EKS-MYL-00168

Eukaryotic Protein Kinase & Protein Phosphatase Database

Tag

Content

EKPD ID

EKS-MYL-00168

Classification

Group/Family	Score	E-Value	Start	End	Domain Length
Other/TLK	623.5	4.0E-188	462	741	280

Status

Unreviewed

Ensembl Protein

ENSMLUP00000010924

UniProt Accession

G1PJJ2;

Protein Name

Protein Synonyms/Alias

Gene Name

TLK2

Gene Synonyms/Alias

TLK2;

Ensembl Information

Ensembl Gene ID	Ensembl Protein ID	Ensembl Transcript ID
ENSMLUG00000011980	ENSMLUP00000010924	ENSMLUT00000011994

Organism

Myotis lucifugus

Functional Description

Protein Length

772

Protein Sequence
(FASTA)

MMEELHSLDP RRQELLEARF TGVGVSKGPL NSESSNQSLC SVGSLSDKEV ETPEKKQNDQ 60

RNRKRKAEPY ETSQGKGTPR GHKISDYFEF AGGSGPGTSP GRSVPPVARS SPQHSLSNPL 120

PRRVEQPLYG LDGSAAKEVS EEQSALPTLM SVMLAKPRLD TEQLAQRGAG LCFTFVSAQQ 180

NSPSSTGSGN TEHSCSSQKQ ISIQHRQTQS DLTIEKISAL ENSKNSDLEK KEGRIDDLLR 240

ANCDLRRQID EQQKMLEKYK ERLNRCVTMS KKLLIEKSKQ EKMACRDKSM QDRLRLGHFT 300

TVRHGASFTE QWTDGYAFQN LIKQQERINS QREEIERQRK MLAKRKPPAM GQAPPATNEQ 360

KQRKSKTNGA ENETPTCTLS NLRALRRALS NPVFSRLTLA EYHEQEEIFK LRLGHLKKEE 420

AEIQAELERL ERVRNLHIRE LKRIHNEDNS QFKDHPTLND RYLLLHLLGR GGFSEVYKAF 480

DLTEQRYVAV KIHQLNKNWR DEKKENYHKH ACREYRIHKE LDHPRIVKLY DYFSLDTDSF 540

CTVLEYCEGN DLDFYLKQHK LMSEKEARSI IMQIVNALKY LNEIKPPIIH YDLKPGNILL 600

VNGTACGEIK ITDFGLSKIM DDDSYNSVDG MELTSQGAGT YWYLPPECFV VGKEPPKISN 660

KVDVWSVGVI FYQCLYGRKP FGHNQSQQDI LQENTILKAT EVQFPPKPVV TPEAKAFIRR 720

CLAYRKEDRI DVQQLACDPY LLPHIRKSVS TSSPAGAAIA STSGVSNNSS SN 772

Nucleotide Sequence
(FASTA)

ATGATGGAAG AATTGCATAG CCTGGACCCA CGACGGCAGG AATTATTAGA GGCCAGGTTT 60

ACTGGAGTTG GTGTTAGTAA GGGGCCACTT AATAGCGAGT CTTCAAACCA GAGTTTGTGC 120

AGTGTGGGGT CCTTGAGTGA TAAAGAAGTA GAGACTCCTG AGAAAAAACA GAATGACCAG 180

AGAAACCGGA AAAGAAAAGC TGAACCATAT GAAACTAGCC AAGGGAAAGG CACACCTAGG 240

GGACATAAAA TTAGTGATTA CTTTGAGTTT GCTGGGGGAA GCGGGCCAGG AACCAGCCCT 300

GGCAGAAGTG TTCCACCAGT TGCACGATCC TCACCGCAAC ATTCCTTATC CAATCCCTTA 360

CCGCGACGAG TAGAACAGCC CCTCTATGGT TTAGATGGCA GCGCTGCAAA GGAGGTATCG 420

GAGGAGCAGT CTGCTCTGCC AACCCTGATG TCAGTAATGC TAGCAAAACC TCGGCTCGAC 480

ACAGAGCAGC TGGCACAGAG GGGAGCTGGC CTCTGCTTCA CTTTTGTTTC AGCTCAGCAA 540

AATAGTCCCT CTTCTACAGG ATCTGGTAAC ACAGAGCATT CCTGCAGCTC CCAGAAACAG 600

ATCTCCATCC AGCACAGACA GACCCAGTCT GACCTCACAA TAGAAAAAAT ATCTGCACTA 660

GAAAACAGTA AGAATTCTGA CTTAGAGAAG AAGGAGGGAA GAATAGATGA TTTGTTAAGA 720

GCCAACTGTG ATTTGAGACG GCAGATTGAT GAACAGCAAA AGATGCTAGA GAAATACAAA 780

GAACGATTAA ATCGATGTGT GACAATGAGC AAGAAACTCC TTATAGAAAA GTCAAAACAA 840

GAGAAGATGG CATGTAGAGA TAAGAGCATG CAAGACCGCT TGAGATTGGG CCACTTTACC 900

ACTGTCCGAC ACGGGGCCTC TTTTACTGAA CAATGGACAG ATGGTTATGC TTTCCAGAAC 960

CTTATCAAGC AGCAGGAAAG GATAAATTCA CAGAGGGAAG AAATTGAAAG ACAGCGGAAA 1020

ATGTTAGCAA AGCGGAAACC TCCTGCCATG GGACAGGCCC CTCCAGCAAC CAATGAGCAG 1080

AAACAGCGGA AAAGCAAGAC CAACGGAGCT GAAAATGAAA CCCCAACCTG CACCCTCTCC 1140

AATTTGAGAG CCCTCAGGAG AGCCCTCTCC AATCCAGTAT TTTCCAGGTT AACATTAGCA 1200

GAATACCATG AACAAGAAGA AATCTTCAAA CTCCGATTAG GTCATCTTAA AAAGGAGGAA 1260

GCGGAGATCC AGGCAGAGCT GGAAAGGCTA GAAAGGGTTA GAAATCTACA TATCAGGGAA 1320

CTAAAAAGGA TACATAACGA AGATAACTCA CAATTTAAAG ATCATCCAAC GTTAAATGAC 1380

AGATATTTGT TGTTACATCT TTTGGGTAGA GGAGGTTTCA GTGAAGTTTA CAAGGCATTT 1440

GACCTAACAG AACAAAGATA TGTAGCTGTG AAAATTCACC AGTTAAATAA AAACTGGAGA 1500

GATGAAAAAA AGGAGAATTA CCACAAGCAT GCGTGTAGGG AGTACCGGAT TCACAAAGAA 1560

CTGGATCATC CCAGAATAGT TAAGCTGTAC GATTACTTTT CACTGGACAC GGACTCGTTT 1620

TGTACAGTAT TAGAATACTG TGAGGGAAAT GATCTGGACT TCTACCTGAA ACAGCACAAA 1680

TTAATGTCGG AGAAAGAGGC CCGATCCATT ATCATGCAGA TTGTGAATGC TTTAAAGTAC 1740

TTAAATGAAA TAAAACCTCC CATCATACAC TATGACCTCA AACCAGGTAA TATTCTTTTA 1800

GTAAATGGTA CAGCATGTGG AGAGATAAAA ATCACAGATT TTGGTCTTTC CAAGATCATG 1860

GATGATGATA GCTACAATTC AGTGGATGGC ATGGAGCTCA CGTCACAAGG TGCTGGTACT 1920

TATTGGTATT TACCACCAGA GTGTTTTGTG GTTGGGAAAG AACCACCAAA GATCTCAAAT 1980

AAAGTTGATG TCTGGTCAGT GGGTGTGATC TTCTACCAGT GTCTTTATGG AAGGAAGCCT 2040

TTTGGCCATA ACCAGTCCCA GCAAGACATT CTGCAAGAAA ATACTATTCT TAAAGCTACT 2100

GAAGTGCAGT TTCCTCCAAA GCCAGTAGTA ACACCTGAAG CAAAGGCATT TATTCGGCGA 2160

TGCTTGGCCT ACCGAAAGGA GGACCGCATC GATGTCCAGC AGCTGGCCTG TGACCCCTAC 2220

TTGCTGCCTC ACATCCGAAA GTCGGTCTCC ACAAGTAGCC CTGCTGGAGC TGCTATTGCA 2280

TCAACCTCCG GGGTGTCCAA TAACAGTTCT TCGAATTGA 2319

Domain Profile

S: 1     ylllkllgkggfsevykafdlkeqryvavkihqlnkdwkdekkenyvkhalreyrihkel  60

         ylll+llg+ggfsevykafdl+eqryvavkihqlnk+w+dekkeny+kha+reyrihkel

Q: 462   YLLLHLLGRGGFSEVYKAFDLTEQRYVAVKIHQLNKNWRDEKKENYHKHACREYRIHKEL  521

         9***********************************************************

S: 61    dhprivklydllsldtdsfctvleyvegndldfylkqhkllsekearsiimqivsalkyl  120

         dhprivklyd++sldtdsfctvley+egndldfylkqhkl+sekearsiimqiv+alkyl

Q: 522   DHPRIVKLYDYFSLDTDSFCTVLEYCEGNDLDFYLKQHKLMSEKEARSIIMQIVNALKYL  581

         ************************************************************

S: 121   neikppiihydlkpgnillvegtacgeikitdfglskimdddsydsddgleltsqgagty  180

         neikppiihydlkpgnillv+gtacgeikitdfglskimdddsy+s+dg+eltsqgagty

Q: 582   NEIKPPIIHYDLKPGNILLVNGTACGEIKITDFGLSKIMDDDSYNSVDGMELTSQGAGTY  641

         ************************************************************

S: 181   wylppecfvvgkeppkisnkvdvwsvgvifyqclygkkpfghnqsqqdileentilkate  240

         wylppecfvvgkeppkisnkvdvwsvgvifyqclyg+kpfghnqsqqdil+entilkate

Q: 642   WYLPPECFVVGKEPPKISNKVDVWSVGVIFYQCLYGRKPFGHNQSQQDILQENTILKATE  701

         ************************************************************

S: 241   vqfpskpvvsseakafirrclayrkedridvqqlakdeyl  280

         vqfp+kpvv++eakafirrclayrkedridvqqla+d+yl

Q: 702   VQFPPKPVVTPEAKAFIRRCLAYRKEDRIDVQQLACDPYL  741

         **************************************97

Domain Sequence
(FASTA)

YLLLHLLGRG GFSEVYKAFD LTEQRYVAVK IHQLNKNWRD EKKENYHKHA CREYRIHKEL 60

DHPRIVKLYD YFSLDTDSFC TVLEYCEGND LDFYLKQHKL MSEKEARSII MQIVNALKYL 120

NEIKPPIIHY DLKPGNILLV NGTACGEIKI TDFGLSKIMD DDSYNSVDGM ELTSQGAGTY 180

WYLPPECFVV GKEPPKISNK VDVWSVGVIF YQCLYGRKPF GHNQSQQDIL QENTILKATE 240

VQFPPKPVVT PEAKAFIRRC LAYRKEDRID VQQLACDPYL 280

Keyword

ATP-binding; Complete proteome; Nucleotide-binding; Reference proteome.

Sequence Source

Ensembl

Orthology

Ortholog group

Ailuropoda melanoleuca"; ?>Anolis carolinensis"; ?>Bos taurus"; ?>Caenorhabditis elegans"; ?>Callithrix jacchus"; ?>Canis familiaris"; ?>Cavia porcellus"; ?>Danio rerio"; ?>Drosophila melanogaster"; ?>Equus caballus"; ?>Felis catus"; ?>Gadus morhua"; ?>Gallus gallus"; ?>Gasterosteus aculeatus"; ?>Gorilla gorilla"; ?>Homo sapiens"; ?>Latimeria chalumnae"; ?>Loxodonta africana"; ?>Macaca mulatta"; ?>Meleagris gallopavo"; ?>Mus musculus"; ?>Mustela putorius furo"; ?>Nomascus leucogenys"; ?>Oreochromis niloticus"; ?>Oryctolagus cuniculus"; ?>Oryzias latipes"; ?>Otolemur garnettii"; ?>Pan troglodytes"; ?>Petromyzon marinus"; ?>Pongo abelii"; ?>Rattus norvegicus"; ?>Sarcophilus harrisii"; ?>Sus scrofa"; ?>Taeniopygia guttata"; ?>Takifugu rubripes"; ?>Xenopus tropicalis"; ?>Xiphophorus maculatus"; ?>

Gene Ontology

GO:0005524	; F:ATP binding
GO:0004674	; F:protein serine/threonine kinase activity

KEGG

InterPros

IPR011009	; Kinase-like_dom.
IPR000719	; Prot_kinase_cat_dom.
IPR017441	; Protein_kinase_ATP_BS.
IPR002290	; Ser/Thr_dual-sp_kinase_dom.
IPR008271	; Ser/Thr_kinase_AS.

Pfam

PF00069

; Pkinase; 1.

SMARTs

SM00220

; S_TKc; 1.

Prosites

PS00107	; PROTEIN_KINASE_ATP; 1.
PS50011	; PROTEIN_KINASE_DOM; 1.
PS00108	; PROTEIN_KINASE_ST; 1.

Prints

Created Date

20-Feb-2013