EKS-MYL-00238

Eukaryotic Protein Kinase & Protein Phosphatase Database

Tag

Content

EKPD ID

EKS-MYL-00238

Classification

Group/Family	Score	E-Value	Start	End	Domain Length
TK/Abl	552.3	1.4E-166	215	466	252

Status

Unreviewed

Ensembl Protein

ENSMLUP00000006579

UniProt Accession

G1P8R6;

Protein Name

Protein Synonyms/Alias

Gene Name

ABL2

Gene Synonyms/Alias

ABL2;

Ensembl Information

Ensembl Gene ID	Ensembl Protein ID	Ensembl Transcript ID
ENSMLUG00000007200	ENSMLUP00000006579	ENSMLUT00000007211

Organism

Myotis lucifugus

Functional Description

Protein Length

1109

Protein Sequence
(FASTA)

EALHRPYGCD VEPQALNEAI RWSSKENLLG ATESDPNLFV ALYDFVASGD NTLSITKGEK 60

LRVLGYNQNG EWSEVRSKNG QGWVPSNYIT PVNSLEKHSW YHGPVSRSAA EYLLSSLING 120

SFLVRESESS PGQLSISLRY EGRVYHYRIN TTTDGKVYVT AESRFSTLAE LVHHHSTVAD 180

GLVTTLHYPA PKCNKPTVYG VSPIHDKWEM ERTDITMKHK LGGGQYGEVY VGVWKKYSLT 240

VAVKTLKEDT MEVEEFLKEA AVMKEIKHPN LVQLLGVCTL EPPFYIVTEY MPYGNLLDYL 300

RECNREEVTA VVLLYMATQI SSAMEYLEKK NFIHRDLAAR NCLVGENHVV KVADFGLSRL 360

MTGDTYTAHA GAKFPIKWTA PESLAYNTFS IKSDVWAFGV LLWEIATYGM SPYPGIDLSQ 420

VYDLLEKGYR MEQPEGCPPK VYELMRACWK WSPADRPSFA ETHQAFETMF HDSSISEEVA 480

EELGRAAAAS SVVPYLPRLP ILPSKTRTLK KQVENKENIE GSLDAPDNSA SSSAPGFIRS 540

AQVPSGSPAL PRKQRDKSPS SLLEDAKETC FTRDRKGGFF SSFMKKRNAP TPPKRSSSFR 600

EMENQPHKKY ELTGNFSSVA SLQHADGFSF TPAQQEANLV PPKCYGGSFA QRNLCNDDGG 660

GGGGSGTAGG GWSGITGFFT PRLIKKTLGL RAGKPTASDD TSKPFPRSNS TSSMSSGLPE 720

QDRMAMTLPR NCQRSKIQLE RTVSTSSQPE ESVDRANDTP PKKSEEGAAP TRERPKAKLL 780

PRGTTALPLR SPSGDPAITE KDCPGVGAAG VAAAPKSKER NGGARLGMAG VPEDGEQTGW 840

ASPAKVAAML PTTHNHKVPV LISPTLKHTP ADVQLIGTDS QGNKFKLLSE HQVTSSGDKD 900

RPRRVKPKCA PPPPPVMRLL QHPSVCSDPT EEPAAPAAGQ PTSETQEGGK KAAPGAVPTS 960

GKAGRPVVPP PQVPLPTSSI SPAKMANGTA GTKVALRKTK QAAEKISADK ISKEALLECA 1020

DLLSSAISEP VPNSQLVDTG HQLLDYCSGY VDCIPQTRNK FAFREAVSKL ELSLQELQVS 1080

SATAGVPGAN PVLNNLLSCV QEISDVVQR 1109

Nucleotide Sequence
(FASTA)

GAAGCCTTGC ACCGCCCCTA TGGTTGTGAT GTTGAACCCC AAGCACTGAA CGAGGCCATC 60

AGGTGGAGCT CCAAGGAAAA CTTGCTGGGA GCCACTGAGA GTGATCCTAA TCTCTTTGTT 120

GCACTTTATG ATTTTGTAGC AAGTGGTGAT AACACACTCA GCATCACTAA AGGTGAAAAG 180

CTACGAGTCC TTGGTTACAA TCAGAATGGT GAGTGGAGTG AAGTTCGCTC TAAGAATGGC 240

CAAGGTTGGG TGCCAAGCAA CTACATCACC CCAGTAAACA GTCTGGAAAA ACATTCCTGG 300

TACCACGGAC CTGTGTCACG CAGTGCAGCT GAGTATCTAC TCAGCAGTTT AATCAATGGC 360

AGTTTCCTGG TGCGAGAAAG TGAGAGCAGC CCCGGGCAGC TGTCCATTTC GCTCAGGTAC 420

GAGGGGCGCG TGTATCACTA CAGGATCAAT ACCACCACAG ATGGCAAGGT ATATGTGACC 480

GCTGAGAGCC GCTTCAGCAC CTTAGCAGAG CTTGTCCACC ATCACTCTAC AGTGGCTGAT 540

GGGCTGGTGA CAACATTGCA CTACCCCGCA CCCAAGTGTA ACAAGCCTAC AGTTTACGGT 600

GTGTCCCCCA TCCATGACAA ATGGGAAATG GAACGAACAG ATATTACCAT GAAGCACAAG 660

CTTGGGGGTG GTCAGTATGG AGAGGTTTAC GTTGGCGTCT GGAAGAAATA CAGCCTGACG 720

GTTGCTGTGA AAACATTGAA GGAAGATACC ATGGAGGTGG AGGAGTTCCT GAAAGAAGCT 780

GCAGTGATGA AGGAAATCAA ACATCCTAAT CTGGTACAGC TATTAGGTGT GTGTACTTTG 840

GAGCCACCAT TTTACATTGT GACTGAATAC ATGCCATATG GGAATCTCCT TGATTATCTC 900

CGAGAATGCA ACCGAGAAGA GGTGACTGCA GTTGTACTGC TTTACATGGC CACTCAGATA 960

TCTTCGGCAA TGGAATATTT AGAGAAGAAG AATTTCATCC ATAGAGATCT TGCAGCTCGG 1020

AACTGCCTAG TGGGAGAAAA CCATGTGGTA AAAGTGGCTG ACTTCGGCTT AAGTAGATTG 1080

ATGACTGGAG ACACCTACAC TGCTCATGCT GGAGCCAAGT TTCCTATTAA ATGGACAGCA 1140

CCAGAGAGCC TTGCCTACAA TACCTTCTCA ATTAAATCTG ATGTCTGGGC TTTTGGGGTA 1200

CTGTTGTGGG AAATTGCTAC CTATGGAATG TCACCATATC CAGGTATTGA CCTGTCTCAG 1260

GTCTATGATC TACTGGAAAA GGGATATCGA ATGGAACAGC CTGAAGGATG CCCCCCTAAG 1320

GTTTATGAAC TTATGAGAGC ATGCTGGAAG TGGAGCCCTG CTGACAGGCC CTCTTTTGCT 1380

GAAACACATC AAGCTTTTGA AACCATGTTC CATGACTCCA GCATTTCCGA AGAGGTAGCT 1440

GAGGAGCTTG GGAGGGCCGC CGCCGCCTCA TCTGTCGTCC CCTACCTGCC CCGATTACCT 1500

ATTCTTCCTT CCAAGACCCG GACACTGAAG AAACAGGTGG AGAACAAGGA GAATATCGAA 1560

GGGTCCCTAG ATGCCCCCGA CAATTCTGCT TCCAGTTCAG CACCAGGGTT CATTAGAAGT 1620

GCACAGGTCC CCAGTGGGTC CCCAGCACTG CCTCGAAAAC AAAGAGACAA GTCACCCAGC 1680

AGCCTCTTGG AAGATGCTAA AGAGACGTGC TTCACCAGGG ATAGGAAGGG AGGCTTCTTC 1740

AGCTCCTTCA TGAAAAAGAG AAATGCTCCC ACACCCCCCA AACGCAGCAG CTCCTTCCGA 1800

GAAATGGAGA ATCAGCCCCA CAAGAAATAT GAACTCACGG GTAACTTCTC ATCTGTTGCT 1860

TCTCTACAGC ATGCTGATGG GTTCTCTTTC ACTCCTGCCC AGCAAGAGGC GAATCTGGTG 1920

CCCCCCAAGT GCTATGGGGG GAGCTTTGCA CAGAGGAACC TCTGTAATGA CGACGGTGGC 1980

GGGGGTGGGG GCAGTGGCAC TGCGGGGGGT GGGTGGTCTG GCATCACAGG CTTCTTTACA 2040

CCACGTTTAA TCAAAAAGAC ACTGGGCTTA CGAGCAGGTA AACCCACAGC CAGTGATGAC 2100

ACTTCCAAGC CTTTTCCAAG GTCAAACTCT ACATCTTCCA TGTCCTCAGG GCTTCCAGAG 2160

CAGGATAGGA TGGCAATGAC CCTTCCCAGG AACTGCCAGA GGTCCAAAAT CCAGCTGGAA 2220

AGGACAGTGT CCACCTCTTC TCAGCCAGAA GAGAGTGTGG ACAGGGCCAA TGACACACCT 2280

CCCAAAAAGT CAGAGGAAGG TGCTGCTCCA ACCAGGGAGA GACCAAAAGC CAAACTTTTG 2340

CCCAGAGGAA CCACAGCTCT TCCCCTAAGA AGCCCCTCTG GGGATCCAGC CATTACAGAG 2400

AAGGACTGTC CAGGGGTGGG GGCAGCTGGA GTGGCAGCTG CCCCAAAGAG CAAGGAGAGG 2460

AATGGTGGGG CACGACTTGG CATGGCTGGA GTCCCAGAGG ATGGCGAGCA GACAGGCTGG 2520

GCTTCTCCAG CCAAGGTTGC GGCCATGCTC CCCACCACAC ACAACCACAA AGTGCCCGTC 2580

CTCATCTCCC CCACTCTGAA GCACACTCCA GCCGACGTGC AGCTCATTGG CACAGACTCT 2640

CAGGGGAACA AATTCAAGCT CTTATCTGAG CATCAGGTCA CATCCTCTGG AGACAAAGAC 2700

CGACCCCGAC GGGTAAAACC AAAGTGTGCC CCACCCCCAC CACCAGTGAT GAGACTACTG 2760

CAGCATCCGT CCGTGTGCTC AGACCCCACG GAAGAGCCGG CGGCCCCGGC TGCCGGACAG 2820

CCCACATCAG AAACACAGGA AGGAGGGAAA AAGGCAGCTC CAGGGGCAGT GCCCACCAGT 2880

GGGAAAGCTG GGAGGCCTGT GGTGCCTCCA CCTCAAGTGC CTCTGCCCAC ATCTTCCATC 2940

TCGCCAGCCA AAATGGCCAA CGGCACAGCA GGTACTAAAG TGGCTCTGAG GAAAACCAAA 3000

CAGGCAGCTG AGAAAATCTC CGCAGACAAA ATCAGCAAAG AGGCCCTGCT GGAATGTGCT 3060

GATCTGTTGT CCAGTGCCAT CTCAGAACCA GTGCCCAACA GCCAGCTGGT GGACACTGGG 3120

CACCAGCTGC TTGACTACTG CTCAGGCTAC GTGGACTGCA TCCCTCAAAC TCGCAACAAG 3180

TTTGCCTTCA GAGAGGCCGT GAGCAAACTG GAACTCAGCC TGCAGGAGCT GCAGGTGTCT 3240

TCAGCCACTG CGGGCGTGCC TGGGGCAAAT CCTGTCCTTA ATAACTTACT ATCGTGTGTA 3300

CAGGAAATCA GCGATGTGGT GCAGAGGTAG 3330

Domain Profile

S: 1     iimkhklgggqygevyegvwkkysltvavktlkedtmeveeflkeaavmkelkhpnlvql  60

         i+mkhklgggqygevy+gvwkkysltvavktlkedtmeveeflkeaavmke+khpnlvql

Q: 215   ITMKHKLGGGQYGEVYVGVWKKYSLTVAVKTLKEDTMEVEEFLKEAAVMKEIKHPNLVQL  274

         89**********************************************************

S: 61    lgvctreppfyiitefmsygnlldylreadreeveavvllymatqissameylekknfih  120

         lgvct eppfyi+te+m+ygnlldylre++reev+avvllymatqissameylekknfih

Q: 275   LGVCTLEPPFYIVTEYMPYGNLLDYLRECNREEVTAVVLLYMATQISSAMEYLEKKNFIH  334

         ************************************************************

S: 121   rdlaarnclvgenklvkvadfglsrlmkedtytahagakfpikwtapeslaynkfsiksd  180

         rdlaarnclvgen++vkvadfglsrlm++dtytahagakfpikwtapeslayn+fsiksd

Q: 335   RDLAARNCLVGENHVVKVADFGLSRLMTGDTYTAHAGAKFPIKWTAPESLAYNTFSIKSD  394

         ************************************************************

S: 181   vwafgvllweiatygmspypgidlsqvyellekgyrmerpegcppkvyelmracwkwsps  240

         vwafgvllweiatygmspypgidlsqvy+llekgyrme+pegcppkvyelmracwkwsp+

Q: 395   VWAFGVLLWEIATYGMSPYPGIDLSQVYDLLEKGYRMEQPEGCPPKVYELMRACWKWSPA  454

         ************************************************************

S: 241   drpsfaeihqal  252

         drpsfae+hqa+

Q: 455   DRPSFAETHQAF  466

         *********986

Domain Sequence
(FASTA)

ITMKHKLGGG QYGEVYVGVW KKYSLTVAVK TLKEDTMEVE EFLKEAAVMK EIKHPNLVQL 60

LGVCTLEPPF YIVTEYMPYG NLLDYLRECN REEVTAVVLL YMATQISSAM EYLEKKNFIH 120

RDLAARNCLV GENHVVKVAD FGLSRLMTGD TYTAHAGAKF PIKWTAPESL AYNTFSIKSD 180

VWAFGVLLWE IATYGMSPYP GIDLSQVYDL LEKGYRMEQP EGCPPKVYEL MRACWKWSPA 240

DRPSFAETHQ AF 252

Keyword

ATP-binding; Complete proteome; Kinase; Nucleotide-binding; Reference proteome; SH3 domain; Transferase; Tyrosine-protein kinase.

Sequence Source

Ensembl

Orthology

Ortholog group

Ailuropoda melanoleuca"; ?>Anolis carolinensis"; ?>Bos taurus"; ?>Callithrix jacchus"; ?>Canis familiaris"; ?>Cavia porcellus"; ?>Danio rerio"; ?>Equus caballus"; ?>Felis catus"; ?>Gallus gallus"; ?>Gorilla gorilla"; ?>Homo sapiens"; ?>Ictidomys tridecemlineatus"; ?>Latimeria chalumnae"; ?>Loxodonta africana"; ?>Macaca mulatta"; ?>Meleagris gallopavo"; ?>Monodelphis domestica"; ?>Mus musculus"; ?>Mustela putorius furo"; ?>Nomascus leucogenys"; ?>Oreochromis niloticus"; ?>Ornithorhynchus anatinus"; ?>Oryctolagus cuniculus"; ?>Oryzias latipes"; ?>Otolemur garnettii"; ?>Pan troglodytes"; ?>Pelodiscus sinensis"; ?>Pongo abelii"; ?>Rattus norvegicus"; ?>Sarcophilus harrisii"; ?>Sus scrofa"; ?>Taeniopygia guttata"; ?>Tetraodon nigroviridis"; ?>Tursiops truncatus"; ?>Xenopus tropicalis"; ?>Xiphophorus maculatus"; ?>

Gene Ontology

GO:0005524	; F:ATP binding
GO:0004715	; F:non-membrane spanning protein tyrosine kinase activity

KEGG

InterPros

IPR015015	; F-actin_binding.
IPR011009	; Kinase-like_dom.
IPR000719	; Prot_kinase_cat_dom.
IPR017441	; Protein_kinase_ATP_BS.
IPR001245	; Ser-Thr/Tyr_kinase_cat_dom.
IPR000980	; SH2.
IPR001452	; SH3_domain.
IPR008266	; Tyr_kinase_AS.
IPR020635	; Tyr_kinase_cat_dom.

Pfam

PF08919	; F_actin_bind; 1.
PF07714	; Pkinase_Tyr; 1.
PF00017	; SH2; 1.
PF00018	; SH3_1; 1.

SMARTs

SM00808	; FABD; 1.
SM00252	; SH2; 1.
SM00326	; SH3; 1.
SM00219	; TyrKc; 1.

Prosites

PS00107	; PROTEIN_KINASE_ATP; 1.
PS50011	; PROTEIN_KINASE_DOM; 1.
PS00109	; PROTEIN_KINASE_TYR; 1.
PS50001	; SH2; 1.
PS50002	; SH3; 1.

Prints

PR00401	; SH2DOMAIN.
PR00109	; TYRKINASE.

Created Date

20-Feb-2013