EKS-MYL-00197

Eukaryotic Protein Kinase & Protein Phosphatase Database

Tag

Content

EKPD ID

EKS-MYL-00197

Classification

Group/Family	Score	E-Value	Start	End	Domain Length
TKL/LISK	471.3	8.1E-142	363	632	270

Status

Unreviewed

Ensembl Protein

ENSMLUP00000009033

UniProt Accession

G1PET0;

Protein Name

Protein Synonyms/Alias

Gene Name

LIMK2

Gene Synonyms/Alias

LIMK2;

Ensembl Information

Ensembl Gene ID	Ensembl Protein ID	Ensembl Transcript ID
ENSMLUG00000009892	ENSMLUP00000009033	ENSMLUT00000009907

Organism

Myotis lucifugus

Functional Description

Protein Length

670

Protein Sequence
(FASTA)

LFSCSGGRGE RWAAGPQPEV PGAPGLSWWP TAAGLRRSQT GLQLSLFVWC GKKMGSYLSI 60

SAYFTSRDPF RCSECQESLT NWYYEKDGKL YCHKDYWRKF GEFCHGCSLL MTGPVMVAGE 120

FKYHPECFAC MSCKVIIEDG DAYALVQHAT LYCGKCHNEV VLAPMFERLS TESVQDQLPY 180

SVTHISMPAT TESRRGFSVS VESACSNYAT SVQVKEVNRM HISPNNRNAI HPGDRILEIN 240

GTPVRTLRVE EVEDAISQTS QTLQLLIEHD PVSQRLDQLR LDARLSPHLQ NAGHSHTLST 300

LDIKENLEGT LRRRSLRRSN SISKSPGPSS PKEPLLFSRD ISRSESLRCS SSYSQQIFRP 360

CDLIHGEVLG KGFFGQAIKV THKATGKVMV MKELIRCDEE TQKTFLTEVK VMRSLDHPNV 420

LKFIGVLYKD KKLNLLTEYI EGGTLKDFVR SVDPLPWQQK VRFAKGIASG MAYLHSMCII 480

HRDLNSHNCL IKLDKTVVVA DFGLSRLIVE ERKKPPVEKA TSKKRTLRKN DRKKRYTVVG 540

NPYWMAPEML NGKSYDETVD VFSFGIVLCE IIGQVYADPD CLPRTLDYGL NVKLFWEKFV 600

PTDCPPAFFP LATICCKLEP ESRPAFSKLE DSFEALSLYL GELGIPLPAE LEELDHTVSV 660

QYGLIRDSPP 670

Nucleotide Sequence
(FASTA)

CTCTTCAGCT GCTCCGGAGG GAGAGGTGAG CGCTGGGCAG CCGGCCCGCA GCCAGAGGTG 60

CCGGGAGCCC CGGGCCTGTC ATGGTGGCCG ACTGCAGCCG GCCTGAGGCG CTCCCAGACG 120

GGTTTGCAGC TGAGCTTGTT TGTCTGGTGT GGGAAGAAGA TGGGGAGTTA CTTGTCCATC 180

TCGGCTTACT TCACCTCCAG AGACCCCTTT CGGTGTTCGG AATGCCAGGA GTCCCTCACC 240

AACTGGTACT ACGAGAAGGA CGGGAAGCTG TACTGCCACA AGGACTACTG GAGGAAATTT 300

GGGGAATTCT GCCACGGGTG CTCTCTGCTG ATGACCGGGC CTGTCATGGT GGCCGGGGAG 360

TTCAAGTACC ACCCAGAGTG CTTTGCCTGT ATGAGCTGCA AGGTGATCAT CGAGGATGGG 420

GACGCATATG CCCTGGTGCA GCACGCCACC CTCTACTGTG GGAAGTGCCA TAATGAGGTG 480

GTGCTGGCAC CCATGTTTGA GAGGCTCTCC ACGGAGTCTG TTCAGGACCA GCTGCCCTAC 540

TCCGTCACAC ACATCTCCAT GCCAGCCACC ACCGAGAGCC GGCGGGGCTT CTCCGTGTCC 600

GTGGAGAGCG CCTGCTCCAA CTACGCCACC TCTGTGCAAG TAAAAGAGGT CAACCGGATG 660

CATATCAGTC CCAACAACCG CAATGCCATC CACCCTGGGG ACCGCATCCT GGAGATCAAT 720

GGGACCCCCG TCCGCACACT GCGCGTAGAG GAGGTAGAGG ATGCAATTAG CCAGACGAGC 780

CAGACACTTC AGCTCCTGAT TGAACACGAC CCCGTCTCCC AGCGCCTGGA CCAGCTGCGG 840

CTGGATGCAC GGCTCTCTCC CCACCTGCAG AATGCTGGGC ACTCGCACAC CCTCAGCACC 900

CTGGACATCA AGGAGAACCT GGAAGGGACT CTGAGGAGAC GTTCCCTAAG GCGCAGTAAC 960

AGCATCTCCA AGTCCCCCGG CCCCAGCTCC CCAAAGGAAC CCCTGCTGTT TAGCCGTGAC 1020

ATCAGCCGTT CCGAATCCCT TCGCTGCTCT AGCAGCTACT CCCAGCAGAT CTTTCGGCCG 1080

TGTGACCTGA TCCACGGGGA GGTCCTGGGG AAGGGCTTCT TTGGGCAGGC CATCAAGGTG 1140

ACACACAAAG CCACGGGCAA AGTGATGGTC ATGAAGGAGC TGATTCGGTG TGACGAGGAG 1200

ACCCAGAAGA CCTTTCTGAC TGAGGTGAAG GTGATGCGCA GCCTGGACCA CCCCAACGTG 1260

CTCAAGTTCA TCGGGGTGCT ATACAAGGAC AAGAAGCTGA ACCTGCTGAC AGAGTACATT 1320

GAGGGGGGCA CGTTGAAGGA CTTTGTGCGC AGCGTGGACC CGTTGCCCTG GCAGCAGAAG 1380

GTCAGGTTTG CCAAAGGCAT CGCCTCTGGA ATGGCCTATC TGCACTCCAT GTGCATCATC 1440

CACCGGGACC TGAACTCACA CAACTGCCTC ATCAAGTTGG ACAAGACCGT GGTGGTGGCA 1500

GACTTTGGGC TGTCACGGCT CATCGTAGAG GAGAGGAAAA AGCCCCCAGT GGAGAAGGCC 1560

ACCAGCAAGA AGCGTACGCT GCGCAAAAAT GACCGCAAGA AGCGCTACAC GGTGGTGGGG 1620

AACCCCTACT GGATGGCCCC TGAGATGCTG AATGGAAAGA GCTACGACGA GACGGTGGAT 1680

GTCTTCTCTT TCGGGATCGT TCTCTGCGAG ATCATCGGGC AGGTGTATGC AGATCCTGAC 1740

TGCCTGCCCC GCACACTGGA CTATGGCCTC AACGTGAAGC TTTTCTGGGA GAAGTTTGTC 1800

CCCACAGACT GCCCCCCAGC CTTCTTCCCC CTGGCCACCA TCTGCTGCAA ACTGGAGCCC 1860

GAGAGCAGAC CGGCATTCTC AAAACTGGAG GACTCCTTTG AGGCCCTCTC CCTGTACCTG 1920

GGAGAGCTGG GCATCCCGCT GCCTGCAGAG CTGGAGGAGC TGGACCACAC TGTGAGCGTG 1980

CAGTACGGCC TGATCCGGGA CTCGCCCCCC TAG 2013

Domain Profile

S: 1     livgeklGkGffsevfkvthrasGevmvlkeliradeenrknllkevkllrklehpnvlk  60

         li+ge+lGkGff++++kvth+a+G+vmv+kelir+dee++k++l+evk++r+l+hpnvlk

Q: 363   LIHGEVLGKGFFGQAIKVTHKATGKVMVMKELIRCDEETQKTFLTEVKVMRSLDHPNVLK  422

         689*********************************************************

S: 61    fiGvlvkdkklhllteyiegGtlkellkskeslpwtqrvrlakdiasGlsylhskgiihr  120

         fiGvl+kdkkl+llteyiegGtlk++++s ++lpw+q+vr+ak+iasG++ylhs++iihr

Q: 423   FIGVLYKDKKLNLLTEYIEGGTLKDFVRSVDPLPWQQKVRFAKGIASGMAYLHSMCIIHR  482

         ************************************************************

S: 121   dlnsknclvredksvvvadfGlarlvveerkks......eklrslkkkdrkkrltvvGsP  174

         dlns+ncl++ dk+vvvadfGl+rl+veerkk+      +k+r+l+k+drkkr+tvvG+P

Q: 483   DLNSHNCLIKLDKTVVVADFGLSRLIVEERKKPpvekatSKKRTLRKNDRKKRYTVVGNP  542

         *******************************9999999999*******************

S: 175   ywmaPevlkgksydekvdvfsfGivlceiiarveadPdylPrtedfgldvkafreklvae  234

         ywmaPe+l+gksyde+vdvfsfGivlceii++v+adPd+lPrt d+gl+vk f+ek+v++

Q: 543   YWMAPEMLNGKSYDETVDVFSFGIVLCEIIGQVYADPDCLPRTLDYGLNVKLFWEKFVPT  602

         ************************************************************

S: 235   dcPeaflklavvccdldpesrpsfeelekk  264

         dcP+af++la +cc+l+pesrp+f++le++

Q: 603   DCPPAFFPLATICCKLEPESRPAFSKLEDS  632

         ***************************986

Domain Sequence
(FASTA)

LIHGEVLGKG FFGQAIKVTH KATGKVMVMK ELIRCDEETQ KTFLTEVKVM RSLDHPNVLK 60

FIGVLYKDKK LNLLTEYIEG GTLKDFVRSV DPLPWQQKVR FAKGIASGMA YLHSMCIIHR 120

DLNSHNCLIK LDKTVVVADF GLSRLIVEER KKPPVEKATS KKRTLRKNDR KKRYTVVGNP 180

YWMAPEMLNG KSYDETVDVF SFGIVLCEII GQVYADPDCL PRTLDYGLNV KLFWEKFVPT 240

DCPPAFFPLA TICCKLEPES RPAFSKLEDS 270

Keyword

Complete proteome; LIM domain; Metal-binding; Reference proteome; Zinc.

Sequence Source

Ensembl

Orthology

Ortholog group

Ailuropoda melanoleuca"; ?>Bos taurus"; ?>Callithrix jacchus"; ?>Canis familiaris"; ?>Cavia porcellus"; ?>Choloepus hoffmanni"; ?>Ciona intestinalis"; ?>Danio rerio"; ?>Echinops telfairi"; ?>Equus caballus"; ?>Felis catus"; ?>Gallus gallus"; ?>Gasterosteus aculeatus"; ?>Gorilla gorilla"; ?>Homo sapiens"; ?>Ictidomys tridecemlineatus"; ?>Loxodonta africana"; ?>Macaca mulatta"; ?>Meleagris gallopavo"; ?>Monodelphis domestica"; ?>Mus musculus"; ?>Mustela putorius furo"; ?>Nomascus leucogenys"; ?>Oreochromis niloticus"; ?>Ornithorhynchus anatinus"; ?>Oryctolagus cuniculus"; ?>Oryzias latipes"; ?>Otolemur garnettii"; ?>Pan troglodytes"; ?>Pelodiscus sinensis"; ?>Pongo abelii"; ?>Procavia capensis"; ?>Pteropus vampyrus"; ?>Rattus norvegicus"; ?>Sarcophilus harrisii"; ?>Sus scrofa"; ?>Taeniopygia guttata"; ?>Takifugu rubripes"; ?>Tetraodon nigroviridis"; ?>Tursiops truncatus"; ?>Xenopus tropicalis"; ?>Xiphophorus maculatus"; ?>

Gene Ontology

GO:0005524	; F:ATP binding
GO:0004672	; F:protein kinase activity
GO:0008270	; F:zinc ion binding

KEGG

InterPros

IPR011009	; Kinase-like_dom.
IPR001478	; PDZ.
IPR000719	; Prot_kinase_cat_dom.
IPR017441	; Protein_kinase_ATP_BS.
IPR001245	; Ser-Thr/Tyr_kinase_cat_dom.
IPR001781	; Znf_LIM.

Pfam

PF00412	; LIM; 2.
PF00595	; PDZ; 1.
PF07714	; Pkinase_Tyr; 1.

SMARTs

SM00132	; LIM; 2.
SM00228	; PDZ; 1.

Prosites

PS00478	; LIM_DOMAIN_1; 1.
PS50023	; LIM_DOMAIN_2; 1.
PS50106	; PDZ; 1.
PS00107	; PROTEIN_KINASE_ATP; 1.
PS50011	; PROTEIN_KINASE_DOM; 1.

Prints

Created Date

20-Feb-2013