EKS-MYL-00374

Eukaryotic Protein Kinase & Protein Phosphatase Database

Tag

Content

EKPD ID

EKS-MYL-00374

Classification

Group/Family	Score	E-Value	Start	End	Domain Length
TKL/MLK	347.5	4.7E-104	118	375	258

Status

Unreviewed

Ensembl Protein

ENSMLUP00000007864

UniProt Accession

G1PBV3;

Protein Name

Protein Synonyms/Alias

Gene Name

MAP3K11

Gene Synonyms/Alias

MAP3K11;

Ensembl Information

Ensembl Gene ID	Ensembl Protein ID	Ensembl Transcript ID
ENSMLUG00000008611	ENSMLUP00000007864	ENSMLUT00000008628

Organism

Myotis lucifugus

Functional Description

Protein Length

856

Protein Sequence
(FASTA)

MEPLKNLFLK SPLGSWNGGG SGGGGGSGGS WPEGSPKAAA YANPVWTALF DYEPNGQDEL 60

ALRKGDRVEV LSRDAAISGD EGWWAGQVGG QVGIFPSNYV SRGGPPPCEV ANFQELRLEE 120

VIGIGGFGKV YRGSWRGELV AVKAARQDPD EDISVTAESV RQEARLFAML AHPNIIALKA 180

VCLEEPNLCL VMEYAAGGPL SRALAGRRVP PHVLVNWAVQ IARGMHYLHC EALVPVIHRD 240

LKSNNILLLQ PIEGDDMEHK TLKITDFGLA REWHKTTQMS AAGTYAWMAP EVIKASTFSK 300

GSDVWSFGVL LWELLTGEVP YRGIDCLAVA YGVAVNKLTL PIPSTCPEPF AQLMADCWAQ 360

DPHRRPDFAS ILQQLEALEA QVLREMPRDS FHSMQEGWKR EIQGLFDELR AKEKELLSRE 420

EELTRAAREQ RSQAEQLRRR EHLLAQWELE VFERELTLLL QQVDRERPHV RRRRGTFKRS 480

KLRARDGGER ISMPLDFKHR ITVQASPGLD RRRNVFEVGA GDSPTFPRFR AIQLEPAEPG 540

QAWGRQSPRR QEDSSNGERR ACWAWGPSSP KPGEAQNGRR RSRMDEATWY LDSDDSSPLG 600

SPSTPPTLNG NPPRPSPEPE EPRRPAPAER SSGSGTPKLI QRALLRGTAL LASLGLGRDL 660

QPPGGQGRER GEPQPTPPTL PPTHPPSPLP SRLIRSSPKT PQAPISRLSP DAPGPPTPAP 720

LLLELGVPAG QPSAKSPRRE EGRRGSTVSP PPGISRSAPG TPGTPRSPPL GLISRPRPSP 780

LRSRIDPWSF VSAGPRPSPL PSPQPAPRRA PWTLFPDSDP FWDSPPANPF RGGPQDCRAQ 840

TKDMGAQAPW MPEAGP 856

Nucleotide Sequence
(FASTA)

ATGGAGCCCT TGAAGAACCT CTTCCTCAAG AGCCCGCTGG GTTCATGGAA CGGCGGTGGC 60

AGTGGGGGCG GCGGTGGCAG CGGCGGAAGC TGGCCAGAGG GGTCCCCGAA AGCAGCGGCT 120

TATGCCAACC CTGTGTGGAC AGCCTTGTTT GACTACGAGC CCAACGGGCA GGACGAGCTG 180

GCCCTGCGGA AGGGGGACCG AGTGGAGGTG CTGTCCCGGG ATGCAGCTAT CTCCGGCGAC 240

GAGGGCTGGT GGGCGGGCCA GGTAGGCGGC CAGGTAGGCA TCTTTCCGTC CAACTATGTG 300

TCTCGGGGCG GCCCGCCCCC CTGCGAGGTG GCCAACTTCC AGGAGCTGCG GCTAGAGGAG 360

GTGATCGGCA TTGGTGGCTT CGGCAAGGTC TACCGTGGGA GCTGGCGAGG TGAGCTGGTG 420

GCTGTGAAGG CAGCTCGACA GGACCCCGAC GAGGACATCA GTGTGACGGC TGAGAGCGTG 480

CGCCAGGAGG CCCGGCTTTT CGCCATGCTG GCACACCCCA ACATCATCGC CCTCAAGGCG 540

GTGTGCCTGG AGGAGCCCAA CCTGTGCCTG GTGATGGAGT ACGCAGCTGG TGGTCCCCTC 600

AGCCGTGCCC TGGCTGGGCG GCGTGTACCC CCCCACGTGC TGGTCAACTG GGCTGTGCAG 660

ATCGCCCGTG GGATGCACTA CCTGCATTGC GAGGCCCTGG TGCCCGTCAT CCACCGAGAC 720

CTCAAGTCCA ACAACATTCT GCTGCTGCAG CCCATTGAGG GTGACGACAT GGAGCACAAG 780

ACCCTGAAGA TCACTGACTT CGGCCTGGCC CGCGAGTGGC ACAAAACCAC ACAAATGAGT 840

GCCGCTGGCA CCTATGCCTG GATGGCGCCC GAGGTCATCA AGGCTTCCAC CTTCTCCAAG 900

GGCAGCGATG TCTGGAGCTT TGGGGTGCTG TTGTGGGAAT TGCTGACTGG AGAGGTGCCC 960

TACCGGGGCA TCGACTGCCT TGCTGTAGCC TACGGAGTGG CTGTTAACAA GCTTACACTG 1020

CCCATCCCAT CCACCTGCCC CGAGCCCTTC GCGCAGCTCA TGGCCGATTG TTGGGCGCAG 1080

GACCCCCACC GCAGGCCCGA CTTCGCCTCC ATCCTGCAGC AGTTGGAGGC GCTGGAGGCC 1140

CAGGTCCTGC GGGAAATGCC GCGGGACTCC TTCCATTCCA TGCAGGAAGG CTGGAAGCGT 1200

GAGATCCAAG GCCTTTTCGA TGAGCTGCGG GCCAAGGAAA AGGAACTACT GAGCCGCGAG 1260

GAGGAGCTGA CCCGCGCGGC GCGTGAGCAG CGCTCCCAGG CCGAGCAGCT GCGGCGGCGC 1320

GAACACCTGC TGGCTCAGTG GGAGCTGGAG GTGTTCGAGC GCGAGCTGAC GCTGCTGTTG 1380

CAGCAGGTGG ACCGCGAGCG CCCGCACGTG CGCCGCCGCC GCGGCACCTT CAAGCGCAGC 1440

AAGCTCCGCG CGCGCGACGG CGGCGAGCGC ATCAGTATGC CACTCGACTT CAAACACCGA 1500

ATCACTGTGC AGGCCTCGCC CGGCCTGGAC CGGAGGAGGA ACGTGTTCGA GGTCGGAGCT 1560

GGGGACTCGC CCACCTTTCC CCGGTTTCGG GCCATCCAGT TGGAGCCTGC AGAACCAGGC 1620

CAGGCATGGG GCCGCCAGTC CCCCCGACGC CAGGAGGACT CAAGCAATGG AGAACGCCGA 1680

GCATGCTGGG CCTGGGGTCC CAGTTCCCCC AAGCCTGGGG AAGCCCAGAA TGGGAGGAGA 1740

AGGTCCCGCA TGGACGAAGC CACCTGGTAC CTGGATTCAG ATGACTCATC CCCCTTAGGA 1800

TCTCCGTCCA CACCCCCAAC ACTCAATGGT AACCCCCCAA GGCCGAGCCC AGAGCCAGAG 1860

GAGCCCCGGC GGCCAGCCCC GGCTGAACGC AGCAGCGGCT CTGGGACCCC CAAGCTGATC 1920

CAGCGCGCAC TGCTGCGCGG CACTGCCCTG CTCGCCTCAC TGGGCCTTGG CCGTGACCTG 1980

CAGCCGCCTG GGGGCCAGGG CCGAGAGCGT GGGGAGCCCC AGCCAACGCC CCCCACCCTG 2040

CCTCCCACCC ATCCCCCTTC CCCACTCCCC TCTCGGCTCA TCCGCTCTTC CCCCAAGACG 2100

CCCCAAGCCC CCATTTCTCG GTTGAGCCCC GACGCCCCAG GCCCACCCAC CCCCGCGCCC 2160

CTACTGCTGG AGCTGGGTGT CCCTGCAGGT CAGCCATCGG CCAAGAGTCC CAGACGCGAG 2220

GAAGGGAGGC GCGGAAGCAC TGTTTCACCC CCGCCAGGGA TATCCCGCTC TGCTCCTGGC 2280

ACCCCGGGCA CCCCACGCTC ACCGCCCCTG GGCCTCATCA GCCGACCTCG GCCCTCACCC 2340

CTTCGCAGCC GCATCGACCC GTGGAGCTTC GTGTCAGCTG GACCACGGCC TTCGCCCCTG 2400

CCCTCGCCAC AGCCTGCGCC CCGCCGGGCG CCCTGGACCT TGTTCCCAGA CTCAGACCCC 2460

TTCTGGGACT CTCCACCCGC CAACCCCTTC CGGGGGGGGC CTCAGGACTG CAGGGCGCAG 2520

ACCAAAGACA TGGGTGCCCA GGCCCCGTGG ATGCCGGAGG CAGGGCCGTG A 2571

Domain Profile

S: 3     leeligsgafgkvykakwrkkevavKklreeaee..kekleklereakllsklshpniie  60

         lee+ig g fgkvy+++wr++ vavK++r++  e  + ++e++++ea+l+++l+hpnii+

Q: 118   LEEVIGIGGFGKVYRGSWRGELVAVKAARQDPDEdiSVTAESVRQEARLFAMLAHPNIIA  177

         789****************************99988999*********************

S: 61    llGvcleepnlllvmeyveggsLsnvlhekskreidlevlvswalqiArGmaYLhseapk  120

         l++vcleepnl+lvmey++gg Ls++l++   r+++++vlv+wa+qiArGm+YLh ea +

Q: 178   LKAVCLEEPNLCLVMEYAAGGPLSRALAG---RRVPPHVLVNWAVQIARGMHYLHCEALV  234

         *****************************...9***************************

S: 121   kiihrdLksknvLl.......seekktlkicdFGtarelskstkmsaagtlawmaPEvlk  173

         ++ihrdLks+n+Ll       ++e+ktlki+dFG are++k+t+msaagt+awmaPEv+k

Q: 235   PVIHRDLKSNNILLlqpiegdDMEHKTLKITDFGLAREWHKTTQMSAAGTYAWMAPEVIK  294

         *********************9**************************************

S: 174   eekvseksDvwSygvvLWelltrevPykdlselaiaykvalkglrlpipsscpeklkkLm  233

         ++++s+ sDvwS+gv+LWellt+evPy++++ la+ay+va+++l+lpips+cpe++++Lm

Q: 295   ASTFSKGSDVWSFGVLLWELLTGEVPYRGIDCLAVAYGVAVNKLTLPIPSTCPEPFAQLM  354

         ************************************************************

S: 234   kecwnedpekRpsfseivksl  254

          +cw++dp++Rp+f++i+++l

Q: 355   ADCWAQDPHRRPDFASILQQL  375

         *****************9986

Domain Sequence
(FASTA)

LEEVIGIGGF GKVYRGSWRG ELVAVKAARQ DPDEDISVTA ESVRQEARLF AMLAHPNIIA 60

LKAVCLEEPN LCLVMEYAAG GPLSRALAGR RVPPHVLVNW AVQIARGMHY LHCEALVPVI 120

HRDLKSNNIL LLQPIEGDDM EHKTLKITDF GLAREWHKTT QMSAAGTYAW MAPEVIKAST 180

FSKGSDVWSF GVLLWELLTG EVPYRGIDCL AVAYGVAVNK LTLPIPSTCP EPFAQLMADC 240

WAQDPHRRPD FASILQQL 258

Keyword

ATP-binding; Complete proteome; Kinase; Nucleotide-binding; Reference proteome; Serine/threonine-protein kinase; Transferase; Tyrosine-protein kinase.

Sequence Source

Ensembl

Orthology

Ortholog group

Bos taurus"; ?>Callithrix jacchus"; ?>Canis familiaris"; ?>Cavia porcellus"; ?>Dipodomys ordii"; ?>Equus caballus"; ?>Felis catus"; ?>Gasterosteus aculeatus"; ?>Gorilla gorilla"; ?>Homo sapiens"; ?>Ictidomys tridecemlineatus"; ?>Latimeria chalumnae"; ?>Loxodonta africana"; ?>Macaca mulatta"; ?>Monodelphis domestica"; ?>Mus musculus"; ?>Mustela putorius furo"; ?>Nomascus leucogenys"; ?>Oreochromis niloticus"; ?>Oryctolagus cuniculus"; ?>Oryzias latipes"; ?>Otolemur garnettii"; ?>Pan troglodytes"; ?>Pelodiscus sinensis"; ?>Pongo abelii"; ?>Pteropus vampyrus"; ?>Rattus norvegicus"; ?>Sarcophilus harrisii"; ?>Takifugu rubripes"; ?>Tetraodon nigroviridis"; ?>Xiphophorus maculatus"; ?>

Gene Ontology

GO:0005524	; F:ATP binding
GO:0004709	; F:MAP kinase kinase kinase activity
GO:0004713	; F:protein tyrosine kinase activity
GO:0000186	; P:activation of MAPKK activity
GO:0000165	; P:MAPK cascade

KEGG

InterPros

IPR011009	; Kinase-like_dom.
IPR015785	; MAPKKK9/10/11-like.
IPR000719	; Prot_kinase_cat_dom.
IPR017441	; Protein_kinase_ATP_BS.
IPR001245	; Ser-Thr/Tyr_kinase_cat_dom.
IPR008271	; Ser/Thr_kinase_AS.
IPR011511	; SH3_2.
IPR001452	; SH3_domain.
IPR020635	; Tyr_kinase_cat_dom.

Pfam

PF07714	; Pkinase_Tyr; 1.
PF07653	; SH3_2; 1.

SMARTs

SM00326	; SH3; 1.
SM00219	; TyrKc; 1.

Prosites

PS00107	; PROTEIN_KINASE_ATP; 1.
PS50011	; PROTEIN_KINASE_DOM; 1.
PS00108	; PROTEIN_KINASE_ST; 1.
PS50002	; SH3; 1.

Prints

PR00452	; SH3DOMAIN.
PR00109	; TYRKINASE.

Created Date

20-Feb-2013