EKS-MYL-00125

Eukaryotic Protein Kinase & Protein Phosphatase Database

Tag

Content

EKPD ID

EKS-MYL-00125

Classification

Group/Family	Score	E-Value	Start	End	Domain Length
CAMK/MLCK	406.1	5.7E-122	57	310	254

Status

Unreviewed

Ensembl Protein

ENSMLUP00000010192

UniProt Accession

G1PHN5;

Protein Name

Protein Synonyms/Alias

Gene Name

MYLK4

Gene Synonyms/Alias

MYLK4;

Ensembl Information

Ensembl Gene ID	Ensembl Protein ID	Ensembl Transcript ID
ENSMLUG00000011182	ENSMLUP00000010192	ENSMLUT00000011181

Organism

Myotis lucifugus

Functional Description

Protein Length

336

Protein Sequence
(FASTA)

QAKEKVWSYP NLKEMAPVKG KRTLAPTDDG PAPPAPFHHR IVTAKQTAVN SLYTVSRTEI 60

LGGGRFGQVH KCEEKATGLK LAAKIIKTRG LKDKDEVKNE ITVMNQLDHV NLIQLYDAFE 120

SKNDIVLVME YVDGGELFDR IIDNNYNLTE LDTILFIKQI CEGIRHMHQM YILHLDLKPE 180

NILCVNRDTK QIKIIDFGLA RRYKPREKLK VNFGTPEFLA PEVVNYDFVS FPTDMWSVGV 240

IAYMLLSGLS PFLGDNDAET LNNILACRWD LEEEEFQNIS EEAKEFISKL LIKEKSWRIS 300

ASEALKHPWL SDHKLHLRLK TQEKNCCSDA QDLVTQ 336

Nucleotide Sequence
(FASTA)

CAGGCTAAGG AGAAGGTGTG GTCATATCCC AACCTGAAAG AAATGGCACC TGTCAAAGGC 60

AAGAGGACAT TGGCCCCCAC AGATGACGGC CCGGCTCCTC CCGCACCCTT TCATCACCGG 120

ATTGTAACAG CCAAACAGAC GGCAGTCAAC AGTCTCTATA CTGTGAGCAG AACAGAAATT 180

TTAGGAGGGG GGCGCTTTGG CCAGGTTCAC AAGTGTGAAG AGAAAGCAAC AGGTCTGAAG 240

CTGGCCGCCA AGATCATCAA GACCAGAGGC CTGAAGGATA AGGATGAAGT GAAGAATGAG 300

ATCACCGTCA TGAACCAGCT GGATCACGTG AACCTCATTC AGCTCTACGA TGCCTTCGAG 360

TCTAAGAATG ACATCGTCCT GGTCATGGAG TATGTGGACG GAGGCGAGCT ATTTGATCGG 420

ATCATTGACA ACAACTACAA TCTGACTGAG TTGGACACCA TCCTGTTCAT CAAGCAGATA 480

TGTGAGGGAA TACGACACAT GCATCAGATG TACATTCTCC ATCTGGACCT GAAGCCTGAG 540

AATATCCTGT GTGTGAATCG GGATACTAAA CAAATAAAAA TTATTGATTT TGGATTGGCC 600

AGAAGATACA AACCCAGAGA GAAGCTGAAG GTGAACTTTG GAACCCCAGA GTTTCTTGCC 660

CCTGAAGTCG TGAACTATGA TTTTGTTTCC TTTCCCACTG ACATGTGGAG CGTGGGGGTC 720

ATCGCCTATA TGCTACTTAG TGGTTTGTCC CCCTTCCTGG GTGATAATGA TGCTGAGACC 780

CTGAACAACA TCCTGGCCTG CAGGTGGGAC TTAGAGGAGG AAGAATTTCA AAACATCTCA 840

GAAGAGGCCA AGGAGTTCAT CTCCAAGCTT CTCATTAAGG AGAAAAGCTG GCGAATAAGT 900

GCAAGTGAGG CTCTCAAGCA TCCTTGGTTG TCAGACCACA AGCTCCACTT GAGACTCAAA 960

ACACAGGAGA AGAATTGCTG CTCTGACGCT CAGGACCTTG TGACCCAATA G 1011

Domain Profile

S: 3     ikeelgkGkfgvvvkavekstgkklaakivkvrkekdkeevkkEieilnqlrHekliqly  62

          +e lg G+fg+v+k+ ek+tg klaaki+k+r  kdk+evk+Ei ++nql+H +liqly

Q: 57    RTEILGGGRFGQVHKCEEKATGLKLAAKIIKTRGLKDKDEVKNEITVMNQLDHVNLIQLY  116

         5789********************************************************

S: 63    dafeskeeivlvlElveggelferiveedyeltEeevvlfvrqvlealeylHkkgivHld  122

         dafesk++ivlv+E+v+ggelf+ri++++y+ltE +++lf++q++e+++++H+++i+Hld

Q: 117   DAFESKNDIVLVMEYVDGGELFDRIIDNNYNLTELDTILFIKQICEGIRHMHQMYILHLD  176

         ************************************************************

S: 123   lkpenillqskkskqiKlidFGlarklkkkeklkvlfgtpefvaPEvvnkepvslatDmW  182

         lkpenil++++++kqiK+idFGlar++k++eklkv+fgtpef+aPEvvn+++vs+ tDmW

Q: 177   LKPENILCVNRDTKQIKIIDFGLARRYKPREKLKVNFGTPEFLAPEVVNYDFVSFPTDMW  236

         ************************************************************

S: 183   svGvityvLlsGlsPFlgdndeetlenvssakydfdeeafkevseeakdFiskllvkekk  242

         svGvi+y+LlsGlsPFlgdnd+etl+n+ ++++d++ee+f+++seeak+Fiskll+kek+

Q: 237   SVGVIAYMLLSGLSPFLGDNDAETLNNILACRWDLEEEEFQNISEEAKEFISKLLIKEKS  296

         ************************************************************

S: 243   kRmsaeeaLkhkwl  256

         +R+sa+eaLkh+wl

Q: 297   WRISASEALKHPWL  310

         *************8

Domain Sequence
(FASTA)

RTEILGGGRF GQVHKCEEKA TGLKLAAKII KTRGLKDKDE VKNEITVMNQ LDHVNLIQLY 60

DAFESKNDIV LVMEYVDGGE LFDRIIDNNY NLTELDTILF IKQICEGIRH MHQMYILHLD 120

LKPENILCVN RDTKQIKIID FGLARRYKPR EKLKVNFGTP EFLAPEVVNY DFVSFPTDMW 180

SVGVIAYMLL SGLSPFLGDN DAETLNNILA CRWDLEEEEF QNISEEAKEF ISKLLIKEKS 240

WRISASEALK HPWL 254

Keyword

ATP-binding; Complete proteome; Kinase; Nucleotide-binding; Reference proteome; Serine/threonine-protein kinase; Transferase.

Sequence Source

Ensembl

Orthology

Ortholog group

Ailuropoda melanoleuca"; ?>Anolis carolinensis"; ?>Bos taurus"; ?>Callithrix jacchus"; ?>Canis familiaris"; ?>Cavia porcellus"; ?>Ciona savignyi"; ?>Danio rerio"; ?>Equus caballus"; ?>Erinaceus europaeus"; ?>Felis catus"; ?>Gadus morhua"; ?>Gallus gallus"; ?>Gasterosteus aculeatus"; ?>Gorilla gorilla"; ?>Homo sapiens"; ?>Ictidomys tridecemlineatus"; ?>Latimeria chalumnae"; ?>Loxodonta africana"; ?>Macaca mulatta"; ?>Meleagris gallopavo"; ?>Microcebus murinus"; ?>Monodelphis domestica"; ?>Mus musculus"; ?>Mustela putorius furo"; ?>Nomascus leucogenys"; ?>Ochotona princeps"; ?>Oreochromis niloticus"; ?>Ornithorhynchus anatinus"; ?>Oryctolagus cuniculus"; ?>Oryzias latipes"; ?>Otolemur garnettii"; ?>Pan troglodytes"; ?>Pelodiscus sinensis"; ?>Petromyzon marinus"; ?>Pongo abelii"; ?>Pteropus vampyrus"; ?>Rattus norvegicus"; ?>Sarcophilus harrisii"; ?>Sus scrofa"; ?>Taeniopygia guttata"; ?>Takifugu rubripes"; ?>Tarsius syrichta"; ?>Tetraodon nigroviridis"; ?>Tursiops truncatus"; ?>Xenopus tropicalis"; ?>Xiphophorus maculatus"; ?>

Gene Ontology

GO:0005524	; F:ATP binding
GO:0004674	; F:protein serine/threonine kinase activity

KEGG

InterPros

IPR020636	; Ca/CaM-dep_Ca-dep_prot_Kinase.
IPR011009	; Kinase-like_dom.
IPR000719	; Prot_kinase_cat_dom.
IPR017441	; Protein_kinase_ATP_BS.
IPR002290	; Ser/Thr_dual-sp_kinase_dom.
IPR008271	; Ser/Thr_kinase_AS.

Pfam

PF00069

; Pkinase; 1.

SMARTs

SM00220

; S_TKc; 1.

Prosites

PS00107	; PROTEIN_KINASE_ATP; 1.
PS50011	; PROTEIN_KINASE_DOM; 1.
PS00108	; PROTEIN_KINASE_ST; 1.

Prints

Created Date

20-Feb-2013