EKS-MYL-00249

Eukaryotic Protein Kinase & Protein Phosphatase Database

Tag

Content

EKPD ID

EKS-MYL-00249

Classification

Group/Family	Score	E-Value	Start	End	Domain Length
CAMK/CAMKL	317.5	5.7E-95	11	263	253

Status

Unreviewed

Ensembl Protein

ENSMLUP00000006621

UniProt Accession

G1P8V3;

Protein Name

Protein Synonyms/Alias

Gene Name

MELK

Gene Synonyms/Alias

MELK;

Ensembl Information

Ensembl Gene ID	Ensembl Protein ID	Ensembl Transcript ID
ENSMLUG00000007244	ENSMLUP00000006621	ENSMLUT00000007256

Organism

Myotis lucifugus

Functional Description

Protein Length

651

Protein Sequence
(FASTA)

MKDYDELLKY YEIYETIGTG GFAKVKLACH ILTGEMVAIK IMDKNALGSD LPRVKTEIDA 60

LKNLRHQHIC QLYHVLETTN KIFMVLEYCP GGELFDYIIS QDRLSEEETR VVFRQIVSAV 120

AYMHSQGYAH RDLKPENLLF DEYHKIKLID FGLCAKPKGN KDYHLQTCCG SLAYAAPELI 180

QGKSYLGSEA DVWSMGILLY VLMCGFLPFD DDNVMVLYKK IMKGKYEVPK WLSPSSILLL 240

QQMLQVDPKK RISVKNLLNH PWIMQDYNCP VEWQSKNPLI HLDEDCITEL SVHHKNNRQT 300

MEDLISLWQY DHLTATYLLL LAKKARGKPV RLRLPPFSWG QVSGTPFTNV KSKNLSLEDM 360

TTSDENYVAG LIDYEWYEDN SSTGVATPQT PQFAKHWTES NGLESKSLTP VSCKASANKL 420

KNKENIYTPK SAVKNEDGFV LPEPKTPVNK NQHKREILTT PNHYTTPSKV RNQCLEETPI 480

KMPVNSAGTE KLMTGVISPE RRCRSVELDL NQAHVEDTPK RKGTKVFGSL ERGLDKVITV 540

FTRSKRKGCA KDGPRRLKLH YNVTTTRLVN PDQLLNEIMS ILPKKHVDFV RKGYTLKCQT 600

QSDFGKVTMQ FELEVCQLQK PDVVGIRRQR LKGDAWVYKR LVEDILSSCK V 651

Nucleotide Sequence
(FASTA)

ATGAAAGATT ATGATGAGCT TCTCAAATAC TATGAAATAT ATGAAACTAT TGGGACAGGT 60

GGCTTTGCAA AGGTCAAACT TGCCTGCCAT ATCCTTACTG GAGAAATGGT AGCTATAAAA 120

ATCATGGATA AAAATGCACT GGGGAGTGAT TTGCCCCGGG TCAAAACAGA GATTGATGCC 180

TTGAAGAACC TGAGACATCA GCATATATGT CAACTCTACC ATGTGTTGGA GACAACCAAC 240

AAAATATTCA TGGTTCTTGA GTATTGCCCT GGAGGAGAGC TGTTTGACTA CATAATTTCC 300

CAGGATCGCC TGTCGGAGGA GGAGACCCGT GTCGTCTTCC GTCAGATCGT TTCTGCAGTT 360

GCTTACATGC ACAGCCAGGG CTATGCTCAC AGGGACCTCA AACCGGAAAA TTTGTTGTTT 420

GATGAATATC ATAAAATAAA GCTGATTGAC TTTGGTCTCT GTGCGAAACC CAAGGGTAAC 480

AAGGACTACC ATCTACAGAC ATGCTGTGGG AGTCTGGCTT ATGCAGCACC CGAATTAATA 540

CAAGGCAAAT CGTATTTGGG ATCAGAGGCA GATGTTTGGA GCATGGGCAT ACTCTTATAT 600

GTACTTATGT GTGGCTTTCT ACCATTTGAT GATGATAATG TTATGGTTTT GTACAAGAAG 660

ATTATGAAAG GGAAATATGA GGTTCCTAAG TGGCTCTCTC CCAGTAGCAT TCTGCTTCTT 720

CAACAAATGC TACAGGTGGA CCCAAAGAAA CGGATTTCTG TGAAAAATCT ATTGAACCAT 780

CCCTGGATCA TGCAAGATTA CAACTGTCCT GTTGAGTGGC AAAGCAAGAA TCCTCTTATT 840

CACCTTGATG AAGATTGTAT AACAGAACTT TCTGTACATC ATAAAAACAA CAGGCAGACA 900

ATGGAGGATT TAATTTCATT GTGGCAATAT GATCATCTCA CAGCTACCTA TCTTCTGCTT 960

CTAGCCAAGA AGGCTCGGGG GAAACCAGTT CGTTTAAGGC TTCCTCCTTT TTCCTGGGGA 1020

CAAGTCAGTG GTACCCCATT CACAAACGTC AAGTCAAAGA ACCTGAGTTT AGAAGATATG 1080

ACCACAAGTG ATGAAAATTA TGTGGCTGGA TTAATAGACT ATGAGTGGTA TGAAGACAAT 1140

TCATCAACAG GTGTGGCTAC TCCCCAAACA CCACAGTTTG CCAAGCATTG GACAGAATCA 1200

AACGGTTTGG AATCTAAATC ATTAACTCCA GTTTCATGCA AAGCATCTGC CAATAAATTA 1260

AAGAACAAAG AGAATATATA TACTCCCAAG TCTGCTGTAA AGAATGAAGA TGGCTTTGTA 1320

CTTCCAGAGC CAAAGACTCC AGTTAATAAG AACCAGCATA AAAGAGAAAT ACTCACTACA 1380

CCAAATCATT ACACTACACC CTCGAAAGTT AGAAACCAGT GCCTGGAGGA AACCCCAATT 1440

AAAATGCCAG TAAATTCCGC AGGAACAGAG AAGTTAATGA CAGGTGTCAT TAGCCCTGAG 1500

AGGCGGTGTC GCTCAGTGGA ACTGGATCTC AACCAAGCAC ATGTAGAGGA CACTCCAAAA 1560

AGAAAAGGAA CCAAAGTGTT TGGGAGCCTT GAAAGGGGCT TGGATAAGGT TATTACTGTG 1620

TTTACCAGGA GCAAAAGGAA GGGCTGTGCC AAAGATGGAC CGAGAAGATT AAAGCTTCAC 1680

TATAATGTGA CTACAACCAG ATTGGTGAAT CCAGATCAGC TCTTGAATGA AATAATGTCT 1740

ATTCTTCCAA AGAAGCACGT TGACTTTGTG CGGAAGGGCT ATACACTGAA GTGTCAAACA 1800

CAGTCAGATT TTGGCAAAGT GACAATGCAG TTTGAACTAG AAGTATGCCA GCTTCAGAAA 1860

CCCGATGTGG TGGGTATCAG GAGGCAGCGG CTTAAGGGTG ATGCCTGGGT TTACAAGAGA 1920

TTAGTGGAAG ACATCCTGTC TAGCTGCAAG GTGTAA 1956

Domain Profile

S: 1     ykllktlGegsfgkVklakhketkekvavKiikkkklseeslekikrEieilkklkhpni  60

         y++ +t+G+g f+kVkla+h +t+e+va+Ki++k++l +  l ++k+Ei++lk+l+h++i

Q: 11    YEIYETIGTGGFAKVKLACHILTGEMVAIKIMDKNALGS-DLPRVKTEIDALKNLRHQHI  69

         99********************************88875.589*****************

S: 61    ikllevietkkklylvleyasggeLfdyieekgrlkekearklfkqlvsavkYlhskgiv  120

         ++l++v+et++k+++vley+ ggeLfdyi ++ rl+e+e+r +f+q+vsav Y+hs+g +

Q: 70    CQLYHVLETTNKIFMVLEYCPGGELFDYIISQDRLSEEETRVVFRQIVSAVAYMHSQGYA  129

         ************************************************************

S: 121   HrDlKpeNllldkkenikiaDFGlanlfkeg..klletfcGsppYaaPellkgkkYegpk  178

         HrDlKpeNll+d+ ++ik++DFGl+++ k +   +l+t+cGs++YaaPel++gk+Y g++

Q: 130   HRDLKPENLLFDEYHKIKLIDFGLCAKPKGNkdYHLQTCCGSLAYAAPELIQGKSYLGSE  189

         *************************9665443389*************************

S: 179   vDvWslGvvLyalvtgklPfdeenlkellekilkgkleipkklskelesLlrklLvvdpe  238

         +DvWs+G++Ly+l++g lPfd++n+  l++ki+kgk+e+pk+ls++ + Ll+++L+vdp+

Q: 190   ADVWSMGILLYVLMCGFLPFDDDNVMVLYKKIMKGKYEVPKWLSPSSILLLQQMLQVDPK  249

         ************************************************************

S: 239   kRatieeilkhewl  252

         kR++++++l+h+w+

Q: 250   KRISVKNLLNHPWI  263

         *************7

Domain Sequence
(FASTA)

YEIYETIGTG GFAKVKLACH ILTGEMVAIK IMDKNALGSD LPRVKTEIDA LKNLRHQHIC 60

QLYHVLETTN KIFMVLEYCP GGELFDYIIS QDRLSEEETR VVFRQIVSAV AYMHSQGYAH 120

RDLKPENLLF DEYHKIKLID FGLCAKPKGN KDYHLQTCCG SLAYAAPELI QGKSYLGSEA 180

DVWSMGILLY VLMCGFLPFD DDNVMVLYKK IMKGKYEVPK WLSPSSILLL QQMLQVDPKK 240

RISVKNLLNH PWI 253

Keyword

ATP-binding; Complete proteome; Nucleotide-binding; Reference proteome.

Sequence Source

Ensembl

Orthology

Ortholog group

Ailuropoda melanoleuca"; ?>Anolis carolinensis"; ?>Bos taurus"; ?>Caenorhabditis elegans"; ?>Callithrix jacchus"; ?>Canis familiaris"; ?>Cavia porcellus"; ?>Ciona intestinalis"; ?>Ciona savignyi"; ?>Danio rerio"; ?>Equus caballus"; ?>Felis catus"; ?>Gallus gallus"; ?>Gasterosteus aculeatus"; ?>Gorilla gorilla"; ?>Homo sapiens"; ?>Ictidomys tridecemlineatus"; ?>Latimeria chalumnae"; ?>Macaca mulatta"; ?>Meleagris gallopavo"; ?>Monodelphis domestica"; ?>Mus musculus"; ?>Mustela putorius furo"; ?>Nomascus leucogenys"; ?>Oreochromis niloticus"; ?>Ornithorhynchus anatinus"; ?>Oryctolagus cuniculus"; ?>Oryzias latipes"; ?>Otolemur garnettii"; ?>Pan troglodytes"; ?>Pelodiscus sinensis"; ?>Petromyzon marinus"; ?>Pongo abelii"; ?>Pteropus vampyrus"; ?>Rattus norvegicus"; ?>Sarcophilus harrisii"; ?>Sus scrofa"; ?>Taeniopygia guttata"; ?>Takifugu rubripes"; ?>Tarsius syrichta"; ?>Tetraodon nigroviridis"; ?>Xenopus tropicalis"; ?>Xiphophorus maculatus"; ?>

Gene Ontology

GO:0005524	; F:ATP binding
GO:0004674	; F:protein serine/threonine kinase activity

KEGG

InterPros

IPR001772	; Kinase-assoc_KA1.
IPR011009	; Kinase-like_dom.
IPR000719	; Prot_kinase_cat_dom.
IPR017441	; Protein_kinase_ATP_BS.
IPR002290	; Ser/Thr_dual-sp_kinase_dom.
IPR008271	; Ser/Thr_kinase_AS.

Pfam

PF02149	; KA1; 1.
PF00069	; Pkinase; 1.

SMARTs

SM00220

; S_TKc; 1.

Prosites

PS50032	; KA1; 1.
PS00107	; PROTEIN_KINASE_ATP; 1.
PS50011	; PROTEIN_KINASE_DOM; 1.
PS00108	; PROTEIN_KINASE_ST; 1.

Prints

Created Date

20-Feb-2013