EKS-MYL-00293

Eukaryotic Protein Kinase & Protein Phosphatase Database

Tag

Content

EKPD ID

EKS-MYL-00293

Classification

Group/Family	Score	E-Value	Start	End	Domain Length
Other/BUB	371.5	2.0E-111	782	1049	268

Status

Unreviewed

Ensembl Protein

ENSMLUP00000008467

UniProt Accession

G1PDD0;

Protein Name

Protein Synonyms/Alias

Gene Name

BUB1

Gene Synonyms/Alias

BUB1;

Ensembl Information

Ensembl Gene ID	Ensembl Protein ID	Ensembl Transcript ID
ENSMLUG00000009264	ENSMLUP00000008467	ENSMLUT00000009288

Organism

Myotis lucifugus

Functional Description

Protein Length

1081

Protein Sequence
(FASTA)

MDSPENVLQM FEAHMQSYKG NDPLSVWQSY MQWIEENFPE NKEYFTTLLE RLLKEFLDNK 60

RYHNDPRFIN YCLKFAECNT DPHQFFEFLY NHGIGKLSSP LYIAWAEHLE GQGHLQHASA 120

VFRRGIQNQA EPKELLQQQY RLFQTRVTKT HLPAQARTSE PLHNAQILNQ MMTSKSNPAC 180

VSKNQGSEVS KVTSSACDKE SNMEQRVVVI SKSEYSGHPS LTAKTDIQQV VMYCKEKLIC 240

GESEFSFEEL RAHKYNQRRK HEQWVNEDRH YMKMKEANAF EERLLKEKMD ELHKKLHQVV 300

ETSQEDLPAF QESPEVNPAC MGPSVDSQQE LSTPSLPTIT QQTSEDMGEK PRQAPAAVPP 360

EANVVTVALV SPAISQSAAP PAPLAAQQGT DSMFSVAGND ARCVTRTTQE FKPQSRAEMK 420

EGFETHKVVN TSSFHTTPNT SLGMVQATPS KVQPSPTVHT KEALGFIMNM FQAPTLPDVS 480

DDKDEWPSLD QNEDAFEAQF QKKARSSGTW GVNKIISSLS SAFSVFEDGN KENYGLPQHI 540

NKPIGARAFG ERSISRVSPR PKQEVPHAEE FWDDSTVWGV RCTKTLAPSP KSPGDFTSAA 600

QLASTPFHKL PVDSAHALED KENVIAAQCT HVTLDSCEKN VVQPSKDRKF RSSPIQEKSP 660

EAAFPISASL LHPSQPAAGG MLTSEAERNL KACTLTDTNL PVVRKPSDTS AGLQAEWVQP 720

RSLGSVDTSS FTVENPWDDR LIFKLLSGLS QPVRSSPNAF EWQCKLPAIK PKTEFQLGSL 780

LVYIDHLLGE GAFAQVYEVT HGDVKDTKSK QKFVLKVQKP ANAWEFYIGT QLMERLSPSE 840

RHMFIKFYSA HFFQDGSVLV GDLYSYGTLL NAINLYKNTP EKVMPQALVL SFAIRMLHMI 900

EQVHSCEIIH GDIKPDNFIL GSRFLEQDRE DDNLSDGLAL IDLGQSIDMK LFPKGTTFTA 960

KCETSGFQCT EMLSNKPWNY QIDYFGVAAT VYCMLFGSYM KLKNEGGVWK PEGLFRRLPH 1020

LDMWNEFFHI MLNIPDCHHL PSLDLLRQKL KKIFQQHYTN KIKTLRNRLI VLLLEHKRSR 1080

K 1081

Nucleotide Sequence
(FASTA)

ATGGACAGCC CGGAAAACGT CCTGCAAATG TTCGAAGCCC ACATGCAGAG CTACAAGGGC 60

AATGACCCAC TTAGTGTATG GCAAAGTTAT ATGCAATGGA TAGAAGAGAA TTTTCCTGAG 120

AACAAAGAAT ACTTTACAAC TCTATTAGAA CGTTTACTGA AGGAATTTTT AGATAACAAG 180

AGATACCATA ATGATCCAAG ATTCATCAAT TATTGTTTAA AGTTTGCTGA GTGCAACACT 240

GACCCTCATC AGTTTTTTGA GTTTCTGTAC AACCATGGGA TTGGGAAGCT GTCCTCTCCT 300

CTGTACATAG CCTGGGCTGA GCATCTGGAG GGCCAAGGAC ACCTGCAACA TGCCAGCGCC 360

GTCTTCCGGA GAGGAATTCA AAACCAGGCA GAACCTAAAG AGCTGCTGCA GCAACAGTAC 420

AGGTTATTTC AGACACGTGT TACCAAAACC CATTTGCCAG CTCAAGCTAG AACCTCAGAA 480

CCTCTGCATA ATGCTCAGAT TTTAAACCAA ATGATGACAT CAAAATCAAA TCCAGCCTGT 540

GTTTCTAAGA ATCAGGGTTC AGAAGTTTCT AAAGTAACAT CTTCAGCTTG TGATAAAGAG 600

TCGAATATGG AACAACGGGT GGTCGTGATT TCTAAATCAG AATACTCTGG ACATCCCTCT 660

CTGACAGCCA AAACTGACAT TCAGCAGGTT GTTATGTACT GCAAGGAGAA GCTCATTTGT 720

GGAGAGTCAG AATTCTCCTT TGAAGAGCTG AGAGCCCACA AGTACAATCA ACGGAGAAAG 780

CATGAGCAGT GGGTAAATGA AGACAGACAT TACATGAAAA TGAAAGAAGC AAATGCTTTT 840

GAAGAACGAC TACTGAAAGA GAAAATGGAT GAACTTCATA AGAAGTTGCA TCAAGTGGTA 900

GAGACATCCC AGGAGGACCT TCCTGCTTTT CAGGAAAGTC CTGAGGTTAA TCCAGCATGC 960

ATGGGGCCAA GTGTCGACTC CCAGCAGGAA CTGAGCACTC CATCTCTGCC AACCATAACT 1020

CAGCAAACCT CAGAGGACAT GGGAGAAAAA CCCAGACAAG CACCTGCTGC TGTTCCTCCT 1080

GAAGCCAATG TGGTCACTGT GGCTTTGGTG TCCCCAGCCA TCAGCCAGAG TGCAGCTCCT 1140

CCTGCTCCTT TGGCAGCCCA GCAAGGCACA GACTCCATGT TTTCAGTGGC CGGAAATGAT 1200

GCCAGATGTG TGACTAGAAC TACTCAGGAA TTCAAGCCAC AGAGCAGAGC AGAGATGAAA 1260

GAAGGGTTTG AAACACATAA GGTTGTTAAC ACAAGTTCTT TTCACACAAC TCCAAACACA 1320

TCCCTGGGAA TGGTTCAGGC AACACCATCC AAAGTGCAGC CATCACCCAC CGTGCACACA 1380

AAAGAAGCAT TAGGGTTCAT CATGAATATG TTCCAGGCTC CTACACTTCC TGATGTTTCT 1440

GATGACAAAG ATGAATGGCC ATCTCTAGAT CAAAATGAAG ATGCATTTGA AGCTCAGTTT 1500

CAAAAAAAGG CAAGATCTTC TGGAACTTGG GGAGTCAATA AGATTATCTC TTCTTTGTCA 1560

TCTGCTTTTT CCGTGTTTGA AGATGGAAAC AAAGAAAATT ATGGATTACC ACAACATATA 1620

AACAAACCCA TAGGAGCCAG GGCTTTTGGA GAACGCTCTA TAAGCAGAGT TTCTCCAAGA 1680

CCAAAGCAGG AAGTACCTCA TGCTGAAGAG TTTTGGGATG ACTCGACAGT GTGGGGCGTC 1740

CGCTGCACCA AGACGCTGGC ACCCAGTCCT AAGAGCCCAG GAGACTTTAC ATCTGCTGCA 1800

CAGCTTGCAT CTACTCCTTT CCACAAACTT CCGGTGGACT CAGCACACGC TCTGGAAGAT 1860

AAAGAAAATG TGATAGCAGC ACAGTGCACC CATGTGACTT TGGATTCATG TGAAAAAAAC 1920

GTGGTGCAAC CCTCAAAAGA CAGAAAGTTC AGATCCAGTC CAATTCAAGA GAAAAGCCCA 1980

GAAGCAGCAT TCCCCATCAG TGCATCCTTA CTGCATCCGA GCCAGCCAGC TGCGGGTGGC 2040

ATGCTGACCA GCGAGGCAGA GCGGAACCTG AAAGCTTGTA CACTCACAGA TACTAACCTT 2100

CCTGTTGTGC GGAAGCCATC GGACACCAGT GCTGGACTCC AGGCAGAATG GGTGCAGCCT 2160

CGGTCACTTG GGAGTGTCGA TACTTCAAGC TTCACTGTTG AGAATCCATG GGATGATCGA 2220

TTGATTTTCA AACTTCTGTC CGGGCTTTCT CAACCAGTGC GCTCCAGTCC AAATGCTTTC 2280

GAGTGGCAGT GTAAACTTCC TGCCATCAAG CCCAAGACTG AGTTTCAGCT GGGTTCTTTG 2340

CTGGTCTATA TTGATCACCT TCTTGGAGAA GGCGCTTTTG CCCAAGTTTA TGAAGTTACC 2400

CATGGAGATG TGAAGGATAC CAAAAGTAAA CAGAAATTTG TTTTGAAGGT CCAGAAGCCC 2460

GCCAATGCCT GGGAATTCTA CATTGGGACC CAGCTAATGG AGAGACTATC ACCCAGTGAG 2520

CGACACATGT TTATCAAGTT CTATTCTGCC CACTTCTTCC AGGATGGCAG CGTATTAGTG 2580

GGAGATCTCT ACAGCTATGG AACATTACTG AATGCTATCA ATCTCTATAA AAACACCCCT 2640

GAGAAAGTGA TGCCTCAAGC TCTAGTGCTT TCCTTTGCTA TAAGAATGCT GCACATGATT 2700

GAACAAGTCC ACAGCTGCGA GATCATCCAT GGAGACATTA AGCCAGACAA CTTCATACTT 2760

GGAAGCAGAT TTTTGGAACA GGACAGAGAA GATGATAATT TATCTGATGG CTTGGCACTT 2820

ATTGACCTGG GTCAGAGTAT AGATATGAAA CTTTTTCCAA AAGGAACTAC ATTTACAGCA 2880

AAGTGTGAAA CGTCCGGTTT TCAATGTACT GAGATGCTCA GTAACAAACC GTGGAACTAC 2940

CAGATTGATT ACTTTGGAGT TGCTGCAACC GTGTACTGCA TGCTTTTTGG CTCTTACATG 3000

AAATTGAAAA ATGAAGGAGG AGTCTGGAAG CCTGAAGGTC TTTTTAGAAG GCTTCCGCAT 3060

TTGGATATGT GGAATGAATT TTTCCACATC ATGTTGAATA TACCAGATTG TCATCATCTT 3120

CCGTCTTTGG ATTTGTTAAG GCAAAAGCTA AAGAAGATAT TTCAACAACA CTATACAAAC 3180

AAGATTAAGA CCCTCCGTAA CAGGCTAATT GTACTGCTCT TAGAACATAA ACGTTCTCGA 3240

AAATAA 3246

Domain Profile

S: 1     leiekeigeGayakvykaeh....dsksgelvalKvekpansWefYIclqlkeRlkeeel  56

         ++i++++geGa+a+vy+ +h    d+ks+++++lKv+kpan WefYI +ql+eRl  ++

Q: 782   VYIDHLLGEGAFAQVYEVTHgdvkDTKSKQKFVLKVQKPANAWEFYIGTQLMERLS-PSE  840

         589******************99999*****************************9.668

S: 57    lksiieissallfqdasllvleyasygtlldlinkvkevtnkvmdeelvvllivqllkiv  116

          +++i+++sa+ fqd+s+lv +++sygtll++in++k++ +kvm+++lv+++++++l+++

Q: 841   RHMFIKFYSAHFFQDGSVLVGDLYSYGTLLNAINLYKNTPEKVMPQALVLSFAIRMLHMI  900

         9***********************************************************

S: 117   eklHeveIiHgDlkPdnfllgnrimdkad.kdkeekglkliDfgrsiDmkllpdgtkfkg  175

         e++H++eIiHgD+kPdnf+lg r+ ++   +d+ + gl+liD+g+siDmkl+p+gt+f++

Q: 901   EQVHSCEIIHGDIKPDNFILGSRFLEQDReDDNLSDGLALIDLGQSIDMKLFPKGTTFTA  960

         *************************998735667889***********************

S: 176   kaktdafeciemlagkswsYqvDlfglaavihvllfgkyleviqeggswklkqkikrllk  235

         k++t++f+c+eml++k+w+Yq+D+fg+aa+++++lfg+y+++++egg wk++  ++rl++

Q: 961   KCETSGFQCTEMLSNKPWNYQIDYFGVAATVYCMLFGSYMKLKNEGGVWKPEGLFRRLPH  1020

         ************************************************************

S: 236   kelwekiferlLNisdastlpsleelveek  265

          ++w+++f+ +LNi+d+++lpsl+ l++ k

Q: 1021  LDMWNEFFHIMLNIPDCHHLPSLDLLRQ-K  1049

         **************************95.4

Domain Sequence
(FASTA)

VYIDHLLGEG AFAQVYEVTH GDVKDTKSKQ KFVLKVQKPA NAWEFYIGTQ LMERLSPSER 60

HMFIKFYSAH FFQDGSVLVG DLYSYGTLLN AINLYKNTPE KVMPQALVLS FAIRMLHMIE 120

QVHSCEIIHG DIKPDNFILG SRFLEQDRED DNLSDGLALI DLGQSIDMKL FPKGTTFTAK 180

CETSGFQCTE MLSNKPWNYQ IDYFGVAATV YCMLFGSYMK LKNEGGVWKP EGLFRRLPHL 240

DMWNEFFHIM LNIPDCHHLP SLDLLRQK 268

Keyword

Complete proteome; Reference proteome.

Sequence Source

Ensembl

Orthology

Ortholog group

Ailuropoda melanoleuca"; ?>Anolis carolinensis"; ?>Bos taurus"; ?>Caenorhabditis elegans"; ?>Callithrix jacchus"; ?>Canis familiaris"; ?>Cavia porcellus"; ?>Ciona intestinalis"; ?>Ciona savignyi"; ?>Danio rerio"; ?>Drosophila melanogaster"; ?>Equus caballus"; ?>Felis catus"; ?>Gadus morhua"; ?>Gallus gallus"; ?>Gasterosteus aculeatus"; ?>Gorilla gorilla"; ?>Homo sapiens"; ?>Latimeria chalumnae"; ?>Loxodonta africana"; ?>Macaca mulatta"; ?>Meleagris gallopavo"; ?>Monodelphis domestica"; ?>Mus musculus"; ?>Mustela putorius furo"; ?>Nomascus leucogenys"; ?>Oreochromis niloticus"; ?>Ornithorhynchus anatinus"; ?>Oryctolagus cuniculus"; ?>Oryzias latipes"; ?>Otolemur garnettii"; ?>Pan troglodytes"; ?>Pongo abelii"; ?>Rattus norvegicus"; ?>Sarcophilus harrisii"; ?>Sus scrofa"; ?>Taeniopygia guttata"; ?>Takifugu rubripes"; ?>Tetraodon nigroviridis"; ?>Xenopus tropicalis"; ?>Saccharomyces cerevisiae"; ?>Schizosaccharomyces pombe"; ?>

Gene Ontology

GO:0005524	; F:ATP binding
GO:0004674	; F:protein serine/threonine kinase activity

KEGG

InterPros

IPR011009	; Kinase-like_dom.
IPR013212	; Mad3_BUB1_I.
IPR000719	; Prot_kinase_cat_dom.
IPR017441	; Protein_kinase_ATP_BS.
IPR008271	; Ser/Thr_kinase_AS.
IPR015661	; Ser/Thr_kinase_Bub1.

Pfam

PF08311	; Mad3_BUB1_I; 1.
PF00069	; Pkinase; 1.

SMARTs

SM00777

; Mad3_BUB1_I; 1.

Prosites

PS51489	; BUB1_N; 1.
PS00107	; PROTEIN_KINASE_ATP; 1.
PS50011	; PROTEIN_KINASE_DOM; 1.
PS00108	; PROTEIN_KINASE_ST; 1.

Prints

Created Date

20-Feb-2013