EPS-MYL-00029

Eukaryotic Protein Kinase & Protein Phosphatase Database

Tag

Content

EKPD ID

EPS-MYL-00029

Classification

Group/Family	Score	E-Value	Start	End	Domain Length
PPM/PP2C	193.8	4.4E-57	155	411	257

Status

Unreviewed

Ensembl Protein

ENSMLUP00000007245

UniProt Accession

G1PAD9;

Protein Name

Protein Synonyms/Alias

Gene Name

PPM1F

Gene Synonyms/Alias

PPM1F;

Ensembl Information

Ensembl Gene ID	Ensembl Protein ID	Ensembl Transcript ID
ENSMLUG00000007934	ENSMLUP00000007245	ENSMLUT00000007933

Organism

Myotis lucifugus

Functional Description

Protein Length

454

Protein Sequence
(FASTA)

MASGAPEQSS QMAEETPSFL DAFLRDFPAP LSAESPLPWK IPGTVLSQEE VEGELAELAV 60

GFLSSSPRNA PPPLAASLAH EAVSQLLQTD LSEFRKLPRQ EEEDSEEVEE EKAPVTLLDA 120

KGLALSFFNR LWDVCSQWQK QVPSTARAPQ RQWLVSIHAI RNTRRRMEDR HVCLPAFNQL 180

FGLSDPVDRA YFAVFDGHGG VDAARYAAVH VHANAARQPE LPTHPEGALR EAFRRTDEMF 240

LWKAKRERLQ SGTTGVCALI TGKTLHIAWL GDSQVILVQQ GQVVKMMEPH KPERQDEKER 300

IEALGGFVSY MDCWRVNGTL AVSRAIGPGD VFQKPYVSGE ADVASRELTG SEDYLLLACD 360

GFFDVVSHQE VAGLVQSHLA SQRGSGLHVA EELVAAARER GSHDNITVMV VFLRDPRDLL 420

EGWAQGAGES QADRRSQDLP SALSEPENNT PWRS 454

Nucleotide Sequence
(FASTA)

ATGGCCTCTG GAGCCCCAGA GCAGAGCAGC CAGATGGCAG AGGAGACCCC CAGCTTCCTG 60

GACGCGTTTC TCCGCGACTT CCCAGCCCCA CTGAGCGCAG AGAGCCCTTT GCCATGGAAG 120

ATCCCGGGGA CGGTGCTGAG CCAGGAGGAG GTGGAGGGCG AGCTGGCCGA GTTGGCAGTG 180

GGCTTCCTGA GCAGCAGTCC CAGGAACGCT CCGCCGCCAC TTGCTGCATC TTTGGCCCAT 240

GAAGCCGTTT CCCAGCTGCT GCAGACAGAC CTGTCCGAAT TCAGGAAGCT GCCCAGGCAG 300

GAGGAGGAGG ACAGCGAGGA AGTGGAGGAG GAGAAGGCCC CTGTGACCTT GCTGGATGCC 360

AAGGGCCTGG CGCTGAGCTT CTTCAACCGG CTCTGGGACG TATGCAGCCA GTGGCAGAAG 420

CAGGTGCCCT CGACTGCCCG GGCTCCGCAG CGGCAGTGGC TGGTCTCCAT TCATGCCATC 480

CGGAACACTC GCCGCAGGAT GGAGGACCGG CACGTGTGCC TTCCTGCCTT CAACCAGCTC 540

TTTGGCCTGT CCGACCCCGT GGATCGCGCC TACTTTGCAG TGTTTGATGG TCACGGAGGA 600

GTGGATGCCG CGAGGTATGC CGCTGTGCAC GTCCACGCCA ATGCTGCTCG CCAGCCGGAG 660

CTGCCCACGC ACCCCGAGGG AGCCCTCAGA GAAGCTTTCC GGCGCACCGA TGAGATGTTC 720

CTCTGGAAAG CCAAGCGAGA GCGGCTGCAA AGTGGAACCA CAGGCGTGTG TGCACTCATC 780

ACGGGAAAGA CCCTGCACAT CGCCTGGCTG GGGGACTCCC AGGTCATCCT GGTGCAGCAG 840

GGACAGGTGG TGAAGATGAT GGAGCCGCAT AAACCCGAGC GACAGGACGA GAAGGAGCGC 900

ATCGAAGCAC TGGGTGGCTT CGTGTCTTAC ATGGACTGCT GGAGAGTCAA CGGGACCCTG 960

GCCGTCTCCA GAGCCATCGG CCCAGGGGAT GTCTTCCAGA AGCCCTATGT GTCTGGAGAG 1020

GCAGACGTGG CCTCCCGGGA GCTGACCGGC TCTGAGGACT ACCTGCTGCT GGCCTGTGAT 1080

GGCTTCTTTG ACGTCGTCTC CCACCAGGAG GTGGCCGGCC TTGTGCAAAG CCACCTGGCC 1140

AGCCAGCGGG GCAGCGGGCT GCATGTCGCC GAGGAGCTGG TGGCTGCAGC CAGGGAGCGG 1200

GGCTCCCATG ACAACATCAC GGTCATGGTG GTCTTCCTCA GGGACCCCCG AGACCTGCTG 1260

GAGGGGTGGG CCCAGGGGGC CGGGGAATCC CAGGCTGACA GGAGAAGCCA GGACTTGCCC 1320

TCTGCCCTCT CAGAGCCAGA GAACAACACC CCATGGAGAA GCTAG 1365

Domain Profile

S: 3     vgvvsvngrrnemedavtsspnflkspekkdr..laffgvyDGhggsevakfcseklhei  60

         v++ ++ + r+ med++   p f +  + +d    a+f+v+DGhgg ++a++++ ++h

Q: 155   VSIHAIRNTRRRMEDRHVCLPAFNQLFGLSDPvdRAYFAVFDGHGGVDAARYAAVHVHAN  214

         6678899****************999888887778*************************

S: 61    laeelesseseerkvkkalakaFlstdeelkvleeksldidksGstavvalikdsklyva  120

          a++ e      ++ + al++aF +tde +  l +++ +  +sG+t v+ali++++l++a

Q: 215   AARQPE----LPTHPEGALREAFRRTDEMF--LWKAKRERLQSGTTGVCALITGKTLHIA  268

         ****77....7899999*************..5555568889******************

S: 121   nvGdSravLcrngkavelssdHkpsredEleRieeaggsvilkdgaRvlGvLavsRalG.  179

          +GdS+++L ++g++v++ + Hkp+r+dE+eRie+ gg v + d+ Rv+G LavsRa+G

Q: 269   WLGDSQVILVQQGQVVKMMEPHKPERQDEKERIEALGGFVSYMDCWRVNGTLAVSRAIGp  328

         ********************************************99************54

S: 180   .dlylkpyvtpePevtshrltsedefliLasDGlwdvvsneeavslvrdvle.kkeaeqe  237

          d++ kpyv+ e +v s +lt ++++l La+DG +dvvs +e+  lv+++l  +  +

Q: 329   gDVFQKPYVSGEADVASRELTGSEDYLLLACDGFFDVVSHQEVAGLVQSHLAsQRGSGLH  388

         499************************************************966778899

S: 238   aakkLvklalargskdnvsaivv  260

         +a++Lv+ a++rgs+dn++++vv

Q: 389   VAEELVAAARERGSHDNITVMVV  411

         *******************9997

Domain Sequence
(FASTA)

VSIHAIRNTR RRMEDRHVCL PAFNQLFGLS DPVDRAYFAV FDGHGGVDAA RYAAVHVHAN 60

AARQPELPTH PEGALREAFR RTDEMFLWKA KRERLQSGTT GVCALITGKT LHIAWLGDSQ 120

VILVQQGQVV KMMEPHKPER QDEKERIEAL GGFVSYMDCW RVNGTLAVSR AIGPGDVFQK 180

PYVSGEADVA SRELTGSEDY LLLACDGFFD VVSHQEVAGL VQSHLASQRG SGLHVAEELV 240

AAARERGSHD NITVMVV 257

Keyword

Complete proteome; Hydrolase; Magnesium; Metal-binding; Protein phosphatase; Reference proteome.

Sequence Source

Ensembl

Orthology

Ortholog group

Ailuropoda melanoleuca"; ?>Anolis carolinensis"; ?>Bos taurus"; ?>Callithrix jacchus"; ?>Canis familiaris"; ?>Cavia porcellus"; ?>Danio rerio"; ?>Equus caballus"; ?>Erinaceus europaeus"; ?>Felis catus"; ?>Gallus gallus"; ?>Gorilla gorilla"; ?>Homo sapiens"; ?>Ictidomys tridecemlineatus"; ?>Latimeria chalumnae"; ?>Loxodonta africana"; ?>Macaca mulatta"; ?>Meleagris gallopavo"; ?>Microcebus murinus"; ?>Monodelphis domestica"; ?>Mus musculus"; ?>Mustela putorius furo"; ?>Nomascus leucogenys"; ?>Oreochromis niloticus"; ?>Oryctolagus cuniculus"; ?>Otolemur garnettii"; ?>Pan troglodytes"; ?>Pelodiscus sinensis"; ?>Pongo abelii"; ?>Procavia capensis"; ?>Pteropus vampyrus"; ?>Rattus norvegicus"; ?>Sarcophilus harrisii"; ?>Sorex araneus"; ?>Sus scrofa"; ?>Taeniopygia guttata"; ?>Takifugu rubripes"; ?>Xenopus tropicalis"; ?>Xiphophorus maculatus"; ?>

Gene Ontology

GO:0005829	; C:cytosol
GO:0043234	; C:protein complex
GO:0033192	; F:calmodulin-dependent protein phosphatase activity
GO:0046872	; F:metal ion binding
GO:0035690	; P:cellular response to drug
GO:0097193	; P:intrinsic apoptotic signaling pathway
GO:0033137	; P:negative regulation of peptidyl-serine phosphorylation
GO:0044387	; P:negative regulation of protein kinase activity by regulation of protein phosphorylation
GO:0045892	; P:negative regulation of transcription, DNA-dependent
GO:0035970	; P:peptidyl-threonine dephosphorylation
GO:0050921	; P:positive regulation of chemotaxis
GO:0043280	; P:positive regulation of cysteine-type endopeptidase activity involved in apoptotic process
GO:0010634	; P:positive regulation of epithelial cell migration
GO:0051894	; P:positive regulation of focal adhesion assembly
GO:0010628	; P:positive regulation of gene expression
GO:0045927	; P:positive regulation of growth

KEGG

InterPros

IPR001932	; PP2C-like.
IPR000222	; PP2C_Mn2_Asp60_BS.
IPR015655	; Protein_Pase_2C.

Pfam

PF00481

; PP2C; 1.

SMARTs

SM00331	; PP2C_SIG; 1.
SM00332	; PP2Cc; 1.

Prosites

PS01032

; PP2C; 1.

Prints

Created Date

20-Feb-2013