EKS-MYL-00034
Eukaryotic Protein Kinase & Protein Phosphatase Database
TagContent
EKPD IDEKS-MYL-00034
Classification
Group/FamilyScoreE-ValueStartEndDomain Length
TK/Jak326.81.2E-978971167271
StatusUnreviewed
Ensembl ProteinENSMLUP00000011245
UniProt AccessionG1PKC8;
Protein NameTyrosine-protein kinase
Protein Synonyms/Alias
Gene NameTYK2
Gene Synonyms/Alias TYK2;
Ensembl Information
Ensembl Gene IDEnsembl Protein IDEnsembl Transcript ID
ENSMLUG00000012345ENSMLUP00000011245ENSMLUT00000012352
OrganismMyotis lucifugus
Functional Description
Protein Length1187
Protein Sequence
(FASTA)
AVKSMPLCHG GATAGGSKPD GDETQLTAIT GGLKVFLHWA GPGNREPWVT FSEATLTAEE 60
VCIHIAHKVG ITPPCFNLFA LFDAQAQVWL PPNHIFEVSR DTNLTLHFRM RFYFRNWHGT 120
NPQEPAVYRC RPPGAEASSE QAEQGVQLLD PASFEYLFEQ GKHEFVNDVA SLWELSSEEE 180
IHHFKNESLG MAFLHLCHLA LCRGVPLEKV AKKTSFKDCI PRSFRQQIRQ YNAFTRLRLR 240
IIFRRFLHAF QPDSLSQHVV MVKYLATLER LAPRFGTERV PVCHLELLAQ AEGEPCYIQD 300
SAQAPGDPKP KSAVEPPTHE VLVTGTGGIQ WRPIQAEGPG GGDGGSSRNP HAGLSGKKAK 360
AQQRGGQPVD RPREAPWAYF CDFRDITHVV LRERHVSIHC QDKRLELTLP SPASALSLVS 420
LVDGYFRLTA DSNHYLCHEV APPRLVMSIQ DGVHGPLLDP FVLAKMQRED GLYLIHWSTS 480
HFNRLILTVA QQDQAPGTPR LRLWKFPIEL CEGTFRLQSW DRSFPSVREL RAALQGCSLR 540
AGDHCFSLRH CCLPQPGEIS NLIITRGPQA SARSLNLSQL SFHRVCQDDL TQLSHLGQGT 600
RTNVYEGLLR VGGGGPEEDE AYVGDPTLPG GGHGQELRVV LKVLDTSHHD IALAFYETAS 660
LMSQVSHVHL TFVHGVCVHG SQNIMVTEYV EHGPLDVWLR RERGRVPVAW KVAVAQQLAS 720
ALSYLEDKRL AHGNVCGRNI LLARLGLAEG TSPFIKLSDP GMGLGALSRE ERVERIPWMA 780
PECLFGGANS LSTAADKWGF GATLLEICFD GEAPLQDRSP AEKEYFYQKQ HQLPEPSCPE 840
LATLTSQCLT YEPAQRPSFR TILRDLTHLQ PQNLVEILCV NPTSPASDPT VFHKRYLKKI 900
RDLGEGHFGK VSLYCYDPTN EGTGEMVAVK ALKADCGPQL RTSWRREIDI LRTLYHEHIV 960
KYKGCCEDQG EKSVQLVMEY VPLGSLRDYL PRHRVGLAQL LLFAQQICEG MAYLHTQHYV 1020
HRDLAARNVL LDNDRLVKIG DFGLAKAVPE GHDYYRVRED GDSPVFWYAP ECLKECKFYY 1080
ASDVWSFGVT MYELLTYCDS SQSPPSKFIE LIGLTQGQMT VLRLTELLER GERLPRPEKC 1140
PHEIYVLMKN CWEAEASFRP TFQNLIPILK TAHEKYQGQA PSVFSVG 1187
Nucleotide Sequence
(FASTA)
GCTGTCAAGA GCATGCCTCT GTGCCATGGG GGGGCCACCG CCGGGGGCAG CAAGCCCGAT 60
GGGGACGAAA CTCAGCTCAC AGCCATCACA GGAGGCCTGA AGGTGTTCCT GCACTGGGCT 120
GGCCCTGGCA ACAGGGAGCC CTGGGTCACT TTCAGCGAGG CCACACTGAC CGCAGAGGAG 180
GTCTGCATTC ACATCGCACA CAAAGTCGGC ATCACTCCAC CCTGTTTCAA TCTCTTTGCC 240
CTCTTTGATG CCCAGGCCCA GGTCTGGCTG CCCCCAAACC ACATTTTTGA GGTCTCCAGA 300
GACACAAACT TGACGCTGCA CTTCCGCATG AGGTTTTATT TCCGCAACTG GCATGGCACA 360
AATCCTCAGG AGCCAGCTGT GTACCGCTGC AGGCCCCCAG GGGCCGAGGC TTCGTCAGAA 420
CAGGCAGAGC AGGGGGTGCA ACTCCTGGAC CCAGCCTCCT TTGAGTACCT CTTTGAGCAG 480
GGCAAGCACG AGTTTGTGAA TGATGTGGCA TCGCTGTGGG AGCTGTCGAG TGAGGAGGAG 540
ATCCACCACT TTAAGAACGA GAGCCTGGGC ATGGCCTTTC TGCACCTCTG TCACCTTGCT 600
CTCTGCCGCG GTGTTCCCCT GGAGAAGGTG GCCAAGAAGA CCAGCTTCAA GGACTGTATC 660
CCGCGCTCTT TCCGGCAACA GATCCGGCAG TACAATGCGT TCACACGGCT GCGCCTGCGG 720
ATCATCTTCC GCAGGTTCCT GCACGCCTTC CAGCCGGACA GCCTTTCCCA GCACGTCGTC 780
ATGGTCAAGT ACCTGGCCAC ACTCGAGCGG CTGGCACCCC GCTTCGGCAC GGAGCGTGTG 840
CCTGTGTGCC ACCTGGAGCT GCTAGCCCAG GCCGAGGGGG AGCCCTGCTA TATCCAGGAC 900
AGTGCGCAGG CCCCTGGAGA TCCCAAGCCC AAGTCTGCGG TCGAACCGCC CACCCACGAG 960
GTGCTGGTGA CCGGCACTGG CGGCATCCAG TGGCGGCCAA TACAGGCAGA GGGTCCCGGT 1020
GGTGGTGACG GTGGCAGCAG CAGGAATCCT CATGCTGGCT TATCTGGGAA GAAAGCCAAG 1080
GCCCAGCAGC GGGGCGGCCA GCCCGTGGAC AGGCCGCGGG AGGCGCCGTG GGCCTACTTC 1140
TGTGACTTCC GGGACATCAC CCATGTGGTG CTGAGAGAAC GCCACGTCAG CATCCACTGT 1200
CAGGACAAGC GCCTGGAGCT GACCCTGCCG TCCCCGGCCA GCGCCCTGTC CTTGGTGTCA 1260
CTGGTGGACG GCTATTTCCG CCTGACGGCC GACTCGAACC ACTACCTGTG CCACGAGGTG 1320
GCTCCTCCAC GGCTGGTGAT GAGCATCCAG GACGGTGTCC ACGGGCCCCT GCTGGATCCA 1380
TTTGTGCTGG CCAAGATGCA GCGCGAGGAT GGCCTCTACC TTATCCACTG GAGCACCAGC 1440
CACTTCAACC GCCTCATCCT CACGGTGGCC CAGCAGGACC AGGCACCTGG CACGCCGCGT 1500
TTGCGCCTGT GGAAGTTCCC CATTGAGCTG TGCGAGGGCA CCTTCCGGCT GCAGAGCTGG 1560
GACCGGTCCT TCCCCAGCGT GCGGGAGCTG CGGGCTGCCC TGCAGGGCTG CTCACTGCGG 1620
GCCGGTGACC ACTGCTTCTC CCTGCGCCAC TGCTGCCTGC CGCAGCCCGG AGAGATCTCC 1680
AACCTCATCA TCACGCGGGG GCCTCAAGCC AGCGCCAGGT CTCTCAACCT CAGCCAGCTC 1740
AGCTTCCACC GGGTCTGCCA GGATGACCTC ACCCAGCTGT CCCACTTGGG CCAGGGCACG 1800
AGGACCAATG TGTATGAGGG CCTCTTGCGA GTTGGGGGCG GAGGCCCTGA GGAAGACGAA 1860
GCATATGTTG GGGACCCCAC CTTGCCCGGC GGGGGCCATG GGCAGGAGCT GCGAGTGGTG 1920
CTGAAGGTGT TAGACACTAG TCACCATGAC ATCGCCCTGG CTTTCTACGA GACGGCCAGC 1980
CTCATGAGCC AGGTGTCCCA CGTGCACCTG ACCTTCGTCC ACGGTGTCTG CGTGCACGGC 2040
TCTCAAAATA TCATGGTGAC AGAGTACGTG GAGCATGGAC CCCTGGACGT GTGGCTGCGG 2100
CGGGAGAGGG GCCGTGTGCC CGTGGCCTGG AAGGTGGCAG TGGCCCAGCA GCTGGCCAGT 2160
GCCCTCAGCT ACCTGGAGGA CAAGCGCCTG GCTCATGGTA ACGTGTGTGG CCGGAACATC 2220
CTGCTGGCAC GTCTAGGGCT GGCGGAGGGC ACCAGCCCAT TCATCAAACT GAGCGACCCT 2280
GGCATGGGCC TGGGCGCCCT CTCCAGGGAG GAGCGGGTAG AGCGGATCCC CTGGATGGCC 2340
CCCGAGTGCC TGTTTGGTGG GGCCAACAGC CTCAGCACCG CCGCTGACAA GTGGGGCTTC 2400
GGTGCCACCC TCCTGGAGAT CTGCTTCGAT GGGGAGGCCC CCCTGCAGGA CCGCAGCCCC 2460
GCCGAGAAGG AGTACTTCTA CCAGAAGCAG CACCAGCTGC CTGAACCCTC ATGCCCGGAG 2520
CTAGCCACGC TCACCAGCCA GTGCCTGACC TATGAGCCGG CTCAGCGGCC TTCCTTCCGC 2580
ACCATCCTTC GTGACCTCAC TCACCTTCAG CCCCAAAATC TTGTTGAAAT CTTGTGTGTG 2640
AATCCAACCT CGCCAGCATC AGACCCCACA GTTTTCCACA AGCGCTACTT GAAGAAGATC 2700
CGGGATCTGG GTGAGGGTCA CTTCGGCAAG GTCAGCCTGT ACTGCTATGA CCCGACCAAC 2760
GAAGGCACCG GCGAGATGGT GGCCGTGAAG GCTCTCAAGG CGGACTGCGG CCCTCAGCTC 2820
CGCACCAGCT GGAGGCGGGA GATCGACATC CTGCGCACGC TCTACCACGA GCACATTGTC 2880
AAGTACAAGG GCTGCTGTGA GGACCAAGGC GAGAAATCGG TCCAGCTCGT CATGGAGTAC 2940
GTGCCTCTGG GCAGCCTCCG AGACTACCTG CCCCGGCACC GCGTAGGGCT GGCCCAGCTG 3000
CTGCTGTTCG CCCAGCAGAT CTGCGAGGGC ATGGCCTACC TGCACACCCA GCACTATGTC 3060
CACCGAGACC TGGCTGCCCG CAACGTGCTG CTGGACAACG ACAGGCTGGT CAAGATCGGG 3120
GACTTTGGCC TCGCCAAGGC CGTGCCCGAA GGCCACGACT ACTACCGCGT GCGCGAGGAT 3180
GGGGACAGCC CCGTGTTCTG GTACGCTCCT GAGTGTCTGA AGGAGTGTAA GTTCTACTAC 3240
GCGTCCGATG TCTGGTCCTT TGGAGTCACC ATGTATGAAC TGCTGACCTA CTGTGACTCC 3300
AGCCAAAGCC CCCCCTCGAA ATTCATCGAG CTCATAGGCC TCACCCAGGG GCAGATGACG 3360
GTACTGAGGC TCACTGAGCT GCTGGAACGA GGGGAGAGGC TGCCACGGCC AGAGAAATGT 3420
CCCCATGAGA TATATGTCCT CATGAAGAAC TGCTGGGAGG CAGAGGCCTC ATTTCGCCCA 3480
ACCTTCCAGA ACCTCATACC CATCCTGAAA ACGGCCCACG AGAAGTACCA GGGCCAGGCC 3540
CCCTCGGTGT TCAGTGTCGG CTAA 3564
Domain Profile
S: 1     lkqiesLgkgtftkvfevredaegdsteeevalkvLk.esgedisrdfkreaeilsqlsh  59
         lk+i++Lg+g+f+kv ++++d++++ t+e+va+k+Lk ++g++ ++++ re++il++l+h
Q: 897   LKKIRDLGEGHFGKVSLYCYDPTNEGTGEMVAVKALKaDCGPQLRTSWRREIDILRTLYH  956
         6899********************************************************
S: 60    ehivklkgvcvaegen..rlVmeyvesGsLdiyLrkkkealslsslldvakqlakameYL  117
         ehivk+kg+c ++ge+  +lVmeyv+ GsL++yL+++  ++ l++ll +a+q++++m+YL
Q: 957   EHIVKYKGCCEDQGEKsvQLVMEYVPLGSLRDYLPRH--RVGLAQLLLFAQQICEGMAYL  1014
         ****************9********************..9********************
S: 118   edkklvhrdvaarnvLveresnegtppfvklsdpglakavnqd.eYylvreerdsripwl  176
         +++++vhrd+aarnvL+++++       vk++d+glakav+++ +Yy vre++ds+++w+
Q: 1015  HTQHYVHRDLAARNVLLDNDRL------VKIGDFGLAKAVPEGhDYYRVREDGDSPVFWY  1068
         **********************......********************************
S: 177   apeclseaknlstasdvWsFgvtlyellt.cskgesp.........lrsesle.......  219
         apecl+e+k +++asdvWsFgvt+yellt c++++sp         l     +       
Q: 1069  APECLKECK-FYYASDVWSFGVTMYELLTyCDSSQSPpskfieligL-----Tqgqmtvl  1122
         *********.****************************999555443.....45555588
S: 220   rklelleekerlpkpk.cpaelaelmtnclsyepsqrpsFraile  263
         r++elle++erlp+p+ cp e+++lm+nc+++e+s+rp+F++++ 
Q: 1123  RLTELLERGERLPRPEkCPHEIYVLMKNCWEAEASFRPTFQNLIP  1167
         *****************************************9975
Domain Sequence
(FASTA)
LKKIRDLGEG HFGKVSLYCY DPTNEGTGEM VAVKALKADC GPQLRTSWRR EIDILRTLYH 60
EHIVKYKGCC EDQGEKSVQL VMEYVPLGSL RDYLPRHRVG LAQLLLFAQQ ICEGMAYLHT 120
QHYVHRDLAA RNVLLDNDRL VKIGDFGLAK AVPEGHDYYR VREDGDSPVF WYAPECLKEC 180
KFYYASDVWS FGVTMYELLT YCDSSQSPPS KFIELIGLTQ GQMTVLRLTE LLERGERLPR 240
PEKCPHEIYV LMKNCWEAEA SFRPTFQNLI P 271
KeywordATP-binding; Complete proteome; Kinase; Nucleotide-binding; Phosphoprotein; Reference proteome; SH2 domain; Transferase; Tyrosine-protein kinase.
Sequence SourceEnsembl
Orthology
Ortholog group
Ailuropoda melanoleuca"; ?>Anolis carolinensis"; ?>Bos taurus"; ?>Callithrix jacchus"; ?>Canis familiaris"; ?>Cavia porcellus"; ?>Danio rerio"; ?>Equus caballus"; ?>Felis catus"; ?>Gadus morhua"; ?>Gasterosteus aculeatus"; ?>Gorilla gorilla"; ?>Homo sapiens"; ?>Ictidomys tridecemlineatus"; ?>Loxodonta africana"; ?>Macaca mulatta"; ?>Meleagris gallopavo"; ?>Monodelphis domestica"; ?>Mus musculus"; ?>Mustela putorius furo"; ?>Nomascus leucogenys"; ?>Ochotona princeps"; ?>Oreochromis niloticus"; ?>Oryctolagus cuniculus"; ?>Oryzias latipes"; ?>Otolemur garnettii"; ?>Pan troglodytes"; ?>Pongo abelii"; ?>Procavia capensis"; ?>Pteropus vampyrus"; ?>Rattus norvegicus"; ?>Sarcophilus harrisii"; ?>Takifugu rubripes"; ?>Xenopus tropicalis"; ?>Xiphophorus maculatus"; ?>
EKS-AIM-00028
EKS-ANC-00027
EKS-BOT-00034
EKS-CAJ-00031
EKS-CAF-00033
EKS-CAP-00033
EKS-DAR-00045
EKS-EQC-00392
EKS-FEC-00030
EKS-GAM-00233
EKS-GAA-00049
EKS-GOG-00031
EKS-HOS-00033
EKS-ICT-00028
EKS-LOA-00031
EKS-MAM-00032
EKS-MEG-00026
EKS-MOD-00031
EKS-MUM-00034
EKS-MUP-00034
EKS-NOL-00030
EKS-OCP-00021
EKS-ORN-00049
EKS-ORC-00032
EKS-ORL-00046
EKS-OTG-00034
EKS-PAT-00030
EKS-POA-00029
EKS-PRC-00015
EKS-PTV-00032
EKS-RAN-00033
EKS-SAH-00031
EKS-TAR-00049
EKS-XET-00032
EKS-XIM-00047
Gene Ontology
GO:0005856; C:cytoskeleton
GO:0016020; C:membrane
GO:0005524; F:ATP binding
GO:0004715; F:non-membrane spanning protein tyrosine kinase activity
GO:0007243; P:intracellular protein kinase cascade
KEGG
InterPros
IPR019749; Band_41_domain.
IPR019748; FERM_central.
IPR000299; FERM_domain.
IPR011009; Kinase-like_dom.
IPR000719; Prot_kinase_cat_dom.
IPR017441; Protein_kinase_ATP_BS.
IPR001245; Ser-Thr/Tyr_kinase_cat_dom.
IPR000980; SH2.
IPR008266; Tyr_kinase_AS.
IPR020635; Tyr_kinase_cat_dom.
IPR016251; Tyr_kinase_non-rcpt_Jak/Tyk2.
IPR016045; Tyr_kinase_non-rcpt_TYK2_N.
Pfam
PF07714; Pkinase_Tyr; 2.
SMARTs
SM00295; B41; 1.
SM00252; SH2; 1.
SM00219; TyrKc; 2.
Prosites
PS50057; FERM_3; 1.
PS00107; PROTEIN_KINASE_ATP; 1.
PS50011; PROTEIN_KINASE_DOM; 2.
PS00109; PROTEIN_KINASE_TYR; 1.
Prints
PR01823; JANUSKINASE.
PR00109; TYRKINASE.
PR01827; YKINASETYK2.
Created Date20-Feb-2013