EKS-MYL-00408

Eukaryotic Protein Kinase & Protein Phosphatase Database

Tag

Content

EKPD ID

EKS-MYL-00408

Classification

Group/Family	Score	E-Value	Start	End	Domain Length
CAMK/DAPK	467.8	8.6E-141	3	257	255

Status

Unreviewed

Ensembl Protein

ENSMLUP00000011343

UniProt Accession

G1PKL0;

Protein Name

Protein Synonyms/Alias

Gene Name

DAPK1

Gene Synonyms/Alias

DAPK1;

Ensembl Information

Ensembl Gene ID	Ensembl Protein ID	Ensembl Transcript ID
ENSMLUG00000012450	ENSMLUP00000011343	ENSMLUT00000012458

Organism

Myotis lucifugus

Functional Description

Protein Length

1108

Protein Sequence
(FASTA)

LFSGQFAVVK KCREKSTGLQ YAAKFIKKRR TKSSRRGVSR EDIEREVGIL KEIQHPNVIT 60

LHEVYENKTD VILILELVAG GELFDFLAEK ESLTEEEATE FLKQILNGVY YLHSLQIAHF 120

DLKPENIMLL DRNVPKPRIK IIDFGLAHKI DFGNEFKNIF GTPEFVAPEI VNYEPLGLEA 180

DMWSIGVITY ILLSGASPFL GDTKQETLAN VSAVNYEFEE EYFSNTSALA KDFIRRLLVK 240

DPKKRMTIQD SLQHPWIKPK DTQQALSRKA SAVNMEKFKK FAARKKWKQS VRLISLCQRL 300

SRSFLSRSNM SVARSDDTLD EEDSFVMKAI IHAINDDNVP GLQHLLGSLS NYDVNQPNKH 360

GTPPLLIAAG CGNIQMLQLL IKRGSRIDVQ DKGGSNAIYW ASRHGHVDTL KFLHENKCPL 420

DVKDKSGETA LHVAARYGHA DVVQLLCSFG SNPNFQDKEE ETPLHCAAWH GYYSVAKALC 480

EAGCNVNIKN REGETPLLTA SARGYHDIVE CLAEHGGDLN ASDKDGHIAL HLAVRRCQME 540

VIQTLLSQGS FVNFQDRHGN TPLHVACKDG NVPIVVALCE AGCDPDISNK YGRTPLHLAA 600

NNGILDVVRY LCLTGANVEA LTSDGKTAED LARSEQHEHV AGLLARLRKD THRSLFIQQL 660

RPTQNLQPRI KLKLFGHSGS GKTTLVESLK CGLLRSFFRR RRPRLSSTNS TRFPPSPLAS 720

KPAVSVSINN LYPGCENVSV RSRSMMFEPG LTKGMLEVFV APSHHPHCSA DDQSTKAIDI 780

QNAYLNGVGD FSVWEFSGNP VYFCSYDYFA ANDPTSIHVI VFSLEEPYEI QLNQVVFWLS 840

FLKSLVPVEE PIAFGGKLKN PLRVVLVATH ADIMNVPRPA GGEFGYDKDT ALLKEIRNRF 900

GNDLHISDKL FVLDAGASGS KDMKVLRNHL QEIRSQIVAI AKEFKSDLNI MIQVWHNVHF 960

THTPSTTEVC PPMTHLCEKI ISTLPSWRKL NGPNQLMSLQ QFVYDVQDQL NPLASEEDLR 1020

GIAQQLHSAG EINIMQSETV QDVLLLDPRW LCTNVLGKLL SVETPRALHH YRGRYTMEDI 1080

QRLVPDSDVE ELLQILDAMD ICARDLSS 1108

Nucleotide Sequence
(FASTA)

CTCTTCAGCG GGCAGTTTGC AGTGGTGAAG AAATGCCGCG AGAAGAGCAC GGGTCTGCAG 60

TATGCCGCCA AGTTCATCAA GAAAAGGAGG ACGAAATCCA GCCGGCGGGG CGTGAGCCGC 120

GAGGACATCG AGCGCGAGGT CGGCATCCTG AAGGAGATCC AGCACCCCAA CGTCATCACC 180

CTGCACGAGG TGTACGAGAA CAAGACGGAC GTCATCCTGA TTCTGGAGCT TGTTGCAGGT 240

GGCGAGCTGT TTGACTTCTT AGCTGAAAAG GAATCTTTGA CTGAAGAGGA AGCAACTGAA 300

TTTCTCAAAC AAATTCTTAA TGGTGTTTAC TACCTGCACT CCCTCCAGAT TGCCCACTTT 360

GATCTTAAGC CTGAAAACAT AATGCTTTTG GATAGAAATG TTCCCAAACC TCGGATCAAG 420

ATCATCGACT TTGGGCTGGC CCATAAAATT GACTTTGGAA ATGAATTCAA AAACATATTT 480

GGAACACCAG AATTTGTTGC TCCTGAGATA GTCAACTATG AACCTCTTGG TCTCGAGGCA 540

GATATGTGGA GTATTGGAGT AATCACCTAT ATTCTCCTAA GTGGGGCCTC GCCATTTCTC 600

GGAGACACTA AGCAAGAGAC GTTAGCAAAT GTATCCGCTG TCAACTACGA ATTTGAAGAA 660

GAATACTTCA GTAATACCAG TGCCCTCGCC AAAGATTTCA TAAGAAGACT GCTCGTCAAG 720

GATCCAAAGA AGAGAATGAC CATTCAAGAT AGTTTGCAGC ACCCCTGGAT CAAGCCTAAA 780

GATACCCAAC AAGCACTTAG TAGAAAAGCA TCAGCAGTAA ACATGGAGAA ATTCAAGAAG 840

TTTGCAGCCC GGAAAAAATG GAAACAATCA GTTCGCTTGA TATCACTGTG CCAAAGATTA 900

TCCAGGTCGT TCTTGTCCAG AAGTAACATG AGTGTTGCCA GAAGCGACGA TACTCTGGAT 960

GAGGAAGACT CCTTTGTGAT GAAAGCCATC ATCCATGCCA TCAACGATGA CAATGTCCCA 1020

GGCCTGCAGC ACCTCCTGGG CTCATTGTCC AACTATGATG TTAACCAACC CAACAAGCAT 1080

GGGACGCCTC CGTTACTTAT TGCTGCTGGC TGTGGGAACA TTCAAATGCT ACAGTTGCTT 1140

ATTAAAAGAG GCTCAAGAAT CGATGTCCAG GATAAGGGTG GATCCAATGC CATCTACTGG 1200

GCCTCTCGGC ACGGCCACGT GGACACCTTG AAATTTCTCC ATGAGAACAA ATGCCCTTTG 1260

GATGTTAAAG ACAAGTCTGG AGAGACAGCC CTGCACGTGG CGGCTCGCTA CGGCCACGCC 1320

GATGTGGTTC AGTTACTGTG CAGCTTTGGC TCCAATCCCA ATTTCCAGGA CAAGGAAGAA 1380

GAAACCCCCC TGCACTGTGC TGCCTGGCAC GGCTACTACT CTGTGGCCAA AGCCCTGTGT 1440

GAAGCCGGCT GCAACGTGAA CATTAAGAAC CGAGAAGGAG AGACGCCCCT CCTGACAGCG 1500

TCCGCCAGGG GCTACCACGA CATCGTGGAG TGTCTGGCCG AACACGGAGG CGACCTGAAT 1560

GCCTCTGACA AGGATGGACA CATCGCTCTT CATCTCGCTG TGAGGCGGTG TCAGATGGAG 1620

GTCATCCAGA CGCTGCTCAG CCAGGGAAGC TTCGTCAATT TCCAAGACAG GCACGGCAAC 1680

ACCCCCCTGC ACGTGGCCTG CAAGGACGGC AACGTGCCCA TTGTGGTGGC CCTCTGCGAG 1740

GCCGGCTGCG ATCCGGATAT CTCCAACAAG TATGGCCGCA CACCCCTGCA CCTGGCCGCC 1800

AACAACGGGA TTCTCGACGT GGTCCGCTAC CTCTGTCTGA CGGGCGCCAA CGTGGAGGCG 1860

CTGACCTCGG ATGGGAAGAC AGCAGAAGAT CTCGCCCGGT CGGAGCAGCA CGAGCATGTA 1920

GCAGGTCTCC TTGCAAGACT CCGAAAGGAC ACGCACAGAA GCCTCTTCAT CCAGCAGCTG 1980

CGGCCCACAC AGAACCTGCA GCCCAGAATC AAACTGAAGC TGTTCGGCCA CTCGGGCTCG 2040

GGGAAAACCA CGCTGGTGGA ATCGCTCAAG TGCGGGCTGC TCAGGAGCTT CTTCCGACGG 2100

CGCCGGCCCC GGCTCTCCTC TACCAACTCC ACCAGGTTCC CGCCCTCGCC CCTGGCTTCC 2160

AAGCCAGCAG TCTCCGTGAG CATCAACAAC CTGTACCCGG GCTGCGAGAA CGTGAGCGTG 2220

AGGAGCCGCA GCATGATGTT CGAGCCGGGC CTCACCAAGG GGATGCTGGA GGTGTTCGTG 2280

GCCCCGTCCC ACCACCCGCA CTGCTCCGCC GATGACCAGT CCACGAAGGC CATCGACATC 2340

CAGAACGCCT ATCTGAACGG GGTTGGCGAT TTCAGCGTGT GGGAGTTCTC TGGAAACCCT 2400

GTCTACTTCT GCTCATATGA TTATTTTGCT GCAAATGACC CCACGTCAAT CCATGTCATC 2460

GTTTTTAGTC TAGAAGAACC CTATGAGATC CAGCTGAATC AAGTGGTTTT CTGGCTCAGT 2520

TTCCTGAAGT CTCTTGTGCC GGTTGAGGAG CCCATAGCCT TCGGCGGCAA GCTGAAGAAC 2580

CCACTCCGCG TCGTCCTGGT GGCCACGCAC GCCGACATCA TGAACGTTCC TCGTCCGGCT 2640

GGAGGCGAGT TTGGATACGA CAAAGACACG GCTTTGTTGA AAGAGATCAG GAACAGGTTT 2700

GGGAATGATC TTCACATTTC AGATAAGCTG TTTGTTCTGG ATGCTGGGGC TTCTGGGTCG 2760

AAGGACATGA AGGTACTTCG AAATCACCTG CAAGAAATAC GGAGCCAGAT TGTTGCCATT 2820

GCAAAAGAAT TCAAAAGTGA CTTGAATATA ATGATACAGG TGTGGCACAA TGTCCACTTC 2880

ACACACACAC CCTCCACTAC TGAGGTCTGC CCTCCGATGA CTCACCTGTG TGAGAAAATC 2940

ATCTCCACGC TGCCGTCCTG GAGGAAGCTC AATGGGCCCA ACCAGCTGAT GTCACTGCAG 3000

CAGTTTGTGT ACGACGTGCA GGACCAGCTG AACCCGCTGG CCAGCGAGGA GGACCTCCGG 3060

GGCATCGCCC AGCAGCTCCA CAGTGCCGGC GAGATCAACA TCATGCAGAG TGAAACGGTC 3120

CAGGACGTGC TGCTCCTGGA CCCCCGCTGG CTCTGCACCA ACGTCCTGGG CAAGCTGCTC 3180

TCCGTGGAGA CCCCGCGGGC CCTGCACCAC TACCGCGGCC GTTACACCAT GGAGGACATC 3240

CAGCGCCTGG TGCCCGACAG TGACGTGGAG GAGCTGCTGC AGATCCTCGA TGCCATGGAC 3300

ATCTGTGCCC GGGACCTGAG CAGT 3324

Domain Profile

S: 9     sGkfavvrkcrekstGkeyaakflkkrrlkssrrgvsreeierevavlkeirsepnvinl  68

         sG+favv+kcrekstG +yaakf+kkrr+kssrrgvsre+ierev +lkei+ +pnvi+l

Q: 3     SGQFAVVKKCREKSTGLQYAAKFIKKRRTKSSRRGVSREDIEREVGILKEIQ-HPNVITL  61

         8***************************************************.*******

S: 69    hevyenksdvililelvaGGelfdllaekeslseeeatellkqilegvkylhskkivhld  128

         hevyenk+dvililelvaGGelfd+laekesl+eeeate+lkqil+gv+ylhs +i+h+d

Q: 62    HEVYENKTDVILILELVAGGELFDFLAEKESLTEEEATEFLKQILNGVYYLHSLQIAHFD  121

         ************************************************************

S: 129   lkPenillldkkvpkgdiklidfGlsrkieegaelkeilGtPefvaPeivnyeplsletd  188

         lkPeni+lld++vpk++ik+idfGl++ki+ g+e+k+i+GtPefvaPeivnyepl+le+d

Q: 122   LKPENIMLLDRNVPKPRIKIIDFGLAHKIDFGNEFKNIFGTPEFVAPEIVNYEPLGLEAD  181

         ************************************************************

S: 189   mwsiGvityillsgasPflGdtkqetllnisavnldfseelfssvselakdfirrllvkd  248

         mwsiGvityillsgasPflGdtkqetl+n+savn++f+ee+fs++s lakdfirrllvkd

Q: 182   MWSIGVITYILLSGASPFLGDTKQETLANVSAVNYEFEEEYFSNTSALAKDFIRRLLVKD  241

         ************************************************************

S: 249   pekrltieeclehswl  264

         p+kr+ti+++l+h+w+

Q: 242   PKKRMTIQDSLQHPWI  257

         ***************8

Domain Sequence
(FASTA)

SGQFAVVKKC REKSTGLQYA AKFIKKRRTK SSRRGVSRED IEREVGILKE IQHPNVITLH 60

EVYENKTDVI LILELVAGGE LFDFLAEKES LTEEEATEFL KQILNGVYYL HSLQIAHFDL 120

KPENIMLLDR NVPKPRIKII DFGLAHKIDF GNEFKNIFGT PEFVAPEIVN YEPLGLEADM 180

WSIGVITYIL LSGASPFLGD TKQETLANVS AVNYEFEEEY FSNTSALAKD FIRRLLVKDP 240

KKRMTIQDSL QHPWI 255

Keyword

ANK repeat; Complete proteome; Reference proteome; Repeat.

Sequence Source

Ensembl

Orthology

Ortholog group

Ailuropoda melanoleuca"; ?>Anolis carolinensis"; ?>Bos taurus"; ?>Caenorhabditis elegans"; ?>Callithrix jacchus"; ?>Canis familiaris"; ?>Cavia porcellus"; ?>Danio rerio"; ?>Equus caballus"; ?>Felis catus"; ?>Gallus gallus"; ?>Gasterosteus aculeatus"; ?>Gorilla gorilla"; ?>Homo sapiens"; ?>Ictidomys tridecemlineatus"; ?>Latimeria chalumnae"; ?>Loxodonta africana"; ?>Macaca mulatta"; ?>Meleagris gallopavo"; ?>Monodelphis domestica"; ?>Mus musculus"; ?>Mustela putorius furo"; ?>Nomascus leucogenys"; ?>Oreochromis niloticus"; ?>Oryctolagus cuniculus"; ?>Oryzias latipes"; ?>Otolemur garnettii"; ?>Pan troglodytes"; ?>Pelodiscus sinensis"; ?>Petromyzon marinus"; ?>Pongo abelii"; ?>Rattus norvegicus"; ?>Sus scrofa"; ?>Taeniopygia guttata"; ?>Takifugu rubripes"; ?>Tetraodon nigroviridis"; ?>Tursiops truncatus"; ?>Xenopus tropicalis"; ?>Xiphophorus maculatus"; ?>

Gene Ontology

GO:0005524	; F:ATP binding
GO:0004674	; F:protein serine/threonine kinase activity

KEGG

InterPros

IPR002110	; Ankyrin_rpt.
IPR020683	; Ankyrin_rpt-contain_dom.
IPR020676	; Death-assoc_prot_kinase.
IPR011009	; Kinase-like_dom.
IPR020675	; Myosin_light_ch_kinase-rel.
IPR000719	; Prot_kinase_cat_dom.
IPR002290	; Ser/Thr_dual-sp_kinase_dom.
IPR008271	; Ser/Thr_kinase_AS.

Pfam

PF00023	; Ank; 1.
PF12796	; Ank_2; 2.
PF00069	; Pkinase; 1.

SMARTs

SM00248	; ANK; 9.
SM00220	; S_TKc; 1.

Prosites

PS50297	; ANK_REP_REGION; 1.
PS50088	; ANK_REPEAT; 7.
PS50011	; PROTEIN_KINASE_DOM; 1.
PS00108	; PROTEIN_KINASE_ST; 1.

Prints

PR01415

; ANKYRIN.

Created Date

20-Feb-2013