EKS-MYL-00282

Eukaryotic Protein Kinase & Protein Phosphatase Database

Tag

Content

EKPD ID

EKS-MYL-00282

Classification

Group/Family	Score	E-Value	Start	End	Domain Length
TKL/STKR	449.0	6.9E-135	229	516	288

Status

Unreviewed

Ensembl Protein

ENSMLUP00000008280

UniProt Accession

G1PCW7;

Protein Name

Protein Synonyms/Alias

Gene Name

BMPR1B

Gene Synonyms/Alias

BMPR1B;

Ensembl Information

Ensembl Gene ID	Ensembl Protein ID	Ensembl Transcript ID
ENSMLUG00000009090	ENSMLUP00000008280	ENSMLUT00000009088

Organism

Myotis lucifugus

Functional Description

Protein Length

527

Protein Sequence
(FASTA)

LSSLRPNTRY LNAYLFSFSA DFLDNMLLRS SGKLNVGTKK EDGDSTAPTA RPKILRCKCH 60

HHCPEDSVNN ICSTDGYCFT MIEEDDSGMP VITSGCLGLE GSDFQCRDTP IPHQRRSIEC 120

CTERNECNKD LHPTLPPLKN RDFVDGSVHH KALLISVTVC SFLLVLIILF CYFRYKRQEA 180

RPRYSIGLEQ DETYIPPGES LKDLIEQSQS SGSGSGLPLL VQRTIAKQIQ MVKQIGKGRY 240

GEVWMGKWRG EKVAVKVFFT TEEASWFRET EIYQTVLMRH ENILGFIAAD IKGTGSWTQL 300

YLITDYHENG SLYDYLKSTT LDVKSMLKLA YSSVSGLCHL HTEIFSTQGK PAIAHRDLKS 360

KNILVKKNGT CCIADLGLAV KFISDTNEVD IPPNTRVGTK RYMPPEVLDE SLNRNHFQSY 420

IMADMYSFGL ILWEVTRRCV SGGAVEEYQL PYHDLVPSDP SYEDMREIVC IKKLRPSFPS 480

RWSGDECLRQ MGKLMTECWA HNPASRLTAL RVKKTLAKMS ESQDIKL 527

Nucleotide Sequence
(FASTA)

TTGAGCTCCT TGCGCCCAAA TACAAGATAC TTAAATGCTT ACCTTTTCTC CTTTTCAGCA 60

GACTTCCTTG ATAACATGCT TTTGCGAAGT TCAGGAAAAT TAAATGTGGG CACCAAGAAA 120

GAGGATGGTG ACAGTACAGC CCCCACTGCT CGTCCAAAGA TCTTGCGTTG TAAATGCCAC 180

CACCACTGTC CGGAAGACTC GGTCAACAAT ATTTGCAGCA CAGATGGATA TTGCTTCACG 240

ATGATAGAAG AAGATGATTC TGGGATGCCT GTGATCACGT CGGGATGTCT GGGACTAGAA 300

GGCTCAGATT TTCAGTGCCG GGACACTCCC ATTCCTCACC AAAGGAGATC AATTGAATGC 360

TGCACAGAAC GCAATGAATG TAATAAAGAT CTACACCCTA CATTGCCTCC ACTGAAAAAC 420

AGAGATTTTG TTGACGGATC TGTACACCAC AAAGCCTTAC TTATATCTGT GACTGTCTGT 480

AGTTTCCTGT TGGTCCTTAT CATTTTATTC TGTTACTTCA GGTATAAAAG ACAAGAAGCC 540

CGACCTCGGT ACAGCATTGG GTTGGAACAG GATGAAACTT ACATTCCTCC AGGCGAATCC 600

CTGAAAGACT TAATTGAGCA GTCTCAGAGC TCAGGAAGTG GGTCAGGCCT CCCTCTGCTG 660

GTCCAAAGGA CTATCGCTAA GCAGATTCAG ATGGTGAAAC AGATTGGGAA GGGTCGCTAC 720

GGGGAAGTTT GGATGGGAAA GTGGCGTGGC GAAAAGGTGG CCGTGAAAGT GTTCTTCACC 780

ACCGAGGAGG CCAGCTGGTT CCGCGAGACA GAGATTTATC AGACGGTGTT GATGAGGCAT 840

GAAAACATTT TGGGGTTCAT TGCCGCCGAT ATCAAAGGGA CAGGGTCCTG GACCCAGTTG 900

TACCTAATCA CAGACTATCA TGAAAACGGT TCCCTCTATG ATTACTTGAA GTCCACCACC 960

CTGGATGTTA AATCGATGCT GAAATTAGCC TATTCTTCCG TCAGTGGCTT ATGTCATTTA 1020

CACACCGAGA TCTTTAGTAC CCAAGGCAAG CCAGCAATCG CCCATCGAGA CCTGAAAAGT 1080

AAGAACATCC TGGTGAAGAA AAATGGCACT TGCTGTATAG CCGACCTGGG TCTGGCTGTT 1140

AAATTTATTA GCGATACAAA TGAAGTTGAC ATACCACCCA ACACTCGTGT TGGCACCAAG 1200

CGCTATATGC CTCCAGAAGT GTTGGATGAG AGCTTGAATA GAAATCACTT TCAGTCTTAC 1260

ATCATGGCCG ACATGTACAG CTTTGGGCTC ATTCTTTGGG AGGTGACTAG GAGATGCGTG 1320

TCAGGAGGTG CAGTGGAAGA ATACCAGCTT CCCTATCACG ACCTGGTGCC CAGTGACCCC 1380

TCTTATGAGG ACATGAGAGA GATCGTGTGC ATCAAGAAGC TCCGTCCCTC ATTCCCCAGC 1440

CGGTGGAGTG GCGATGAGTG TCTGAGGCAG ATGGGGAAGC TAATGACCGA GTGCTGGGCT 1500

CACAATCCCG CGTCCAGACT GACAGCCCTG CGTGTGAAGA AAACACTTGC CAAAATGTCA 1560

GAGTCCCAGG ACATTAAACT CTGA 1584

Domain Profile

S: 1     lklleligkGrygeVwkaklrgeevAvKifstedeaswkrEkeiyqtvllrhenilqfia  60

         ++++++igkGrygeVw++k+rge+vAvK+f+t++easw+rE+eiyqtvl+rhenil+fia

Q: 229   IQMVKQIGKGRYGEVWMGKWRGEKVAVKVFFTTEEASWFRETEIYQTVLMRHENILGFIA  288

         799*********************************************************

S: 61    adkkeedsltelllvteyhekgsLsdyLkretldveellrlalslasGlahLHeeivgtk  120

         ad+k ++s+t+l+l+t+yhe+gsL+dyLk++tldv+++l+la+s +sGl+hLH+ei+ t+

Q: 289   ADIKGTGSWTQLYLITDYHENGSLYDYLKSTTLDVKSMLKLAYSSVSGLCHLHTEIFSTQ  348

         ************************************************************

S: 121   gkkKpaiaHRDlkskNilvkkdltcciaDlGLalkleeekeeldlaansqvGtkRYmaPE  180

         g  KpaiaHRDlkskNilvkk++tcciaDlGLa+k+ ++++e+d+  n++vGtkRYm PE

Q: 349   G--KPAIAHRDLKSKNILVKKNGTCCIADLGLAVKFISDTNEVDIPPNTRVGTKRYMPPE  406

         *..*********************************************************

S: 181   vleealnlkdfeafkraDvYslgLvlWEvasRceevdeeveeyklpfeevvgsdPsleem  240

         vl+e+ln ++f+++ +aD+Ys+gL+lWEv++Rc + +++veey+lp+++ v+sdPs+e+m

Q: 407   VLDESLNRNHFQSYIMADMYSFGLILWEVTRRCVS-GGAVEEYQLPYHDLVPSDPSYEDM  465

         ***********************************.************************

S: 241   kevvvekklrPkipeawkkkealkelsklleecWdadpeaRltalrvkkrl  291

         +e+v+ kklrP++p++w+ +e+l+++ kl++ecW+++p++Rltalrvkk+l

Q: 466   REIVCIKKLRPSFPSRWSGDECLRQMGKLMTECWAHNPASRLTALRVKKTL  516

         *************************************************97

Domain Sequence
(FASTA)

IQMVKQIGKG RYGEVWMGKW RGEKVAVKVF FTTEEASWFR ETEIYQTVLM RHENILGFIA 60

ADIKGTGSWT QLYLITDYHE NGSLYDYLKS TTLDVKSMLK LAYSSVSGLC HLHTEIFSTQ 120

GKPAIAHRDL KSKNILVKKN GTCCIADLGL AVKFISDTNE VDIPPNTRVG TKRYMPPEVL 180

DESLNRNHFQ SYIMADMYSF GLILWEVTRR CVSGGAVEEY QLPYHDLVPS DPSYEDMREI 240

VCIKKLRPSF PSRWSGDECL RQMGKLMTEC WAHNPASRLT ALRVKKTL 288

Keyword

ATP-binding; Complete proteome; Kinase; Nucleotide-binding; Reference proteome; Serine/threonine-protein kinase; Transferase.

Sequence Source

Ensembl

Orthology

Ortholog group

Ailuropoda melanoleuca"; ?>Anolis carolinensis"; ?>Bos taurus"; ?>Caenorhabditis elegans"; ?>Callithrix jacchus"; ?>Canis familiaris"; ?>Cavia porcellus"; ?>Drosophila melanogaster"; ?>Equus caballus"; ?>Felis catus"; ?>Gadus morhua"; ?>Gallus gallus"; ?>Gasterosteus aculeatus"; ?>Gorilla gorilla"; ?>Homo sapiens"; ?>Ictidomys tridecemlineatus"; ?>Latimeria chalumnae"; ?>Loxodonta africana"; ?>Macaca mulatta"; ?>Meleagris gallopavo"; ?>Monodelphis domestica"; ?>Mus musculus"; ?>Mustela putorius furo"; ?>Nomascus leucogenys"; ?>Ochotona princeps"; ?>Oreochromis niloticus"; ?>Oryctolagus cuniculus"; ?>Oryzias latipes"; ?>Otolemur garnettii"; ?>Pan troglodytes"; ?>Pelodiscus sinensis"; ?>Pongo abelii"; ?>Sarcophilus harrisii"; ?>Taeniopygia guttata"; ?>Takifugu rubripes"; ?>Tetraodon nigroviridis"; ?>Tupaia belangeri"; ?>Tursiops truncatus"; ?>Vicugna pacos"; ?>Xenopus tropicalis"; ?>Xiphophorus maculatus"; ?>

Gene Ontology

GO:0016020	; C:membrane
GO:0005524	; F:ATP binding
GO:0004702	; F:receptor signaling protein serine/threonine kinase activity
GO:0005024	; F:transforming growth factor beta-activated receptor activity
GO:0023014	; P:signal transduction by phosphorylation

KEGG

InterPros

IPR000333	; Activin_II/TGFBeta-II_recpt.
IPR000472	; Activin_rcpt.
IPR011009	; Kinase-like_dom.
IPR000719	; Prot_kinase_cat_dom.
IPR017441	; Protein_kinase_ATP_BS.
IPR008271	; Ser/Thr_kinase_AS.
IPR003605	; TGF_beta_rcpt_GS.

Pfam

PF01064	; Activin_recp; 1.
PF00069	; Pkinase; 1.
PF08515	; TGF_beta_GS; 1.

SMARTs

SM00467

; GS; 1.

Prosites

PS51256	; GS; 1.
PS00107	; PROTEIN_KINASE_ATP; 1.
PS50011	; PROTEIN_KINASE_DOM; 1.
PS00108	; PROTEIN_KINASE_ST; 1.

Prints

PR00653

; ACTIVIN2R.

Created Date

20-Feb-2013