EKS-MYL-00394
Eukaryotic Protein Kinase & Protein Phosphatase Database
TagContent
EKPD IDEKS-MYL-00394
Classification
Group/FamilyScoreE-ValueStartEndDomain Length
TK/Axl547.45.3E-165536801266
StatusUnreviewed
Ensembl ProteinENSMLUP00000011895
UniProt AccessionG1PLY8;
Protein Name
Protein Synonyms/Alias
Gene NameAXL
Gene Synonyms/Alias AXL;
Ensembl Information
Ensembl Gene IDEnsembl Protein IDEnsembl Transcript ID
ENSMLUG00000013069ENSMLUP00000011895ENSMLUT00000013077
OrganismMyotis lucifugus
Functional Description
Protein Length894
Protein Sequence
(FASTA)
SSRAAPRMGR VPLAWWLALC CLVCMAPNGS QAQEDPFVGS PGNITGAREL TGTLQCELLV 60
HGEPPEVTWL RDGQALELAD STQIQVPLGE DEQDDWKVVS KLRILSLQLS DVGWYQCAVV 120
LGGRNFVSQP GYIGLEGLPY FLEEPEDRTV TANTPFNLSC RAQGPPEPVD LFWLQDAVPL 180
AAAKGHTPQH ILHVPGLNKT SSFSCEAHNA KGVTTSRTAI ITVLPQRPHD LHLVSSLPTK 240
LEVVWTPGLS GIYPLTHCTL QAPLQPHPQA LSISLDNQPS PSFVWQVSVP PHKLQLDNLR 300
PHSPYHIRVA CASSQGPSPW THWLPVETPE GVPLGPPKNV TAIRNGSQAI VRWQKPMAPL 360
QGTLLGYRLA YRGQDTPEVL MDIGLKQEVT LELREDRTVP NLTVCVAAYT ASGDGPWSLP 420
VPLELWRPGQ RQPVHQLVSE PPAPSFSWPW WYVLLGAVVA AACVFILALF LIHRRKKETR 480
YGEVFEPTVE RGELVVRYRV RKSYSRRTTE ATLNSLGISE ELKEKLRDVM VDRHKVALGK 540
TLGEGEFGAV MEGQLNQDDS ILKVAVKTMK IAICTRSELE DFLSEAVCMK EFDHPNVMRL 600
IGVCFQGSEL DGFPAPVVIL PFMKHGDLHS FLLYSRLGDQ PVFLPTQMLV KFMADIASGM 660
EYLSTKRFIH RDLAARNCML NENMSVCVAD FGLSKKIYNG DYYRQGRIAK MPVKWIAIES 720
LADRVYTSKS DVWSFGVTMW EIATRGQTPY PGVENSEIYD YLRQGNRLKQ PVDCLDGLYA 780
LMSQCWELNP QDRPSFSQLR EDLENTLKTL PPAQEPDEIL YVNMDEGGSH AEPLGAAGGA 840
DPPTQPDPKD SCSCLTAAEV HPAGRYVLCP STAPGPTLPA DRGSPAPPGQ EDGA 894
Nucleotide Sequence
(FASTA)
AGCTCGCGCG CTGCCCCGAG GATGGGCAGG GTCCCGCTGG CCTGGTGGCT GGCTCTGTGC 60
TGCTTGGTGT GCATGGCCCC CAACGGCTCA CAGGCTCAGG AGGACCCCTT TGTGGGGAGC 120
CCAGGGAACA TCACTGGTGC CCGGGAACTC ACGGGGACCC TTCAGTGTGA GCTTCTGGTT 180
CATGGGGAGC CCCCTGAGGT GACCTGGCTT CGGGATGGAC AGGCCCTGGA GCTGGCAGAC 240
AGCACCCAGA TCCAGGTGCC CCTGGGCGAA GATGAGCAGG ACGACTGGAA AGTGGTCAGC 300
AAGCTCAGGA TCTTGTCCCT GCAGCTCTCG GACGTGGGAT GGTACCAGTG CGCAGTGGTC 360
CTGGGAGGAA GGAACTTTGT GTCCCAGCCC GGCTATATTG GACTGGAGGG CCTGCCCTAC 420
TTCTTGGAGG AGCCTGAGGA CAGGACTGTT ACTGCCAACA CCCCCTTCAA CCTGAGCTGC 480
CGGGCCCAGG GTCCCCCAGA GCCCGTGGAC CTGTTCTGGC TCCAGGATGC TGTCCCCCTG 540
GCTGCGGCCA AGGGCCACAC CCCCCAGCAC ATACTTCATG TTCCAGGCCT GAACAAGACG 600
TCTTCTTTCT CCTGTGAAGC CCATAATGCC AAGGGGGTCA CCACATCCCG CACAGCCATC 660
ATCACAGTGC TTCCCCAGCG GCCCCATGAC CTCCACTTGG TTTCCAGTCT GCCCACAAAG 720
CTGGAGGTGG TTTGGACACC AGGCCTGAGC GGCATCTATC CCCTCACCCA CTGCACCCTG 780
CAGGCTCCCC TCCAACCACA CCCACAAGCC CTCAGCATCT CCCTGGATAA TCAGCCCTCC 840
CCATCTTTTG TGTGGCAAGT ATCCGTCCCC CCTCACAAAC TACAGCTGGA CAACCTCCGT 900
CCTCACAGTC CTTATCACAT CAGGGTGGCA TGTGCCAGTA GCCAGGGCCC CTCACCCTGG 960
ACCCACTGGC TTCCCGTGGA GACGCCTGAG GGAGTGCCTC TGGGCCCCCC TAAGAACGTT 1020
ACCGCCATAC GGAATGGGAG CCAAGCCATC GTGCGTTGGC AGAAGCCAAT GGCACCCCTG 1080
CAGGGCACTC TGTTAGGGTA CCGGCTGGCC TATCGAGGCC AGGACACTCC TGAGGTGCTA 1140
ATGGACATAG GACTAAAGCA AGAGGTGACC CTGGAGCTGC GGGAGGACAG GACTGTGCCC 1200
AACCTGACGG TGTGTGTGGC AGCCTACACC GCCTCTGGAG ATGGACCCTG GAGCCTCCCT 1260
GTGCCCCTAG AGCTTTGGCG CCCAGGGCAA AGACAGCCAG TGCACCAGCT GGTGAGTGAA 1320
CCTCCAGCCC CCTCCTTCTC ATGGCCCTGG TGGTATGTAC TGCTGGGAGC AGTTGTGGCC 1380
GCTGCCTGTG TCTTCATCTT GGCCCTGTTC CTCATCCATC GGCGGAAGAA AGAGACCCGC 1440
TATGGAGAGG TGTTTGAACC AACAGTGGAG AGGGGCGAGC TGGTGGTCAG GTATCGCGTT 1500
CGCAAGTCCT ACAGTCGCCG GACCACTGAA GCCACCTTGA ACAGCCTGGG AATCAGCGAA 1560
GAGTTGAAGG AGAAGCTGCG GGATGTGATG GTGGACCGGC ATAAGGTGGC CCTGGGGAAG 1620
ACCCTGGGGG AAGGAGAGTT TGGAGCTGTG ATGGAGGGCC AGCTCAACCA GGATGACTCC 1680
ATCCTCAAGG TGGCTGTGAA GACAATGAAG ATTGCCATCT GCACAAGGTC GGAGCTGGAG 1740
GATTTCCTGA GTGAAGCTGT CTGCATGAAA GAATTTGACC ACCCAAATGT CATGAGGCTC 1800
ATCGGCGTTT GTTTCCAGGG TTCCGAACTA GATGGCTTCC CTGCACCTGT GGTCATCTTA 1860
CCTTTCATGA AACATGGAGA TCTACACAGC TTCCTTCTCT ATTCTCGACT CGGGGACCAG 1920
CCAGTGTTCC TGCCCACTCA GATGCTGGTG AAGTTTATGG CAGACATTGC CAGTGGCATG 1980
GAGTATTTGA GTACCAAGAG ATTCATACAT CGGGACCTGG CCGCCAGGAA CTGCATGCTG 2040
AATGAGAACA TGTCCGTGTG TGTGGCAGAC TTCGGGCTCT CCAAAAAAAT CTACAATGGG 2100
GACTACTACC GCCAGGGACG TATTGCCAAG ATGCCAGTCA AGTGGATCGC CATTGAGAGC 2160
CTGGCTGACC GTGTCTACAC CAGCAAGAGT GATGTGTGGT CCTTCGGGGT GACAATGTGG 2220
GAAATTGCCA CTCGGGGCCA AACCCCATAT CCAGGAGTGG AGAACAGCGA GATTTATGAC 2280
TACCTGCGTC AGGGAAACCG CCTGAAGCAG CCTGTGGACT GTCTGGATGG ACTGTATGCC 2340
CTGATGTCCC AGTGCTGGGA GCTAAACCCC CAGGACCGGC CAAGTTTTTC ACAGCTACGG 2400
GAAGATCTGG AGAACACACT AAAGACCCTG CCACCTGCCC AGGAGCCTGA TGAAATCCTC 2460
TATGTCAACA TGGATGAGGG TGGGAGTCAT GCTGAACCAC TTGGAGCTGC TGGAGGAGCT 2520
GATCCCCCAA CCCAGCCTGA TCCTAAGGAT TCCTGCAGCT GCCTCACCGC GGCTGAGGTC 2580
CATCCTGCTG GGCGCTATGT CCTCTGCCCT TCTACAGCCC CTGGCCCCAC CCTACCTGCT 2640
GACAGGGGCT CCCCAGCACC ACCAGGGCAG GAGGATGGAG CCTGA 2685
Domain Profile
S: 1     lvlgkvlgegefgsvmegqlkqedgsilkvavktlkldiiarseieeflseaacmkefdh  60
         ++lgk+lgegefg+vmegql+q+d silkvavkt+k++i++rse+e+flsea+cmkefdh
Q: 536   VALGKTLGEGEFGAVMEGQLNQDD-SILKVAVKTMKIAICTRSELEDFLSEAVCMKEFDH  594
         68**********************.***********************************
S: 61    pnvirlvgvslessekgrlpkpvvilpfmkygdlhafllysrlgenpvylplqtlvkfmv  120
         pnv+rl+gv++++se + +p+pvvilpfmk+gdlh+fllysrlg++pv+lp+q+lvkfm+
Q: 595   PNVMRLIGVCFQGSELDGFPAPVVILPFMKHGDLHSFLLYSRLGDQPVFLPTQMLVKFMA  654
         ************************************************************
S: 121   diasgmeylssrnfihrdlaarncmlaedmtvcvadfglskkiysgdyyrqgriaklpvk  180
         diasgmeyls+++fihrdlaarncml+e+m+vcvadfglskkiy+gdyyrqgriak+pvk
Q: 655   DIASGMEYLSTKRFIHRDLAARNCMLNENMSVCVADFGLSKKIYNGDYYRQGRIAKMPVK  714
         ************************************************************
S: 181   wiaiesladrvytsksdvwafgvtmweiatrgqtpyagvenaeiydyllqgnrlkqpedc  240
         wiaiesladrvytsksdvw+fgvtmweiatrgqtpy+gven+eiydyl+qgnrlkqp+dc
Q: 715   WIAIESLADRVYTSKSDVWSFGVTMWEIATRGQTPYPGVENSEIYDYLRQGNRLKQPVDC  774
         ************************************************************
S: 241   ldelydlmyrcweadpkdrpsfsvlre  267
         ld+ly+lm++cwe++p+drpsfs+lre
Q: 775   LDGLYALMSQCWELNPQDRPSFSQLRE  801
         *************************96
Domain Sequence
(FASTA)
VALGKTLGEG EFGAVMEGQL NQDDSILKVA VKTMKIAICT RSELEDFLSE AVCMKEFDHP 60
NVMRLIGVCF QGSELDGFPA PVVILPFMKH GDLHSFLLYS RLGDQPVFLP TQMLVKFMAD 120
IASGMEYLST KRFIHRDLAA RNCMLNENMS VCVADFGLSK KIYNGDYYRQ GRIAKMPVKW 180
IAIESLADRV YTSKSDVWSF GVTMWEIATR GQTPYPGVEN SEIYDYLRQG NRLKQPVDCL 240
DGLYALMSQC WELNPQDRPS FSQLRE 266
KeywordATP-binding; Complete proteome; Immunoglobulin domain; Kinase; Membrane; Nucleotide-binding; Phosphoprotein; Receptor; Reference proteome; Transferase; Transmembrane; Transmembrane helix; Tyrosine-protein kinase.
Sequence SourceEnsembl
Orthology
Ortholog group
Ailuropoda melanoleuca"; ?>Anolis carolinensis"; ?>Bos taurus"; ?>Callithrix jacchus"; ?>Cavia porcellus"; ?>Ciona intestinalis"; ?>Equus caballus"; ?>Gasterosteus aculeatus"; ?>Gorilla gorilla"; ?>Homo sapiens"; ?>Ictidomys tridecemlineatus"; ?>Latimeria chalumnae"; ?>Loxodonta africana"; ?>Macaca mulatta"; ?>Monodelphis domestica"; ?>Mus musculus"; ?>Mustela putorius furo"; ?>Oreochromis niloticus"; ?>Oryctolagus cuniculus"; ?>Oryzias latipes"; ?>Otolemur garnettii"; ?>Pan troglodytes"; ?>Petromyzon marinus"; ?>Pongo abelii"; ?>Rattus norvegicus"; ?>Sarcophilus harrisii"; ?>Takifugu rubripes"; ?>Tetraodon nigroviridis"; ?>Xenopus tropicalis"; ?>Xiphophorus maculatus"; ?>
EKS-AIM-00371
EKS-ANC-00385
EKS-BOT-00398
EKS-CAJ-00402
EKS-CAP-00425
EKS-CII-00235
EKS-EQC-00386
EKS-GAA-00486
EKS-GOG-00386
EKS-HOS-00402
EKS-ICT-00374
EKS-LAC-00413
EKS-LOA-00405
EKS-MAM-00398
EKS-MOD-00383
EKS-MUM-00431
EKS-MUP-00391
EKS-ORN-00509
EKS-ORC-00373
EKS-ORL-00466
EKS-OTG-00401
EKS-PAT-00376
EKS-PEM-00218
EKS-POA-00389
EKS-RAN-00410
EKS-SAH-00366
EKS-TAR-00500
EKS-TEN-00498
EKS-XET-00509
EKS-XIM-00501
Gene Ontology
GO:0016021; C:integral to membrane
GO:0005524; F:ATP binding
GO:0004713; F:protein tyrosine kinase activity
KEGG
InterPros
IPR003961; Fibronectin_type3.
IPR007110; Ig-like.
IPR013783; Ig-like_fold.
IPR003599; Ig_sub.
IPR011009; Kinase-like_dom.
IPR000719; Prot_kinase_cat_dom.
IPR017441; Protein_kinase_ATP_BS.
IPR001245; Ser-Thr/Tyr_kinase_cat_dom.
IPR008266; Tyr_kinase_AS.
IPR020635; Tyr_kinase_cat_dom.
Pfam
PF00041; fn3; 2.
PF07714; Pkinase_Tyr; 1.
SMARTs
SM00060; FN3; 2.
SM00409; IG; 2.
SM00219; TyrKc; 1.
Prosites
PS50853; FN3; 2.
PS50835; IG_LIKE; 2.
PS00107; PROTEIN_KINASE_ATP; 1.
PS50011; PROTEIN_KINASE_DOM; 1.
PS00109; PROTEIN_KINASE_TYR; 1.
Prints
PR00109; TYRKINASE.
Created Date20-Feb-2013