EKS-MYL-00382

Eukaryotic Protein Kinase & Protein Phosphatase Database

Tag

Content

EKPD ID

EKS-MYL-00382

Classification

Group/Family	Score	E-Value	Start	End	Domain Length
TKL/MLK	257.3	1.5E-76	196	445	250

Status

Unreviewed

Ensembl Protein

ENSMLUP00000008179

UniProt Accession

G1PCN1;

Protein Name

Protein Synonyms/Alias

Gene Name

ILK

Gene Synonyms/Alias

ILK;

Ensembl Information

Ensembl Gene ID	Ensembl Protein ID	Ensembl Transcript ID
ENSMLUG00000008954	ENSMLUP00000008179	ENSMLUT00000008973

Organism

Myotis lucifugus

Functional Description

Protein Length

452

Protein Sequence
(FASTA)

MDDIFTQCRE GNAVAVRLWL DNTENDLNQG DDHGFSPLHW ACREGRSAVV EMLIMRGARI 60

NVMNRGDDTP LHLAASHGHR DIVQKLLQYK ADINAVNEHG NVPLHYACFW GQDQVAEDLV 120

ANGALVSICN KYGEMPVDKA KAPLRELLRE RAEKMGQNLN RIPYKDTFWK GTTRTRPRNG 180

TLNKHSGIDF KQLHFIAQIN QNHSGELWKG RWQGNDIVMK VLKVRDWSTR KSRDFNEECP 240

RLRIFSHPNV LPVLGFCHAP PAPHPTLITH LMPHGSLYNI LHEGTNLVVD QSQAVKFALD 300

MARGMAFLHT LEPLIPRHAL NSRSVMIDED MTARISMADV KFSFQCPGRM YAPAWVAPEA 360

LQKKPEDTNR RSADMWSFAV LLWELVTREV PFADLSNMEI GMKVALEGLR PTIPPGISPH 420

VCKLMKICMN EDPAKRPKFD MIVPILEKMQ DK 452

Nucleotide Sequence
(FASTA)

ATGGACGACA TTTTCACTCA GTGCCGGGAA GGCAACGCGG TAGCCGTTCG CCTGTGGCTG 60

GACAACACGG AGAACGACCT CAACCAGGGG GACGATCATG GCTTCTCCCC CTTGCACTGG 120

GCTTGCCGAG AGGGCCGCTC TGCTGTGGTT GAGATGCTGA TCATGCGGGG GGCACGAATC 180

AATGTGATGA ACCGTGGGGA TGACACACCC TTGCACCTGG CAGCCAGTCA TGGGCACCGT 240

GATATTGTAC AGAAGCTGCT GCAGTACAAA GCTGACATCA ATGCAGTCAA TGAGCATGGG 300

AATGTGCCCC TGCACTATGC CTGTTTTTGG GGTCAAGATC AGGTGGCAGA GGACCTGGTG 360

GCTAATGGGG CCCTTGTCAG CATCTGCAAC AAATATGGAG AAATGCCTGT GGACAAAGCC 420

AAGGCACCCC TGAGAGAGCT GCTTCGAGAG CGGGCAGAGA AGATGGGCCA GAATCTCAAC 480

CGTATTCCAT ACAAGGACAC ATTCTGGAAG GGGACCACCC GCACTCGGCC CAGGAATGGG 540

ACTCTGAACA AACACTCCGG CATTGACTTC AAACAACTCC ACTTCATTGC ACAGATCAAC 600

CAGAATCACT CTGGAGAGCT ATGGAAGGGC CGCTGGCAGG GCAATGACAT TGTCATGAAG 660

GTGCTGAAGG TTCGAGACTG GAGTACAAGG AAAAGCAGGG ACTTCAACGA GGAGTGTCCC 720

CGGCTCAGGA TTTTCTCGCA TCCGAATGTG CTCCCAGTGC TAGGTTTCTG TCATGCTCCA 780

CCTGCTCCTC ACCCGACTCT CATCACACAC TTGATGCCAC ATGGATCCTT GTACAACATA 840

CTACATGAAG GCACCAATCT TGTTGTGGAC CAGAGTCAGG CTGTGAAGTT TGCACTGGAC 900

ATGGCAAGGG GCATGGCCTT CCTACACACA CTAGAGCCCC TCATCCCACG ACATGCACTC 960

AACAGCCGAA GTGTAATGAT TGATGAGGAC ATGACCGCCC GCATCAGCAT GGCTGACGTC 1020

AAGTTCTCTT TCCAATGCCC TGGGCGCATG TATGCACCTG CCTGGGTGGC CCCTGAAGCT 1080

CTGCAGAAGA AGCCTGAAGA CACAAACAGA CGCTCAGCAG ACATGTGGAG TTTTGCAGTG 1140

CTTCTATGGG AACTGGTGAC ACGCGAAGTA CCCTTTGCTG ACCTCTCCAA CATGGAGATT 1200

GGAATGAAGG TGGCACTGGA AGGCCTTCGG CCTACCATCC CACCAGGCAT TTCTCCCCAT 1260

GTGTGTAAGC TCATGAAGAT CTGCATGAAT GAAGACCCTG CTAAGCGGCC CAAGTTTGAC 1320

ATGATCGTGC CTATCCTGGA GAAGATGCAG GACAAGTAG 1359

Domain Profile

S: 4     eeligsgafgkvykakwrkkevavKklreeaeekekleklereakllsklshpniiellG  63

           +i+++++g+++k++w+++++++K l++++++++k++++++e+ +l+ +shpn++ +lG

Q: 196   IAQINQNHSGELWKGRWQGNDIVMKVLKVRDWSTRKSRDFNEECPRLRIFSHPNVLPVLG  255

         5789********************************************************

S: 64    vcleepn..lllvmeyveggsLsnvlhekskreidlevlvswalqiArGmaYLhseapkk  121

          c+++p+   +l+++++++gsL+n+lhe ++ ++d++++v++al++ArGma+Lh+ +p

Q: 256   FCHAPPAphPTLITHLMPHGSLYNILHEGTNLVVDQSQAVKFALDMARGMAFLHTLEPL-  314

         *****99745**********************************************997.

S: 122   iihrdLksknvLlseekktlkicdFGtarelskstkmsaa.gtlawmaPEvlkeekvs..  178

         i ++ L+s++v++ +e++t++i++ +++++   s+++  + +++aw+aPE+l++++ +

Q: 315   IPRHALNSRSVMI-DEDMTARISM-ADVKF---SFQCPGRmYAPAWVAPEALQKKPEDtn  369

         *************.**********.88888...78999998**************99988

S: 179   .eksDvwSygvvLWelltrevPykdlselaiaykvalkglrlpipsscpeklkkLmkecw  237

          +++D+wS++v+LWel+trevP++dls+++i +kval+glr++ip+ ++++++kLmk c+

Q: 370   rRSADMWSFAVLLWELVTREVPFADLSNMEIGMKVALEGLRPTIPPGISPHVCKLMKICM  429

         899*********************************************************

S: 238   nedpekRpsfseivks  253

         nedp+kRp+f++iv +

Q: 430   NEDPAKRPKFDMIVPI  445

         *************986

Domain Sequence
(FASTA)

IAQINQNHSG ELWKGRWQGN DIVMKVLKVR DWSTRKSRDF NEECPRLRIF SHPNVLPVLG 60

FCHAPPAPHP TLITHLMPHG SLYNILHEGT NLVVDQSQAV KFALDMARGM AFLHTLEPLI 120

PRHALNSRSV MIDEDMTARI SMADVKFSFQ CPGRMYAPAW VAPEALQKKP EDTNRRSADM 180

WSFAVLLWEL VTREVPFADL SNMEIGMKVA LEGLRPTIPP GISPHVCKLM KICMNEDPAK 240

RPKFDMIVPI 250

Keyword

ANK repeat; Complete proteome; Reference proteome; Repeat.

Sequence Source

Ensembl

Orthology

Ortholog group

Ailuropoda melanoleuca"; ?>Anolis carolinensis"; ?>Bos taurus"; ?>Caenorhabditis elegans"; ?>Callithrix jacchus"; ?>Canis familiaris"; ?>Cavia porcellus"; ?>Ciona intestinalis"; ?>Ciona savignyi"; ?>Danio rerio"; ?>Drosophila melanogaster"; ?>Equus caballus"; ?>Erinaceus europaeus"; ?>Felis catus"; ?>Gadus morhua"; ?>Gallus gallus"; ?>Gasterosteus aculeatus"; ?>Gorilla gorilla"; ?>Homo sapiens"; ?>Ictidomys tridecemlineatus"; ?>Latimeria chalumnae"; ?>Loxodonta africana"; ?>Macaca mulatta"; ?>Meleagris gallopavo"; ?>Microcebus murinus"; ?>Monodelphis domestica"; ?>Mus musculus"; ?>Mustela putorius furo"; ?>Nomascus leucogenys"; ?>Oreochromis niloticus"; ?>Oryctolagus cuniculus"; ?>Oryzias latipes"; ?>Otolemur garnettii"; ?>Pan troglodytes"; ?>Pelodiscus sinensis"; ?>Pongo abelii"; ?>Pteropus vampyrus"; ?>Rattus norvegicus"; ?>Sarcophilus harrisii"; ?>Sus scrofa"; ?>Taeniopygia guttata"; ?>Takifugu rubripes"; ?>Tetraodon nigroviridis"; ?>Tupaia belangeri"; ?>Tursiops truncatus"; ?>Xenopus tropicalis"; ?>Xiphophorus maculatus"; ?>

Gene Ontology

GO:0005524	; F:ATP binding
GO:0004674	; F:protein serine/threonine kinase activity
GO:0009966	; P:regulation of signal transduction

KEGG

InterPros

IPR002110	; Ankyrin_rpt.
IPR020683	; Ankyrin_rpt-contain_dom.
IPR016253	; Integrin-linked_kinase.
IPR011009	; Kinase-like_dom.
IPR000719	; Prot_kinase_cat_dom.
IPR001245	; Ser-Thr/Tyr_kinase_cat_dom.

Pfam

PF12796	; Ank_2; 1.
PF07714	; Pkinase_Tyr; 1.

SMARTs

SM00248

; ANK; 3.

Prosites

PS50297	; ANK_REP_REGION; 1.
PS50088	; ANK_REPEAT; 3.
PS50011	; PROTEIN_KINASE_DOM; 1.

Prints

Created Date

20-Feb-2013