EKS-MYL-00133
Eukaryotic Protein Kinase & Protein Phosphatase Database
TagContent
EKPD IDEKS-MYL-00133
Classification
Group/FamilyScoreE-ValueStartEndDomain Length
TK/Met478.55.0E-14410791339261
StatusUnreviewed
Ensembl ProteinENSMLUP00000007213
UniProt AccessionG1PAA9;
Protein Name
Protein Synonyms/Alias
Gene NameMET
Gene Synonyms/Alias MET;
Ensembl Information
Ensembl Gene IDEnsembl Protein IDEnsembl Transcript ID
ENSMLUG00000007884ENSMLUP00000007213ENSMLUT00000007899
OrganismMyotis lucifugus
Functional Description
Protein Length1382
Protein Sequence
(FASTA)
MKAPTVLTPG ILVLLITLVR KSDGECKEAL VKSEMNVNMK YQLPNFTAET PIQNVVLHKH 60
HIYLGAINYM YVLNDKDLQK VAEYKTGPML EHPDCFPCQD CSHLANASGG VWKDNINMAL 120
LVDTYYDDQL ISCGSVRRGT CQRHMLPAYN TADIQSEVHC MYSPPTDEEP RQCPDCVVSA 180
LGTKVLMSEK QRFVNFFVGN TINSSYPPDY SLHSISVRRL KETQDGFKFL TDQSYIDVLP 240
EFRDSYPIKY VHAFESNHFI YFLTVQRETL NAQSFHTRII RFCSVDSGLH SYMEMPLECI 300
LTEKRRKRSP REEVFNILQA AYVSKPGAHL ARQIGANPDD DILYGVFAQS KPDSAEPMNR 360
SAVCAFPIKY VNEFFNKIVN KNNVRCLQHF YGPNHEHCFN RTLLRNSSGC EVHSDEYRTE 420
FTTALQRVDL FMGQFNQVLL TSISTFIKGE LTIANLGTSE GRFMQVVVSR SGSSTPHVNF 480
RLDSHPVSPE MIVAHPLDQN GYTLVVTGKR ITKIPLTGLG CEHFQSCSQC LSAPPFVQCG 540
WCHDKCARLE ECANGTWTQE LCHPTIYEVF PTSAPLEGGT TLTICGWDFG FRKNSKFDVK 600
KTRILLGNES CTLTLSESTT NMLKCTVGPA MNEHFNMSII ISNGRGTVQY STFSYVDPII 660
TSISPSYGPK TGGTLLTLTG KYLNSGNSRH VSIGGKTCTL KSVSDSILEC YTPAQNSPTE 720
FPVKLKIDLA NKVIDSFSYQ EDPIVYKIHP TKSFISGGST ITGVGKNLHS VSVLRMVISV 780
REAGRNFTVA CHHRSNSEII CCTTPSLQQL NLQLPLKTKA FFMLDGIHSK YFDLIYVHNP 840
IFKHFEKPVM ISIGNGNVVE IKGNDIDPEA VQGEVLKVGN KSCEKISSDS EAVLCTVPSD 900
LLKLNSELNI EWKQAVSSTV LGKVIVQPDQ NFTGLIVGGV TISTILLLLL GLFLWLKRRK 960
HIKDLGSEPV RYDPRVHTPH LDRLVSARSV SPTTEMVSHE SVDYRATFPE DHYPNSSQNG 1020
SCRQVQYPLM DLSPILTGGD SDISSPLLQD AVHIDLSALN PELVQAVQHV VIGPSNLIVH 1080
FNEVIGRGHF GCVYHGTLLD YDDKKIHCAV KSLNRITDIG EVSQFLTEGI IMKDFSHPNV 1140
LSLLGICLRS EGSPLVVLPY MKHGDLRNFI RNETHNPTVK DLIGFGLQVA KGMKYLASKK 1200
FVHRDLAARN CMLDEKFTVK VADFGLARDM YDKEYYSVHN KTGAKLPVKW MALESLQTQK 1260
FTTKSDVWSF GVLLWELMTR GAPPYPDVNT FDITVYLLQG RRLLQPEYCP DPLYEVMLKC 1320
WHPKAEMRPT FSELVSKISV IFSTFIGEHY VHVNSTYVNI NNGSPYPSLL SSQDNVDGEG 1380
DT 1382
Nucleotide Sequence
(FASTA)
ATGAAGGCCC CTACTGTGCT TACACCTGGC ATCCTTGTGC TTCTGATTAC CTTGGTGCGG 60
AAGAGTGATG GGGAGTGCAA GGAGGCACTA GTAAAGTCTG AGATGAATGT GAACATGAAG 120
TATCAGCTTC CCAACTTCAC AGCGGAAACG CCCATCCAGA ATGTGGTTTT ACACAAGCAT 180
CACATTTACC TCGGTGCCAT TAACTACATG TATGTTTTAA ATGACAAAGA CCTGCAGAAG 240
GTTGCTGAGT ACAAGACGGG GCCCATGCTG GAACACCCGG ATTGCTTCCC ATGTCAGGAT 300
TGCAGCCACC TAGCCAATGC TTCTGGTGGC GTTTGGAAAG ATAACATCAA CATGGCTCTG 360
CTTGTTGACA CGTACTATGA CGATCAGCTC ATTAGCTGTG GCAGCGTCCG CAGAGGGACC 420
TGCCAGCGGC ACATGCTTCC TGCCTACAAC ACTGCTGACA TACAGTCCGA GGTACATTGC 480
ATGTACTCTC CACCGACAGA TGAAGAGCCC AGACAGTGTC CTGACTGTGT GGTGAGTGCC 540
CTGGGAACCA AGGTCCTGAT GTCTGAAAAG CAACGGTTCG TCAACTTCTT TGTGGGCAAT 600
ACCATAAATT CTTCTTACCC TCCGGACTAT TCTTTGCATT CGATATCGGT GAGAAGGTTA 660
AAGGAAACTC AAGATGGTTT TAAGTTTCTG ACAGACCAGT CCTATATTGA TGTTCTACCT 720
GAATTCCGAG ATTCTTACCC CATCAAGTAT GTCCACGCCT TTGAAAGCAA CCATTTTATT 780
TACTTTTTGA CAGTCCAACG GGAAACACTC AATGCTCAGT CTTTTCACAC AAGAATAATC 840
AGGTTCTGTT CCGTAGACTC TGGGTTGCAT TCCTACATGG AAATGCCTCT GGAGTGTATT 900
CTCACGGAAA AGAGAAGAAA GCGATCCCCA AGGGAGGAGG TGTTTAATAT TCTTCAAGCT 960
GCCTATGTCA GTAAGCCTGG GGCCCATCTC GCTAGGCAGA TAGGCGCCAA CCCGGATGAT 1020
GACATTCTCT ATGGAGTGTT TGCACAAAGC AAGCCAGATT CTGCTGAACC AATGAATCGC 1080
TCTGCCGTCT GTGCATTCCC TATCAAGTAT GTCAATGAAT TCTTCAACAA GATCGTCAAC 1140
AAAAACAATG TGAGATGTCT TCAGCATTTT TATGGACCCA ACCATGAACA CTGCTTTAAT 1200
AGGACACTTT TGAGAAATTC ATCAGGCTGT GAAGTGCACA GTGATGAATA TCGAACGGAG 1260
TTTACTACAG CTTTGCAGCG CGTCGACTTA TTCATGGGCC AATTCAACCA AGTCCTCTTA 1320
ACATCCATAT CCACCTTCAT TAAAGGGGAG CTCACCATCG CTAACCTGGG GACCTCAGAA 1380
GGCCGCTTCA TGCAGGTTGT AGTTTCTCGA TCGGGATCGT CAACACCTCA TGTGAATTTT 1440
CGCCTGGATT CCCACCCCGT GTCTCCAGAA ATGATTGTGG CGCACCCATT GGACCAAAAC 1500
GGCTACACAT TGGTGGTCAC GGGGAAGAGG ATCACCAAGA TCCCACTGAC TGGCTTGGGC 1560
TGTGAGCATT TCCAGTCCTG CAGCCAGTGC CTCTCTGCCC CTCCCTTTGT GCAGTGTGGC 1620
TGGTGCCACG ACAAATGTGC GCGATTGGAG GAATGCGCCA ACGGAACGTG GACTCAAGAG 1680
CTCTGTCATC CTACAATCTA TGAGGTTTTC CCAACTAGTG CCCCTCTGGA AGGAGGGACA 1740
ACGCTGACCA TCTGTGGCTG GGACTTTGGA TTCAGGAAGA ATAGTAAATT TGATGTAAAG 1800
AAAACCAGAA TTCTCCTTGG AAATGAGAGC TGTACCTTGA CCCTAAGTGA GAGTACAACA 1860
AATATGTTAA AATGCACAGT TGGTCCTGCA ATGAATGAGC ATTTCAATAT GTCCATAATT 1920
ATTTCAAATG GTCGAGGGAC AGTGCAATAC AGTACATTTT CTTACGTGGA TCCTATAATA 1980
ACAAGTATTT CCCCAAGTTA TGGTCCTAAA ACTGGTGGCA CTTTACTTAC TTTAACTGGA 2040
AAATACCTAA ACAGTGGGAA TTCTAGACAC GTTTCAATTG GTGGAAAAAC CTGTACTTTA 2100
AAAAGTGTGT CAGATAGCAT TCTCGAATGT TATACCCCAG CCCAAAACTC TCCAACTGAG 2160
TTTCCTGTTA AATTGAAGAT TGACTTGGCC AACAAAGTGA TTGACAGCTT CAGTTACCAG 2220
GAAGACCCCA TTGTCTATAA AATTCATCCA ACCAAATCTT TTATTAGTGG TGGGAGCACA 2280
ATCACAGGTG TTGGGAAAAA CCTGCATTCG GTCAGTGTCC TGAGGATGGT AATCAGTGTG 2340
CGTGAAGCAG GAAGGAACTT CACGGTGGCA TGTCACCATC GCTCTAATTC AGAGATAATC 2400
TGCTGTACAA CGCCTTCACT ACAACAGCTG AATCTGCAAC TCCCCCTGAA AACTAAAGCC 2460
TTTTTCATGT TAGATGGGAT TCATTCCAAA TACTTCGATC TCATTTATGT ACATAATCCT 2520
ATCTTTAAGC ATTTTGAAAA GCCAGTGATG ATCTCAATAG GCAATGGAAA TGTAGTGGAA 2580
ATTAAGGGCA ATGACATTGA CCCCGAAGCA GTTCAGGGTG AAGTGTTAAA AGTCGGAAAC 2640
AAGAGCTGTG AGAAGATCTC CTCGGACTCT GAAGCTGTTT TATGTACGGT CCCCAGTGAC 2700
CTGCTGAAAC TGAACAGCGA GCTAAATATA GAGTGGAAGC AAGCAGTTTC TTCAACTGTC 2760
CTTGGAAAAG TGATCGTTCA ACCAGATCAG AATTTCACAG GATTGATTGT TGGTGGCGTC 2820
ACAATATCAA CAATACTCTT ACTATTGCTT GGGCTTTTCC TGTGGCTGAA AAGGAGGAAG 2880
CACATTAAAG ATCTGGGCAG TGAACCAGTT CGCTATGATC CAAGAGTACA CACTCCTCAT 2940
TTGGATAGGC TTGTAAGTGC CCGAAGTGTG AGCCCGACTA CAGAAATGGT TTCCCATGAA 3000
TCTGTAGACT ACCGAGCTAC TTTTCCGGAA GATCACTATC CTAACTCATC TCAGAACGGA 3060
TCATGCAGAC AAGTGCAATA TCCTCTGATG GACCTGTCCC CCATCCTCAC TGGTGGTGAC 3120
TCTGATATAT CCAGTCCATT ACTGCAAGAT GCTGTCCACA TTGACCTCAG TGCTCTAAAT 3180
CCAGAGCTGG TCCAGGCAGT CCAGCACGTG GTGATCGGGC CCAGCAACCT GATTGTGCAT 3240
TTCAATGAAG TCATAGGAAG GGGTCATTTT GGGTGTGTAT ATCATGGGAC TTTGTTGGAC 3300
TACGATGACA AGAAAATTCA TTGTGCTGTG AAATCCTTGA ATAGAATCAC GGATATAGGA 3360
GAAGTTTCCC AGTTTCTGAC TGAGGGGATC ATCATGAAGG ATTTTAGTCA TCCCAACGTG 3420
CTCTCGCTCC TGGGAATCTG CCTTCGAAGT GAGGGGTCTC CGCTGGTGGT CCTGCCGTAC 3480
ATGAAACACG GAGATCTTCG AAACTTCATC AGAAATGAGA CTCATAACCC AACTGTAAAA 3540
GATCTTATTG GCTTTGGTCT TCAAGTAGCC AAAGGCATGA AATACCTCGC AAGCAAAAAG 3600
TTTGTCCACA GAGACTTGGC TGCAAGGAAC TGTATGCTAG ATGAAAAATT CACTGTCAAG 3660
GTTGCTGATT TTGGTCTTGC CAGAGACATG TATGATAAAG AATACTACAG TGTACACAAC 3720
AAAACAGGTG CAAAACTGCC AGTGAAGTGG ATGGCTTTAG AAAGTCTTCA GACTCAGAAG 3780
TTTACCACCA AGTCAGATGT GTGGTCCTTT GGTGTGCTCC TCTGGGAACT GATGACAAGA 3840
GGGGCACCAC CCTACCCTGA CGTCAACACC TTTGATATAA CAGTTTACTT GTTGCAAGGC 3900
AGAAGGCTCT TACAACCCGA ATACTGCCCA GATCCCTTGT ATGAAGTGAT GCTAAAATGC 3960
TGGCATCCCA AAGCTGAAAT GCGCCCAACC TTTTCTGAAC TGGTCTCCAA GATATCAGTG 4020
ATATTCTCTA CTTTCATTGG GGAACACTAT GTCCATGTGA ATTCTACTTA TGTGAATATC 4080
AACAATGGTT CTCCATACCC CTCTCTGCTG TCATCTCAAG ATAACGTTGA TGGCGAGGGA 4140
GACACATGA 4149
Domain Profile
S: 1     vdkeeviGkGhfGvvykgelsdsaskkikvavksleritdiekveeflreglvmkeldhp  60
         v+++eviG+GhfG+vy+g+l+d ++kki++avksl+ritdi++v++fl+eg++mk+++hp
Q: 1079  VHFNEVIGRGHFGCVYHGTLLDYDDKKIHCAVKSLNRITDIGEVSQFLTEGIIMKDFSHP  1138
         799*********************************************************
S: 61    nvlsllGialddeglplvvlpymkkGdlksfirneernltvkdllefalqvakgmeylas  120
         nvlsllGi+l++eg+plvvlpymk+Gdl++firne++n+tvkdl++f+lqvakgm+ylas
Q: 1139  NVLSLLGICLRSEGSPLVVLPYMKHGDLRNFIRNETHNPTVKDLIGFGLQVAKGMKYLAS  1198
         ************************************************************
S: 121   kkfvhrdlaarnclldekltvkvadfGlardvldkelyvveeerdarlpvkwlaleslqt  180
         kkfvhrdlaarnc+ldek+tvkvadfGlard++dke+y+v+++++a+lpvkw+aleslqt
Q: 1199  KKFVHRDLAARNCMLDEKFTVKVADFGLARDMYDKEYYSVHNKTGAKLPVKWMALESLQT  1258
         ************************************************************
S: 181   fkqfttksdvwsfGvllwelltrgatpysevasfdltlylkegrrlrkpeycpdklydvm  240
         +k fttksdvwsfGvllwel+trga+py++v++fd+t+yl +grrl +peycpd ly+vm
Q: 1259  QK-FTTKSDVWSFGVLLWELMTRGAPPYPDVNTFDITVYLLQGRRLLQPEYCPDPLYEVM  1317
         **.*********************************************************
S: 241   lkcwkakpaerpqfsdlvsiis  262
         lkcw++k+++rp+fs+lvs+is
Q: 1318  LKCWHPKAEMRPTFSELVSKIS  1339
         *******************997
Domain Sequence
(FASTA)
VHFNEVIGRG HFGCVYHGTL LDYDDKKIHC AVKSLNRITD IGEVSQFLTE GIIMKDFSHP 60
NVLSLLGICL RSEGSPLVVL PYMKHGDLRN FIRNETHNPT VKDLIGFGLQ VAKGMKYLAS 120
KKFVHRDLAA RNCMLDEKFT VKVADFGLAR DMYDKEYYSV HNKTGAKLPV KWMALESLQT 180
QKFTTKSDVW SFGVLLWELM TRGAPPYPDV NTFDITVYLL QGRRLLQPEY CPDPLYEVML 240
KCWHPKAEMR PTFSELVSKI S 261
KeywordATP-binding; Complete proteome; Disulfide bond; Kinase; Membrane; Nucleotide-binding; Phosphoprotein; Receptor; Reference proteome; Transferase; Transmembrane; Transmembrane helix; Tyrosine-protein kinase.
Sequence SourceEnsembl
Orthology
Ortholog group
Ailuropoda melanoleuca"; ?>Anolis carolinensis"; ?>Bos taurus"; ?>Caenorhabditis elegans"; ?>Callithrix jacchus"; ?>Canis familiaris"; ?>Cavia porcellus"; ?>Ciona intestinalis"; ?>Ciona savignyi"; ?>Danio rerio"; ?>Equus caballus"; ?>Felis catus"; ?>Gallus gallus"; ?>Gasterosteus aculeatus"; ?>Gorilla gorilla"; ?>Homo sapiens"; ?>Ictidomys tridecemlineatus"; ?>Latimeria chalumnae"; ?>Loxodonta africana"; ?>Macaca mulatta"; ?>Meleagris gallopavo"; ?>Monodelphis domestica"; ?>Mus musculus"; ?>Mustela putorius furo"; ?>Nomascus leucogenys"; ?>Ochotona princeps"; ?>Oreochromis niloticus"; ?>Ornithorhynchus anatinus"; ?>Oryctolagus cuniculus"; ?>Oryzias latipes"; ?>Otolemur garnettii"; ?>Pan troglodytes"; ?>Pelodiscus sinensis"; ?>Petromyzon marinus"; ?>Pongo abelii"; ?>Rattus norvegicus"; ?>Sarcophilus harrisii"; ?>Sus scrofa"; ?>Taeniopygia guttata"; ?>Takifugu rubripes"; ?>Tetraodon nigroviridis"; ?>Vicugna pacos"; ?>Xenopus tropicalis"; ?>
EKS-AIM-00115
EKS-ANC-00111
EKS-BOT-00123
EKS-CAE-00100
EKS-CAJ-00125
EKS-CAF-00126
EKS-CAP-00120
EKS-CII-00062
EKS-CIS-00142
EKS-DAR-00379
EKS-EQC-00119
EKS-FEC-00114
EKS-GAG-00103
EKS-GAA-00142
EKS-GOG-00122
EKS-HOS-00125
EKS-ICT-00115
EKS-LAC-00128
EKS-LOA-00118
EKS-MAM-00119
EKS-MEG-00093
EKS-MOD-00120
EKS-MUM-00124
EKS-MUP-00126
EKS-NOL-00115
EKS-OCP-00079
EKS-ORN-00150
EKS-ORA-00101
EKS-ORC-00115
EKS-ORL-00139
EKS-OTG-00126
EKS-PAT-00111
EKS-PES-00105
EKS-PEM-00067
EKS-POA-00116
EKS-RAN-00120
EKS-SAH-00115
EKS-SUS-00109
EKS-TAG-00152
EKS-TAR-00154
EKS-TEN-00142
EKS-VIP-00058
EKS-XET-00102
Gene Ontology
GO:0016021; C:integral to membrane
GO:0005524; F:ATP binding
GO:0004714; F:transmembrane receptor protein tyrosine kinase activity
GO:0007275; P:multicellular organismal development
GO:0007169; P:transmembrane receptor protein tyrosine kinase signaling pathway
KEGG
InterPros
IPR013783; Ig-like_fold.
IPR014756; Ig_E-set.
IPR002909; IPT_TIG_rcpt.
IPR011009; Kinase-like_dom.
IPR003659; Plexin-like.
IPR016201; Plexin-like_fold.
IPR002165; Plexin_repeat.
IPR000719; Prot_kinase_cat_dom.
IPR017441; Protein_kinase_ATP_BS.
IPR001627; Semaphorin/CD100_Ag.
IPR001245; Ser-Thr/Tyr_kinase_cat_dom.
IPR008266; Tyr_kinase_AS.
IPR020635; Tyr_kinase_cat_dom.
IPR016244; Tyr_kinase_HGF/MSP_rcpt.
IPR015943; WD40/YVTN_repeat-like_dom.
Pfam
PF07714; Pkinase_Tyr; 1.
PF01437; PSI; 1.
PF01403; Sema; 1.
PF01833; TIG; 3.
SMARTs
SM00429; IPT; 4.
SM00423; PSI; 1.
SM00630; Sema; 1.
SM00219; TyrKc; 1.
Prosites
PS00107; PROTEIN_KINASE_ATP; 1.
PS50011; PROTEIN_KINASE_DOM; 1.
PS00109; PROTEIN_KINASE_TYR; 1.
PS51004; SEMA; 1.
Prints
PR00109; TYRKINASE.
Created Date20-Feb-2013