EKS-MYL-00240

Eukaryotic Protein Kinase & Protein Phosphatase Database

Tag

Content

EKPD ID

EKS-MYL-00240

Classification

Group/Family	Score	E-Value	Start	End	Domain Length
CAMK/CAMKL	386.9	3.6E-116	54	305	252

Status

Unreviewed

Ensembl Protein

ENSMLUP00000011132

UniProt Accession

G1PK31;

Protein Name

Protein Synonyms/Alias

Gene Name

MARK2

Gene Synonyms/Alias

MARK2;

Ensembl Information

Ensembl Gene ID	Ensembl Protein ID	Ensembl Transcript ID
ENSMLUG00000012201	ENSMLUP00000011132	ENSMLUT00000012219

Organism

Myotis lucifugus

Functional Description

Protein Length

780

Protein Sequence
(FASTA)

LSQAAHPKPA SSYCYTERKP TLGHLDSKPS SKSNMLRGRN SATSADEQPH IGNYRLLKTI 60

GKGNFAKVKL ARHILTGKEV AVKIIDKTQL NSSSLQKLFR EVRIMKVLNH PNIVKLFEVI 120

ETEKTLYLVM EYASGGEVFD YLVAHGRMKE KEARAKFRQI VSAVQYCHQK FIVHRDLKAE 180

NLLLDADMNI KIADFGFSNE FTFGNKLDTF CGSPPYAAPE LFQGKKYDGP EVDVWSLGVI 240

LYTLVSGSLP FDGQNLKELR ERVLRGKYRI PFYMSTDCEN LLKKFLILNP SKRGTLEQIM 300

KDRWMNVGHE DDELKPYVEP LPDYKDPRRT ELMVSMGYTR EEIQDSLVGQ RYNEVMATYL 360

LLGYKSSEQE GDAITLKPRP SADMTNSSAP SPSHKVQRSV SANPKQRRFS DQAAGPAIPT 420

SNSYSKKTQS NNAENKRPEE DRESGRKASS TAKVPASPLP GLERKKTTPT PSTNSILSTS 480

TNRSRNSPLL ERASLGQASI QNGKDSLTMP GSRASTASAS AAVSAARPRQ HQKSMSASVH 540

PNKATGLPPT DSNCEVPRPS TAPQRVPVAS PSAHNISSSG GAPDRTNFPR GVSSRSTFHA 600

GQLRQVRDQQ NLPYGVTPAS PSGNSQGRRG ASGSIFSKFT SKFVRRNLNE PESKDRVETL 660

RPHVVGGGGS DKEKEESREA KPRSLRFTWS MKTTSSMEPN EMMREIRKVL DANSCQNELH 720

EKYMLLCMHG TPGHEDFVQW EMEVCKLPRL SLNGVRFKRI SGTSMAFKNI ASKIANELKL 780

Nucleotide Sequence
(FASTA)

CTGAGTCAAG CAGCTCACCC CAAACCAGCC AGCAGCTACT GCTATACAGA GAGAAAGCCC 60

ACCTTGGGAC ACCTCGACTC CAAGCCCAGC AGTAAGTCCA ACATGCTGCG GGGCCGCAAC 120

TCAGCCACCT CTGCTGACGA GCAGCCCCAC ATCGGCAACT ATCGACTCCT CAAGACCATT 180

GGCAAGGGCA ACTTCGCCAA GGTGAAGCTG GCTCGGCACA TCCTGACCGG GAAAGAGGTG 240

GCTGTGAAGA TCATCGACAA GACTCAACTG AACTCCTCCA GCCTCCAGAA ACTATTCCGG 300

GAAGTAAGAA TAATGAAGGT TTTGAATCAT CCCAACATAG TTAAATTATT TGAAGTGATT 360

GAGACTGAAA AAACTCTCTA CCTTGTCATG GAGTATGCCA GTGGAGGAGA GGTGTTTGAT 420

TACCTCGTGG CTCATGGCAG GATGAAAGAA AAAGAGGCTC GAGCCAAATT CCGCCAGATA 480

GTGTCTGCTG TGCAGTACTG CCACCAGAAG TTTATTGTTC ACAGAGACTT AAAGGCAGAA 540

AACCTGCTCC TGGATGCTGA CATGAACATC AAGATCGCAG ACTTTGGTTT CAGCAACGAG 600

TTCACCTTTG GGAACAAGCT GGACACCTTC TGTGGGAGCC CCCCGTACGC GGCCCCAGAG 660

CTCTTCCAGG GCAAGAAGTA CGACGGGCCC GAGGTGGACG TGTGGAGCCT GGGCGTCATC 720

CTGTACACAC TGGTCAGCGG ATCCCTGCCG TTTGACGGAC AGAACCTCAA GGAACTGCGG 780

GAGCGGGTGC TGAGGGGAAA ATACCGTATT CCGTTCTACA TGTCCACAGA CTGTGAAAAC 840

CTGCTTAAGA AATTCCTCAT TCTCAATCCC AGCAAGAGAG GCACTTTAGA GCAAATCATG 900

AAAGATCGAT GGATGAATGT GGGTCACGAA GATGATGAAT TAAAGCCTTA TGTGGAGCCA 960

CTCCCTGACT ACAAGGACCC CCGGCGGACA GAGCTGATGG TGTCCATGGG TTACACACGA 1020

GAAGAGATCC AGGACTCGCT GGTGGGCCAG CGGTACAACG AGGTGATGGC CACCTACCTG 1080

CTCCTCGGCT ACAAGAGCTC GGAGCAGGAA GGCGATGCCA TCACCTTGAA GCCCAGGCCT 1140

TCAGCTGACA TGACCAATAG CAGTGCTCCT TCCCCCTCCC ACAAGGTACA GCGCAGCGTC 1200

TCTGCCAACC CCAAGCAGCG GCGCTTCAGC GACCAGGCAG CTGGTCCTGC CATTCCCACC 1260

TCAAATTCCT ACTCTAAGAA GACTCAGAGT AACAACGCGG AAAACAAGCG GCCTGAGGAG 1320

GACCGGGAGT CAGGGCGGAA GGCCAGCAGC ACAGCCAAAG TGCCTGCCAG CCCCCTGCCC 1380

GGCCTAGAGA GGAAAAAGAC CACCCCTACC CCCTCCACGA ACAGCATCCT CTCCACCAGC 1440

ACAAATCGAA GCAGGAATTC CCCACTTTTG GAGAGGGCCA GCCTGGGCCA GGCCTCCATC 1500

CAGAATGGCA AAGACAGCCT AACCATGCCA GGGTCCCGGG CCTCCACGGC TTCTGCTTCT 1560

GCCGCAGTCT CTGCGGCCCG ACCCCGCCAG CACCAGAAAT CCATGTCGGC CTCCGTGCAC 1620

CCCAACAAGG CCACTGGGCT GCCCCCCACG GACAGTAACT GTGAGGTGCC GCGGCCCAGC 1680

ACAGCCCCCC AGCGCGTCCC TGTCGCCTCC CCCTCCGCCC ACAACATCAG CAGCAGTGGA 1740

GGAGCCCCAG ACCGAACTAA TTTCCCCCGG GGTGTATCCA GTCGGAGCAC CTTCCATGCT 1800

GGGCAGCTCC GGCAGGTGCG GGACCAGCAG AATTTGCCCT ACGGTGTAAC CCCAGCCTCT 1860

CCCTCCGGCA ACAGCCAGGG ACGGCGGGGG GCCTCCGGGA GCATTTTCAG CAAATTCACC 1920

TCCAAGTTTG TACGAAGGAA CCTGAATGAA CCTGAAAGCA AAGATCGAGT GGAGACTCTC 1980

AGACCTCACG TGGTGGGCGG TGGTGGCAGC GACAAGGAGA AGGAGGAGTC CCGGGAGGCC 2040

AAGCCGCGCT CGCTCCGCTT CACGTGGAGC ATGAAGACCA CGAGCTCCAT GGAGCCCAAC 2100

GAGATGATGC GGGAGATCCG CAAGGTGCTG GACGCCAACA GCTGCCAGAA CGAGCTGCAC 2160

GAGAAGTACA TGCTGCTGTG CATGCACGGC ACGCCGGGCC ACGAGGACTT CGTGCAGTGG 2220

GAGATGGAGG TGTGCAAACT GCCGCGGCTC TCCCTCAACG GGGTGCGGTT TAAGCGGATA 2280

TCGGGCACCT CCATGGCCTT CAAAAACATT GCCTCCAAAA TAGCCAACGA GCTGAAGCTT 2340

TAA 2343

Domain Profile

S: 1     ykllktlGegsfgkVklakhketkekvavKiikkkklseeslekikrEieilkklkhpni  60

         y+llkt+G+g+f+kVkla+h +t+++vavKii+k++l+++sl+k++rE++i+k l+hpni

Q: 54    YRLLKTIGKGNFAKVKLARHILTGKEVAVKIIDKTQLNSSSLQKLFREVRIMKVLNHPNI  113

         99**********************************************************

S: 61    ikllevietkkklylvleyasggeLfdyieekgrlkekearklfkqlvsavkYlhskgiv  120

         +kl+eviet+k+lylv+eyasgge+fdy++++gr+kekear+ f+q+vsav+Y+h+k iv

Q: 114   VKLFEVIETEKTLYLVMEYASGGEVFDYLVAHGRMKEKEARAKFRQIVSAVQYCHQKFIV  173

         ************************************************************

S: 121   HrDlKpeNllldkkenikiaDFGlanlfkegklletfcGsppYaaPellkgkkYegpkvD  180

         HrDlK+eNllld+++nikiaDFG++n+f+ g++l+tfcGsppYaaPel++gkkY+gp+vD

Q: 174   HRDLKAENLLLDADMNIKIADFGFSNEFTFGNKLDTFCGSPPYAAPELFQGKKYDGPEVD  233

         ************************************************************

S: 181   vWslGvvLyalvtgklPfdeenlkellekilkgkleipkklskelesLlrklLvvdpekR  240

         vWslGv+Ly+lv+g+lPfd++nlkel+e++l+gk++ip+++s+++e+Ll+k+L  +p+kR

Q: 234   VWSLGVILYTLVSGSLPFDGQNLKELRERVLRGKYRIPFYMSTDCENLLKKFLILNPSKR  293

         ************************************************************

S: 241   atieeilkhewl  252

          t+e+i+k++w+

Q: 294   GTLEQIMKDRWM  305

         ***********8

Domain Sequence
(FASTA)

YRLLKTIGKG NFAKVKLARH ILTGKEVAVK IIDKTQLNSS SLQKLFREVR IMKVLNHPNI 60

VKLFEVIETE KTLYLVMEYA SGGEVFDYLV AHGRMKEKEA RAKFRQIVSA VQYCHQKFIV 120

HRDLKAENLL LDADMNIKIA DFGFSNEFTF GNKLDTFCGS PPYAAPELFQ GKKYDGPEVD 180

VWSLGVILYT LVSGSLPFDG QNLKELRERV LRGKYRIPFY MSTDCENLLK KFLILNPSKR 240

GTLEQIMKDR WM 252

Keyword

ATP-binding; Complete proteome; Nucleotide-binding; Reference proteome.

Sequence Source

Ensembl

Orthology

Ortholog group

Ailuropoda melanoleuca"; ?>Anolis carolinensis"; ?>Bos taurus"; ?>Caenorhabditis elegans"; ?>Callithrix jacchus"; ?>Canis familiaris"; ?>Cavia porcellus"; ?>Ciona intestinalis"; ?>Danio rerio"; ?>Dipodomys ordii"; ?>Drosophila melanogaster"; ?>Equus caballus"; ?>Erinaceus europaeus"; ?>Felis catus"; ?>Gasterosteus aculeatus"; ?>Gorilla gorilla"; ?>Homo sapiens"; ?>Ictidomys tridecemlineatus"; ?>Latimeria chalumnae"; ?>Loxodonta africana"; ?>Macaca mulatta"; ?>Macropus eugenii"; ?>Microcebus murinus"; ?>Mus musculus"; ?>Mustela putorius furo"; ?>Nomascus leucogenys"; ?>Ochotona princeps"; ?>Oreochromis niloticus"; ?>Oryctolagus cuniculus"; ?>Oryzias latipes"; ?>Otolemur garnettii"; ?>Pelodiscus sinensis"; ?>Pongo abelii"; ?>Pteropus vampyrus"; ?>Rattus norvegicus"; ?>Sus scrofa"; ?>Takifugu rubripes"; ?>Tursiops truncatus"; ?>Xenopus tropicalis"; ?>Xiphophorus maculatus"; ?>

Gene Ontology

GO:0005524	; F:ATP binding
GO:0004674	; F:protein serine/threonine kinase activity

KEGG

InterPros

IPR001772	; Kinase-assoc_KA1.
IPR011009	; Kinase-like_dom.
IPR000719	; Prot_kinase_cat_dom.
IPR017441	; Protein_kinase_ATP_BS.
IPR002290	; Ser/Thr_dual-sp_kinase_dom.
IPR008271	; Ser/Thr_kinase_AS.
IPR015940	; UBA/transl_elong_EF1B_N_euk.

Pfam

PF02149	; KA1; 1.
PF00069	; Pkinase; 1.

SMARTs

SM00220	; S_TKc; 1.
SM00165	; UBA; 1.

Prosites

PS50032	; KA1; 1.
PS00107	; PROTEIN_KINASE_ATP; 1.
PS50011	; PROTEIN_KINASE_DOM; 1.
PS00108	; PROTEIN_KINASE_ST; 1.
PS50030	; UBA; 1.

Prints

Created Date

20-Feb-2013