EKS-MYL-00031

Eukaryotic Protein Kinase & Protein Phosphatase Database

Tag

Content

EKPD ID

EKS-MYL-00031

Classification

Group/Family	Score	E-Value	Start	End	Domain Length
TK/Jak	349.4	1.5E-104	874	1146	273

Status

Unreviewed

Ensembl Protein

ENSMLUP00000007075

UniProt Accession

G1P9Z2;

Protein Name

Tyrosine-protein kinase

Protein Synonyms/Alias

Gene Name

JAK1

Gene Synonyms/Alias

JAK1;

Ensembl Information

Ensembl Gene ID	Ensembl Protein ID	Ensembl Transcript ID
ENSMLUG00000007723	ENSMLUP00000007075	ENSMLUT00000007748

Organism

Myotis lucifugus

Functional Description

Protein Length

1153

Protein Sequence
(FASTA)

MQYLNIKEDC NAMAFCAKMR SSKKTEVNLE APEPGVEVLF YLSDREPLRL GSGEYTAEEL 60

CIRAAQECCI SPLCHNLFAL YDESTKLWYA PNRSITVDDK TSLRLHYRMR FYFTNWHGTN 120

DNEQSVWRHS PKKQKNGYEK KKVPDATPLL DASSLEYLFA QGQYDLVKCL APIRDPKTEQ 180

DGHDIENECL GMAVLAISHY AMIKKMQLPE LPKDISYKRY IPETLNKSIR QRNLLTRMRI 240

NNVFKDFLKE FNNKTICDSS VSTHDLKVKY LATLETLTKH YGAEIFETSM LLISSENEMN 300

WLNPNDSGNV LYYEVMVTGN LGIQWRQKPN VVPVEKEKNK LKRKKLENKH KKDEEKNKIR 360

EEWNNFSYFP EITHIVIKES VVSINKQDNK KMELKLSSHE EALSFVSLVD GYFRLTADAH 420

HYLCTDVAPP LIVHNIQNGC HGPICTEYAI NKLRQEGSEE GMYVLRWSCT DFDNILMTVT 480

CFEKPEVLGG QKQFKNFQIE VQKGRYSLHG SDRGFPSLGE LMSHLKKQIL RTDNISFVLK 540

RCCQPKPREI SNLLVATKKA QEWQPVYPMS QLSFDRILKK DIMQGEHLGR GTRTHIYSGT 600

LMDYKDDEGT SEEKKIKVIL KVLDPSHRDI SLAFFEAASM MRQVSHKHIV YLYGVCVRDV 660

ENIMVEEFVE GGPLDLFMHR KSDVLTTPWK FKVAKQLASA LSYLEDKDLV HGNVCTKNLL 720

LAREGIDSEC GPFIKLSDPG IPITVLSRQE CIERIPWIAP ECVEDSKNLS VAADKWSFGT 780

TLWEICYNGE IPLKDKTLIE KERFYESRCR PVTPSCKELA DLMTRCMNYD PNQRPFFRAI 840

MRDINKLEEQ NPDIVSEKQP ATEVDPTHFE KRFLKRIRDL GEGHFGKVEL CRYDPEGDNT 900

GEQVAVKSLK PESGGNHIAD LKKEIEILRN LYHENIVKYK GICTEDGGNG IKLIMEFLPS 960

GSLKEYLPKN KNKINLKQQL KYAVQICKGM DYLGSRQYVH RDLAARNVLV ESEHQVKIGD 1020

FGLTKAIETD KEYYTVKDDR DSPVFWYAPE CLIQCKFYIA SDVWSFGVTL HELLTYCDSD 1080

SSPMALFLKM IGPTHGQMTV TRLVNTLKEG KRLPCPPNCP DEVYQLMRKC WEFQPNNRTT 1140

FQNLIEGFEA LLK 1153

Nucleotide Sequence
(FASTA)

ATGCAGTATC TAAATATAAA GGAGGACTGC AATGCCATGG CTTTCTGTGC TAAAATGCGG 60

AGCTCCAAGA AGACCGAGGT GAACCTGGAG GCCCCTGAGC CAGGGGTGGA AGTGCTCTTC 120

TATCTGTCGG ACAGGGAGCC CCTCCGGCTG GGCAGCGGGG AGTACACGGC GGAGGAGCTG 180

TGCATCAGGG CGGCGCAGGA GTGCTGTATC TCTCCCCTGT GCCACAACCT CTTTGCCCTG 240

TATGATGAGA GCACCAAGCT CTGGTATGCT CCAAATCGCA GCATTACTGT TGACGACAAG 300

ACATCGCTCC GGCTCCACTA CCGGATGAGG TTCTATTTTA CCAACTGGCA CGGGACTAAT 360

GATAATGAGC AGTCGGTATG GCGACATTCT CCAAAGAAGC AGAAAAATGG CTACGAGAAA 420

AAAAAAGTTC CAGATGCAAC CCCTCTCCTT GACGCCAGCT CTCTGGAGTA TCTGTTTGCC 480

CAGGGACAGT ATGATTTGGT CAAATGCCTG GCTCCCATCC GAGACCCCAA GACTGAGCAG 540

GATGGGCACG ACATTGAGAA CGAGTGCCTG GGCATGGCCG TACTGGCCAT CTCACACTAC 600

GCCATGATCA AGAAGATGCA GTTGCCAGAA CTCCCCAAGG ACATCAGCTA CAAGCGATAT 660

ATTCCAGAAA CATTGAATAA GTCCATCAGA CAGAGGAACC TTCTTACCAG GATGCGGATA 720

AATAATGTCT TCAAGGATTT CCTAAAGGAA TTTAACAACA AGACCATTTG TGACAGCAGC 780

GTGTCCACGC ATGACCTGAA GGTGAAATAC CTGGCGACCT TGGAAACTTT GACAAAACAT 840

TACGGTGCTG AAATATTTGA GACTTCCATG TTACTGATTT CATCGGAAAA TGAGATGAAT 900

TGGCTTAATC CGAATGACAG TGGAAATGTT CTCTACTATG AAGTGATGGT GACTGGAAAT 960

CTTGGAATCC AATGGAGGCA GAAACCAAAT GTGGTTCCTG TTGAAAAGGA AAAAAATAAA 1020

TTGAAACGGA AAAAACTGGA AAATAAACAC AAGAAGGACG AGGAGAAAAA CAAAATCCGA 1080

GAAGAGTGGA ACAATTTTTC GTACTTCCCT GAAATCACTC ACATTGTAAT AAAGGAGTCT 1140

GTGGTCAGCA TTAACAAGCA GGACAACAAA AAGATGGAAC TGAAGCTCTC TTCCCACGAG 1200

GAGGCCTTGT CTTTTGTGTC CCTGGTAGAT GGCTACTTTC GGCTCACAGC AGACGCCCAT 1260

CATTACCTCT GCACCGATGT GGCTCCTCCA TTGATAGTCC ACAACATACA GAATGGCTGT 1320

CACGGCCCAA TCTGCACAGA GTATGCCATC AATAAACTGC GGCAAGAAGG AAGCGAGGAG 1380

GGCATGTATG TGCTGCGGTG GAGCTGCACG GACTTTGACA ACATCCTCAT GACCGTCACC 1440

TGCTTTGAAA AGCCTGAGGT GCTGGGTGGC CAGAAACAGT TCAAGAACTT TCAGATCGAG 1500

GTGCAGAAGG GTCGCTACAG TCTGCACGGC TCGGACCGCG GCTTCCCCAG CCTGGGGGAG 1560

CTCATGAGCC ACCTCAAGAA GCAGATCCTG CGCACGGACA ACATCAGCTT CGTGTTGAAG 1620

CGCTGCTGCC AGCCCAAGCC CCGAGAAATC TCCAATCTGC TGGTGGCTAC GAAGAAAGCC 1680

CAGGAGTGGC AGCCAGTCTA CCCCATGAGT CAGCTGAGTT TCGATCGGAT CCTCAAGAAA 1740

GACATCATGC AAGGAGAGCA CCTTGGGAGA GGCACGCGGA CACACATCTA CTCTGGGACC 1800

CTGATGGATT ACAAGGATGA CGAAGGAACT TCTGAAGAGA AGAAAATAAA AGTGATCCTC 1860

AAAGTCTTGG ACCCCAGCCA CAGGGACATT TCTCTGGCCT TCTTCGAGGC AGCCAGCATG 1920

ATGAGACAGG TCTCCCACAA ACACATCGTG TACCTCTACG GTGTCTGTGT CCGAGACGTG 1980

GAGAATATCA TGGTGGAAGA GTTTGTGGAG GGCGGGCCTC TGGATCTCTT CATGCACCGG 2040

AAAAGCGACG TCCTCACCAC TCCGTGGAAA TTCAAAGTTG CTAAACAGCT GGCCAGTGCC 2100

CTGAGTTACT TGGAGGATAA AGACCTGGTC CACGGAAACG TGTGCACTAA AAACCTCCTC 2160

CTGGCCCGTG AAGGCATCGA CAGCGAGTGT GGCCCGTTCA TCAAGCTCAG TGACCCTGGC 2220

ATCCCCATCA CTGTGCTGTC CAGGCAAGAA TGCATAGAAC GAATCCCATG GATTGCTCCC 2280

GAGTGTGTAG AAGATTCCAA GAACCTGAGC GTGGCCGCTG ACAAATGGAG CTTTGGAACC 2340

ACACTCTGGG AAATCTGCTA TAATGGCGAG ATCCCCCTGA AAGATAAGAC ACTGATTGAG 2400

AAAGAGAGAT TCTACGAAAG CCGGTGCAGA CCAGTGACAC CGTCTTGTAA GGAGCTGGCT 2460

GACCTTATGA CTCGCTGCAT GAACTACGAC CCCAACCAGA GACCCTTTTT CCGAGCCATC 2520

ATGAGAGACA TCAATAAGCT GGAAGAGCAG AATCCAGACA TCGTTTCAGA GAAACAGCCA 2580

GCAACTGAAG TGGATCCCAC ACATTTTGAA AAGCGCTTCT TAAAGAGAAT CCGAGACTTG 2640

GGAGAGGGCC ACTTTGGGAA GGTTGAGCTC TGCAGGTATG ACCCTGAAGG GGACAATACA 2700

GGAGAGCAGG TGGCTGTCAA ATCCCTGAAG CCTGAGAGTG GAGGGAACCA CATAGCTGAT 2760

CTGAAGAAGG AAATTGAAAT CTTAAGGAAC CTCTATCACG AGAACATTGT CAAGTACAAA 2820

GGCATCTGCA CAGAGGATGG AGGAAATGGT ATTAAGCTCA TCATGGAATT TCTGCCTTCT 2880

GGAAGCCTTA AGGAATATCT TCCAAAGAAT AAGAACAAAA TTAACCTCAA ACAGCAGTTA 2940

AAATATGCTG TTCAGATTTG TAAGGGGATG GACTATTTGG GGTCACGACA GTATGTTCAC 3000

CGGGACTTAG CAGCAAGGAA TGTCCTTGTT GAAAGTGAGC ACCAAGTGAA AATTGGAGAC 3060

TTCGGTTTAA CTAAAGCAAT TGAAACCGAT AAGGAGTACT ACACAGTCAA GGATGACCGG 3120

GACAGCCCTG TGTTCTGGTA CGCCCCAGAA TGTCTGATTC AGTGTAAATT TTATATTGCC 3180

TCTGACGTCT GGTCCTTCGG AGTGACTCTG CACGAGCTGC TTACTTACTG TGATTCCGAT 3240

TCCAGTCCCA TGGCCTTGTT CCTGAAAATG ATAGGCCCCA CTCACGGCCA GATGACAGTA 3300

ACGAGACTTG TGAACACATT GAAAGAAGGA AAACGTTTGC CTTGTCCTCC CAACTGTCCA 3360

GATGAGGTTT ATCAACTTAT GAGAAAATGC TGGGAATTCC AACCAAATAA TCGGACAACC 3420

TTCCAGAACC TTATTGAAGG ATTTGAGGCA CTTTTAAAAT AA 3462

Domain Profile

S: 1     lkqiesLgkgtftkvfevredaegdsteeevalkvLk.esgedisrdfkreaeilsqlsh  59

         lk+i++Lg+g+f+kv+++r+d+egd+t+e+va+k Lk esg ++++d+k+e+eil++l+h

Q: 874   LKRIRDLGEGHFGKVELCRYDPEGDNTGEQVAVKSLKpESGGNHIADLKKEIEILRNLYH  933

         6899********************************************************

S: 60    ehivklkgvcvaegen..rlVmeyvesGsLdiyLrkkkealslsslldvakqlakameYL  117

         e+ivk+kg+c+++g n  +l+me+++sGsL++yL+k+k++++l+++l++a q++k+m+YL

Q: 934   ENIVKYKGICTEDGGNgiKLIMEFLPSGSLKEYLPKNKNKINLKQQLKYAVQICKGMDYL  993

         ************************************************************

S: 118   edkklvhrdvaarnvLveresnegtppfvklsdpglakavnqd.eYylvreerdsripwl  176

         +++++vhrd+aarnvLve+e++      vk++d+gl+ka+++d eYy+v+++rds+++w+

Q: 994   GSRQYVHRDLAARNVLVESEHQ------VKIGDFGLTKAIETDkEYYTVKDDRDSPVFWY  1047

         **********************......********************************

S: 177   apeclseaknlstasdvWsFgvtlyellt.cskgesp....lrsesle.......rklel  224

         apecl+++k +++asdvWsFgvtl+ellt c++++sp    l++++++       r++++

Q: 1048  APECLIQCK-FYIASDVWSFGVTLHELLTyCDSDSSPmalfLKMIGPThgqmtvtRLVNT  1106

         *********.*******************************9****999***********

S: 225   leekerlpkpk.cpaelaelmtnclsyepsqrpsFraile  263

         l+e++rlp+p+ cp+e+++lm++c++ +p++r++F++++e

Q: 1107  LKEGKRLPCPPnCPDEVYQLMRKCWEFQPNNRTTFQNLIE  1146

         *************************************987

Domain Sequence
(FASTA)

LKRIRDLGEG HFGKVELCRY DPEGDNTGEQ VAVKSLKPES GGNHIADLKK EIEILRNLYH 60

ENIVKYKGIC TEDGGNGIKL IMEFLPSGSL KEYLPKNKNK INLKQQLKYA VQICKGMDYL 120

GSRQYVHRDL AARNVLVESE HQVKIGDFGL TKAIETDKEY YTVKDDRDSP VFWYAPECLI 180

QCKFYIASDV WSFGVTLHEL LTYCDSDSSP MALFLKMIGP THGQMTVTRL VNTLKEGKRL 240

PCPPNCPDEV YQLMRKCWEF QPNNRTTFQN LIE 273

Keyword

ATP-binding; Complete proteome; Kinase; Nucleotide-binding; Phosphoprotein; Reference proteome; SH2 domain; Transferase; Tyrosine-protein kinase.

Sequence Source

Ensembl

Orthology

Ortholog group

Ailuropoda melanoleuca"; ?>Anolis carolinensis"; ?>Bos taurus"; ?>Callithrix jacchus"; ?>Canis familiaris"; ?>Cavia porcellus"; ?>Danio rerio"; ?>Equus caballus"; ?>Felis catus"; ?>Gallus gallus"; ?>Gasterosteus aculeatus"; ?>Gorilla gorilla"; ?>Homo sapiens"; ?>Ictidomys tridecemlineatus"; ?>Latimeria chalumnae"; ?>Loxodonta africana"; ?>Macaca mulatta"; ?>Meleagris gallopavo"; ?>Microcebus murinus"; ?>Mus musculus"; ?>Mustela putorius furo"; ?>Oreochromis niloticus"; ?>Oryctolagus cuniculus"; ?>Oryzias latipes"; ?>Otolemur garnettii"; ?>Pan troglodytes"; ?>Pelodiscus sinensis"; ?>Pongo abelii"; ?>Rattus norvegicus"; ?>Sarcophilus harrisii"; ?>Taeniopygia guttata"; ?>Takifugu rubripes"; ?>Tetraodon nigroviridis"; ?>Xenopus tropicalis"; ?>Xiphophorus maculatus"; ?>

Gene Ontology

GO:0005856	; C:cytoskeleton
GO:0016020	; C:membrane
GO:0005524	; F:ATP binding
GO:0004715	; F:non-membrane spanning protein tyrosine kinase activity
GO:0007243	; P:intracellular protein kinase cascade

KEGG

InterPros

IPR019749	; Band_41_domain.
IPR019748	; FERM_central.
IPR000299	; FERM_domain.
IPR011009	; Kinase-like_dom.
IPR000719	; Prot_kinase_cat_dom.
IPR017441	; Protein_kinase_ATP_BS.
IPR001245	; Ser-Thr/Tyr_kinase_cat_dom.
IPR000980	; SH2.
IPR008266	; Tyr_kinase_AS.
IPR020635	; Tyr_kinase_cat_dom.
IPR016251	; Tyr_kinase_non-rcpt_Jak/Tyk2.
IPR020776	; Tyr_kinase_non-rcpt_Jak1.

Pfam

PF07714

; Pkinase_Tyr; 2.

SMARTs

SM00295	; B41; 1.
SM00252	; SH2; 1.
SM00219	; TyrKc; 2.

Prosites

PS50057	; FERM_3; 1.
PS00107	; PROTEIN_KINASE_ATP; 1.
PS50011	; PROTEIN_KINASE_DOM; 2.
PS00109	; PROTEIN_KINASE_TYR; 1.
PS50001	; SH2; 1.

Prints

PR01823	; JANUSKINASE.
PR01824	; JANUSKINASE1.
PR00109	; TYRKINASE.

Created Date

20-Feb-2013