EPS-MYL-00023

Eukaryotic Protein Kinase & Protein Phosphatase Database

Tag

Content

EKPD ID

EPS-MYL-00023

Classification

Group/Family	Score	E-Value	Start	End	Domain Length
PPM/PP2C	274.4	1.2E-81	23	286	264

Status

Unreviewed

Ensembl Protein

ENSMLUP00000006795

UniProt Accession

G1P9A3;

Protein Name

Protein Synonyms/Alias

Gene Name

PPM1A

Gene Synonyms/Alias

PPM1A;

Ensembl Information

Ensembl Gene ID	Ensembl Protein ID	Ensembl Transcript ID
ENSMLUG00000007446	ENSMLUP00000006795	ENSMLUT00000007446

Organism

Myotis lucifugus

Functional Description

Protein Length

379

Protein Sequence
(FASTA)

MGAFLDKPKM EKHNAQGQGN GLRYGLSSMQ GWRVEMEDAH TAVIGLPSGL ETWSFFAVYD 60

GHAGSQVAKY CCEHLLDHIT NNQDFKGSAG APSVENVKNG IRTGFLEIDE HMRVMSEKKH 120

GADRSGSTAV GVLISPHHTY FINCGDSRGL LCRNRKVYFF TQDHKPNNPL EKERIQNAGG 180

SVMIQRVNGS LAVSRALGDF DYKCVHGKGP TEQLVSPEPE VHDIERSEED DQFIILACDG 240

IWDVMGNEEL CDFVRSRISY YKKLEAQCTN SCTAQGSRDN MSVILICFPN APKVLPEAVK 300

KEAELDKYLE SRVEEIIKKQ GEGVPDLVHV MRTLASENIP SLPPGGELAS KRNIIEAVYN 360

RLNPYKNDDT DSTSTDDMW 379

Nucleotide Sequence
(FASTA)

ATGGGAGCAT TTTTAGACAA GCCAAAGATG GAAAAACATA ATGCCCAGGG GCAGGGTAAT 60

GGGTTGCGAT ATGGGCTAAG CAGCATGCAA GGCTGGCGAG TTGAAATGGA GGATGCACAT 120

ACAGCTGTGA TTGGTTTGCC AAGCGGACTT GAAACATGGT CATTCTTTGC TGTGTATGAT 180

GGGCATGCTG GTTCTCAGGT TGCCAAATAC TGTTGTGAGC ATTTGTTAGA TCACATCACC 240

AATAACCAGG ATTTTAAAGG GTCTGCAGGA GCACCTTCTG TTGAAAATGT AAAGAATGGA 300

ATCAGAACAG GTTTTCTGGA GATTGATGAA CACATGAGAG TTATGTCAGA GAAGAAACAT 360

GGTGCAGATA GAAGTGGGTC AACAGCTGTG GGTGTCTTAA TTTCTCCTCA CCATACTTAC 420

TTCATTAACT GTGGAGACTC GAGAGGTTTA CTTTGTAGGA ACAGAAAAGT TTATTTCTTC 480

ACACAAGATC ACAAACCAAA TAATCCGCTG GAAAAAGAAC GGATTCAGAA TGCAGGTGGC 540

TCTGTAATGA TTCAGCGTGT GAATGGCTCT CTGGCTGTAT CGAGGGCACT TGGGGACTTT 600

GATTACAAAT GTGTCCATGG AAAAGGTCCT ACAGAGCAGC TTGTCTCACC AGAGCCTGAA 660

GTCCATGATA TTGAAAGATC TGAAGAAGAT GATCAGTTCA TTATCCTTGC ATGTGATGGT 720

ATTTGGGATG TTATGGGAAA TGAAGAGCTC TGTGATTTTG TAAGATCCAG AATAAGCTAT 780

TATAAAAAAC TAGAGGCTCA ATGCACAAAT TCTTGCACAG CCCAGGGAAG TCGAGACAAC 840

ATGAGTGTGA TATTGATCTG TTTCCCAAAT GCACCCAAAG TATTGCCAGA AGCAGTGAAG 900

AAGGAGGCAG AGTTGGACAA GTACCTGGAA AGCAGAGTAG AAGAAATCAT AAAGAAGCAG 960

GGGGAAGGCG TCCCTGACTT AGTCCATGTG ATGCGCACAT TAGCAAGTGA GAACATCCCC 1020

AGCCTCCCAC CAGGAGGTGA ATTGGCAAGC AAGCGGAATA TAATTGAAGC CGTTTACAAT 1080

AGACTGAATC CTTACAAAAA TGATGACACT GACTCTACAT CGACTGATGA TATGTGGTAA 1140

Domain Profile

S: 2     lvgvvsvngrrnemedavtsspnflkspekkdrlaffgvyDGhggsevakfcseklheil  61

         ++g++s++g+r emeda+t++ ++ +     + ++ff+vyDGh+gs+vak+c e+l +++

Q: 23    RYGLSSMQGWRVEMEDAHTAVIGLPSGL---ETWSFFAVYDGHAGSQVAKYCCEHLLDHI  79

         69****************9855554444...45***************************

S: 62    aeele....sseseerkvkkalakaFlstdeelkvleeksldidksGstavvalikdskl  117

         +++ +    +++++ ++vk+ ++++Fl++de+++v++ek++  d+sGstav +li++ +

Q: 80    TNNQDfkgsAGAPSVENVKNGIRTGFLEIDEHMRVMSEKKHGADRSGSTAVGVLISPHHT  139

         ***9999999999***********************************************

S: 118   yvanvGdSravLcrngkavelssdHkpsredEleRieeaggsvilkdgaRvlGvLavsRa  177

         y++n+GdSr +Lcrn+k+   ++dHkp+++ E+eRi++aggsv+ +   Rv+G+LavsRa

Q: 140   YFINCGDSRGLLCRNRKVYFFTQDHKPNNPLEKERIQNAGGSVMIQ---RVNGSLAVSRA  196

         **********************************************...***********

S: 178   lGdlylk.........pyvtpePevtshrltsede.fliLasDGlwdvvsneeavslvrd  227

         lGd+++k         ++v+pePev+ +++++ed+ f+iLa+DG+wdv+ nee++++vr+

Q: 197   LGDFDYKcvhgkgpteQLVSPEPEVHDIERSEEDDqFIILACDGIWDVMGNEELCDFVRS  256

         ******************************999999************************

S: 228   vlekkeaeqeaakkLvklalargskdnvsaivv  260

         +++     ++   + ++ + a+gs+dn+s+i++

Q: 257   RIS---YYKKLEAQCTNSCTAQGSRDNMSVILI  286

         ***...666666677899**********99976

Domain Sequence
(FASTA)

RYGLSSMQGW RVEMEDAHTA VIGLPSGLET WSFFAVYDGH AGSQVAKYCC EHLLDHITNN 60

QDFKGSAGAP SVENVKNGIR TGFLEIDEHM RVMSEKKHGA DRSGSTAVGV LISPHHTYFI 120

NCGDSRGLLC RNRKVYFFTQ DHKPNNPLEK ERIQNAGGSV MIQRVNGSLA VSRALGDFDY 180

KCVHGKGPTE QLVSPEPEVH DIERSEEDDQ FIILACDGIW DVMGNEELCD FVRSRISYYK 240

KLEAQCTNSC TAQGSRDNMS VILI 264

Keyword

Complete proteome; Hydrolase; Magnesium; Metal-binding; Protein phosphatase; Reference proteome.

Sequence Source

Ensembl

Orthology

Ortholog group

Ailuropoda melanoleuca"; ?>Anolis carolinensis"; ?>Bos taurus"; ?>Callithrix jacchus"; ?>Canis familiaris"; ?>Cavia porcellus"; ?>Danio rerio"; ?>Dipodomys ordii"; ?>Echinops telfairi"; ?>Equus caballus"; ?>Erinaceus europaeus"; ?>Felis catus"; ?>Gadus morhua"; ?>Gallus gallus"; ?>Gasterosteus aculeatus"; ?>Gorilla gorilla"; ?>Homo sapiens"; ?>Ictidomys tridecemlineatus"; ?>Latimeria chalumnae"; ?>Loxodonta africana"; ?>Macaca mulatta"; ?>Meleagris gallopavo"; ?>Monodelphis domestica"; ?>Mus musculus"; ?>Mustela putorius furo"; ?>Nomascus leucogenys"; ?>Oreochromis niloticus"; ?>Ornithorhynchus anatinus"; ?>Oryctolagus cuniculus"; ?>Oryzias latipes"; ?>Otolemur garnettii"; ?>Pan troglodytes"; ?>Pelodiscus sinensis"; ?>Pongo abelii"; ?>Pteropus vampyrus"; ?>Rattus norvegicus"; ?>Sarcophilus harrisii"; ?>Sorex araneus"; ?>Sus scrofa"; ?>Taeniopygia guttata"; ?>Takifugu rubripes"; ?>Tarsius syrichta"; ?>Tetraodon nigroviridis"; ?>Tursiops truncatus"; ?>Vicugna pacos"; ?>Xenopus tropicalis"; ?>Xiphophorus maculatus"; ?>Schizosaccharomyces pombe"; ?>

Gene Ontology

GO:0000287	; F:magnesium ion binding
GO:0030145	; F:manganese ion binding
GO:0004722	; F:protein serine/threonine phosphatase activity
GO:0006470	; P:protein dephosphorylation

KEGG

InterPros

IPR001932	; PP2C-like.
IPR012911	; PP2C_C.
IPR000222	; PP2C_Mn2_Asp60_BS.
IPR015655	; Protein_Pase_2C.

Pfam

PF00481	; PP2C; 1.
PF07830	; PP2C_C; 1.

SMARTs

SM00331	; PP2C_SIG; 1.
SM00332	; PP2Cc; 1.

Prosites

PS01032

; PP2C; 1.

Prints

Created Date

20-Feb-2013