EKS-MYL-00369
Eukaryotic Protein Kinase & Protein Phosphatase Database
TagContent
EKPD IDEKS-MYL-00369
Classification
Group/FamilyScoreE-ValueStartEndDomain Length
TK/Src415.19.6E-125264513250
StatusUnreviewed
Ensembl ProteinENSMLUP00000007621
UniProt AccessionG1PBA7;
Protein Name
Protein Synonyms/Alias
Gene NameHCK
Gene Synonyms/Alias HCK;
Ensembl Information
Ensembl Gene IDEnsembl Protein IDEnsembl Transcript ID
ENSMLUG00000008355ENSMLUP00000007621ENSMLUT00000008353
OrganismMyotis lucifugus
Functional Description
Protein Length528
Protein Sequence
(FASTA)
WNPASKTPLP GLRASRAHLP SLCRRMGCVK SKFLRDRDKV SKSEASANPH SPLYVPDPTS 60
TGKRRPDPNN GNPPGPRRGS KDNIVIALYD YEAIHHEDLS FQKGDQMAVL EESGEWWKAR 120
SLATRKEGYI PSNYVARVDS LETEEWFFKG ISRKDAERQL LAPGNVLGSF MIRDSETTKG 180
SYSLSVRDYD PQHRDAVKHY KIRTLDNGGF YISPRNTFST LQELVAHYMK GSDGLCQKLT 240
VPCVSSKPQK PWEKDAWEIP RESLELEKKL GAGQFGEVWM ATYNKHTKVA VKTMKPGSMS 300
VEAFLAEANL MKTLQHDKLV KLHAVVTEEP IYIITEFMAK GNYLFFLKKT SGSTGVLPDL 360
APIQVEISEG MAFIEQRNYI HRDLRAANIL VSATLVCKIA DFGLARVIED NEYTAREGAK 420
FPIKWTAPEA INFGSFTIKS DVWSFGILLM EIVTYGRIPY PGMTNPEVIR ALERGYRMPR 480
PEHCPEELYN IMTRCWKNRP EERPTFEYIQ SVLDDFYTAT ESQYQQQP 528
Nucleotide Sequence
(FASTA)
TGGAACCCAG CATCAAAGAC TCCCCTGCCT GGGCTCAGGG CCAGCAGGGC TCACCTCCCT 60
TCTCTCTGCC GCAGGATGGG GTGCGTGAAG TCCAAGTTCC TCCGGGATAG AGACAAGGTC 120
TCAAAAAGCG AGGCCAGTGC CAACCCACAC AGCCCGTTGT ATGTGCCAGA TCCCACGTCC 180
ACGGGCAAGC GGCGACCTGA CCCCAACAAC GGCAACCCCC CGGGTCCACG GAGGGGTTCT 240
AAGGATAACA TCGTGATTGC CCTGTATGAC TACGAGGCCA TTCACCATGA AGACCTCAGC 300
TTCCAGAAGG GAGACCAGAT GGCGGTCCTG GAGGAGTCGG GGGAATGGTG GAAGGCTCGG 360
TCTCTGGCCA CCCGGAAAGA GGGCTACATC CCAAGCAACT ACGTGGCCCG CGTTGACTCT 420
CTGGAGACAG AGGAGTGGTT CTTCAAGGGC ATCAGCCGGA AGGATGCAGA GCGCCAACTT 480
CTGGCCCCTG GCAACGTGCT GGGCTCCTTC ATGATCCGCG ACAGCGAGAC CACCAAAGGG 540
AGCTACTCTT TGTCGGTACG AGACTACGAC CCCCAGCATA GGGATGCAGT GAAACATTAT 600
AAGATCCGGA CCCTGGACAA CGGGGGCTTC TACATCTCCC CACGAAACAC CTTCAGCACC 660
CTGCAGGAGC TGGTGGCCCA CTACATGAAA GGGAGTGATG GGCTCTGCCA GAAGCTGACG 720
GTGCCCTGCG TGTCCTCCAA GCCCCAGAAG CCGTGGGAGA AAGACGCCTG GGAGATCCCT 780
CGGGAATCCC TCGAGCTGGA GAAAAAGCTT GGAGCCGGGC AGTTTGGGGA AGTCTGGATG 840
GCCACCTACA ACAAGCACAC CAAGGTGGCC GTGAAGACCA TGAAGCCAGG GAGCATGTCT 900
GTGGAGGCCT TCCTGGCAGA GGCCAACCTG ATGAAAACTC TGCAGCATGA CAAGCTGGTG 960
AAGCTGCATG CAGTGGTCAC AGAGGAGCCC ATTTATATCA TCACGGAGTT CATGGCCAAA 1020
GGAAATTATC TGTTCTTTTT AAAAAAAACA TCAGGGAGCA CAGGGGTTTT GCCTGACTTA 1080
GCACCTATTC AAGTGGAGAT TTCGGAGGGC ATGGCCTTCA TCGAGCAGAG GAACTACATT 1140
CACCGAGACC TCCGAGCCGC CAACATCCTG GTCTCTGCGA CCCTGGTGTG TAAGATTGCT 1200
GACTTCGGCC TGGCGAGGGT CATCGAGGAC AACGAGTACA CGGCCCGGGA AGGGGCCAAG 1260
TTCCCCATCA AGTGGACAGC TCCTGAAGCC ATCAACTTTG GCTCCTTCAC CATCAAGTCG 1320
GACGTCTGGT CCTTTGGTAT TCTGCTGATG GAGATCGTCA CCTACGGCCG GATCCCATAC 1380
CCAGGCATGA CAAACCCTGA GGTGATCCGG GCGCTGGAGC GTGGATACCG CATGCCCCGG 1440
CCGGAGCACT GCCCCGAGGA GCTCTACAAC ATCATGACGC GCTGCTGGAA GAACCGCCCC 1500
GAGGAGCGGC CCACCTTCGA ATACATCCAG AGTGTGCTGG ACGACTTCTA CACGGCCACG 1560
GAGAGCCAGT ACCAGCAGCA GCCGTGA 1587
Domain Profile
S: 1     lklvkklGeGqfGevwlgkwkgsvkvavktlkegtlspeafleeaqilkklrheklvkly  60
         l+l+kklG+GqfGevw++++++++kvavkt+k+g++s eafl+ea+++k+l+h+klvkl+
Q: 264   LELEKKLGAGQFGEVWMATYNKHTKVAVKTMKPGSMSVEAFLAEANLMKTLQHDKLVKLH  323
         5799********************************************************
S: 61    avvseeePiyivtelmakGslldflkeeegkklklpklvdlaaqvaeGmayleeknlihr  120
         avv+e ePiyi+te+makG+ l flk+++g++  lp+l  + + ++eGma++e++n+ihr
Q: 324   AVVTE-EPIYIITEFMAKGNYLFFLKKTSGSTGVLPDLAPIQVEISEGMAFIEQRNYIHR  382
         ****9.******************************************************
S: 121   dlaarnvlvgeslvvkvadfGlarlieddeytakegaklPikWtaPeaiklgkftiksdv  180
         dl+a+n+lv+ +lv+k+adfGlar+ied+eyta+egak+PikWtaPeai++g+ftiksdv
Q: 383   DLRAANILVSATLVCKIADFGLARVIEDNEYTAREGAKFPIKWTAPEAINFGSFTIKSDV  442
         ************************************************************
S: 181   WsfGillteivtkGkvPypGmtneevleqvergyrlprpeecpeelyelllecwkkdpee  240
         WsfGill+eivt+G++PypGmtn ev++++ergyr+prpe+cpeely+++++cwk++pee
Q: 443   WSFGILLMEIVTYGRIPYPGMTNPEVIRALERGYRMPRPEHCPEELYNIMTRCWKNRPEE  502
         ************************************************************
S: 241   rPtfetlqevl  251
         rPtfe++q+vl
Q: 503   RPTFEYIQSVL  513
         *******9976
Domain Sequence
(FASTA)
LELEKKLGAG QFGEVWMATY NKHTKVAVKT MKPGSMSVEA FLAEANLMKT LQHDKLVKLH 60
AVVTEEPIYI ITEFMAKGNY LFFLKKTSGS TGVLPDLAPI QVEISEGMAF IEQRNYIHRD 120
LRAANILVSA TLVCKIADFG LARVIEDNEY TAREGAKFPI KWTAPEAINF GSFTIKSDVW 180
SFGILLMEIV TYGRIPYPGM TNPEVIRALE RGYRMPRPEH CPEELYNIMT RCWKNRPEER 240
PTFEYIQSVL 250
KeywordATP-binding; Complete proteome; Kinase; Nucleotide-binding; Reference proteome; SH3 domain; Transferase; Tyrosine-protein kinase.
Sequence SourceEnsembl
Orthology
Ortholog group
Ailuropoda melanoleuca"; ?>Anolis carolinensis"; ?>Bos taurus"; ?>Callithrix jacchus"; ?>Canis familiaris"; ?>Cavia porcellus"; ?>Danio rerio"; ?>Equus caballus"; ?>Felis catus"; ?>Gallus gallus"; ?>Gasterosteus aculeatus"; ?>Gorilla gorilla"; ?>Homo sapiens"; ?>Ictidomys tridecemlineatus"; ?>Loxodonta africana"; ?>Macaca mulatta"; ?>Meleagris gallopavo"; ?>Monodelphis domestica"; ?>Mus musculus"; ?>Mustela putorius furo"; ?>Nomascus leucogenys"; ?>Ochotona princeps"; ?>Oreochromis niloticus"; ?>Oryctolagus cuniculus"; ?>Oryzias latipes"; ?>Otolemur garnettii"; ?>Pan troglodytes"; ?>Petromyzon marinus"; ?>Pteropus vampyrus"; ?>Rattus norvegicus"; ?>Sarcophilus harrisii"; ?>Taeniopygia guttata"; ?>Takifugu rubripes"; ?>Xiphophorus maculatus"; ?>
EKS-AIM-00343
EKS-ANC-00359
EKS-BOT-00369
EKS-CAJ-00373
EKS-CAF-00370
EKS-CAP-00404
EKS-DAR-00749
EKS-EQC-00360
EKS-FEC-00356
EKS-GAG-00313
EKS-GAA-00451
EKS-GOG-00360
EKS-HOS-00375
EKS-ICT-00350
EKS-LOA-00378
EKS-MAM-00369
EKS-MEG-00306
EKS-MOD-00358
EKS-MUM-00401
EKS-MUP-00363
EKS-NOL-00337
EKS-OCP-00073
EKS-ORN-00478
EKS-ORC-00347
EKS-ORL-00440
EKS-OTG-00371
EKS-PAT-00354
EKS-PEM-00194
EKS-PTV-00094
EKS-RAN-00383
EKS-SAH-00339
EKS-TAG-00442
EKS-TAR-00474
EKS-XIM-00467
Gene Ontology
GO:0005524; F:ATP binding
GO:0004713; F:protein tyrosine kinase activity
KEGG
InterPros
IPR011009; Kinase-like_dom.
IPR000719; Prot_kinase_cat_dom.
IPR017441; Protein_kinase_ATP_BS.
IPR001245; Ser-Thr/Tyr_kinase_cat_dom.
IPR000980; SH2.
IPR001452; SH3_domain.
IPR008266; Tyr_kinase_AS.
IPR020635; Tyr_kinase_cat_dom.
Pfam
PF07714; Pkinase_Tyr; 1.
PF00017; SH2; 1.
PF00018; SH3_1; 1.
SMARTs
SM00252; SH2; 1.
SM00326; SH3; 1.
SM00219; TyrKc; 1.
Prosites
PS00107; PROTEIN_KINASE_ATP; 1.
PS50011; PROTEIN_KINASE_DOM; 1.
PS00109; PROTEIN_KINASE_TYR; 1.
PS50001; SH2; 1.
PS50002; SH3; 1.
Prints
PR00401; SH2DOMAIN.
PR00452; SH3DOMAIN.
PR00109; TYRKINASE.
Created Date20-Feb-2013