EKS-MYL-00319

Eukaryotic Protein Kinase & Protein Phosphatase Database

Tag

Content

EKPD ID

EKS-MYL-00319

Classification

Group/Family	Score	E-Value	Start	End	Domain Length
STE/STE20	325.8	1.9E-97	407	655	249

Status

Unreviewed

Ensembl Protein

ENSMLUP00000007487

UniProt Accession

G1PAZ1;

Protein Name

Protein Synonyms/Alias

Gene Name

PAK6

Gene Synonyms/Alias

PAK6;

Ensembl Information

Ensembl Gene ID	Ensembl Protein ID	Ensembl Transcript ID
ENSMLUG00000008201	ENSMLUP00000007487	ENSMLUT00000008201

Organism

Myotis lucifugus

Functional Description

Protein Length

678

Protein Sequence
(FASTA)

MFRKKKKKRP EISAPQNFQH RVHTSFDPKE GKFVGLPPQW QNILDTLRRP KPVVDPSRIT 60

PVQLQPMKTV VRGSSVPTDG YISGLLNDIQ KLSVISSNTL RGHSPTNRRR AQSLGLLGEE 120

HWTADPDMYL QSPQSERTDL YLSCNGGAPA GRRQVPWPEP QSPRVPPNGL ATKAQSLGPA 180

EFQGATQRCL QLGACLQSTP PGTSPPAATG RRGAKAVRHG SEEARPQSCL VGSAAGRPGG 240

EGSPSPKTQE SSLKHRLFRS MFLSTPATAP PSSSQPGPAP QSKPNSSFRP PQKDSPASLV 300

AKAQSLPADQ PMGTFSPLTT SDTSSPQKSL RTAPAAGPPP GRSSPAGSPR TRHAQISTSN 360

LYLPQDPAVA KGALAGEDTG IVTHEQFKAA LRMVVDQGDP RLLLDSYVKI GEGSTGIVCL 420

AREKHSGRQV AVKMMDLRKQ QRRELLFNEV VIMRDYQHLN VVEMYKSYLV GEELWVLMEF 480

LQGGALTDII SQVRLNEEQI ATVCEAVLQA LAYLHAQGVI HRDIKSDSIL LTLDGRVKLS 540

DFGFCAQISK DVPKRKSLVG TPYWMAPEVI SRSLYATEVD IWSLGIMVIE MVDGEPPYFS 600

DSPVQAMKRL RDSSPPKLKN SHKVSPVLRD FLERMLVRDP QERATAQELL DHPFLLQTGL 660

PECLVPLIQL YRKPTSTC 678

Nucleotide Sequence
(FASTA)

ATGTTCCGCA AGAAAAAGAA GAAACGCCCT GAGATCTCAG CCCCACAGAA CTTCCAGCAC 60

CGCGTCCACA CCTCCTTTGA CCCTAAAGAA GGCAAGTTTG TGGGCCTCCC CCCTCAATGG 120

CAGAACATCC TGGACACTCT CCGACGCCCC AAGCCCGTGG TGGACCCTTC GCGCATTACG 180

CCGGTGCAGC TCCAGCCCAT GAAGACTGTG GTGCGGGGCA GCTCTGTGCC CACAGACGGC 240

TACATCTCGG GGCTGCTCAA CGACATCCAG AAGCTGTCAG TCATCAGCTC CAACACCCTT 300

CGCGGGCACA GCCCCACCAA CCGGCGGCGG GCACAGTCCC TGGGGCTGCT GGGGGAGGAG 360

CACTGGACTG CGGACCCAGA CATGTACCTG CAGAGCCCCC AGTCTGAGCG CACTGACCTC 420

TACCTCAGCT GCAATGGGGG TGCACCCGCA GGCCGCCGGC AGGTGCCATG GCCAGAACCA 480

CAGAGTCCAC GGGTCCCGCC CAATGGGCTG GCCACCAAGG CACAGTCCCT GGGCCCCGCC 540

GAGTTCCAGG GTGCCACCCA GCGCTGCCTG CAGCTGGGTG CCTGCCTGCA GAGCACCCCA 600

CCCGGCACTT CACCCCCGGC AGCCACGGGA AGGCGTGGGG CCAAAGCCGT CAGGCATGGC 660

TCTGAGGAGG CCCGGCCACA GTCCTGCCTG GTGGGCTCTG CTGCGGGCAG GCCGGGCGGG 720

GAGGGCAGCC CCAGCCCTAA GACTCAGGAG AGCAGCTTGA AGCACAGGCT GTTCCGGAGC 780

ATGTTCCTGT CAACTCCTGC TACAGCCCCT CCGAGCAGCA GCCAGCCAGG CCCCGCACCA 840

CAGAGCAAGC CCAACTCCTC ATTCCGGCCA CCACAGAAAG ACTCCCCCGC AAGCCTGGTG 900

GCCAAGGCCC AGTCCTTGCC CGCAGACCAG CCCATGGGGA CCTTCAGCCC TCTGACCACC 960

TCAGATACCA GCAGCCCCCA GAAGTCCCTC CGCACAGCCC CAGCTGCCGG CCCTCCTCCA 1020

GGCCGGTCTT CCCCTGCTGG TTCCCCCCGC ACCCGGCACG CCCAGATCAG CACCAGCAAC 1080

CTGTACCTGC CCCAGGACCC CGCAGTAGCC AAGGGTGCCC TGGCCGGTGA GGACACGGGC 1140

ATCGTGACAC ACGAGCAGTT CAAGGCTGCA CTCAGGATGG TGGTGGACCA GGGCGACCCC 1200

CGGCTGCTGC TGGACAGCTA CGTGAAGATT GGCGAGGGCT CCACGGGCAT CGTCTGCCTG 1260

GCGCGGGAGA AGCACTCGGG CCGCCAGGTG GCCGTCAAGA TGATGGACCT CAGGAAGCAG 1320

CAGCGCAGGG AGCTGCTCTT TAATGAGGTG GTGATCATGC GGGACTACCA GCACCTCAAC 1380

GTGGTGGAGA TGTACAAGAG CTACCTGGTG GGCGAGGAGC TGTGGGTGCT CATGGAGTTC 1440

CTGCAGGGCG GGGCCCTCAC GGACATCATC TCCCAAGTCA GGCTGAACGA GGAGCAGATC 1500

GCCACCGTGT GCGAGGCCGT GCTGCAGGCC CTGGCGTACC TGCACGCCCA GGGCGTCATA 1560

CACCGGGACA TCAAGAGCGA CTCCATCCTG CTGACCCTGG ATGGCAGGGT GAAACTGTCA 1620

GACTTCGGAT TCTGTGCTCA GATCAGCAAA GATGTCCCTA AGAGGAAGTC CCTGGTGGGA 1680

ACGCCCTACT GGATGGCCCC TGAAGTGATC TCCAGGTCTC TGTACGCCAC TGAGGTGGAT 1740

ATCTGGTCTC TGGGCATCAT GGTGATTGAG ATGGTGGACG GGGAGCCACC CTACTTCAGC 1800

GACTCCCCAG TGCAAGCGAT GAAGAGGCTC CGGGACAGCT CCCCCCCCAA GCTGAAAAAT 1860

TCCCACAAGG TTTCCCCAGT GCTGCGAGAC TTCCTGGAAC GGATGCTGGT GCGGGACCCC 1920

CAGGAGAGAG CCACAGCCCA GGAGCTCCTG GACCATCCCT TCCTGCTGCA GACTGGGCTC 1980

CCCGAGTGCC TGGTCCCCCT GATCCAGCTC TACCGCAAGC CGACCTCCAC CTGCTGA 2037

Domain Profile

S: 4     leeigkGalgkvylarekktgelvaikkinlekqekleelqkeisvlkklkhpniveyle  63

         + +ig+G++g v+larek++g++va+k+++l+kq++ e+l++e+ ++++++h n+ve+++

Q: 407   YVKIGEGSTGIVCLAREKHSGRQVAVKMMDLRKQQRRELLFNEVVIMRDYQHLNVVEMYK  466

         679*********************************************************

S: 64    sflkeeelwlvmeylagGslsdlvkeelkselkEeqiayilrevlkaLeylHskkviHrd  123

         s+l+ eelw++me+l+gG+l+d+++   + +l+Eeqia++++ vl+aL+ylH+++viHrd

Q: 467   SYLVGEELWVLMEFLQGGALTDIIS---QVRLNEEQIATVCEAVLQALAYLHAQGVIHRD  523

         *************************...99******************************

S: 124   ikakniLlteegeVkLsdfgvaaqlektrkkrktvvgtpywmAPEviaqeekgYdekaDi  183

         ik+++iLlt +g+VkLsdfg++aq++k++ krk++vgtpywmAPEvi+  ++ Y +++Di

Q: 524   IKSDSILLTLDGRVKLSDFGFCAQISKDVPKRKSLVGTPYWMAPEVIS--RSLYATEVDI  581

         ************************************************..9*********

S: 184   wslGItaielaegepPfkdleplkallkilkneppklkskkkfskefkefvekclqknpe  243

         wslGI++ie+++gepP+++ +p++a+ +  +++ppklk+++k+s+ +++f+e++l ++p+

Q: 582   WSLGIMVIEMVDGEPPYFSDSPVQAMKRLRDSSPPKLKNSHKVSPVLRDFLERMLVRDPQ  641

         ************************************************************

S: 244   kRpsasellkhkFl  257

         +R++a+ell+h+Fl

Q: 642   ERATAQELLDHPFL  655

         *************7

Domain Sequence
(FASTA)

YVKIGEGSTG IVCLAREKHS GRQVAVKMMD LRKQQRRELL FNEVVIMRDY QHLNVVEMYK 60

SYLVGEELWV LMEFLQGGAL TDIISQVRLN EEQIATVCEA VLQALAYLHA QGVIHRDIKS 120

DSILLTLDGR VKLSDFGFCA QISKDVPKRK SLVGTPYWMA PEVISRSLYA TEVDIWSLGI 180

MVIEMVDGEP PYFSDSPVQA MKRLRDSSPP KLKNSHKVSP VLRDFLERML VRDPQERATA 240

QELLDHPFL 249

Keyword

ATP-binding; Complete proteome; Kinase; Nucleotide-binding; Reference proteome; Serine/threonine-protein kinase; Transferase.

Sequence Source

Ensembl

Orthology

Ortholog group

Ailuropoda melanoleuca"; ?>Anolis carolinensis"; ?>Bos taurus"; ?>Callithrix jacchus"; ?>Canis familiaris"; ?>Cavia porcellus"; ?>Danio rerio"; ?>Echinops telfairi"; ?>Equus caballus"; ?>Felis catus"; ?>Gallus gallus"; ?>Gasterosteus aculeatus"; ?>Gorilla gorilla"; ?>Homo sapiens"; ?>Ictidomys tridecemlineatus"; ?>Loxodonta africana"; ?>Macaca mulatta"; ?>Meleagris gallopavo"; ?>Microcebus murinus"; ?>Monodelphis domestica"; ?>Mus musculus"; ?>Mustela putorius furo"; ?>Nomascus leucogenys"; ?>Ochotona princeps"; ?>Oryctolagus cuniculus"; ?>Oryzias latipes"; ?>Otolemur garnettii"; ?>Pan troglodytes"; ?>Pelodiscus sinensis"; ?>Pongo abelii"; ?>Procavia capensis"; ?>Rattus norvegicus"; ?>Sarcophilus harrisii"; ?>Sus scrofa"; ?>Taeniopygia guttata"; ?>Takifugu rubripes"; ?>Tupaia belangeri"; ?>Tursiops truncatus"; ?>Xenopus tropicalis"; ?>Xiphophorus maculatus"; ?>

Gene Ontology

GO:0005524	; F:ATP binding
GO:0004674	; F:protein serine/threonine kinase activity

KEGG

InterPros

IPR011009	; Kinase-like_dom.
IPR000095	; PAK_box_Rho-bd.
IPR000719	; Prot_kinase_cat_dom.
IPR017441	; Protein_kinase_ATP_BS.
IPR002290	; Ser/Thr_dual-sp_kinase_dom.

Pfam

PF00786	; PBD; 1.
PF00069	; Pkinase; 1.

SMARTs

SM00285	; PBD; 1.
SM00220	; S_TKc; 1.

Prosites

PS50108	; CRIB; 1.
PS00107	; PROTEIN_KINASE_ATP; 1.
PS50011	; PROTEIN_KINASE_DOM; 1.

Prints

Created Date

20-Feb-2013