EKS-MYL-00480

Eukaryotic Protein Kinase & Protein Phosphatase Database

Tag

Content

EKPD ID

EKS-MYL-00480

Classification

Group/Family	Score	E-Value	Start	End	Domain Length
Other/TBCK	429.7	2.9E-129	18	273	256

Status

Unreviewed

Ensembl Protein

ENSMLUP00000011301

UniProt Accession

G1PKH5;

Protein Name

Protein Synonyms/Alias

Gene Name

TBCK

Gene Synonyms/Alias

TBCK;

Ensembl Information

Ensembl Gene ID	Ensembl Protein ID	Ensembl Transcript ID
ENSMLUG00000012409	ENSMLUP00000011301	ENSMLUT00000012412
ENSMLUG00000012409	ENSMLUP00000022151	ENSMLUT00000025969

Organism

Myotis lucifugus

Functional Description

Protein Length

892

Protein Sequence
(FASTA)

MFPLKDVEMG AFTFFASALP HDVCGSNGLP LTPNSIKILG RFQILKTIIH PRLCQYVDIS 60

RGKHERLVVV AEHCEQSLED LLRERKPVSY SKVLCIAFEV LQGLQYMNKH GIVHRALSPH 120

NILLDRKGHV KLAKFGLYHM TAHGDDVDFP IGYPSYLAPE VIAQGISKTT DHVPNEKPLP 180

SGPKSDVWSL GIILFELCVG RKLFQSLDVS ERLKFLLTLD CVDDTIIVLA EEHGCLDIIK 240

ELPENVIDLL KKCLTFHPSK RPTPDELMQD KVFSEVSPLY TPFTKPVSLF SSSLRCADLT 300

LPEDISQLCK DVNSDYLAER SIEEVYYLWC LAGGDLEKEL INKEIIRSKP PICTLPNFLF 360

EDGESFGQGR DRSSLLDDTT VTLSLCQLRN RLKDVGGEAF YPLLEDDQSN LPHSNSSNEL 420

SAAATLPLII RERDTEYQLN RIVLFDRLLK AYPYKKNQIW KEARVDIPPL MRGLTWAALL 480

GVEGAIHAKY DAIDKDTPIP TDRQIEVDIP RCHQYDELLS SPEGHAKFRR VLKAWVVSHP 540

DLVYWQGLDS LCAPFLYLNF NNEALAYACM SAFIPKYLYN FFLKDNSHVI QEYLTVFSQM 600

IAFHDPELSN HLNEIGFIPD LYAIPWFLTM FTHVFPLHKI FHLWDTLLLG NSSFPFCIGV 660

AILQQLRDRL LANGFNECIL LFSDLPEIDI ERCVRESINL FCWTPKSATY RQHAQLPKPT 720

SDNSGVRSST PYFSECPDTP KTDLSRESIP LNDLKSEVSP RISAEDLIDL CELTVTGHFK 780

TPTKKTKSSK PKLLVVDIRN SEDFIRGHIS GSINIPFSTA FTAEGELTQG PHTAMLQSFK 840

GKVIVIVGNS AKYTAEFAAH LVKMKYPRVC ILDGGINKIK PTGLLTVPSP QI 892

Nucleotide Sequence
(FASTA)

ATGTTTCCCT TGAAGGATGT CGAAATGGGT GCCTTTACCT TCTTTGCCTC TGCTCTACCA 60

CATGATGTTT GTGGAAGCAA CGGGCTTCCT CTCACACCAA ATTCCATCAA AATTTTAGGG 120

CGCTTTCAAA TCCTTAAGAC CATCATCCAT CCAAGACTGT GCCAATATGT GGATATTTCT 180

AGGGGAAAAC ATGAGAGACT GGTGGTAGTG GCTGAACACT GTGAACAGAG CCTAGAAGAT 240

TTACTCCGAG AAAGAAAACC TGTGAGCTAT TCAAAGGTTT TGTGCATAGC ATTTGAGGTA 300

CTCCAGGGCT TGCAGTATAT GAACAAACAT GGGATAGTAC ATCGGGCGCT GTCTCCTCAT 360

AATATCCTTT TGGACCGAAA GGGACATGTT AAATTGGCTA AATTTGGACT TTATCACATG 420

ACAGCTCATG GTGATGATGT TGATTTTCCA ATTGGGTATC CATCATACTT GGCACCTGAG 480

GTAATTGCAC AAGGAATTTC CAAAACGACT GATCATGTGC CAAATGAAAA ACCATTGCCT 540

TCTGGCCCCA AATCAGATGT ATGGTCTCTA GGAATCATTT TATTTGAGCT CTGTGTGGGA 600

AGAAAATTAT TTCAGAGCTT GGATGTTTCT GAAAGACTAA AATTTTTGCT TACATTGGAC 660

TGCGTGGATG ACACTATAAT AGTTCTGGCT GAAGAGCATG GTTGCCTGGA CATTATAAAG 720

GAGCTTCCTG AAAATGTGAT AGATCTTTTG AAGAAATGTC TGACCTTCCA CCCTTCCAAG 780

AGGCCAACCC CAGATGAATT AATGCAGGAC AAAGTGTTCA GTGAAGTGTC ACCTTTATAC 840

ACCCCATTTA CAAAACCTGT CAGTTTGTTT TCATCTTCTC TGAGATGTGC TGACTTAACT 900

CTGCCTGAGG ATATCAGTCA GCTGTGTAAA GATGTAAACA GTGATTACCT GGCAGAAAGA 960

TCAATTGAGG AAGTGTATTA CCTTTGGTGT TTAGCTGGAG GTGACTTGGA GAAAGAGCTT 1020

ATCAACAAGG AAATCATTCG ATCCAAACCA CCTATCTGCA CACTCCCCAA TTTTCTCTTT 1080

GAAGATGGTG AAAGCTTTGG ACAAGGTCGA GATAGAAGCT CACTATTGGA TGATACCACT 1140

GTGACATTGT CATTATGCCA GCTAAGAAAT AGATTAAAAG ATGTTGGTGG AGAAGCATTT 1200

TACCCACTGC TTGAAGATGA CCAGTCTAAT TTACCTCATT CAAACAGCAG TAATGAGTTG 1260

TCTGCTGCTG CCACGTTGCC TTTAATCATC CGAGAGAGGG ACACAGAGTA CCAGCTTAAC 1320

AGAATCGTTC TCTTTGACAG GCTGCTAAAG GCTTATCCAT ATAAAAAAAA TCAAATCTGG 1380

AAAGAAGCAA GAGTTGATAT TCCTCCACTT ATGAGAGGTT TAACCTGGGC TGCTCTTCTG 1440

GGAGTTGAGG GGGCTATTCA TGCCAAGTAT GACGCAATTG ATAAAGATAC TCCAATTCCT 1500

ACAGATAGAC AAATTGAAGT GGATATTCCT CGTTGTCATC AGTATGATGA ACTGTTATCA 1560

TCACCAGAAG GTCATGCAAA ATTTAGGCGT GTATTAAAAG CCTGGGTAGT ATCCCATCCT 1620

GATCTGGTGT ATTGGCAAGG TCTTGACTCA CTTTGTGCTC CATTCCTATA TTTAAATTTC 1680

AATAATGAAG CCTTGGCGTA TGCATGTATG TCTGCTTTTA TTCCCAAATA CCTGTATAAC 1740

TTCTTCTTGA AAGACAACTC ACATGTAATA CAAGAGTATT TGACTGTGTT CTCTCAGATG 1800

ATTGCATTCC ATGATCCAGA GCTGAGTAAT CATCTCAATG AGATTGGATT TATTCCAGAT 1860

CTCTACGCCA TCCCTTGGTT TCTCACCATG TTTACTCATG TATTTCCACT GCACAAAATT 1920

TTTCACCTCT GGGATACCTT GCTACTTGGA AATTCCTCTT TCCCATTCTG TATCGGAGTA 1980

GCAATTCTTC AGCAACTGCG GGACCGGCTT TTGGCCAATG GCTTTAATGA GTGCATTCTT 2040

CTCTTCTCTG ATTTACCAGA AATTGACATT GAACGTTGTG TACGAGAATC AATCAACCTG 2100

TTTTGTTGGA CTCCTAAAAG TGCTACTTAC AGACAGCATG CTCAACTTCC AAAGCCAACT 2160

TCAGATAACA GTGGAGTCAG AAGTTCAACA CCTTATTTCT CGGAGTGTCC AGATACTCCA 2220

AAAACAGATC TGTCAAGAGA ATCCATCCCA TTAAATGACC TAAAGTCAGA AGTTTCTCCC 2280

CGGATTTCAG CAGAGGACCT GATTGACTTG TGTGAGCTCA CAGTGACAGG CCACTTCAAA 2340

ACACCCACCA AGAAGACCAA GTCCAGTAAA CCGAAGCTCC TGGTGGTTGA CATCCGGAAT 2400

AGTGAAGATT TTATTCGGGG TCACATTTCA GGCAGCATCA ACATTCCATT CAGCACTGCA 2460

TTCACCGCGG AAGGGGAACT TACCCAGGGC CCTCACACCG CTATGCTCCA AAGCTTCAAA 2520

GGAAAGGTCA TTGTCATCGT GGGGAATTCT GCCAAGTACA CAGCAGAGTT TGCAGCACAT 2580

CTTGTGAAGA TGAAATATCC AAGAGTCTGT ATTCTAGATG GTGGCATTAA TAAGATCAAG 2640

CCAACAGGCC TCCTCACCGT GCCCTCTCCT CAAATATGA 2679

Domain Profile

S: 1     llaqdkdGsnGlplasnakkilGrfqiLkelqhdrLcqYldisrgkhervivvaehlels  60

         +l++d++GsnGlpl++n++kilGrfqiLk++ h+rLcqY+disrgkher++vvaeh+e s

Q: 18    ALPHDVCGSNGLPLTPNSIKILGRFQILKTIIHPRLCQYVDISRGKHERLVVVAEHCEQS  77

         589*********************************************************

S: 61    LeDllkerkpvseslvlriayevlsgldylnkhnivhralepksilldrkgqkvkLakyG  120

         LeDll+erkpvs s+vl+ia+evl+gl+y+nkh+ivhral+p++illdrkg+ vkLak+G

Q: 78    LEDLLRERKPVSYSKVLCIAFEVLQGLQYMNKHGIVHRALSPHNILLDRKGH-VKLAKFG  136

         ****************************************************.*******

S: 121   LyhltayGkdvdfpigygsylaPerilqd.........edkllaatvksDvWsLglille  171

         Lyh+ta+G+dvdfpigy+sylaPe+i+q+         ++k+l++++ksDvWsLg+il+e

Q: 137   LYHMTAHGDDVDFPIGYPSYLAPEVIAQGiskttdhvpNEKPLPSGPKSDVWSLGIILFE  196

         ************************************************************

S: 172   lilgikLfaeldlserlkillklstvdetliklaeekkcldiikklderleallkkCLtl  231

         l++g+kLf++ld+serlk+ll+l++vd+t+i+laee++cldiik+l+e++++llkkCLt+

Q: 197   LCVGRKLFQSLDVSERLKFLLTLDCVDDTIIVLAEEHGCLDIIKELPENVIDLLKKCLTF  256

         ************************************************************

S: 232   lpskRpspdellkekvf  248

         +pskRp+pdel+++kvf

Q: 257   HPSKRPTPDELMQDKVF  273

         ***************98

Domain Sequence
(FASTA)

ALPHDVCGSN GLPLTPNSIK ILGRFQILKT IIHPRLCQYV DISRGKHERL VVVAEHCEQS 60

LEDLLRERKP VSYSKVLCIA FEVLQGLQYM NKHGIVHRAL SPHNILLDRK GHVKLAKFGL 120

YHMTAHGDDV DFPIGYPSYL APEVIAQGIS KTTDHVPNEK PLPSGPKSDV WSLGIILFEL 180

CVGRKLFQSL DVSERLKFLL TLDCVDDTII VLAEEHGCLD IIKELPENVI DLLKKCLTFH 240

PSKRPTPDEL MQDKVF 256

Keyword

Complete proteome; Reference proteome.

Sequence Source

Ensembl

Orthology

Ortholog group

Ailuropoda melanoleuca"; ?>Anolis carolinensis"; ?>Bos taurus"; ?>Caenorhabditis elegans"; ?>Callithrix jacchus"; ?>Canis familiaris"; ?>Cavia porcellus"; ?>Ciona intestinalis"; ?>Ciona savignyi"; ?>Danio rerio"; ?>Drosophila melanogaster"; ?>Equus caballus"; ?>Felis catus"; ?>Gadus morhua"; ?>Gallus gallus"; ?>Gasterosteus aculeatus"; ?>Gorilla gorilla"; ?>Homo sapiens"; ?>Ictidomys tridecemlineatus"; ?>Latimeria chalumnae"; ?>Loxodonta africana"; ?>Meleagris gallopavo"; ?>Monodelphis domestica"; ?>Mus musculus"; ?>Mustela putorius furo"; ?>Nomascus leucogenys"; ?>Oreochromis niloticus"; ?>Ornithorhynchus anatinus"; ?>Oryctolagus cuniculus"; ?>Oryzias latipes"; ?>Otolemur garnettii"; ?>Pan troglodytes"; ?>Petromyzon marinus"; ?>Pongo abelii"; ?>Rattus norvegicus"; ?>Sarcophilus harrisii"; ?>Sus scrofa"; ?>Taeniopygia guttata"; ?>Takifugu rubripes"; ?>Tetraodon nigroviridis"; ?>Tursiops truncatus"; ?>Xenopus tropicalis"; ?>Xiphophorus maculatus"; ?>

Gene Ontology

GO:0005622	; C:intracellular
GO:0005524	; F:ATP binding
GO:0004672	; F:protein kinase activity
GO:0005097	; F:Rab GTPase activator activity
GO:0032851	; P:positive regulation of Rab GTPase activity

KEGG

InterPros

IPR011009	; Kinase-like_dom.
IPR000719	; Prot_kinase_cat_dom.
IPR000195	; Rab-GTPase-TBC_dom.
IPR001763	; Rhodanese-like_dom.

Pfam

PF00069	; Pkinase; 1.
PF00566	; RabGAP-TBC; 1.
PF00581	; Rhodanese; 1.

SMARTs

SM00450	; RHOD; 1.
SM00164	; TBC; 1.

Prosites

PS50011	; PROTEIN_KINASE_DOM; 1.
PS50206	; RHODANESE_3; 1.
PS50086	; TBC_RABGAP; 1.

Prints

Created Date

20-Feb-2013