EKS-MYL-00370

Eukaryotic Protein Kinase & Protein Phosphatase Database

Tag

Content

EKPD ID

EKS-MYL-00370

Classification

Group/Family	Score	E-Value	Start	End	Domain Length
TK/Src	404.8	1.3E-121	235	486	252

Status

Unreviewed

Ensembl Protein

ENSMLUP00000010063

UniProt Accession

G1PHB8;

Protein Name

Protein Synonyms/Alias

Gene Name

FRK

Gene Synonyms/Alias

FRK;

Ensembl Information

Ensembl Gene ID	Ensembl Protein ID	Ensembl Transcript ID
ENSMLUG00000011037	ENSMLUP00000010063	ENSMLUT00000011043

Organism

Myotis lucifugus

Functional Description

Protein Length

505

Protein Sequence
(FASTA)

MGNICRRLWG YLKPCLPCFF RETDKQVAPE NTESPCPAEA PWPQGSYFVA LFDYQARTEE 60

DLSFHAGDKL QVLDTSHEGW WFARLLERRG ASSGQQLEGY IPSNYVAEDR SLQAEPWFFG 120

AIKRADAENQ LLYSGNQTGA FLIRESESEK GGFALSVLVE RVVKHYKIRR LDEGGFCLTR 180

IRTFTTLNEF VRHYTKTSDG LCVKLGKPCL KIQVPAPFDL SYKTVDQWEI DRKSVQLLKR 240

LGSGQFGEVW EGLWNNTTPV AVKTLKPGSM DPNDFLREAQ IMKNLRHPKL IQLYAVCTLE 300

DPIYIITELM RHGSLLEYLR NDGGSKINLT QQVDMATQVA SGMAYLESQN YIHRDLAARN 360

VLVGEHNIYK VADFGLARVF KVDNEDIYEA THDMKLPVKW TAPEAIRNRF SIKSDVWSFG 420

ILLFEIITYG QTPYSGMTGA QVIQRLLHNY RLPQPSNCPL SLYMIMLECW DAEPRNRPTF 480

EELYLKLEDY FEISCNYNDG KAMLN 505

Nucleotide Sequence
(FASTA)

ATGGGCAACA TCTGCCGGAG GCTCTGGGGG TACTTGAAGC CCTGTCTCCC CTGCTTCTTC 60

CGGGAGACAG ACAAACAGGT GGCGCCTGAG AACACAGAGA GCCCCTGCCC CGCTGAGGCT 120

CCCTGGCCGC AGGGCTCCTA CTTTGTGGCC CTGTTTGACT ACCAGGCTCG GACTGAGGAG 180

GACCTGAGCT TCCATGCGGG CGACAAGCTC CAAGTCCTGG ACACTTCCCA TGAGGGCTGG 240

TGGTTCGCCA GGCTCTTGGA GAGAAGGGGG GCCAGCTCGG GCCAGCAGCT GGAGGGCTAT 300

ATTCCTTCTA ACTATGTGGC CGAGGACAGG AGCCTGCAGG CAGAGCCGTG GTTCTTTGGA 360

GCAATCAAGA GAGCGGATGC AGAAAATCAA CTGTTATACT CAGGAAATCA GACGGGTGCC 420

TTTCTAATCA GAGAAAGTGA AAGCGAGAAA GGAGGCTTCG CCCTTTCAGT TTTAGTTGAA 480

AGGGTCGTGA AACACTACAA AATCAGAAGA CTGGATGAAG GGGGCTTTTG CCTTACTCGG 540

ATAAGAACCT TTACCACGCT GAATGAATTC GTGAGACACT ACACCAAGAC AAGCGATGGC 600

CTGTGTGTCA AGCTGGGGAA ACCATGCTTA AAGATACAAG TGCCAGCTCC TTTTGATTTG 660

TCATATAAAA CTGTGGACCA GTGGGAGATA GACCGCAAGT CTGTGCAACT TCTGAAGCGA 720

TTAGGATCCG GTCAGTTTGG CGAAGTGTGG GAAGGCCTCT GGAACAATAC TACTCCAGTA 780

GCAGTAAAAA CGTTAAAACC AGGTTCAATG GATCCAAATG ACTTCCTGAG GGAGGCTCAG 840

ATAATGAAGA ACCTAAGACA TCCAAAGCTT ATCCAGCTTT ATGCTGTTTG CACTTTAGAA 900

GATCCAATTT ATATTATTAC AGAGTTGATG AGACATGGAA GTCTGCTAGA ATATCTCCGA 960

AATGATGGTG GATCAAAAAT CAATCTGACT CAACAGGTCG ACATGGCAAC ACAAGTTGCC 1020

TCTGGAATGG CCTATCTGGA GTCCCAGAAC TACATCCATA GAGACCTGGC TGCCAGAAAT 1080

GTCCTTGTGG GTGAACATAA TATCTACAAA GTGGCAGATT TTGGACTTGC AAGAGTTTTT 1140

AAGGTAGATA ATGAAGACAT TTATGAAGCT ACACATGATA TGAAGCTGCC AGTGAAGTGG 1200

ACTGCACCTG AAGCCATTCG TAATAGGTTC AGCATTAAGT CCGATGTGTG GTCATTCGGA 1260

ATCCTTCTTT TTGAAATCAT TACTTATGGC CAAACACCTT ATAGTGGAAT GACAGGTGCT 1320

CAGGTAATCC AGAGGTTGCT TCATAACTAT AGACTCCCTC AACCATCTAA CTGTCCACTG 1380

TCATTATACA TGATCATGTT GGAGTGCTGG GATGCAGAGC CTAGGAACCG GCCAACATTT 1440

GAGGAACTGT ATTTGAAACT TGAGGACTAT TTTGAAATAT CCTGCAACTA CAATGATGGT 1500

AAAGCCATGT TAAAT 1515

Domain Profile

S: 1     lklvkklGeGqfGevwlgkwkgsvkvavktlkegtlspeafleeaqilkklrheklvkly  60

         ++l+k+lG+GqfGevw+g+w+++++vavktlk+g+++p++fl+eaqi+k+lrh+kl++ly

Q: 235   VQLLKRLGSGQFGEVWEGLWNNTTPVAVKTLKPGSMDPNDFLREAQIMKNLRHPKLIQLY  294

         6899********************************************************

S: 61    avvseeePiyivtelmakGslldflkeeegkklklpklvdlaaqvaeGmayleeknlihr  120

         av++ e+Piyi+telm++Gsll++l+++ g+k++l+++vd+a+qva+Gmayle++n+ihr

Q: 295   AVCTLEDPIYIITELMRHGSLLEYLRNDGGSKINLTQQVDMATQVASGMAYLESQNYIHR  354

         ************************************************************

S: 121   dlaarnvlvgeslvvkvadfGlarlie...ddeytakegaklPikWtaPeaiklgkftik  177

         dlaarnvlvge++++kvadfGlar+++   +d+y+a ++ klP+kWtaPeai+ ++f+ik

Q: 355   DLAARNVLVGEHNIYKVADFGLARVFKvdnEDIYEATHDMKLPVKWTAPEAIR-NRFSIK  413

         ************************998878999******************97.78****

S: 178   sdvWsfGillteivtkGkvPypGmtneevleqvergyrlprpeecpeelyelllecwkkd  237

         sdvWsfGill+ei+t+G++Py+Gmt ++v++++ ++yrlp+p++cp +ly ++lecw+++

Q: 414   SDVWSFGILLFEIITYGQTPYSGMTGAQVIQRLLHNYRLPQPSNCPLSLYMIMLECWDAE  473

         ************************************************************

S: 238   peerPtfetlqev  250

         p++rPtfe l+ +

Q: 474   PRNRPTFEELYLK  486

         ********99765

Domain Sequence
(FASTA)

VQLLKRLGSG QFGEVWEGLW NNTTPVAVKT LKPGSMDPND FLREAQIMKN LRHPKLIQLY 60

AVCTLEDPIY IITELMRHGS LLEYLRNDGG SKINLTQQVD MATQVASGMA YLESQNYIHR 120

DLAARNVLVG EHNIYKVADF GLARVFKVDN EDIYEATHDM KLPVKWTAPE AIRNRFSIKS 180

DVWSFGILLF EIITYGQTPY SGMTGAQVIQ RLLHNYRLPQ PSNCPLSLYM IMLECWDAEP 240

RNRPTFEELY LK 252

Keyword

ATP-binding; Complete proteome; Kinase; Nucleotide-binding; Reference proteome; SH3 domain; Transferase; Tyrosine-protein kinase.

Sequence Source

Ensembl

Orthology

Ortholog group

Ailuropoda melanoleuca"; ?>Anolis carolinensis"; ?>Bos taurus"; ?>Callithrix jacchus"; ?>Canis familiaris"; ?>Cavia porcellus"; ?>Danio rerio"; ?>Dasypus novemcinctus"; ?>Dipodomys ordii"; ?>Equus caballus"; ?>Felis catus"; ?>Gallus gallus"; ?>Gasterosteus aculeatus"; ?>Gorilla gorilla"; ?>Homo sapiens"; ?>Ictidomys tridecemlineatus"; ?>Latimeria chalumnae"; ?>Loxodonta africana"; ?>Macaca mulatta"; ?>Meleagris gallopavo"; ?>Monodelphis domestica"; ?>Mus musculus"; ?>Mustela putorius furo"; ?>Nomascus leucogenys"; ?>Oreochromis niloticus"; ?>Oryctolagus cuniculus"; ?>Oryzias latipes"; ?>Otolemur garnettii"; ?>Pan troglodytes"; ?>Pelodiscus sinensis"; ?>Petromyzon marinus"; ?>Pongo abelii"; ?>Rattus norvegicus"; ?>Sarcophilus harrisii"; ?>Sus scrofa"; ?>Taeniopygia guttata"; ?>Takifugu rubripes"; ?>Tarsius syrichta"; ?>Tetraodon nigroviridis"; ?>Tursiops truncatus"; ?>Xenopus tropicalis"; ?>Xiphophorus maculatus"; ?>

Gene Ontology

GO:0005524	; F:ATP binding
GO:0004713	; F:protein tyrosine kinase activity

KEGG

InterPros

IPR011009	; Kinase-like_dom.
IPR000719	; Prot_kinase_cat_dom.
IPR017441	; Protein_kinase_ATP_BS.
IPR001245	; Ser-Thr/Tyr_kinase_cat_dom.
IPR000980	; SH2.
IPR001452	; SH3_domain.
IPR008266	; Tyr_kinase_AS.
IPR020635	; Tyr_kinase_cat_dom.

Pfam

PF07714	; Pkinase_Tyr; 1.
PF00017	; SH2; 1.
PF00018	; SH3_1; 1.

SMARTs

SM00252	; SH2; 1.
SM00326	; SH3; 1.
SM00219	; TyrKc; 1.

Prosites

PS00107	; PROTEIN_KINASE_ATP; 1.
PS50011	; PROTEIN_KINASE_DOM; 1.
PS00109	; PROTEIN_KINASE_TYR; 1.
PS50001	; SH2; 1.
PS50002	; SH3; 1.

Prints

PR00401	; SH2DOMAIN.
PR00452	; SH3DOMAIN.
PR00109	; TYRKINASE.

Created Date

20-Feb-2013