EKS-MYL-00234

Eukaryotic Protein Kinase & Protein Phosphatase Database

Tag

Content

EKPD ID

EKS-MYL-00234

Classification

Group/Family	Score	E-Value	Start	End	Domain Length
CAMK/MAPKAPK	400.1	4.3E-120	85	368	284

Status

Unreviewed

Ensembl Protein

ENSMLUP00000007824

UniProt Accession

G1PBR9;

Protein Name

Protein Synonyms/Alias

Gene Name

MKNK2

Gene Synonyms/Alias

MKNK2;

Ensembl Information

Ensembl Gene ID	Ensembl Protein ID	Ensembl Transcript ID
ENSMLUG00000008571	ENSMLUP00000007824	ENSMLUT00000008585

Organism

Myotis lucifugus

Functional Description

Protein Length

463

Protein Sequence
(FASTA)

MVQKKTAELQ GFHRSFKGQN PFELAFSLEQ AHPGETDFSL ECPARPDMPT SQPIDIPDAK 60

KRGKKKKRCR ATDSFSGRFE DVYQLQEDVL GEGAHARVQT CINLITNQEY AVKIIEKQPG 120

HIRSRVFREV EMLYQCQGHR NVLELIEFFE EEDRFYLVFE KMRGGSILSH IHKRRHFNEL 180

EASVVVQDVA SALDFLHNKG IAHRDLKLEN ILCEHPNQVS PVKICDFDLG SGIKLNGDCS 240

PISTPELLTP CGSAEYMAPE VVEAFSEEAS IYDKRCDLWS LGVILYILLS GYPPFVGHCG 300

SDCGWDRGEA CPACQNMLFE SIQEGKYEFP EKDWAHISFA AKDLISKLLV RDAKQRLSAA 360

QVLQHPWVQG CAPENTLPTP MVLQRNSCAK DLTSFAAEAI AMNRQLAQRE EDALEEVGQG 420

QPVVIRATSR YLHLSPPSQS KLAQRRQRAS LSAAPVVLVG DHA 463

Nucleotide Sequence
(FASTA)

ATGGTGCAGA AGAAAACAGC CGAACTTCAG GGCTTCCATC GTTCGTTCAA GGGGCAGAAT 60

CCTTTCGAGC TGGCCTTCTC CCTAGAACAG GCCCACCCCG GGGAGACTGA CTTCAGCCTG 120

GAGTGCCCAG CCCGCCCTGA TATGCCCACG AGCCAGCCCA TTGACATCCC AGACGCCAAG 180

AAGAGGGGCA AGAAGAAGAA GCGGTGTCGG GCAACTGACA GCTTCTCAGG CAGGTTCGAA 240

GATGTCTACC AGCTACAGGA GGATGTGCTT GGGGAGGGCG CCCATGCCCG TGTGCAGACC 300

TGCATCAATC TCATCACCAA CCAGGAGTAT GCGGTCAAGA TCATCGAGAA GCAGCCGGGC 360

CACATTCGGA GTAGGGTTTT CCGGGAGGTG GAGATGCTGT ATCAGTGCCA GGGACACAGG 420

AATGTTCTAG AGCTGATTGA ATTCTTCGAG GAGGAAGACC GATTCTACCT GGTGTTTGAG 480

AAGATGCGGG GCGGCTCCAT CCTAAGCCAC ATTCACAAGC GACGACACTT CAATGAGTTG 540

GAGGCCAGCG TGGTGGTGCA GGACGTGGCC AGCGCCCTGG ATTTCCTGCA CAACAAAGGC 600

ATCGCCCACA GGGACCTAAA GTTGGAAAAC ATCCTCTGTG AGCACCCCAA CCAGGTCTCC 660

CCCGTTAAGA TCTGCGACTT TGACCTGGGC AGTGGCATCA AACTCAATGG GGACTGCTCC 720

CCCATCTCCA CCCCGGAGCT GCTAACCCCA TGCGGCTCTG CAGAGTATAT GGCCCCTGAG 780

GTGGTGGAGG CCTTCAGCGA GGAGGCCAGC ATCTATGACA AGCGCTGCGA CCTCTGGAGC 840

CTGGGTGTCA TCCTCTACAT CCTGCTCAGT GGCTACCCAC CCTTTGTGGG CCACTGCGGC 900

AGTGACTGCG GCTGGGACCG CGGTGAGGCT TGCCCGGCCT GCCAGAACAT GCTGTTCGAG 960

AGCATACAAG AGGGCAAGTA TGAGTTTCCG GAGAAGGACT GGGCCCACAT CTCCTTCGCT 1020

GCCAAAGACC TCATCTCGAA GCTGCTGGTT CGAGACGCCA AGCAGAGGCT AAGCGCTGCC 1080

CAGGTCCTGC AGCACCCCTG GGTGCAGGGG TGCGCCCCAG AGAACACCCT GCCCACGCCC 1140

ATGGTTCTGC AGAGGAACAG CTGTGCCAAA GACCTCACAT CCTTCGCAGC TGAGGCCATC 1200

GCCATGAACC GGCAGCTGGC CCAGCGCGAG GAGGATGCGT TGGAGGAGGT GGGGCAGGGC 1260

CAGCCCGTGG TCATCCGAGC TACCTCACGC TACCTGCATC TGTCCCCACC ATCCCAGTCC 1320

AAGCTGGCCC AGCGGCGGCA GCGAGCCAGC CTCTCTGCAG CCCCCGTGGT CCTGGTGGGG 1380

GACCATGCAT GA 1392

Domain Profile

S: 2     lteevlGeGisgkvlecvkkktgekyalkil.....kdrkkvrrevelhvqasghknive  56

         l+e+vlGeG++++v++c++  t+++ya+ki+     + r++v+reve+++q++gh+n++e

Q: 85    LQEDVLGEGAHARVQTCINLITNQEYAVKIIekqpgHIRSRVFREVEMLYQCQGHRNVLE  144

         789*********************************************************

S: 57    lidvfensfedekrlllvlekleGGellsriqerkaftekeasevvkdiasalkflhskn  116

         li++fe    +e+r++lv+ek++GG++ls+i++r++f+e eas vv+d+asal+flh+k+

Q: 145   LIEFFE----EEDRFYLVFEKMRGGSILSHIHKRRHFNELEASVVVQDVASALDFLHNKG  200

         ******....9*************************************************

S: 117   iahrDlkpenlLyeskeknapvklcDfglaketeee........eelktpcltaeyvaPe  168

         iahrDlk en+L+e++++++pvk+cDf+l+++++ +        +el tpc++aey+aPe

Q: 201   IAHRDLKLENILCEHPNQVSPVKICDFDLGSGIKLNgdcspistPELLTPCGSAEYMAPE  260

         ********************************955556899999****************

S: 169   vleaekeeallydksCDlWslGvilyillcGypPfyskkg...........raiskklke  217

         v+ea++eea++ydk+CDlWslGvilyill+GypPf++++g            a++++l+e

Q: 261   VVEAFSEEASIYDKRCDLWSLGVILYILLSGYPPFVGHCGsdcgwdrgeacPACQNMLFE  320

         ***************************************99**********9********

S: 218   riqegkyefPeeeWsevseeakdlirklLkrdpkerltieevlnhpwv  265

         +iqegkyefPe++W+++s +akdli+klL+rd+k+rl++++vl+hpwv

Q: 321   SIQEGKYEFPEKDWAHISFAAKDLISKLLVRDAKQRLSAAQVLQHPWV  368

         ***********************************************8

Domain Sequence
(FASTA)

LQEDVLGEGA HARVQTCINL ITNQEYAVKI IEKQPGHIRS RVFREVEMLY QCQGHRNVLE 60

LIEFFEEEDR FYLVFEKMRG GSILSHIHKR RHFNELEASV VVQDVASALD FLHNKGIAHR 120

DLKLENILCE HPNQVSPVKI CDFDLGSGIK LNGDCSPIST PELLTPCGSA EYMAPEVVEA 180

FSEEASIYDK RCDLWSLGVI LYILLSGYPP FVGHCGSDCG WDRGEACPAC QNMLFESIQE 240

GKYEFPEKDW AHISFAAKDL ISKLLVRDAK QRLSAAQVLQ HPWV 284

Keyword

ATP-binding; Complete proteome; Nucleotide-binding; Reference proteome.

Sequence Source

Ensembl

Orthology

Ortholog group

Anolis carolinensis"; ?>Bos taurus"; ?>Callithrix jacchus"; ?>Cavia porcellus"; ?>Danio rerio"; ?>Equus caballus"; ?>Felis catus"; ?>Gadus morhua"; ?>Gasterosteus aculeatus"; ?>Gorilla gorilla"; ?>Homo sapiens"; ?>Ictidomys tridecemlineatus"; ?>Latimeria chalumnae"; ?>Macaca mulatta"; ?>Microcebus murinus"; ?>Monodelphis domestica"; ?>Mus musculus"; ?>Mustela putorius furo"; ?>Oreochromis niloticus"; ?>Ornithorhynchus anatinus"; ?>Oryzias latipes"; ?>Otolemur garnettii"; ?>Pan troglodytes"; ?>Pelodiscus sinensis"; ?>Pongo abelii"; ?>Procavia capensis"; ?>Rattus norvegicus"; ?>Sarcophilus harrisii"; ?>Sus scrofa"; ?>Taeniopygia guttata"; ?>Takifugu rubripes"; ?>Tetraodon nigroviridis"; ?>Xenopus tropicalis"; ?>Xiphophorus maculatus"; ?>

Gene Ontology

GO:0005524	; F:ATP binding
GO:0004674	; F:protein serine/threonine kinase activity

KEGG

InterPros

IPR011009	; Kinase-like_dom.
IPR000719	; Prot_kinase_cat_dom.
IPR017441	; Protein_kinase_ATP_BS.
IPR002290	; Ser/Thr_dual-sp_kinase_dom.
IPR008271	; Ser/Thr_kinase_AS.

Pfam

PF00069

; Pkinase; 1.

SMARTs

SM00220

; S_TKc; 1.

Prosites

PS00107	; PROTEIN_KINASE_ATP; 1.
PS50011	; PROTEIN_KINASE_DOM; 1.
PS00108	; PROTEIN_KINASE_ST; 1.

Prints

Created Date

20-Feb-2013