EKS-MYL-00280

Eukaryotic Protein Kinase & Protein Phosphatase Database

Tag

Content

EKPD ID

EKS-MYL-00280

Classification

Group/Family	Score	E-Value	Start	End	Domain Length
TKL/STKR	453.3	3.3E-136	206	493	288

Status

Unreviewed

Ensembl Protein

ENSMLUP00000009233

UniProt Accession

G1PFA1;

Protein Name

Protein Synonyms/Alias

Gene Name

ACVR1

Gene Synonyms/Alias

ACVR1;

Ensembl Information

Ensembl Gene ID	Ensembl Protein ID	Ensembl Transcript ID
ENSMLUG00000010119	ENSMLUP00000009233	ENSMLUT00000010130

Organism

Myotis lucifugus

Functional Description

Protein Length

507

Protein Sequence
(FASTA)

SPHGCIIHSV TPPLPLYPST DEKPKVNPKL YMCVCEGLSC GNEDHCEGQQ CFSSLSINDG 60

FHVYQKGCFQ VYEQGKMTCK TPPSPGQAVE CCQGDWCNRN ITAQLPTKGK SFSGTQNFHL 120

EVGLIILSVV FAVCLLACLL GVALRKFKRR NQERLNPRDV EYGTIEGLIT TNVGDSTLAD 180

LLDHSCTSGS GSGLPFLVQR TVARQITLLE CVGKGRYGEV WRGSWQGENV AVKIFSSRDE 240

KSWFRETELY NTVMLRHENI LGFIASDMTS RHSSTQLWLI THYHEMGSLY DYLQLTTLDT 300

VSCLRIVLSI ASGLAHLHIE IFGTQGKPAI AHRDLKSKNI LVKKNGQCCI ADLGLAVMHS 360

QSTNQLDVGN NPRVGTKRYM APEVLDETIQ VDCFDSYKRV DIWAFGLVLW EVARRMVSNG 420

IVEDYKPPFY DVVPNDPSFE DMRKVVCVDQ QRPNIPNRWF SDPTLTSLAK LMKECWYQNP 480

SARLTALRIK KTLTKIDNSL DKLKTDC 507

Nucleotide Sequence
(FASTA)

TCCCCCCATG GGTGTATAAT CCATTCAGTG ACTCCCCCTC TTCCTCTCTA TCCTTCTACA 60

GATGAGAAGC CCAAGGTGAA CCCCAAACTG TACATGTGTG TGTGTGAAGG CCTCTCCTGT 120

GGGAACGAGG ACCACTGTGA AGGCCAGCAG TGCTTCTCCT CACTGAGCAT AAACGATGGC 180

TTCCACGTCT ACCAGAAAGG CTGCTTCCAG GTCTATGAGC AGGGGAAGAT GACCTGTAAG 240

ACCCCGCCAT CGCCTGGCCA GGCCGTGGAG TGCTGCCAGG GGGACTGGTG CAACAGGAAC 300

ATCACGGCCC AGCTGCCCAC TAAAGGGAAA TCCTTTTCTG GAACACAGAA TTTTCACTTG 360

GAGGTCGGCC TCATCATTCT GTCCGTAGTG TTCGCAGTAT GCCTTCTAGC TTGCCTACTG 420

GGAGTCGCTC TCCGAAAATT TAAAAGGCGC AACCAAGAAC GCCTCAATCC CAGAGATGTG 480

GAGTACGGCA CCATCGAAGG GCTCATCACC ACCAATGTTG GAGACAGCAC TTTAGCAGAT 540

TTACTGGATC ACTCGTGTAC GTCGGGAAGC GGCTCTGGCC TTCCTTTTCT GGTGCAGAGA 600

ACAGTGGCTC GTCAGATCAC ACTGTTGGAG TGTGTCGGGA AAGGCAGGTA TGGTGAGGTG 660

TGGAGGGGCA GCTGGCAAGG GGAGAATGTT GCTGTGAAGA TCTTCTCCTC CCGGGATGAG 720

AAGTCGTGGT TCAGGGAAAC AGAATTGTAC AACACTGTGA TGCTGAGGCA TGAAAATATT 780

TTAGGTTTCA TTGCTTCAGA CATGACATCA AGACACTCCA GTACCCAGCT GTGGTTGATC 840

ACACATTACC ATGAAATGGG ATCATTGTAT GACTATCTCC AGCTTACTAC TCTGGATACG 900

GTTAGCTGCC TGCGAATAGT GCTGTCCATT GCTAGTGGTC TCGCACATTT GCACATAGAG 960

ATATTTGGGA CCCAAGGGAA ACCAGCCATT GCTCATCGAG ATTTGAAAAG CAAAAACATC 1020

CTGGTGAAGA AGAATGGACA GTGTTGCATA GCAGATTTGG GCCTGGCAGT CATGCATTCC 1080

CAGAGCACCA ATCAGCTGGA CGTGGGGAAC AACCCACGCG TAGGCACCAA GCGCTACATG 1140

GCCCCTGAAG TCCTGGATGA AACCATCCAG GTGGACTGCT TTGATTCTTA CAAGAGAGTC 1200

GATATTTGGG CTTTTGGACT TGTCTTGTGG GAAGTGGCCA GGCGGATGGT GAGCAATGGT 1260

ATTGTGGAAG ATTACAAGCC ACCATTCTAT GATGTGGTTC CCAATGACCC AAGTTTTGAA 1320

GATATGAGGA AGGTGGTCTG TGTGGATCAA CAGAGGCCAA ACATACCCAA CAGATGGTTC 1380

TCAGACCCGA CATTAACTTC TCTGGCCAAG CTGATGAAAG AATGCTGGTA TCAAAATCCG 1440

TCCGCAAGAC TCACAGCTCT GCGTATCAAA AAGACTTTGA CCAAAATTGA TAATTCCCTA 1500

GACAAATTGA AAACTGACTG TTGA 1524

Domain Profile

S: 1     lklleligkGrygeVwkaklrgeevAvKifstedeaswkrEkeiyqtvllrhenilqfia  60

         ++lle++gkGrygeVw+++++ge+vAvKifs++de+sw+rE+e+y+tv+lrhenil+fia

Q: 206   ITLLECVGKGRYGEVWRGSWQGENVAVKIFSSRDEKSWFRETELYNTVMLRHENILGFIA  265

         789*********************************************************

S: 61    adkkeedsltelllvteyhekgsLsdyLkretldveellrlalslasGlahLHeeivgtk  120

         +d+++++s+t+l+l+t+yhe+gsL+dyL+ +tld+ ++lr++ls+asGlahLH ei+gt+

Q: 266   SDMTSRHSSTQLWLITHYHEMGSLYDYLQLTTLDTVSCLRIVLSIASGLAHLHIEIFGTQ  325

         ************************************************************

S: 121   gkkKpaiaHRDlkskNilvkkdltcciaDlGLalkleeekeeldlaansqvGtkRYmaPE  180

         g  KpaiaHRDlkskNilvkk+++cciaDlGLa+++++++++ld+ +n +vGtkRYmaPE

Q: 326   G--KPAIAHRDLKSKNILVKKNGQCCIADLGLAVMHSQSTNQLDVGNNPRVGTKRYMAPE  383

         *..*********************************************************

S: 181   vleealnlkdfeafkraDvYslgLvlWEvasRceevdeeveeyklpfeevvgsdPsleem  240

         vl+e++++++f+++kr+D++++gLvlWEva+R+ + +++ve+yk+pf++vv++dPs+e+m

Q: 384   VLDETIQVDCFDSYKRVDIWAFGLVLWEVARRMVS-NGIVEDYKPPFYDVVPNDPSFEDM  442

         **********************************9.************************

S: 241   kevvvekklrPkipeawkkkealkelsklleecWdadpeaRltalrvkkrl  291

         ++vv+++++rP+ip++w ++++l++l+kl++ecW+++p+aRltalr+kk+l

Q: 443   RKVVCVDQQRPNIPNRWFSDPTLTSLAKLMKECWYQNPSARLTALRIKKTL  493

         *************************************************97

Domain Sequence
(FASTA)

ITLLECVGKG RYGEVWRGSW QGENVAVKIF SSRDEKSWFR ETELYNTVML RHENILGFIA 60

SDMTSRHSST QLWLITHYHE MGSLYDYLQL TTLDTVSCLR IVLSIASGLA HLHIEIFGTQ 120

GKPAIAHRDL KSKNILVKKN GQCCIADLGL AVMHSQSTNQ LDVGNNPRVG TKRYMAPEVL 180

DETIQVDCFD SYKRVDIWAF GLVLWEVARR MVSNGIVEDY KPPFYDVVPN DPSFEDMRKV 240

VCVDQQRPNI PNRWFSDPTL TSLAKLMKEC WYQNPSARLT ALRIKKTL 288

Keyword

ATP-binding; Complete proteome; Kinase; Nucleotide-binding; Reference proteome; Serine/threonine-protein kinase; Transferase.

Sequence Source

Ensembl

Orthology

Ortholog group

Ailuropoda melanoleuca"; ?>Anolis carolinensis"; ?>Bos taurus"; ?>Callithrix jacchus"; ?>Canis familiaris"; ?>Cavia porcellus"; ?>Ciona savignyi"; ?>Danio rerio"; ?>Drosophila melanogaster"; ?>Equus caballus"; ?>Felis catus"; ?>Gadus morhua"; ?>Gallus gallus"; ?>Gasterosteus aculeatus"; ?>Gorilla gorilla"; ?>Homo sapiens"; ?>Latimeria chalumnae"; ?>Loxodonta africana"; ?>Macaca mulatta"; ?>Meleagris gallopavo"; ?>Microcebus murinus"; ?>Monodelphis domestica"; ?>Mus musculus"; ?>Mustela putorius furo"; ?>Nomascus leucogenys"; ?>Oreochromis niloticus"; ?>Ornithorhynchus anatinus"; ?>Oryctolagus cuniculus"; ?>Oryzias latipes"; ?>Otolemur garnettii"; ?>Pan troglodytes"; ?>Pelodiscus sinensis"; ?>Petromyzon marinus"; ?>Pongo abelii"; ?>Rattus norvegicus"; ?>Sarcophilus harrisii"; ?>Sus scrofa"; ?>Taeniopygia guttata"; ?>Takifugu rubripes"; ?>Tetraodon nigroviridis"; ?>Xenopus tropicalis"; ?>Xiphophorus maculatus"; ?>

Gene Ontology

GO:0016020	; C:membrane
GO:0005524	; F:ATP binding
GO:0004702	; F:receptor signaling protein serine/threonine kinase activity
GO:0005024	; F:transforming growth factor beta-activated receptor activity
GO:0023014	; P:signal transduction by phosphorylation

KEGG

InterPros

IPR000333	; Activin_II/TGFBeta-II_recpt.
IPR000472	; Activin_rcpt.
IPR011009	; Kinase-like_dom.
IPR000719	; Prot_kinase_cat_dom.
IPR017441	; Protein_kinase_ATP_BS.
IPR008271	; Ser/Thr_kinase_AS.
IPR003605	; TGF_beta_rcpt_GS.

Pfam

PF01064	; Activin_recp; 1.
PF00069	; Pkinase; 1.
PF08515	; TGF_beta_GS; 1.

SMARTs

SM00467

; GS; 1.

Prosites

PS51256	; GS; 1.
PS00107	; PROTEIN_KINASE_ATP; 1.
PS50011	; PROTEIN_KINASE_DOM; 1.
PS00108	; PROTEIN_KINASE_ST; 1.

Prints

PR00653

; ACTIVIN2R.

Created Date

20-Feb-2013