EKS-MYL-00378

Eukaryotic Protein Kinase & Protein Phosphatase Database

Tag

Content

EKPD ID

EKS-MYL-00378

Classification

Group/Family	Score	E-Value	Start	End	Domain Length
TKL/MLK	316.1	1.8E-94	161	396	236

Status

Unreviewed

Ensembl Protein

ENSMLUP00000009125

UniProt Accession

G1PF07;

Protein Name

Protein Synonyms/Alias

Gene Name

MAP3K12

Gene Synonyms/Alias

MAP3K12;

Ensembl Information

Ensembl Gene ID	Ensembl Protein ID	Ensembl Transcript ID
ENSMLUG00000010002	ENSMLUP00000009125	ENSMLUT00000010009

Organism

Myotis lucifugus

Functional Description

Protein Length

892

Protein Sequence
(FASTA)

MACLHETRTP SPSFGGFVST LSEASMRKLD PDTSDCTPEK DLTPTQCVLR DVVPLGGQGG 60

GGPSPSPGGE PPPEPFANSV LQLHEQDAGG PGGAAGSPES RVPRVRADEV RLQCQSGSGF 120

LEGLFGCLRP VWTMIGKAYS TEHKQQQEDL WEVPFEEILD LQWVGSGAQG AVFLGRFHGE 180

EVAVKKVRDL KETDIKHLRK LKHPNIITFK GVCTQAPCYC ILMEFCAQGQ LYEVLRAGRP 240

VTPSLLVDWS MGIAGGMNYL HLHKIIHRDL KSPNMLITYD DVVKISDFGT SKELSDKSTK 300

MSFAGTVAWM APEVIRNEPV SEKVDIWSFG VVLWELLTGE IPYKDVDSSA IIWGVGSNSL 360

HLPVPSSCPD GFKILLRQCW NSKPRNRPSF RQILLHLDIA SADVLSTPQE TYFKSQAEWR 420

EEVKLHFEKI KSEGTCLHRL EEELVMRRRE ELRHALDIRE HYERKLERAN NLYMELNALM 480

LQLELKEREL LRREQALERR CPGLLKSHPS RGLLHGNTME KLIKKRNVPQ KLSPHSKRPD 540

ILKTESLLPK LDAALSGVGL PGCPKGPPSP GRNRRGKTRH RKASAKGSCG DLPGLRAAVP 600

PHEPGGPGSP GVLGGGPSAW EACPPALRGL HHDLLLRKMS SSSPDLLSAA LGARGRGATG 660

GTGDPGSPPP ARGDTPPSEG SAPGSTSPDS PGGAKGEPPP PVGPGDGVGL LGTGREGTAG 720

RGGSRAGSQH LTPAALLYRA AVTRSQKRGI SSEEEEGEVD SEVELTSSHR WPQGLNMRQS 780

LSTFSSENPS DGEEGTASEP SPSGTPDVGS TNTDERPDER SDDMCSQGSE IPLDQPASEV 840

VTGPEPSLPI QHQDLLRGEQ GPPNSEDSDC DSTELDNPNS GEALQPPASL PP 892

Nucleotide Sequence
(FASTA)

ATGGCCTGCC TCCATGAGAC CCGCACACCC TCCCCTTCCT TTGGGGGTTT CGTGTCCACC 60

CTCAGCGAGG CGTCCATGCG CAAGCTGGAC CCAGACACTT CTGACTGCAC CCCTGAGAAA 120

GACCTGACGC CTACCCAGTG TGTACTTCGA GATGTAGTGC CACTGGGCGG GCAGGGCGGG 180

GGTGGACCCA GCCCCTCCCC AGGTGGAGAG CCACCTCCTG AGCCTTTTGC CAACAGTGTC 240

CTGCAGCTAC ATGAGCAGGA TGCAGGAGGC CCAGGGGGAG CCGCTGGGTC CCCTGAGAGT 300

CGGGTGCCCA GAGTTCGAGC AGATGAGGTG CGGCTGCAGT GCCAGAGCGG CAGTGGCTTC 360

CTGGAAGGCC TCTTTGGCTG CCTGCGCCCT GTCTGGACCA TGATCGGCAA AGCCTACTCC 420

ACGGAGCACA AGCAGCAGCA GGAAGACCTT TGGGAGGTCC CCTTTGAGGA AATCCTGGAT 480

CTGCAGTGGG TGGGCTCAGG GGCCCAGGGT GCTGTCTTCC TGGGGCGTTT CCATGGGGAA 540

GAGGTGGCTG TGAAGAAGGT ACGGGACCTG AAGGAGACTG ACATCAAGCA CCTGCGAAAG 600

CTAAAGCACC CCAACATCAT CACTTTCAAG GGTGTGTGCA CCCAGGCTCC CTGCTACTGT 660

ATCCTCATGG AGTTCTGCGC CCAGGGCCAG CTGTATGAGG TACTGCGGGC TGGCCGCCCT 720

GTCACCCCTT CCTTGCTGGT TGACTGGTCC ATGGGCATCG CTGGTGGCAT GAACTACCTG 780

CACCTGCACA AGATTATCCA TAGAGACCTC AAGTCCCCCA ACATGCTAAT CACATACGAC 840

GATGTGGTGA AGATCTCCGA TTTTGGCACT TCCAAGGAGT TGAGTGACAA GAGCACCAAG 900

ATGTCCTTTG CAGGAACAGT AGCCTGGATG GCCCCTGAAG TAATTCGTAA CGAGCCTGTG 960

TCTGAGAAGG TCGACATCTG GTCCTTTGGC GTGGTGCTAT GGGAACTCCT GACTGGTGAG 1020

ATTCCCTACA AAGATGTAGA TTCCTCAGCC ATCATCTGGG GTGTGGGAAG CAACAGTCTC 1080

CATCTGCCTG TGCCCTCCAG CTGCCCAGAT GGCTTCAAAA TCCTGCTTCG CCAGTGCTGG 1140

AACAGCAAAC CACGAAATCG TCCCTCATTC CGACAGATCC TGCTCCATCT AGACATTGCC 1200

TCAGCAGATG TCCTTTCCAC ACCCCAGGAG ACTTATTTTA AGTCCCAGGC AGAGTGGCGT 1260

GAAGAGGTAA AGCTGCATTT TGAAAAAATT AAGTCAGAAG GGACATGTCT GCACCGCCTA 1320

GAAGAGGAGC TGGTGATGCG GAGGAGGGAG GAGCTCAGAC ATGCCTTGGA CATCAGGGAA 1380

CACTATGAAC GGAAGCTGGA GAGAGCCAAC AACCTGTACA TGGAACTTAA TGCCCTTATG 1440

TTGCAACTGG AACTTAAGGA GCGGGAGCTC CTCAGGAGGG AACAAGCTTT AGAGCGGAGG 1500

TGCCCAGGTC TGCTGAAGTC ACACCCTTCG CGGGGCCTCC TGCATGGTAA CACAATGGAG 1560

AAGCTCATCA AGAAGAGGAA TGTTCCACAG AAGCTGTCAC CCCACAGCAA AAGGCCAGAT 1620

ATCCTCAAGA CTGAGTCTTT GCTACCAAAA CTAGATGCAG CCCTGAGTGG GGTGGGTCTT 1680

CCTGGGTGTC CTAAGGGTCC CCCCTCACCA GGACGGAATC GCCGTGGCAA GACCCGTCAT 1740

CGCAAAGCCA GCGCCAAGGG CAGCTGTGGG GACCTGCCTG GGCTTCGTGC AGCTGTGCCA 1800

CCCCATGAAC CTGGGGGACC AGGAAGCCCA GGGGTGCTAG GAGGGGGACC CTCAGCTTGG 1860

GAAGCCTGCC CTCCAGCCCT CCGTGGGCTC CATCATGACC TCCTGCTACG AAAGATGTCC 1920

TCTTCATCCC CAGATCTGCT GTCAGCAGCA CTGGGAGCCC GGGGCCGGGG GGCCACAGGG 1980

GGAACTGGGG ATCCTGGCTC ACCACCTCCA GCCCGGGGTG ACACCCCCCC AAGTGAGGGC 2040

TCAGCACCTG GCTCCACCAG CCCGGATTCA CCTGGGGGAG CCAAAGGGGA GCCACCTCCA 2100

CCAGTAGGGC CTGGTGATGG CGTGGGGCTG CTGGGAACTG GAAGGGAAGG GACGGCGGGA 2160

CGGGGAGGAA GCCGGGCTGG GTCCCAGCAC TTGACCCCAG CTGCACTACT GTACAGGGCT 2220

GCTGTCACCA GAAGTCAGAA ACGTGGCATA TCATCAGAGG AAGAGGAAGG GGAAGTAGAC 2280

AGTGAAGTAG AGCTGACATC AAGCCACAGG TGGCCTCAGG GCCTGAACAT GCGCCAGTCA 2340

CTATCTACCT TCAGCTCAGA GAATCCATCA GATGGGGAGG AAGGCACAGC TAGTGAGCCA 2400

TCCCCCAGTG GCACACCTGA TGTTGGCAGT ACCAACACTG ATGAGCGGCC AGATGAACGG 2460

TCTGATGACA TGTGCTCCCA GGGATCAGAA ATCCCACTAG ACCAACCTGC TTCAGAGGTG 2520

GTTACAGGCC CTGAACCCTC CTTGCCCATC CAGCACCAGG ACCTACTCAG GGGGGAGCAG 2580

GGCCCTCCCA ATTCCGAGGA CTCAGACTGT GACAGCACTG AACTGGACAA CCCCAACAGT 2640

GGCGAAGCCT TGCAGCCCCC AGCCTCCCTC CCTCCATGA 2679

Domain Profile

S: 4     eeligsgafgkvykakwrkkevavKklreeaeekekleklereakllsklshpniiellG  63

          +++gsga+g+v+ ++++++evavKk+r+ +e+         ++k+l+kl+hpnii+++G

Q: 161   LQWVGSGAQGAVFLGRFHGEEVAVKKVRDLKET---------DIKHLRKLKHPNIITFKG  211

         689**************************9999.........******************

S: 64    vcleepnlllvmeyveggsLsnvlhekskreidlevlvswalqiArGmaYLhseapkkii  123

         vc++ p+++++me++++g+L++vl++   r ++++ lv+w++ iA Gm+YLh +   kii

Q: 212   VCTQAPCYCILMEFCAQGQLYEVLRA--GRPVTPSLLVDWSMGIAGGMNYLHLH---KII  266

         **************************..99************************...9**

S: 124   hrdLksknvLlseekktlkicdFGtarelsk.stkmsaagtlawmaPEvlkeekvseksD  182

         hrdLks+n+L+ + ++++ki+dFGt++els+ stkms+agt+awmaPEv+++e+vsek+D

Q: 267   HRDLKSPNMLI-TYDDVVKISDFGTSKELSDkSTKMSFAGTVAWMAPEVIRNEPVSEKVD  325

         ***********.99****************99****************************

S: 183   vwSygvvLWelltrevPykdlselaiaykvalkglrlpipsscpeklkkLmkecwnedpe  242

         +wS+gvvLWellt+e+Pykd+++ ai+++v++++l+lp+psscp+ +k L+++cwn++p+

Q: 326   IWSFGVVLWELLTGEIPYKDVDSSAIIWGVGSNSLHLPVPSSCPDGFKILLRQCWNSKPR  385

         ************************************************************

S: 243   kRpsfseivks  253

         +Rpsf++i+ +

Q: 386   NRPSFRQILLH  396

         ********876

Domain Sequence
(FASTA)

LQWVGSGAQG AVFLGRFHGE EVAVKKVRDL KETDIKHLRK LKHPNIITFK GVCTQAPCYC 60

ILMEFCAQGQ LYEVLRAGRP VTPSLLVDWS MGIAGGMNYL HLHKIIHRDL KSPNMLITYD 120

DVVKISDFGT SKELSDKSTK MSFAGTVAWM APEVIRNEPV SEKVDIWSFG VVLWELLTGE 180

IPYKDVDSSA IIWGVGSNSL HLPVPSSCPD GFKILLRQCW NSKPRNRPSF RQILLH 236

Keyword

Complete proteome; Reference proteome.

Sequence Source

Ensembl

Orthology

Ortholog group

Ailuropoda melanoleuca"; ?>Bos taurus"; ?>Caenorhabditis elegans"; ?>Callithrix jacchus"; ?>Canis familiaris"; ?>Cavia porcellus"; ?>Danio rerio"; ?>Dipodomys ordii"; ?>Drosophila melanogaster"; ?>Equus caballus"; ?>Felis catus"; ?>Gasterosteus aculeatus"; ?>Gorilla gorilla"; ?>Homo sapiens"; ?>Ictidomys tridecemlineatus"; ?>Latimeria chalumnae"; ?>Loxodonta africana"; ?>Macaca mulatta"; ?>Mus musculus"; ?>Mustela putorius furo"; ?>Nomascus leucogenys"; ?>Ochotona princeps"; ?>Oreochromis niloticus"; ?>Oryctolagus cuniculus"; ?>Oryzias latipes"; ?>Otolemur garnettii"; ?>Pan troglodytes"; ?>Petromyzon marinus"; ?>Pongo abelii"; ?>Procavia capensis"; ?>Pteropus vampyrus"; ?>Rattus norvegicus"; ?>Sarcophilus harrisii"; ?>Sus scrofa"; ?>Takifugu rubripes"; ?>Tetraodon nigroviridis"; ?>Xenopus tropicalis"; ?>Xiphophorus maculatus"; ?>

Gene Ontology

GO:0005524	; F:ATP binding
GO:0000287	; F:magnesium ion binding
GO:0004709	; F:MAP kinase kinase kinase activity
GO:0000186	; P:activation of MAPKK activity
GO:0000165	; P:MAPK cascade
GO:0046777	; P:protein autophosphorylation

KEGG

InterPros

IPR011009	; Kinase-like_dom.
IPR017419	; MAP3K12_MAP3K13.
IPR000719	; Prot_kinase_cat_dom.
IPR001245	; Ser-Thr/Tyr_kinase_cat_dom.
IPR008271	; Ser/Thr_kinase_AS.

Pfam

PF07714

; Pkinase_Tyr; 1.

SMARTs

Prosites

PS50011	; PROTEIN_KINASE_DOM; 1.
PS00108	; PROTEIN_KINASE_ST; 1.

Prints

PR00109

; TYRKINASE.

Created Date

20-Feb-2013