EKS-MYL-00391

Eukaryotic Protein Kinase & Protein Phosphatase Database

Tag

Content

EKPD ID

EKS-MYL-00391

Classification

Group/Family	Score	E-Value	Start	End	Domain Length
STE/STE11	325.2	3.7E-97	1096	1360	265

Status

Unreviewed

Ensembl Protein

ENSMLUP00000010663

UniProt Accession

G1PIV9;

Protein Name

Protein Synonyms/Alias

Gene Name

MAP3K1

Gene Synonyms/Alias

MAP3K1;

Ensembl Information

Ensembl Gene ID	Ensembl Protein ID	Ensembl Transcript ID
ENSMLUG00000011693	ENSMLUP00000010663	ENSMLUT00000011707

Organism

Myotis lucifugus

Functional Description

Protein Length

1365

Protein Sequence
(FASTA)

SRAGAQPGVA LTPVSAPFCP AHCRPEMESK DTLRGLHRME DRPEERVIRE RLKATCMPAW 60

RHEWLERRSR RGPVVVKPIP VKGDGSEMNS VAAESQGEAQ ASVCPAPKGR RSPSPGSSPA 120

GRPVKAESPG VRRKRASPVP SQSGRTTPPR RAPSPDGFSP YSPEETSRRV NKVMRARLYL 180

LQQIGPNSFL IGGDSPDNKY RVFIGPQNCS CGRGAFCIHL LFVMLRVFQL EPSDPMLWRK 240

TLKNFEVESL FQKYHSRRSS RIKAPSRSTI QKFVSRMSSS HTLSSPSTAT ASAESSLKDE 300

EEQLCPICLL GMLDEESLTV CEDGCRNKLH HHCMSIWAEE CRRNREPLIC PLCRSKWRSH 360

DFYSHELSSP ADSPSSLRAA PQPPAQPPLA GPQHRDQEGS SGLTHYGAQH IPAAYRDLAE 420

PWIQVFGTEL VGCLFSRNWN VREMALRRLS HDVSGALLLA HGESTGHSGG GGRSSPGAGA 480

SSAPSPPAGD VVGACCSVLS MVCADPVYKV YVAALKTLRA MLVYTPCHSL AERIKLQRLL 540

RPVVDTILVK CADANSRTSQ LSVSTLLELC RGQAGELAVG REILKAGSIG IGGVDYVLSC 600

ILGNQMESNN WQELLGRLCL VDRLLLEFPA EFYPHTVGAE AAPAEPVDVR YKKLLSLLAF 660

ALQSIDHAHA VVGKLARRVY LSSARMVTAV PPVFVKLLEM LSASSSTHFA RMRRRLMAIA 720

EEVDIAEAVQ LGLEDAWDGR RDSFLQASAP ESHPEAPGSS PLQGPDRAEK TGRGLCPARL 780

SASSEDISGR PASTALGPPP SATTEQPKPA VQAKGRPLSQ CLSSSPLSPH SQPVLPPSST 840

PASSAQTAPA GPGDASKYRP QGFVPYNIPS ASPPPQRKFS LQFQRNCSEN RDSDKLSPIF 900

TQSRPLPCSR IHRPKPSRPS PGSPGRRADA ATGSMTLDLH GASEGGDSFS SGSSSSAVIP 960

SEETVFTPVE DKSRLDASTE LSSSIEDLLE ASLPSADTTV TFKSEVAVLS PEKDEHDDTY 1020

QDDVSHNQKC KEKMEAEEEE ALAIAMAMSA SQDALPVVPQ LQVENGEDVI IIQQDTPETL 1080

PGHTKAKLPY REDADWLKGQ QIGLGAFSSC YQAQDVGTGT LMAVKQVTYV RNTSSEQEEV 1140

VEALREEIRM MSHLNHPNII RMLGATCEKS NYNLFIEWMA GGSVAHLLSK YGAFKESVVI 1200

NYTEQLLRGL SYLHENQIIH RDVKGANLLI DSTGQRLRIA DFGAAARLAS KGTGAGEFQG 1260

QLLGTIAFMA PEVLRGQQYG RSCDVWSVGC AIIEMACAKP PWNAEKHSNH LALIFKIASA 1320

TTAPSIPSHL SPGLRDVALR CLELQPQDRP PSRELLKHPV FRTTW 1365

Nucleotide Sequence
(FASTA)

AGCAGGGCAG GAGCACAGCC GGGCGTGGCG CTCACTCCAG TCTCCGCTCC CTTCTGCCCC 60

GCCCACTGCA GGCCGGAGAT GGAGAGCAAG GACACGCTGC GGGGGCTGCA CAGGATGGAG 120

GACCGGCCGG AGGAGCGTGT GATCCGCGAG AGGCTGAAGG CCACCTGCAT GCCCGCCTGG 180

CGGCACGAGT GGCTGGAGCG CAGGAGCCGC AGGGGCCCGG TGGTGGTAAA GCCAATCCCT 240

GTCAAAGGAG ATGGATCTGA AATGAATAGC GTGGCGGCTG AGTCGCAAGG AGAGGCCCAG 300

GCGAGCGTGT GCCCAGCTCC CAAAGGCCGC CGCAGCCCGT CCCCCGGCAG CTCTCCGGCC 360

GGGCGCCCGG TGAAGGCCGA GTCTCCCGGA GTGAGGAGGA AGCGCGCGTC CCCGGTGCCG 420

TCTCAGAGCG GGAGGACCAC GCCTCCGCGC AGAGCCCCGT CCCCCGACGG CTTCTCGCCG 480

TACAGCCCCG AGGAGACCAG CCGCCGGGTG AACAAGGTGA TGCGGGCCCG GCTCTACCTG 540

CTGCAGCAGA TCGGCCCCAA CTCCTTCCTG ATTGGAGGCG ACAGCCCAGA CAACAAGTAC 600

CGCGTGTTCA TCGGGCCGCA GAACTGCAGC TGCGGGCGCG GTGCCTTCTG CATCCACCTG 660

CTGTTCGTCA TGCTCCGCGT GTTTCAGCTG GAACCTTCCG ACCCGATGTT GTGGAGGAAA 720

ACTTTGAAGA ATTTTGAGGT TGAGAGTTTG TTCCAGAAAT ATCACAGCAG GCGTAGCTCG 780

AGGATCAAAG CTCCCTCTCG TAGCACCATC CAGAAGTTCG TGTCCCGCAT GTCCAGCTCC 840

CACACGCTGT CCTCGCCGAG CACGGCCACG GCCAGTGCGG AGAGCAGCCT CAAGGACGAG 900

GAGGAGCAGC TGTGCCCCAT CTGCCTGCTG GGCATGCTGG ACGAGGAGAG CCTGACCGTG 960

TGCGAGGACG GCTGCCGCAA CAAGCTGCAC CACCACTGCA TGTCCATCTG GGCAGAGGAA 1020

TGTCGAAGGA ACAGGGAGCC TCTGATCTGT CCCCTCTGCA GGTCCAAGTG GCGGTCCCAC 1080

GATTTCTACA GTCACGAGCT GTCCAGCCCC GCGGATTCCC CGTCCTCCCT GCGGGCGGCC 1140

CCGCAGCCCC CGGCACAGCC TCCGCTGGCG GGACCGCAGC ACAGAGACCA GGAAGGCAGC 1200

TCCGGCCTCA CGCACTACGG GGCTCAGCAC ATCCCTGCTG CCTACAGAGA CCTGGCTGAG 1260

CCCTGGATCC AGGTGTTTGG GACGGAGCTC GTTGGCTGCT TGTTTTCTAG AAACTGGAAC 1320

GTCCGCGAGA TGGCTCTGCG GCGACTCTCC CACGACGTCA GCGGGGCGCT GCTGCTGGCC 1380

CACGGGGAGA GCACCGGGCA CTCGGGGGGC GGGGGCCGGA GCAGCCCGGG GGCCGGGGCC 1440

AGCAGCGCGC CCTCCCCGCC CGCGGGCGAC GTGGTGGGGG CCTGCTGCAG CGTGCTGTCC 1500

ATGGTCTGCG CCGACCCTGT CTACAAAGTG TACGTTGCCG CTTTAAAAAC CCTGCGGGCC 1560

ATGCTCGTGT ACACGCCCTG CCACAGCCTG GCCGAGCGGA TCAAGCTGCA GAGGCTCCTG 1620

CGGCCGGTCG TGGACACCAT CCTGGTCAAG TGTGCAGACG CCAACAGCCG CACCAGCCAG 1680

CTGTCCGTGT CCACGCTGCT GGAGCTGTGC AGAGGCCAGG CCGGGGAGCT GGCGGTCGGC 1740

AGAGAAATAC TGAAAGCTGG CTCCATTGGG ATTGGGGGCG TGGATTACGT CCTCAGTTGT 1800

ATTCTTGGGA ACCAGATGGA GTCCAACAAC TGGCAGGAGC TGCTGGGCCG CCTCTGCCTG 1860

GTGGACCGGC TGCTGCTGGA GTTCCCCGCC GAGTTCTACC CGCACACCGT CGGCGCCGAG 1920

GCGGCCCCCG CCGAGCCCGT GGACGTCAGG TATAAGAAGC TGCTGTCCCT GCTCGCCTTC 1980

GCCCTGCAGT CCATCGACCA CGCCCACGCG GTGGTCGGGA AGCTCGCGCG CAGGGTCTAC 2040

CTGAGTTCCG CGAGGATGGT CACCGCCGTG CCCCCCGTGT TCGTGAAGCT GTTAGAGATG 2100

CTGAGTGCTT CCAGCTCCAC CCACTTCGCC CGGATGCGCC GCCGCCTGAT GGCGATCGCG 2160

GAGGAGGTGG ACATTGCCGA GGCCGTCCAG CTGGGCCTCG AGGATGCCTG GGACGGCCGG 2220

CGTGACAGCT TCCTGCAGGC GTCGGCCCCT GAGAGCCACC CAGAGGCCCC AGGGAGCAGC 2280

CCCCTGCAGG GCCCAGACCG TGCGGAGAAA ACTGGAAGAG GACTGTGCCC TGCGAGGCTG 2340

AGCGCCAGCT CGGAGGACAT CTCTGGTCGG CCGGCCAGCA CTGCCCTGGG GCCTCCTCCT 2400

TCAGCAACGA CGGAGCAGCC AAAGCCAGCG GTGCAAGCCA AGGGCAGGCC CCTCAGCCAG 2460

TGTCTGAGCT CCTCTCCCCT GTCCCCTCAC TCCCAACCAG TGCTCCCGCC CTCGTCCACC 2520

CCGGCTTCGT CGGCCCAGAC CGCACCAGCG GGCCCCGGGG ACGCCTCCAA GTACAGACCT 2580

CAGGGATTTG TTCCCTACAA CATACCCTCC GCGTCGCCTC CGCCGCAGCG CAAGTTCTCC 2640

CTGCAGTTCC AGAGAAACTG TTCCGAAAAC AGAGACTCGG ACAAGCTCTC CCCCATCTTC 2700

ACGCAGTCCC GGCCCCTGCC CTGCAGTAGG ATACACAGGC CCAAGCCCTC GCGGCCCTCC 2760

CCCGGCAGCC CCGGGAGACG GGCCGACGCC GCGACAGGCA GCATGACCCT GGACCTGCAC 2820

GGGGCCTCCG AGGGCGGCGA CAGCTTCAGC AGCGGCAGCA GCAGCAGCGC CGTGATCCCC 2880

AGCGAGGAGA CGGTGTTCAC CCCCGTGGAG GACAAGAGCC GGCTGGACGC CAGCACCGAG 2940

CTCAGCTCCA GCATCGAGGA CCTGCTCGAG GCGTCCCTGC CCTCCGCTGA CACCACGGTG 3000

ACGTTCAAGT CAGAGGTGGC CGTCCTCTCT CCTGAGAAGG ACGAGCACGA CGACACCTAC 3060

CAAGACGACG TGAGTCACAA TCAGAAGTGC AAAGAGAAGA TGGAGGCCGA GGAGGAGGAA 3120

GCTCTGGCGA TCGCCATGGC GATGTCCGCC TCTCAGGACG CCCTCCCCGT GGTGCCTCAG 3180

CTGCAGGTGG AGAACGGAGA GGACGTCATC ATCATCCAGC AGGACACGCC CGAGACCCTC 3240

CCAGGACACA CCAAAGCGAA GCTGCCGTAC CGGGAGGACG CGGACTGGCT GAAGGGCCAG 3300

CAGATCGGCC TCGGGGCCTT CTCCTCCTGC TACCAGGCTC AGGACGTGGG GACCGGGACC 3360

TTAATGGCTG TGAAGCAGGT GACGTATGTC AGAAACACGT CGTCGGAGCA GGAGGAAGTC 3420

GTGGAGGCGC TGAGAGAGGA GATCAGGATG ATGAGCCACC TGAACCACCC GAACATCATC 3480

AGGATGCTGG GGGCCACCTG CGAGAAGAGC AATTACAACC TCTTCATCGA GTGGATGGCA 3540

GGGGGATCTG TGGCTCATTT GCTCAGTAAA TATGGAGCCT TCAAGGAATC AGTGGTCATT 3600

AACTACACTG AGCAGTTACT CCGTGGCCTC TCCTATCTCC ATGAAAACCA GATCATCCAC 3660

AGAGATGTCA AAGGTGCTAA CCTCCTCATT GACAGCACAG GTCAGAGACT GCGAATCGCA 3720

GACTTCGGAG CGGCAGCCAG GCTGGCATCA AAGGGAACTG GCGCAGGAGA GTTTCAGGGA 3780

CAGTTGCTGG GGACAATCGC ATTTATGGCA CCTGAGGTCC TCCGAGGACA GCAGTATGGG 3840

AGGAGCTGTG ATGTGTGGAG TGTCGGCTGT GCCATCATCG AAATGGCTTG TGCTAAACCA 3900

CCTTGGAACG CAGAGAAACA CTCCAATCAT CTCGCTTTGA TATTTAAGAT CGCGAGTGCG 3960

ACGACCGCCC CATCGATCCC GTCACACTTG TCTCCCGGGT TACGCGACGT GGCTCTTCGC 4020

TGCTTAGAAC TTCAACCTCA GGACAGACCT CCATCAAGGG AGCTGCTGAA GCACCCGGTC 4080

TTCCGCACCA CGTGG 4095

Domain Profile

S: 1     wqkrevigkGsfgsvyaaldvdtgellavKeveikpekksekk.evkalkeEikllkelk  59

         w k+++ig G+f+s+y+a+dv tg+l+avK+v++ ++++se++ +v+al+eEi+++++l+

Q: 1096  WLKGQQIGLGAFSSCYQAQDVGTGTLMAVKQVTYVRNTSSEQEeVVEALREEIRMMSHLN  1155

         899*******************************999998887699**************

S: 60    HenivkyyGveveeeelkiflEyvegGslssllekygkleesvikkytkqileglayLHe  119

         H+ni++++G+++e++++++f+E+++gGs+++ll+kyg+++esv+ +yt+q+l+gl+yLHe

Q: 1156  HPNIIRMLGATCEKSNYNLFIEWMAGGSVAHLLSKYGAFKESVVINYTEQLLRGLSYLHE  1215

         ************************************************************

S: 120   kkivHRDiKgaNillds.sgvvklsDFGaskrlaelntkaae.lesltGtlaymaPEvik  177

         ++i+HRD+KgaN+l+ds  + ++++DFGa++rla++ t a+e + +l Gt+a+maPEv++

Q: 1216  NQIIHRDVKGANLLIDStGQRLRIADFGAAARLASKGTGAGEfQGQLLGTIAFMAPEVLR  1275

         *****************7789******************9996779*************9

S: 178   kkekgygrkaDiWslgcvviemltgkrPfa..eldeelaimfkvgakktkPeipeklsee  235

         ++  +ygr++D+Ws+gc++iem+++k+P++  +++++la++fk+++++t+P+ip++ls+

Q: 1276  GQ--QYGRSCDVWSVGCAIIEMACAKPPWNaeKHSNHLALIFKIASATTAPSIPSHLSPG  1333

         98..8************************87678899***********************

S: 236   gkdflekcleldpkkrpsaeeLLkhef  262

          +d+  +clel+p++rp ++eLLkh++

Q: 1334  LRDVALRCLELQPQDRPPSRELLKHPV  1360

         *************************86

Domain Sequence
(FASTA)

WLKGQQIGLG AFSSCYQAQD VGTGTLMAVK QVTYVRNTSS EQEEVVEALR EEIRMMSHLN 60

HPNIIRMLGA TCEKSNYNLF IEWMAGGSVA HLLSKYGAFK ESVVINYTEQ LLRGLSYLHE 120

NQIIHRDVKG ANLLIDSTGQ RLRIADFGAA ARLASKGTGA GEFQGQLLGT IAFMAPEVLR 180

GQQYGRSCDV WSVGCAIIEM ACAKPPWNAE KHSNHLALIF KIASATTAPS IPSHLSPGLR 240

DVALRCLELQ PQDRPPSREL LKHPV 265

Keyword

ATP-binding; Complete proteome; Metal-binding; Nucleotide-binding; Reference proteome; Zinc; Zinc-finger.

Sequence Source

Ensembl

Orthology

Ortholog group

Ailuropoda melanoleuca"; ?>Anolis carolinensis"; ?>Bos taurus"; ?>Callithrix jacchus"; ?>Canis familiaris"; ?>Cavia porcellus"; ?>Ciona intestinalis"; ?>Ciona savignyi"; ?>Danio rerio"; ?>Dipodomys ordii"; ?>Equus caballus"; ?>Felis catus"; ?>Gallus gallus"; ?>Gorilla gorilla"; ?>Homo sapiens"; ?>Ictidomys tridecemlineatus"; ?>Latimeria chalumnae"; ?>Loxodonta africana"; ?>Macaca mulatta"; ?>Meleagris gallopavo"; ?>Monodelphis domestica"; ?>Mus musculus"; ?>Mustela putorius furo"; ?>Nomascus leucogenys"; ?>Ornithorhynchus anatinus"; ?>Oryctolagus cuniculus"; ?>Otolemur garnettii"; ?>Pan troglodytes"; ?>Pelodiscus sinensis"; ?>Petromyzon marinus"; ?>Pongo abelii"; ?>Rattus norvegicus"; ?>Sarcophilus harrisii"; ?>Sus scrofa"; ?>Taeniopygia guttata"; ?>Vicugna pacos"; ?>

Gene Ontology

GO:0005524	; F:ATP binding
GO:0004674	; F:protein serine/threonine kinase activity
GO:0008270	; F:zinc ion binding

KEGG

InterPros

IPR011009	; Kinase-like_dom.
IPR000719	; Prot_kinase_cat_dom.
IPR017441	; Protein_kinase_ATP_BS.
IPR002290	; Ser/Thr_dual-sp_kinase_dom.
IPR008271	; Ser/Thr_kinase_AS.
IPR001841	; Znf_RING.
IPR013083	; Znf_RING/FYVE/PHD.
IPR007527	; Znf_SWIM.

Pfam

PF00069	; Pkinase; 1.
PF04434	; SWIM; 1.

SMARTs

SM00184	; RING; 1.
SM00220	; S_TKc; 1.

Prosites

PS00107	; PROTEIN_KINASE_ATP; 1.
PS50011	; PROTEIN_KINASE_DOM; 1.
PS00108	; PROTEIN_KINASE_ST; 1.
PS50089	; ZF_RING_2; 1.
PS50966	; ZF_SWIM; 1.

Prints

Created Date

20-Feb-2013