDLMP 600

Nucleotide Sequence
(FASTA)

GCCCCTAAAG ACAATGAAGA GCGCGTGTTC AGGGAGCGCA TGCGGCCCAG GAAGCGGCAA 60

GGGGCCGTCA GGCGCAGGGT CCACCAGGTC AACGGCCACA AGTTCATGGC CACCTACCTT 120

CGGCAGCCCA CCTACTGCTC CCACTGCAGG GATTTTATCT GGGGTGTCAT AGGAAAGCAG 180

GGATACCAAT GTCAAGTGTG CACTTGCGTG GTCCACAAGC GATGCCATGA GCTCATCATC 240

ACGAAGTGTG CTGGATTAAA GAAACAGGAA ACTCCCGACG AGGTGGGCTC CCAGCGGTTC 300

AGCGTCAACA TGCCCCACAA GTTCAGTATC CACAACTACA AGGTCCCCAC CTTCTGCGAC 360

CACTGTGGGT CCCTGCTCTG GGGCCTCTTG CGGCAGGGCC TGCAGTGTAA AGTCTGCAAG 420

ATGAACGTCC ACCGACGCTG CGAGACCAAC GTGGCTCCCA ACTGTGGAGT GGACGCCAGA 480

GGAATCGCCA AAGTCCTGGC AGACCTTGGC GTCACCCCAG ACAAAATCAC CAACAGTGGC 540

CAGAGGAGGA AAAAGCTCCT TGCTGGTGCC GAGTCCCCGC AGCCCGCTTC TGGAGGCTCA 600

CCCTCTGAGG AAGACCGGTC CAAGTCAGCA CCCACCTCCC CTTGTGACCA GGAATTAAAA 660

GAACTTGAAA ACAACATCCG GAAGGCCTTG TCATTTGACA ACCGAGGGGA GGAGCACAGG 720

GCAGCAGGGT CCACCGACGG CCAGCTGGCG AGCCCCGGAG AGAACGGTGA AGTCCGGCAA 780

GGCCAGACCA AGCGCTTGGG CCTGGACGAG TTCAACTTCA TCAAAGTGTT GGGCAAAGGC 840

AGCTTTGGCA AGGTCATGTT GGCGGAGCTC AAAGGCAAAG ACGAAGTATA TGCTGTGAAA 900

GTCTTAAAGA AGGACGTCAT CCTTCAGGAC GACGATGTGG ACTGCACGAT GACAGAGAAG 960

AGGATTTTGG CTCTAGCGCG GAAACACCCG TACCTAACCC AACTCTATTG CTGCTTCCAA 1020

ACCAAGGACC GCCTCTTTTT CGTCATGGAG TATGTCAATG GTGGAGACCT CATGTTCCAG 1080

ATTCAGCGCT CCCGAAAATT CGACGAGCCT CGTTCCCGGT TCTATGCTGC AGAGGTTACG 1140

TCAGCCCTCA TGTTCCTCCA CCAGCATGGA GTCATCTACA GGGATTTGAA ACTGGACAAC 1200

ATCCTTCTGG ATGCAGAAGG TCACTGCAAG CTGGCCGACT TTGGGATGTG CAAGGAAGGG 1260

ATTCTGAACG GTGTGACGAC GACCACGTTC TGTGGGACGC CTGACTACAT CGCTCCCGAG 1320

ATCCTGCAGG AGTTGGAGTA CGGCCCCTCT GTGGACTGGT GGGCGCTGGG GGTGCTGATG 1380

TATGAGATGA TGGCTGGGCA GCCCCCCTTC GAGGCCGACA ACGAGGACGA CCTGTTTGAG 1440

TCCATCCTCC ACGACGACGT GCTCTACCCC GTCTGGCTCA GTAAGGAGGC CGTCAGCATC 1500

CTGAAAGCTT TCATGACCAA GAACCCCCAC AAGCGCCTGG GCTGTGTGGC AGCACAGAAT 1560

GGCGAGGACG CCATCAAGCA GCACCCGTTC TTCAAGGAGA TCGACTGGGT GCTCCTGGAG 1620

CAGAAGAAGA TCAAGCCACC CTTCAAACCT CGAATTAAAA CCAAAAGAGA CGTCAATAAC 1680

TTTGACCAAG ACTTTACCCG GGAAGAGCCA GTACTCACGC TTGTGGATGA AGCAATTGTG 1740

AAGCAGATCA ACCAGGAGGA ATTCAAAGGT TTCTCCTACT TTGGTGAAGA CCTAATGCCC 1800

TGA 1803

Domain Profile

S: 1     fellkvlGkGsfgkvllaelkktdelyaikvlkkdvvlqdddveltlvekrvlalaskkp  60

         f+++kvlGkGsfgkv+laelk++de+ya+kvlkkdv+lqdddv++t++ekr+lala+k+p

Q: 271   FNFIKVLGKGSFGKVMLAELKGKDEVYAVKVLKKDVILQDDDVDCTMTEKRILALARKHP  330

         99**********************************************************

S: 61    flvqlfscfqtedrlffvleyvnGGdlmfhiqkarklkeerarfyaaeiilalkflhekg  120

         +l+ql++cfqt+drlffv+eyvnGGdlmf+iq++rk++e+r+rfyaae+++al+flh++g

Q: 331   YLTQLYCCFQTKDRLFFVMEYVNGGDLMFQIQRSRKFDEPRSRFYAAEVTSALMFLHQHG  390

         ************************************************************

S: 121   iiyrdlkldnvlldaeGhikladfGlckeeilegkttstfcGtPdyiaPeilkeeeygks  180

         +iyrdlkldn+lldaeGh+kladfG+cke+il+g tt+tfcGtPdyiaPeil+e eyg s

Q: 391   VIYRDLKLDNILLDAEGHCKLADFGMCKEGILNGVTTTTFCGTPDYIAPEILQELEYGPS  450

         ************************************************************

S: 181   vdwwalGvllyemlagqsPfegededelfesilekevlyPkslskeaveilkglltkdpe  240

         vdwwalGvl+yem+agq+Pfe+++ed+lfesil+++vlyP++lskeav+ilk+++tk+p+

Q: 451   VDWWALGVLMYEMMAGQPPFEADNEDDLFESILHDDVLYPVWLSKEAVSILKAFMTKNPH  510

         ************************************************************

S: 241   krlGv..keegeedikehaff  259

         krlG+  +++ge++ik+h+ff

Q: 511   KRLGCvaAQNGEDAIKQHPFF  531

         *****6449***********9

Domain Sequence
(FASTA)

FNFIKVLGKG SFGKVMLAEL KGKDEVYAVK VLKKDVILQD DDVDCTMTEK RILALARKHP 60

YLTQLYCCFQ TKDRLFFVME YVNGGDLMFQ IQRSRKFDEP RSRFYAAEVT SALMFLHQHG 120

VIYRDLKLDN ILLDAEGHCK LADFGMCKEG ILNGVTTTTF CGTPDYIAPE ILQELEYGPS 180

VDWWALGVLM YEMMAGQPPF EADNEDDLFE SILHDDVLYP VWLSKEAVSI LKAFMTKNPH 240

KRLGCVAAQN GEDAIKQHPF F 261

Keyword

ATP-binding; Complete proteome; Kinase; Metal-binding; Nucleotide-binding; Reference proteome; Serine/threonine-protein kinase; Transferase; Zinc; Zinc-finger.

Sequence Source

Ensembl

Orthology

Ortholog group

Ailuropoda melanoleuca"; ?>Anolis carolinensis"; ?>Bos taurus"; ?>Caenorhabditis elegans"; ?>Callithrix jacchus"; ?>Canis familiaris"; ?>Cavia porcellus"; ?>Ciona savignyi"; ?>Danio rerio"; ?>Drosophila melanogaster"; ?>Felis catus"; ?>Gallus gallus"; ?>Gasterosteus aculeatus"; ?>Gorilla gorilla"; ?>Homo sapiens"; ?>Ictidomys tridecemlineatus"; ?>Loxodonta africana"; ?>Macaca mulatta"; ?>Meleagris gallopavo"; ?>Microcebus murinus"; ?>Mus musculus"; ?>Mustela putorius furo"; ?>Nomascus leucogenys"; ?>Oreochromis niloticus"; ?>Oryctolagus cuniculus"; ?>Oryzias latipes"; ?>Otolemur garnettii"; ?>Pan troglodytes"; ?>Pelodiscus sinensis"; ?>Petromyzon marinus"; ?>Pongo abelii"; ?>Rattus norvegicus"; ?>Sus scrofa"; ?>Taeniopygia guttata"; ?>Takifugu rubripes"; ?>Tarsius syrichta"; ?>Tetraodon nigroviridis"; ?>Xenopus tropicalis"; ?>Xiphophorus maculatus"; ?>Saccharomyces cerevisiae"; ?>Schizosaccharomyces pombe"; ?>

Gene Ontology

GO:0005622	; C:intracellular
GO:0005524	; F:ATP binding
GO:0046872	; F:metal ion binding
GO:0004697	; F:protein kinase C activity
GO:0035556	; P:intracellular signal transduction

KEGG

InterPros

IPR000961	; AGC-kinase_C.
IPR020454	; DAG/PE-bd.
IPR011009	; Kinase-like_dom.
IPR017892	; Pkinase_C.
IPR014376	; Prot_kin_PKC_delta.
IPR002219	; Prot_Kinase_C-like_PE/DAG-bd.
IPR000719	; Prot_kinase_cat_dom.
IPR017441	; Protein_kinase_ATP_BS.
IPR002290	; Ser/Thr_dual-sp_kinase_dom.
IPR008271	; Ser/Thr_kinase_AS.

Pfam

PF00130	; C1_1; 2.
PF00069	; Pkinase; 1.
PF00433	; Pkinase_C; 1.

SMARTs

SM00109	; C1; 2.
SM00133	; S_TK_X; 1.
SM00220	; S_TKc; 1.

Prosites

PS51285	; AGC_KINASE_CTER; 1.
PS00107	; PROTEIN_KINASE_ATP; 1.
PS50011	; PROTEIN_KINASE_DOM; 1.
PS00108	; PROTEIN_KINASE_ST; 1.
PS00479	; ZF_DAG_PE_1; 2.
PS50081	; ZF_DAG_PE_2; 2.

Prints

PR00008

; DAGPEDOMAIN.

Created Date

20-Feb-2013