EKS-MYL-00262

Eukaryotic Protein Kinase & Protein Phosphatase Database

Tag

Content

EKPD ID

EKS-MYL-00262

Classification

Group/Family	Score	E-Value	Start	End	Domain Length
Other/PLK	424.4	1.6E-127	53	305	253

Status

Unreviewed

Ensembl Protein

ENSMLUP00000011078

UniProt Accession

G1PJY4;

Protein Name

Protein Synonyms/Alias

Gene Name

PLK1

Gene Synonyms/Alias

PLK1;

Ensembl Information

Ensembl Gene ID	Ensembl Protein ID	Ensembl Transcript ID
ENSMLUG00000012154	ENSMLUP00000011078	ENSMLUT00000012160

Organism

Myotis lucifugus

Functional Description

Protein Length

604

Protein Sequence
(FASTA)

MSAAAAAGKL ARAPADPGRA GAPGVAAPGA PAAAPPGKEI PEVLVDPRSR RRYLRGRFLG 60

KGGFAKCFEI SDADTKEVFA GKIVPKSLLL KPHQKEKMSM EISIHRSLAH QHVVGFHGFF 120

EDNDFVFVVL ELCRRRSLLE LHKRRKALTE PEARYYLRQV VLGCQYLHRN RVIHRDLKLG 180

NLFLNEDLEV KIGDFGLATK VEYDGERKKT LCGTPNYIAP EVLSKKGHSF EVDVWSIGCI 240

MYTLLVGKPP FETSCLKETY LRIKKNEYSI PKHINPVAAS LIQKMLQSDP TARPTIHELL 300

SDEFFTSGYI PARLPITCLT IPPRFSIAPS SLDPSGRKPL SVLNKGTENP MPERPREKEE 360

PAVRETNEAV DCHLGDMLQQ LHSVNASKPS ERGLVRQEEA EDPACIPIFW VSKWVDYSDK 420

YGLGYQLCDN SVGVLFNDST RLILYNDGDS LQYIERDGTE SYLTVNSHPN SLIKKITLLK 480

YFRNYMSEHL LKAGANITPR EGDELARLPY LRTWFRTRSA IILHLSNGCV QINFFQDHTK 540

LILCPLMAAV TYINEKRDFR TYRLSLLEEF GCSKELASRL RYARTMVDKL LSSRSATNRL 600

KASS 604

Nucleotide Sequence
(FASTA)

ATGAGTGCGG CGGCGGCTGC AGGGAAGCTG GCGCGGGCAC CGGCCGACCC AGGGAGAGCC 60

GGGGCCCCCG GCGTTGCAGC TCCGGGGGCT CCAGCGGCCG CCCCGCCGGG GAAAGAGATC 120

CCGGAGGTCC TAGTGGACCC ACGCAGCCGG CGGCGCTATC TGCGGGGCCG CTTTCTGGGG 180

AAGGGCGGCT TTGCCAAGTG CTTCGAGATC TCGGACGCGG ACACTAAGGA GGTGTTCGCG 240

GGCAAGATCG TGCCCAAGTC GCTGCTGCTC AAGCCGCACC AGAAGGAGAA GATGTCCATG 300

GAGATATCCA TTCACCGCAG CCTCGCCCAC CAGCATGTCG TCGGCTTCCA CGGCTTCTTC 360

GAGGACAACG ACTTCGTGTT CGTGGTGTTG GAGCTCTGCC GCCGGAGATC TCTCCTGGAA 420

CTGCACAAAC GGAGGAAAGC ACTGACGGAG CCCGAGGCTC GCTACTATCT GCGGCAGGTG 480

GTCCTTGGCT GCCAGTACCT GCACCGAAAC CGGGTCATTC ACCGGGACCT CAAGCTAGGC 540

AACCTCTTCC TGAACGAGGA CCTGGAGGTG AAAATAGGGG ATTTTGGACT GGCAACCAAG 600

GTCGAATATG ACGGGGAAAG GAAGAAGACC CTGTGCGGAA CTCCTAATTA CATAGCTCCT 660

GAGGTGCTGA GCAAGAAAGG ACACAGTTTC GAGGTGGATG TGTGGTCCAT TGGGTGCATT 720

ATGTATACCT TGCTAGTGGG CAAACCACCT TTTGAGACAT CTTGCCTAAA AGAGACCTAC 780

CTCCGGATCA AGAAGAATGA GTACAGTATT CCCAAGCACA TCAACCCCGT GGCCGCCTCC 840

CTCATTCAGA AGATGCTTCA GAGCGACCCC ACCGCCCGCC CCACCATCCA CGAGCTGCTC 900

AGCGACGAGT TCTTTACCTC TGGCTACATC CCCGCCCGAC TGCCCATCAC CTGCCTCACC 960

ATCCCACCCA GGTTTTCCAT TGCTCCCAGC AGCTTGGACC CCAGTGGCCG GAAGCCTCTC 1020

TCAGTCCTCA ATAAAGGTAC GGAGAACCCC ATGCCTGAGC GGCCCCGAGA GAAAGAGGAA 1080

CCTGCAGTCC GGGAGACCAA CGAGGCGGTC GACTGCCACC TTGGGGATAT GCTGCAGCAG 1140

CTGCACAGCG TCAACGCCTC CAAGCCCTCG GAGCGGGGGC TGGTCAGGCA AGAGGAGGCC 1200

GAGGATCCCG CCTGCATCCC CATCTTCTGG GTCAGCAAGT GGGTGGACTA CTCGGACAAG 1260

TACGGCCTTG GATACCAACT GTGTGACAAC AGCGTGGGGG TGCTCTTCAA TGACTCGACT 1320

CGCCTTATCC TCTACAACGA CGGGGACAGC CTGCAGTACA TAGAGCGCGA CGGCACAGAG 1380

TCCTACCTCA CCGTGAACTC CCACCCCAAC TCCCTGATCA AGAAGATCAC CCTCCTTAAG 1440

TATTTCCGGA ACTACATGAG CGAGCACTTG CTGAAGGCAG GGGCCAATAT CACACCACGG 1500

GAAGGTGACG AGCTGGCCCG GCTGCCCTAC CTGCGCACCT GGTTTCGCAC CCGCAGTGCC 1560

ATCATCCTGC ACCTCAGCAA TGGCTGTGTA CAGATCAACT TCTTCCAGGA CCACACCAAG 1620

CTCATCCTGT GCCCGCTGAT GGCCGCCGTG ACTTACATCA ACGAGAAGCG GGACTTCCGC 1680

ACGTACCGCC TGAGCCTCCT GGAGGAGTTT GGCTGCTCCA AGGAGCTGGC CAGCCGGCTC 1740

CGATATGCCC GCACCATGGT GGACAAGCTG CTGAGCTCGC GCTCAGCCAC CAACCGCCTC 1800

AAGGCCTCCT CGTAG 1815

Domain Profile

S: 1     yergkllGkGgfakcyelkdletkevfavkvvpksllakekqrekvekeieihrslkhkn  60

         y rg++lGkGgfakc+e++d++tkevfa k+vpksll k++q+ek+++ei+ihrsl+h++

Q: 53    YLRGRFLGKGGFAKCFEISDADTKEVFAGKIVPKSLLLKPHQKEKMSMEISIHRSLAHQH  112

         889*********************************************************

S: 61    ivklyeffedkenvylvlelcsrrslaellkrrkaltepevryylrqivsglkylhekri  120

         +v ++ ffed+++v++vlelc+rrsl el+krrkaltepe+ryylrq+v g++ylh++r+

Q: 113   VVGFHGFFEDNDFVFVVLELCRRRSLLELHKRRKALTEPEARYYLRQVVLGCQYLHRNRV  172

         ************************************************************

S: 121   lhrdlklgnlflneelevkigdfGlatrlekeeerkktlcGtPnyiaPevlskkghslev  180

         +hrdlklgnlflne+levkigdfGlat++e+++erkktlcGtPnyiaPevlskkghs+ev

Q: 173   IHRDLKLGNLFLNEDLEVKIGDFGLATKVEYDGERKKTLCGTPNYIAPEVLSKKGHSFEV  232

         ************************************************************

S: 181   diWslGcilytllvGkPPfetkelketyekikkaeyslPsslskeaksliakllkkePee  240

         d+Ws+Gci+ytllvGkPPfet++lkety +ikk+eys+P+++++ a+sli+k+l+++P++

Q: 233   DVWSIGCIMYTLLVGKPPFETSCLKETYLRIKKNEYSIPKHINPVAASLIQKMLQSDPTA  292

         ************************************************************

S: 241   rpsleevlkdefl  253

         rp+++e+l+def+

Q: 293   RPTIHELLSDEFF  305

         ************8

Domain Sequence
(FASTA)

YLRGRFLGKG GFAKCFEISD ADTKEVFAGK IVPKSLLLKP HQKEKMSMEI SIHRSLAHQH 60

VVGFHGFFED NDFVFVVLEL CRRRSLLELH KRRKALTEPE ARYYLRQVVL GCQYLHRNRV 120

IHRDLKLGNL FLNEDLEVKI GDFGLATKVE YDGERKKTLC GTPNYIAPEV LSKKGHSFEV 180

DVWSIGCIMY TLLVGKPPFE TSCLKETYLR IKKNEYSIPK HINPVAASLI QKMLQSDPTA 240

RPTIHELLSD EFF 253

Keyword

ATP-binding; Complete proteome; Nucleotide-binding; Reference proteome.

Sequence Source

Ensembl

Orthology

Ortholog group

Ailuropoda melanoleuca"; ?>Anolis carolinensis"; ?>Bos taurus"; ?>Caenorhabditis elegans"; ?>Callithrix jacchus"; ?>Canis familiaris"; ?>Cavia porcellus"; ?>Ciona intestinalis"; ?>Ciona savignyi"; ?>Danio rerio"; ?>Drosophila melanogaster"; ?>Echinops telfairi"; ?>Equus caballus"; ?>Felis catus"; ?>Gadus morhua"; ?>Gallus gallus"; ?>Gasterosteus aculeatus"; ?>Gorilla gorilla"; ?>Homo sapiens"; ?>Ictidomys tridecemlineatus"; ?>Latimeria chalumnae"; ?>Loxodonta africana"; ?>Macaca mulatta"; ?>Macropus eugenii"; ?>Meleagris gallopavo"; ?>Microcebus murinus"; ?>Monodelphis domestica"; ?>Mus musculus"; ?>Mustela putorius furo"; ?>Oreochromis niloticus"; ?>Ornithorhynchus anatinus"; ?>Oryctolagus cuniculus"; ?>Oryzias latipes"; ?>Otolemur garnettii"; ?>Pan troglodytes"; ?>Pelodiscus sinensis"; ?>Pongo abelii"; ?>Rattus norvegicus"; ?>Sarcophilus harrisii"; ?>Taeniopygia guttata"; ?>Takifugu rubripes"; ?>Tetraodon nigroviridis"; ?>Tupaia belangeri"; ?>Tursiops truncatus"; ?>Xenopus tropicalis"; ?>Xiphophorus maculatus"; ?>

Gene Ontology

GO:0005524	; F:ATP binding
GO:0004674	; F:protein serine/threonine kinase activity

KEGG

InterPros

IPR011009	; Kinase-like_dom.
IPR000959	; POLO_box_duplicated_dom.
IPR000719	; Prot_kinase_cat_dom.
IPR017441	; Protein_kinase_ATP_BS.
IPR002290	; Ser/Thr_dual-sp_kinase_dom.
IPR008271	; Ser/Thr_kinase_AS.

Pfam

PF00069	; Pkinase; 1.
PF00659	; POLO_box; 2.

SMARTs

SM00220

; S_TKc; 1.

Prosites

PS50078	; POLO_BOX; 2.
PS00107	; PROTEIN_KINASE_ATP; 1.
PS50011	; PROTEIN_KINASE_DOM; 1.
PS00108	; PROTEIN_KINASE_ST; 1.

Prints

Created Date

20-Feb-2013