EKS-MYL-00462

Eukaryotic Protein Kinase & Protein Phosphatase Database

Tag

Content

EKPD ID

EKS-MYL-00462

Classification

Group/Family	Score	E-Value	Start	End	Domain Length
CMGC/MAPK	374.8	2.5E-112	141	427	287

Status

Unreviewed

Ensembl Protein

ENSMLUP00000007919

UniProt Accession

G1PBZ9;

Protein Name

Protein Synonyms/Alias

Gene Name

NLK

Gene Synonyms/Alias

NLK;

Ensembl Information

Ensembl Gene ID	Ensembl Protein ID	Ensembl Transcript ID
ENSMLUG00000008681	ENSMLUP00000007919	ENSMLUT00000008689

Organism

Myotis lucifugus

Functional Description

Protein Length

527

Protein Sequence
(FASTA)

MSLCGARANA KMMAAYNGGT SAAAAGHHHH HHHHLPHLPP PHLHHHHHPQ HHLHPGSAAA 60

VHPVQQHTSS AAAAAAAAAA AAAMLNPGQQ QPYFPSPAPG QAPGPAAAAP AQVQAAAAAT 120

VKAHHHQHSH HPQQQLDIEP DRPIGYGAFG VVWSVTDPRD GKRVALKKMP NVFQNLVSCK 180

RVFRELKMLC FFKHDNVLSA LDILQPPHID YFEEIYVVTE LMQSDLHKII VSPQPLSSDH 240

VKVFLYQILR GLKYLHSAGI LHRDIKPGNL LVNSNCVLKI CDFGLARVEE LDESRHMTQE 300

VVTQYYRAPE ILMGSRHYSN AIDIWSVGCI FAELLGRRIL FQAQSPIQQL DLITDLLGTP 360

SLEAMRTACE GAKAHILRGP HKQPSLPVLY TLSSQATHEA VHLLCRMLVF DPSKRISAKD 420

ALAHPYLDEG RLRYHTCMCK CCFSTSTGRV YTSDFEPVTN PKFDDTFEKN LSSVRQVKEI 480

IHQFILEQQK GNRVPLCINP QSAAFKSFIS STVAQPSEMP PSPLVWE 527

Nucleotide Sequence
(FASTA)

ATGTCTCTTT GTGGCGCGAG AGCCAACGCA AAAATGATGG CGGCTTACAA TGGCGGTACA 60

TCTGCGGCAG CAGCAGGTCA CCACCACCAC CATCACCACC ACCTCCCACA CCTCCCTCCT 120

CCTCACCTGC ACCACCACCA CCACCCTCAG CACCATCTCC ACCCGGGGTC GGCGGCCGCC 180

GTCCACCCCG TCCAGCAGCA TACCTCTTCG GCCGCGGCCG CCGCCGCCGC AGCGGCCGCC 240

GCTGCTGCCA TGCTAAACCC CGGGCAACAG CAGCCATACT TCCCATCACC GGCCCCTGGC 300

CAGGCCCCTG GACCAGCTGC AGCAGCCCCG GCTCAGGTAC AGGCTGCCGC AGCTGCCACG 360

GTGAAGGCGC ACCATCATCA GCACTCGCAT CACCCGCAAC AGCAGCTGGA CATTGAGCCG 420

GATAGACCGA TCGGATACGG AGCCTTCGGT GTTGTCTGGT CAGTAACAGA TCCAAGAGAT 480

GGAAAGAGAG TAGCACTCAA AAAGATGCCC AACGTCTTCC AGAATCTGGT CTCTTGCAAA 540

AGGGTCTTCC GGGAATTGAA GATGTTGTGT TTTTTTAAAC ATGATAATGT ACTCTCTGCC 600

CTTGACATAC TCCAACCTCC ACACATTGAC TATTTTGAAG AAATATATGT TGTCACAGAA 660

TTGATGCAGA GTGACCTACA TAAAATTATC GTGTCTCCTC AACCACTCAG CTCAGATCAT 720

GTCAAAGTTT TTCTTTATCA GATTTTGCGA GGTTTGAAAT ATCTTCATTC AGCTGGCATT 780

TTACATCGAG ACATTAAGCC AGGGAATCTC CTTGTGAACA GCAACTGTGT TCTAAAGATT 840

TGTGATTTTG GATTGGCCAG AGTGGAAGAA TTAGATGAAT CTCGTCATAT GACTCAGGAA 900

GTTGTTACTC AGTATTATCG GGCTCCAGAA ATCCTGATGG GCAGCCGTCA TTACAGCAAT 960

GCTATTGACA TCTGGTCTGT CGGGTGTATC TTTGCAGAAC TACTAGGACG AAGAATACTG 1020

TTTCAGGCAC AGAGTCCCAT TCAGCAGTTG GATTTGATCA CGGATCTCTT GGGCACACCA 1080

TCACTGGAAG CAATGAGGAC GGCTTGTGAA GGCGCTAAGG CACACATACT CAGGGGTCCT 1140

CATAAACAGC CATCTCTTCC TGTACTTTAT ACCCTGTCTA GTCAGGCTAC ACATGAAGCT 1200

GTTCATCTCC TTTGCAGGAT GTTGGTCTTT GATCCATCCA AAAGAATATC CGCTAAGGAT 1260

GCCTTAGCCC ACCCCTACCT AGATGAAGGG CGACTACGAT ATCACACGTG TATGTGTAAA 1320

TGTTGCTTTT CCACCTCTAC TGGAAGAGTT TATACCAGTG ACTTTGAGCC TGTCACCAAC 1380

CCCAAATTTG ATGACACTTT TGAGAAGAAC CTCAGTTCTG TTCGACAGGT TAAAGAAATT 1440

ATTCACCAGT TCATTCTGGA ACAGCAGAAA GGAAACAGAG TGCCTCTCTG CATCAACCCT 1500

CAGTCTGCTG CTTTTAAGAG CTTTATTAGT TCCACTGTTG CCCAGCCATC TGAGATGCCC 1560

CCATCTCCTC TGGTGTGGGA GTGA 1584

Domain Profile

S: 4     lkplgeGaygvvvsavdkrteervaikklsrpfqketsakrtlRElkllkelkheNiikl  63

          +p+g Ga+gvv+s++d r+++rva+kk+ ++fq+ +s+kr++RElk+l  +kh+N+++

Q: 141   DRPIGYGAFGVVWSVTDPRDGKRVALKKMPNVFQNLVSCKRVFRELKMLCFFKHDNVLSA  200

         689*********************************************************

S: 64    ldvftpeeeleelkdvYlvtelmetdLkkviksq.klsdehiklllyqilrglkylHsan  122

         ld+++p + ++ ++++Y+vtelm++dL+k+i s   ls++h+k++lyqilrglkylHsa+

Q: 201   LDILQPPH-IDYFEEIYVVTELMQSDLHKIIVSPqPLSSDHVKVFLYQILRGLKYLHSAG  259

         *******9.**********************99879************************

S: 123   viHrDlKPsNllvnedcelkildFGlarsadkekekklteyvatrwYraPeillslkeyt  182

         ++HrD+KP+Nllvn++c lki+dFGlar+++ ++++++t++v+t++YraPeil+ +++y+

Q: 260   ILHRDIKPGNLLVNSNCVLKICDFGLARVEELDESRHMTQEVVTQYYRAPEILMGSRHYS  319

         *********************************999************************

S: 183   kavDiWsvGCIlaElltgkplfpgkdeidqlekilevlgtpseeflkkieseearnyiks  242

         +a+DiWsvGCI+aEll +++lf++++ i+ql++i+++lgtps e +++ ++  a+++i +

Q: 320   NAIDIWSVGCIFAELLGRRILFQAQSPIQQLDLITDLLGTPSLEAMRTACEG-AKAHILR  378

         ************************************************9996.7777777

S: 243   lpkkkkk..dfeelfpkaseealdLleklLvldpdkRisveeaLehpYl  289

          p+k+     + +l ++a++ea++Ll ++Lv+dp+kRis+++aL+hpYl

Q: 379   GPHKQPSlpVLYTLSSQATHEAVHLLCRMLVFDPSKRISAKDALAHPYL  427

         77666644457788888*******************************7

Domain Sequence
(FASTA)

DRPIGYGAFG VVWSVTDPRD GKRVALKKMP NVFQNLVSCK RVFRELKMLC FFKHDNVLSA 60

LDILQPPHID YFEEIYVVTE LMQSDLHKII VSPQPLSSDH VKVFLYQILR GLKYLHSAGI 120

LHRDIKPGNL LVNSNCVLKI CDFGLARVEE LDESRHMTQE VVTQYYRAPE ILMGSRHYSN 180

AIDIWSVGCI FAELLGRRIL FQAQSPIQQL DLITDLLGTP SLEAMRTACE GAKAHILRGP 240

HKQPSLPVLY TLSSQATHEA VHLLCRMLVF DPSKRISAKD ALAHPYL 287

Keyword

ATP-binding; Complete proteome; Kinase; Nucleotide-binding; Reference proteome; Serine/threonine-protein kinase; Transferase.

Sequence Source

Ensembl

Orthology

Ortholog group

Ailuropoda melanoleuca"; ?>Anolis carolinensis"; ?>Bos taurus"; ?>Caenorhabditis elegans"; ?>Callithrix jacchus"; ?>Canis familiaris"; ?>Cavia porcellus"; ?>Ciona intestinalis"; ?>Ciona savignyi"; ?>Danio rerio"; ?>Drosophila melanogaster"; ?>Equus caballus"; ?>Felis catus"; ?>Gadus morhua"; ?>Gallus gallus"; ?>Gasterosteus aculeatus"; ?>Homo sapiens"; ?>Ictidomys tridecemlineatus"; ?>Latimeria chalumnae"; ?>Loxodonta africana"; ?>Macaca mulatta"; ?>Monodelphis domestica"; ?>Mus musculus"; ?>Mustela putorius furo"; ?>Nomascus leucogenys"; ?>Ochotona princeps"; ?>Oreochromis niloticus"; ?>Ornithorhynchus anatinus"; ?>Oryctolagus cuniculus"; ?>Oryzias latipes"; ?>Otolemur garnettii"; ?>Pan troglodytes"; ?>Pelodiscus sinensis"; ?>Pongo abelii"; ?>Pteropus vampyrus"; ?>Rattus norvegicus"; ?>Sarcophilus harrisii"; ?>Sorex araneus"; ?>Sus scrofa"; ?>Taeniopygia guttata"; ?>Takifugu rubripes"; ?>Tarsius syrichta"; ?>Tetraodon nigroviridis"; ?>Tursiops truncatus"; ?>Xenopus tropicalis"; ?>Xiphophorus maculatus"; ?>

Gene Ontology

GO:0005524	; F:ATP binding
GO:0004707	; F:MAP kinase activity
GO:0000165	; P:MAPK cascade

KEGG

InterPros

IPR011009	; Kinase-like_dom.
IPR003527	; MAP_kinase_CS.
IPR000719	; Prot_kinase_cat_dom.
IPR017441	; Protein_kinase_ATP_BS.
IPR002290	; Ser/Thr_dual-sp_kinase_dom.
IPR008271	; Ser/Thr_kinase_AS.

Pfam

PF00069

; Pkinase; 1.

SMARTs

SM00220

; S_TKc; 1.

Prosites

PS01351	; MAPK; 1.
PS00107	; PROTEIN_KINASE_ATP; 1.
PS50011	; PROTEIN_KINASE_DOM; 1.
PS00108	; PROTEIN_KINASE_ST; 1.

Prints

Created Date

20-Feb-2013