EKS-MYL-00032

Eukaryotic Protein Kinase & Protein Phosphatase Database

Tag

Content

EKPD ID

EKS-MYL-00032

Classification

Group/Family	Score	E-Value	Start	End	Domain Length
TK/Jak	343.9	6.8E-103	849	1120	272

Status

Unreviewed

Ensembl Protein

ENSMLUP00000011617

UniProt Accession

G1PL96;

Protein Name

Tyrosine-protein kinase

Protein Synonyms/Alias

Gene Name

JAK2

Gene Synonyms/Alias

JAK2;

Ensembl Information

Ensembl Gene ID	Ensembl Protein ID	Ensembl Transcript ID
ENSMLUG00000012756	ENSMLUP00000011617	ENSMLUT00000012768

Organism

Myotis lucifugus

Functional Description

Protein Length

1132

Protein Sequence
(FASTA)

MEMACLTMTE MEGTCTPPMH QNGDIPGITD SVKQIDPVLQ VYLYHSPGKT EGDYLKFSTG 60

EYVAEEICVA ASKACGITPV YHSMFALMSE TERIWYPPNY VFHIDESTRH NVLYRIRFYF 120

PYWYCSGSNR TYRHGISRGA EAPLLDDFVM SYLFAQWRHD FLHGWIKVPV THETQEECLG 180

MAVLDMMRIA KENDQTPLDV YSSISYKTFL PKCIRAKIQD YHILTRKRIR YRFRRFIEQF 240

SHCKATARNL KLKYLINLET LQSAFYTEQF EVKEPGRGPS GEEIFATIII TGNGGIQWSR 300

GKHKESETLT EQDLQLYCDF PDIIDVSIKQ ASQEGSNESR VTIHKQMVKN QEIELSSLKE 360

ALSFVSLIDG YYRLTADAHH YLCKEVASPV VLENIQSNCH GPISMDFAIS KLKKAGNQTG 420

LYVLRCSPKE FNKYFLTFAV EHDNVIEYKH CLITKNENGE YNLSGTKKNF SNLKDLLNCY 480

QMETVRSDNI IFQFTKCCPP KPKDKSNLLV FRTNSVSDVP TSPTLQRHNN VNQMVFHKIR 540

NEDLVFNESL GQGTFTKIFK GVRREVGDYG QLHETEVLLK VLDKAHRNYS ESFFEAASMM 600

SQLSHKHLVL NYGVCVCGEE NILVQEFVKF GSLDTYLKKN KNSINILWKL EVAKQLAWAM 660

HFLEEKNLIH GNVCAKNILL IREEDRKSGN PPFIKLSDPG ISVTVLPKDI LQERIPWVPP 720

ECIENPKNLN LATDKWSFGT TLWEICSGGD KPLSALDSQR KLQFYEDRHQ LPAPKWTELA 780

NLINNCMDYE PDFRPSFRAI IRDLNSLFTP ADYELLTEND MLPNMRIGAL GFSGAFEDRD 840

PTQFEERHLK FLQQLGKGNF GSVEMCRYDP LQDNTGEVVA VKKLQHSTEE HLRDFEREIE 900

ILKSLQHDNI VKYKGVCYSA GRRNLRLIME YLPYGSLRDY LQKHKERIDH KKLLQYTSQI 960

CKGMEYLGTK RYIHRDLATR NILVENENRV KIGDFGLTKV LPQDKEYYKV KEPGESPIFW 1020

YAPESLTESK FSVASDVWSF GVVLYELFTY IEKSKSPPAE FMRMIGNDKQ GQMIVFHLIE 1080

LLKNNGRLPR PDGCPDEIYL IMTECWNNNV NQRPSFRNLA LRVDQIRDNI AG 1132

Nucleotide Sequence
(FASTA)

ATGGAAATGG CTTGCCTCAC AATGACAGAA ATGGAAGGAA CATGCACACC TCCTATGCAT 60

CAGAATGGAG ATATTCCTGG AATTACTGAT TCTGTGAAGC AAATAGATCC AGTCCTTCAG 120

GTGTATCTTT ATCATTCCCC TGGGAAAACT GAGGGAGATT ACCTGAAGTT TTCAACTGGG 180

GAATATGTTG CAGAAGAAAT TTGTGTTGCT GCTTCTAAAG CCTGTGGAAT CACACCTGTG 240

TATCATAGTA TGTTTGCTTT AATGAGTGAA ACAGAAAGGA TCTGGTATCC GCCCAACTAT 300

GTCTTCCATA TAGATGAGTC AACCAGGCAC AATGTACTCT ACAGAATAAG ATTTTACTTT 360

CCTTACTGGT ATTGTAGCGG CAGCAACAGA ACTTATCGGC ATGGAATATC TCGAGGTGCT 420

GAAGCTCCTC TTCTTGATGA CTTTGTTATG TCTTACCTTT TTGCTCAGTG GCGGCATGAT 480

TTTTTGCATG GATGGATAAA AGTACCTGTG ACTCATGAAA CACAGGAAGA ATGTCTTGGG 540

ATGGCAGTGT TAGATATGAT GAGAATAGCC AAAGAAAATG ATCAAACCCC ACTCGACGTC 600

TATAGCTCTA TCAGCTATAA GACATTCTTA CCAAAATGTA TTCGAGCAAA GATCCAAGAC 660

TATCATATTT TGACAAGAAA GCGAATAAGG TACCGATTTC GCAGATTTAT TGAGCAATTC 720

AGCCATTGCA AAGCCACTGC CAGAAACTTG AAACTTAAGT ATCTTATAAA TCTGGAAACT 780

CTTCAGTCTG CCTTCTACAC AGAGCAATTT GAAGTAAAAG AACCTGGAAG AGGTCCTTCA 840

GGTGAGGAGA TTTTTGCAAC CATTATAATA ACTGGAAACG GTGGAATTCA GTGGTCAAGA 900

GGGAAACATA AAGAAAGTGA AACACTGACA GAACAGGATT TACAGTTATA TTGTGACTTT 960

CCCGATATTA TTGATGTCAG TATTAAGCAG GCAAGCCAAG AAGGCTCAAA TGAAAGCAGA 1020

GTAACTATCC ATAAACAGAT GGTAAAAAAT CAGGAAATTG AACTTAGTTC ATTAAAGGAG 1080

GCTTTGTCTT TTGTGTCATT AATTGATGGA TATTATAGAT TAACTGCAGA TGCACATCAT 1140

TACCTCTGTA AAGAAGTAGC ATCTCCAGTG GTGCTTGAAA ATATACAAAG CAATTGTCAT 1200

GGCCCAATTT CAATGGATTT TGCCATAAGT AAACTGAAGA AAGCAGGTAA TCAGACTGGA 1260

CTTTATGTAC TTCGATGCAG TCCTAAGGAG TTTAATAAAT ATTTTTTGAC TTTTGCTGTC 1320

GAGCATGATA ATGTCATTGA ATATAAGCAC TGTCTGATTA CAAAAAATGA GAATGGAGAA 1380

TACAACCTCA GTGGGACTAA GAAGAACTTC AGTAATCTTA AAGATCTTTT GAATTGCTAC 1440

CAGATGGAAA CTGTTCGCTC AGACAATATA ATTTTCCAGT TTACAAAATG CTGTCCTCCA 1500

AAGCCAAAAG ATAAATCAAA CCTTCTAGTC TTTAGAACAA ATAGTGTTTC TGATGTACCA 1560

ACCTCACCAA CATTACAGAG ACATAATAAT GTGAACCAAA TGGTGTTTCA CAAAATCAGA 1620

AATGAAGATT TAGTATTTAA TGAAAGTCTT GGCCAAGGCA CTTTTACAAA AATTTTTAAA 1680

GGTGTAAGAA GAGAAGTAGG AGATTATGGT CAACTGCATG AAACAGAAGT TCTTTTAAAA 1740

GTTCTGGATA AAGCACATAG AAACTATTCA GAGTCTTTCT TTGAAGCAGC AAGCATGATG 1800

AGCCAGCTTT CTCACAAGCA TCTGGTTTTA AATTATGGAG TATGTGTCTG TGGAGAGGAG 1860

AATATTCTGG TTCAGGAGTT TGTGAAATTT GGATCACTAG ATACATATTT GAAAAAGAAT 1920

AAAAATTCTA TAAATATATT ATGGAAACTT GAAGTGGCTA AACAGTTGGC ATGGGCCATG 1980

CATTTTCTAG AAGAAAAAAA CCTTATTCAT GGGAATGTGT GTGCCAAAAA CATTCTACTT 2040

ATCAGAGAAG AAGACAGGAA GTCAGGAAAT CCTCCTTTCA TCAAACTTAG TGATCCTGGC 2100

ATTAGTGTTA CAGTTTTACC AAAGGACATT CTTCAGGAGA GAATACCATG GGTACCACCT 2160

GAATGTATTG AAAATCCTAA AAACTTAAAC TTGGCAACAG ACAAATGGAG TTTTGGTACC 2220

ACTTTGTGGG AAATCTGCAG TGGAGGAGAT AAGCCTCTGA GTGCTTTGGA TTCTCAAAGA 2280

AAGCTACAGT TTTATGAAGA TAGACACCAG CTTCCTGCAC CAAAGTGGAC AGAATTAGCA 2340

AATCTTATTA ATAATTGTAT GGATTATGAA CCAGATTTTA GACCTTCTTT CAGAGCCATC 2400

ATACGAGATC TTAATAGTTT GTTTACTCCA GCAGATTATG AATTGTTAAC AGAGAATGAC 2460

ATGTTACCAA ATATGAGGAT AGGTGCCCTA GGGTTTTCTG GAGCTTTTGA AGACCGAGAC 2520

CCTACTCAGT TTGAAGAGAG ACACTTGAAA TTTCTGCAGC AACTTGGCAA GGGTAACTTT 2580

GGGAGTGTTG AGATGTGCCG GTATGACCCT CTACAAGACA ACACTGGGGA GGTGGTGGCC 2640

GTGAAAAAGC TCCAGCACAG TACTGAAGAG CACCTCAGAG ACTTTGAAAG GGAAATTGAA 2700

ATCCTTAAAT CCCTGCAGCA TGACAACATT GTAAAGTACA AGGGAGTGTG CTACAGTGCT 2760

GGCCGACGTA ATCTAAGATT AATTATGGAA TATTTACCAT ATGGAAGTTT ACGAGACTAT 2820

CTCCAAAAGC ATAAAGAACG AATAGATCAT AAGAAACTTC TGCAATATAC ATCTCAAATA 2880

TGCAAGGGTA TGGAATATCT TGGTACAAAA AGGTATATCC ACAGGGATCT GGCAACAAGG 2940

AATATATTGG TAGAGAATGA AAACAGAGTT AAAATTGGAG ATTTTGGGTT AACCAAAGTC 3000

TTGCCACAAG ACAAAGAATA CTACAAAGTG AAAGAACCTG GTGAAAGTCC TATATTCTGG 3060

TATGCTCCAG AATCACTGAC AGAGAGCAAG TTTTCTGTGG CCTCAGATGT TTGGAGCTTT 3120

GGAGTGGTTC TATATGAACT TTTCACCTAT ATTGAGAAGA GTAAAAGTCC ACCAGCGGAA 3180

TTCATGCGTA TGATTGGCAA TGACAAACAA GGACAGATGA TTGTGTTTCA TTTGATAGAA 3240

CTCTTGAAGA ATAATGGAAG ATTACCAAGA CCAGATGGAT GCCCAGATGA GATCTATCTG 3300

ATCATGACAG AATGCTGGAA TAATAATGTA AATCAACGTC CATCTTTCAG AAACCTAGCT 3360

CTTCGAGTTG ATCAAATAAG GGACAACATA GCTGGATGA 3399

Domain Profile

S: 1     lkqiesLgkgtftkvfevredaegdsteeevalkvLkesgedisrdfkreaeilsqlshe  60

         lk++++Lgkg+f++v+++r+d+ +d+t+e va+k L++s+e++ rdf+re+eil++l+h+

Q: 849   LKFLQQLGKGNFGSVEMCRYDPLQDNTGEVVAVKKLQHSTEEHLRDFEREIEILKSLQHD  908

         6899********************************************************

S: 61    hivklkgvcvaegen..rlVmeyvesGsLdiyLrkkkealslsslldvakqlakameYLe  118

         +ivk+kgvc++ g++  rl+mey+++GsL++yL+k+ke++++++ll++++q++k+meYL+

Q: 909   NIVKYKGVCYSAGRRnlRLIMEYLPYGSLRDYLQKHKERIDHKKLLQYTSQICKGMEYLG  968

         **********999888********************************************

S: 119   dkklvhrdvaarnvLveresnegtppfvklsdpglakavnqd.eYylvreerdsripwla  177

         +k+++hrd+a+rn+Lve+e++      vk++d+gl+k+++qd eYy v+e+++s+i+w+a

Q: 969   TKRYIHRDLATRNILVENENR------VKIGDFGLTKVLPQDkEYYKVKEPGESPIFWYA  1022

         *********************......*********************************

S: 178   peclseaknlstasdvWsFgvtlyellt.cskgesp....lrsesle........rklel  224

         pe+l+e+k +s+asdvWsFgv+lyel+t ++k++sp    +r+++++        +++el

Q: 1023  PESLTESK-FSVASDVWSFGVVLYELFTyIEKSKSPpaefMRMIGNDkqgqmivfHLIEL  1081

         ********.*******************************999999999***********

S: 225   leekerlpkpk.cpaelaelmtnclsyepsqrpsFrail  262

         l+++ rlp+p+ cp+e++ +mt+c++++ +qrpsFr+++

Q: 1082  LKNNGRLPRPDgCPDEIYLIMTECWNNNVNQRPSFRNLA  1120

         ************************************995

Domain Sequence
(FASTA)

LKFLQQLGKG NFGSVEMCRY DPLQDNTGEV VAVKKLQHST EEHLRDFERE IEILKSLQHD 60

NIVKYKGVCY SAGRRNLRLI MEYLPYGSLR DYLQKHKERI DHKKLLQYTS QICKGMEYLG 120

TKRYIHRDLA TRNILVENEN RVKIGDFGLT KVLPQDKEYY KVKEPGESPI FWYAPESLTE 180

SKFSVASDVW SFGVVLYELF TYIEKSKSPP AEFMRMIGND KQGQMIVFHL IELLKNNGRL 240

PRPDGCPDEI YLIMTECWNN NVNQRPSFRN LA 272

Keyword

ATP-binding; Complete proteome; Kinase; Nucleotide-binding; Phosphoprotein; Reference proteome; SH2 domain; Transferase; Tyrosine-protein kinase.

Sequence Source

Ensembl

Orthology

Ortholog group

Ailuropoda melanoleuca"; ?>Anolis carolinensis"; ?>Bos taurus"; ?>Callithrix jacchus"; ?>Canis familiaris"; ?>Cavia porcellus"; ?>Ciona intestinalis"; ?>Danio rerio"; ?>Drosophila melanogaster"; ?>Equus caballus"; ?>Felis catus"; ?>Gadus morhua"; ?>Gallus gallus"; ?>Gasterosteus aculeatus"; ?>Gorilla gorilla"; ?>Homo sapiens"; ?>Latimeria chalumnae"; ?>Loxodonta africana"; ?>Macaca mulatta"; ?>Meleagris gallopavo"; ?>Monodelphis domestica"; ?>Mus musculus"; ?>Mustela putorius furo"; ?>Nomascus leucogenys"; ?>Oreochromis niloticus"; ?>Ornithorhynchus anatinus"; ?>Oryctolagus cuniculus"; ?>Oryzias latipes"; ?>Otolemur garnettii"; ?>Pan troglodytes"; ?>Pelodiscus sinensis"; ?>Pongo abelii"; ?>Pteropus vampyrus"; ?>Rattus norvegicus"; ?>Sarcophilus harrisii"; ?>Sus scrofa"; ?>Taeniopygia guttata"; ?>Takifugu rubripes"; ?>Tetraodon nigroviridis"; ?>Xenopus tropicalis"; ?>Xiphophorus maculatus"; ?>

Gene Ontology

GO:0005856	; C:cytoskeleton
GO:0016020	; C:membrane
GO:0005524	; F:ATP binding
GO:0004715	; F:non-membrane spanning protein tyrosine kinase activity
GO:0007243	; P:intracellular protein kinase cascade

KEGG

InterPros

IPR019749	; Band_41_domain.
IPR019748	; FERM_central.
IPR000299	; FERM_domain.
IPR011009	; Kinase-like_dom.
IPR000719	; Prot_kinase_cat_dom.
IPR017441	; Protein_kinase_ATP_BS.
IPR001245	; Ser-Thr/Tyr_kinase_cat_dom.
IPR000980	; SH2.
IPR008266	; Tyr_kinase_AS.
IPR020635	; Tyr_kinase_cat_dom.
IPR016251	; Tyr_kinase_non-rcpt_Jak/Tyk2.
IPR020693	; Tyr_kinase_non-rcpt_Jak2.

Pfam

PF07714	; Pkinase_Tyr; 2.
PF00017	; SH2; 1.

SMARTs

SM00295	; B41; 1.
SM00252	; SH2; 1.
SM00219	; TyrKc; 2.

Prosites

PS50057	; FERM_3; 1.
PS00107	; PROTEIN_KINASE_ATP; 1.
PS50011	; PROTEIN_KINASE_DOM; 2.
PS00109	; PROTEIN_KINASE_TYR; 1.
PS50001	; SH2; 1.

Prints

PR01823	; JANUSKINASE.
PR01825	; JANUSKINASE2.
PR00109	; TYRKINASE.

Created Date

20-Feb-2013