EKS-MYL-00321

Eukaryotic Protein Kinase & Protein Phosphatase Database

Tag

Content

EKPD ID

EKS-MYL-00321

Classification

Group/Family	Score	E-Value	Start	End	Domain Length
STE/STE20	324.7	4.4E-97	453	700	248

Status

Unreviewed

Ensembl Protein

ENSMLUP00000011403

UniProt Accession

G1PKR0;

Protein Name

Protein Synonyms/Alias

Gene Name

PAK7

Gene Synonyms/Alias

PAK7;

Ensembl Information

Ensembl Gene ID	Ensembl Protein ID	Ensembl Transcript ID
ENSMLUG00000012529	ENSMLUP00000011403	ENSMLUT00000012532

Organism

Myotis lucifugus

Functional Description

Protein Length

719

Protein Sequence
(FASTA)

MFGKKKKKIE ISGPSNFEHR VHTGFDPQEQ KFTGLPQQWH SLLADTANRP KPMVDPSCIT 60

PIQLAPMKTI VRGNKPCQES SINGLLEDFD NISVTRSNSL RKESPPTPDQ GAAGHGPGHR 120

EENGFITFSQ YSSESDTTAD YSTDRYRDKS LYGDDLDPFY KGSHAAKQNG HVMKMKHGEA 180

YYSDMKPLKS DLARFPIDYH THLDSLSKPS DYSDLKWEYQ RASSSSPLDY PFQFTPSRTA 240

GTGGCSKESL AYSESEWGPS LDDYDRRPKS SYLNQTSPQP AMRQRSRSGS GLQEPMMPFG 300

ASAFKTHPQG HTYNSYTYPR LSEPTMCIAK VDYDRAQMVL SPPLSGSDTY PRGPAKLPQS 360

QSKAGYSSSS HQYPSGYHKA TLYHHPSLQT SSQYISTASY LSSLSISSST YPPPSWGSSS 420

DQQPSRVSHE QFRAALQLVV SPGDPREYLD NFIKIGEGST GIVCIATEKH TGKQVAVKKM 480

DLRKQQRREL LFNEVVIMRD YHHDNVVDMY NSYLVSDELW VVMEFLEGGA LTDIVTHTRM 540

NEEQIATVCL SVLRALSYLH NQGVIHRDIK SDSILLTSDG RIKLSDFGFC AQVSKEVPKR 600

KSLVGTPYWM APEVISRLPY GTEVDIWSLG IMVIEMIDGE PPYFNEPPLQ AMRRIRDSLP 660

PRVKDLHKVS SVLRGFLDLM LVREPSQRAT AQELLGHPFL KLAGPPSCIV PLMRQYRHH 719

Nucleotide Sequence
(FASTA)

ATGTTTGGAA AGAAAAAGAA AAAGATTGAA ATCTCTGGTC CATCCAACTT TGAACACAGG 60

GTTCACACAG GGTTTGATCC ACAGGAACAG AAATTCACCG GCCTGCCTCA GCAGTGGCAT 120

AGTCTGTTGG CAGATACGGC CAACAGGCCG AAGCCCATGG TGGACCCGTC ATGCATCACA 180

CCCATCCAGC TGGCTCCCAT GAAGACAATC GTTCGAGGAA ACAAACCCTG CCAGGAATCC 240

TCCATCAACG GCCTCCTGGA GGATTTCGAC AACATCTCGG TGACCCGCTC CAACTCCCTA 300

AGGAAAGAGA GCCCGCCCAC CCCGGACCAG GGCGCCGCGG GCCATGGCCC AGGCCACCGG 360

GAAGAGAACG GCTTCATCAC CTTCTCACAG TATTCCAGCG AATCCGACAC CACCGCCGAC 420

TACTCCACCG ACAGGTACCG CGACAAGAGT CTCTATGGAG ACGATTTGGA TCCGTTTTAT 480

AAAGGCAGCC ATGCGGCCAA GCAGAATGGG CACGTGATGA AAATGAAACA CGGGGAAGCC 540

TACTATTCTG ACATGAAGCC CCTGAAATCC GACCTGGCCC GATTCCCCAT CGATTATCAC 600

ACACACTTGG ACTCACTGAG CAAACCCAGT GACTACAGTG ACCTCAAGTG GGAGTACCAG 660

AGAGCCTCGA GCAGCTCGCC TCTGGATTAC CCGTTCCAAT TCACGCCTTC CAGAACTGCA 720

GGGACCGGCG GCTGCTCCAA GGAGAGCCTG GCCTACAGCG AGAGCGAATG GGGGCCCAGC 780

CTGGATGACT ACGATCGGAG GCCAAAGTCA TCGTACCTGA ATCAGACCAG CCCGCAGCCC 840

GCCATGCGGC AGAGGTCCAG GTCGGGCTCG GGGCTCCAGG AACCGATGAT GCCCTTCGGA 900

GCAAGTGCAT TTAAAACCCA CCCCCAGGGA CACACGTACA ACTCCTACAC CTACCCTCGC 960

TTGTCCGAGC CCACAATGTG CATTGCCAAG GTGGATTACG ATCGAGCACA GATGGTTCTC 1020

AGCCCTCCAC TGTCAGGGTC CGACACCTAC CCCAGGGGCC CCGCCAAACT ACCTCAAAGT 1080

CAAAGCAAAG CGGGCTATTC CTCAAGCAGC CACCAGTACC CATCTGGGTA CCACAAAGCC 1140

ACCCTGTACC ACCACCCCTC CCTACAGACC AGCTCACAGT ACATCTCCAC CGCTTCTTAC 1200

CTGAGCTCTC TCAGCATCTC ATCCAGCACC TACCCCCCAC CCAGCTGGGG CTCCTCCTCA 1260

GACCAGCAGC CCTCTAGGGT GTCCCACGAA CAGTTTCGGG CTGCCCTGCA GCTGGTGGTC 1320

AGCCCAGGAG ACCCCAGGGA GTACTTGGAC AACTTTATCA AAATCGGGGA AGGGTCGACC 1380

GGCATCGTGT GCATCGCCAC CGAGAAACAC ACAGGGAAAC AAGTTGCAGT GAAGAAAATG 1440

GACCTTCGAA AGCAGCAGAG GCGAGAGCTG CTTTTTAATG AGGTTGTGAT AATGCGGGAT 1500

TACCACCATG ACAATGTGGT TGACATGTAC AACAGCTATC TTGTCAGTGA CGAGCTCTGG 1560

GTGGTCATGG AGTTTCTAGA AGGTGGTGCC TTGACAGACA TTGTCACTCA TACCAGAATG 1620

AATGAAGAAC AGATAGCTAC TGTGTGTCTG TCGGTTCTGA GAGCTCTCTC CTACCTTCAC 1680

AACCAAGGAG TGATTCACAG GGACATAAAG AGTGACTCCA TCCTCCTGAC AAGCGATGGA 1740

CGGATAAAGT TATCTGACTT TGGTTTCTGT GCTCAAGTTT CCAAAGAGGT ACCGAAGAGG 1800

AAATCATTGG TTGGCACTCC CTACTGGATG GCACCTGAAG TAATTTCTAG ACTACCGTAC 1860

GGGACGGAGG TGGACATCTG GTCTCTGGGG ATCATGGTGA TAGAAATGAT TGATGGCGAG 1920

CCCCCCTACT TCAACGAGCC TCCCCTGCAG GCAATGCGGA GGATCCGGGA CAGTTTACCT 1980

CCTCGAGTGA AGGACCTACA CAAGGTTTCT TCCGTGCTCC GGGGATTCCT GGACCTGATG 2040

CTGGTGAGGG AGCCCTCTCA GAGAGCCACA GCCCAGGAAC TCCTTGGACA TCCGTTCTTG 2100

AAACTGGCAG GTCCACCTTC TTGCATAGTT CCCCTCATGA GACAGTACAG GCATCACTGA 2160

Domain Profile

S: 5     eeigkGalgkvylarekktgelvaikkinlekqekleelqkeisvlkklkhpniveyles  64

          +ig+G++g v++a+ek+tg++va+kk++l+kq++ e+l++e+ ++++++h n+v++++s

Q: 453   IKIGEGSTGIVCIATEKHTGKQVAVKKMDLRKQQRRELLFNEVVIMRDYHHDNVVDMYNS  512

         68**********************************************************

S: 65    flkeeelwlvmeylagGslsdlvkeelkselkEeqiayilrevlkaLeylHskkviHrdi  124

         +l+++elw+vme+l+gG+l+d+v+   +++++Eeqia+++ +vl+aL+ylH+++viHrdi

Q: 513   YLVSDELWVVMEFLEGGALTDIVT---HTRMNEEQIATVCLSVLRALSYLHNQGVIHRDI  569

         ************************...9********************************

S: 125   kakniLlteegeVkLsdfgvaaqlektrkkrktvvgtpywmAPEviaqeekgYdekaDiw  184

         k+++iLlt++g++kLsdfg++aq++k++ krk++vgtpywmAPEvi+  +  Y +++Diw

Q: 570   KSDSILLTSDGRIKLSDFGFCAQVSKEVPKRKSLVGTPYWMAPEVIS--RLPYGTEVDIW  627

         ***********************************************..9**********

S: 185   slGItaielaegepPfkdleplkallkilkneppklkskkkfskefkefvekclqknpek  244

         slGI++ie+++gepP+++++pl+a+ +i ++ pp++k+ +k+s+ ++ f++ +l ++p++

Q: 628   SLGIMVIEMIDGEPPYFNEPPLQAMRRIRDSLPPRVKDLHKVSSVLRGFLDLMLVREPSQ  687

         ************************************************************

S: 245   RpsasellkhkFl  257

         R++a+ell h+Fl

Q: 688   RATAQELLGHPFL  700

         ************7

Domain Sequence
(FASTA)

IKIGEGSTGI VCIATEKHTG KQVAVKKMDL RKQQRRELLF NEVVIMRDYH HDNVVDMYNS 60

YLVSDELWVV MEFLEGGALT DIVTHTRMNE EQIATVCLSV LRALSYLHNQ GVIHRDIKSD 120

SILLTSDGRI KLSDFGFCAQ VSKEVPKRKS LVGTPYWMAP EVISRLPYGT EVDIWSLGIM 180

VIEMIDGEPP YFNEPPLQAM RRIRDSLPPR VKDLHKVSSV LRGFLDLMLV REPSQRATAQ 240

ELLGHPFL 248

Keyword

ATP-binding; Complete proteome; Kinase; Nucleotide-binding; Reference proteome; Serine/threonine-protein kinase; Transferase.

Sequence Source

Ensembl

Orthology

Ortholog group

Ailuropoda melanoleuca"; ?>Anolis carolinensis"; ?>Bos taurus"; ?>Callithrix jacchus"; ?>Canis familiaris"; ?>Cavia porcellus"; ?>Ciona intestinalis"; ?>Dipodomys ordii"; ?>Drosophila melanogaster"; ?>Equus caballus"; ?>Erinaceus europaeus"; ?>Felis catus"; ?>Gallus gallus"; ?>Gasterosteus aculeatus"; ?>Gorilla gorilla"; ?>Homo sapiens"; ?>Ictidomys tridecemlineatus"; ?>Latimeria chalumnae"; ?>Loxodonta africana"; ?>Macaca mulatta"; ?>Meleagris gallopavo"; ?>Monodelphis domestica"; ?>Mus musculus"; ?>Mustela putorius furo"; ?>Nomascus leucogenys"; ?>Oreochromis niloticus"; ?>Ornithorhynchus anatinus"; ?>Oryctolagus cuniculus"; ?>Oryzias latipes"; ?>Otolemur garnettii"; ?>Pan troglodytes"; ?>Pelodiscus sinensis"; ?>Petromyzon marinus"; ?>Pongo abelii"; ?>Procavia capensis"; ?>Rattus norvegicus"; ?>Sarcophilus harrisii"; ?>Sus scrofa"; ?>Taeniopygia guttata"; ?>Tarsius syrichta"; ?>Tetraodon nigroviridis"; ?>Tursiops truncatus"; ?>Vicugna pacos"; ?>Xenopus tropicalis"; ?>Xiphophorus maculatus"; ?>

Gene Ontology

GO:0005524	; F:ATP binding
GO:0004674	; F:protein serine/threonine kinase activity

KEGG

InterPros

IPR011009	; Kinase-like_dom.
IPR000095	; PAK_box_Rho-bd.
IPR000719	; Prot_kinase_cat_dom.
IPR017441	; Protein_kinase_ATP_BS.
IPR002290	; Ser/Thr_dual-sp_kinase_dom.

Pfam

PF00786	; PBD; 1.
PF00069	; Pkinase; 1.

SMARTs

SM00285	; PBD; 1.
SM00220	; S_TKc; 1.

Prosites

PS50108	; CRIB; 1.
PS00107	; PROTEIN_KINASE_ATP; 1.
PS50011	; PROTEIN_KINASE_DOM; 1.

Prints

Created Date

20-Feb-2013