EKS-MYL-00398
Eukaryotic Protein Kinase & Protein Phosphatase Database
TagContent
EKPD IDEKS-MYL-00398
Classification
Group/FamilyScoreE-ValueStartEndDomain Length
TK/PDGFR577.98.3E-174597962366
StatusUnreviewed
Ensembl ProteinENSMLUP00000012051
UniProt AccessionG1PMC9;
Protein NameTyrosine-protein kinase receptor
Protein Synonyms/Alias
Gene NamePDGFRB
Gene Synonyms/Alias PDGFRB;
Ensembl Information
Ensembl Gene IDEnsembl Protein IDEnsembl Transcript ID
ENSMLUG00000013238ENSMLUP00000012051ENSMLUT00000013245
OrganismMyotis lucifugus
Functional Description
Protein Length1110
Protein Sequence
(FASTA)
MLLLSAMPAP ILKGQALLLP LLLLLGPQAS RGLVITPPGP ELVLNVSSTL VLTCLGPDPV 60
VWKRMSKQPP QEMVRTQDGN FSSILTLANV TGTDTGEYFC VYNNSHELEA GEQKRLYIFV 120
PDPTMGFLPI FPEEFFIFLT EVTETTIPCR VTDPQLVVTL HEKKVDDPLP IPYDHQRGFS 180
GTFEDKTYVC KTTIGDKEVD SEPYYVYSLQ ASSINVSMNA AQTVVRQGEN ITITCIVTGN 240
EVVNFEWTYP REESGRLVEP VTDFDIPHIR STLHIPSAEL GDSGTYICNV SESVYDHQDE 300
KAINVTVVES GYVRLLRELD AVQFAELHRS RTLQVVFEAY PPPTVTWLKD NRTLGDSSAG 360
EIALSTRNVS ETRYVSELTL VRVKVAEAGH YTMLAFHEDA EAQVSFQLQI NVPVHVLELS 420
ESHPADGEQT VRCRGRGMPQ PHLTWSICSD LKRCPRELPP TPLGNSSEEA SQLETNVTYW 480
AEEQQFEVVS TLRLRRVDQP LSVRCTLRNL LGDDVQEVTL VPQSVPFKVV VISAILALVV 540
LTIISLIILI MLWQKKPRYE IRWKVIESVS SDGHEYIYVD PMQLPYDSTW ELPRDQLVLG 600
RTLGSGAFGQ VVEATAHGLS HSQATMKVAV KMLKSERPLS LSHSPQSSEK QALMSELKIM 660
SHLGPHLNVV NLLGACTKGG PIYIITEYCR YGDLVDYLHR NKHTFLQHCS DKRRQPGTEL 720
YSNALPVGLP LPSHMSPGES DGGYMDMSKD ESVDYVPMLD MKGDIKYADI ESSNYMAPYD 780
NYVPSAPERT CRATLINESP VLSYTDLVGF SYQVANGMEF LASKNCVHRD LAARNVLICE 840
GKLVKICDFG LARDIMRDSN YISKGSTFLP LKWMAPESIF NSLYTTLSDV WSFGILLWEI 900
FTLGGTPYPE LPMNEQFYNA IKRGYRMAQP AHASDEIYEI MQKCWEEKFE IRPPFSQLVL 960
LLERLLGEGY KKKYQQVDEE FLRSDHPAVL RSQARFPGFH GLRSPLDTSS VLYTAVQPNE 1020
GDNDYIIPLP DPKPEVADEG PLEGSPSLAS STLNEVNTSS TISCDSPLEP QEEPEPEPKP 1080
ESQVQPEAEP EWLPDSSCPG HQAEAEDSFL 1110
Nucleotide Sequence
(FASTA)
ATGCTGCTTC TGAGTGCCAT GCCAGCTCCT ATCCTCAAAG GCCAGGCGCT GCTGCTGCCC 60
CTGCTGTTGT TGCTGGGACC GCAGGCTTCC CGAGGTCTGG TCATCACCCC TCCGGGGCCA 120
GAGCTTGTCC TCAATGTCTC CAGCACCTTG GTTCTGACCT GCTTGGGCCC AGACCCGGTG 180
GTGTGGAAAC GGATGTCCAA GCAGCCTCCG CAAGAAATGG TCAGGACCCA GGATGGCAAT 240
TTCTCCAGCA TCCTGACGCT GGCCAATGTC ACGGGGACAG ACACGGGAGA ATACTTTTGT 300
GTCTATAATA ACTCCCATGA GCTGGAGGCT GGTGAGCAAA AACGGCTCTA CATCTTTGTG 360
CCAGATCCCA CCATGGGCTT CCTCCCGATC TTCCCCGAGG AATTTTTCAT CTTTCTCACG 420
GAAGTAACCG AGACCACCAT CCCATGCCGA GTGACGGACC CACAGCTGGT GGTGACACTG 480
CATGAGAAGA AGGTGGATGA CCCACTGCCC ATCCCCTACG ACCACCAGCG TGGCTTCTCC 540
GGGACCTTTG AGGACAAGAC CTATGTCTGC AAAACCACCA TTGGGGACAA GGAGGTGGAT 600
TCCGAGCCCT ACTATGTCTA CAGCCTTCAG GCGTCATCCA TCAACGTCTC AATGAATGCA 660
GCGCAGACTG TGGTCCGCCA GGGCGAGAAC ATCACCATCA CCTGCATTGT GACTGGGAAC 720
GAGGTCGTCA ACTTCGAGTG GACGTACCCC CGCGAGGAGA GTGGGCGGCT AGTGGAGCCA 780
GTGACCGACT TTGACATTCC CCACATCCGC TCCACCCTGC ACATCCCCAG TGCCGAGCTG 840
GGCGACTCGG GGACCTACAT CTGCAATGTG TCTGAGAGTG TGTACGACCA TCAGGATGAA 900
AAAGCCATCA ACGTCACCGT GGTTGAGAGT GGCTATGTGC GCCTGCTGAG GGAGCTGGAC 960
GCTGTACAGT TCGCGGAATT GCACCGGAGC CGGACCCTGC AGGTGGTGTT CGAGGCCTAC 1020
CCGCCGCCCA CTGTCACGTG GCTCAAGGAC AACCGCACCC TGGGCGACTC CAGCGCCGGC 1080
GAGATCGCCC TGTCCACGCG CAATGTGTCC GAGACTCGGT ATGTGTCAGA ACTGACCCTG 1140
GTGCGGGTGA AGGTGGCTGA GGCCGGTCAC TACACCATGC TGGCCTTCCA TGAGGACGCC 1200
GAGGCCCAGG TCTCCTTCCA GCTGCAAATC AACGTGCCTG TCCATGTGCT GGAGCTGAGT 1260
GAGAGCCATC CTGCCGACGG GGAGCAGACC GTCCGCTGTC GCGGCCGGGG CATGCCTCAG 1320
CCGCACCTCA CCTGGTCTAT CTGCAGTGAC CTCAAAAGGT GTCCGCGTGA GCTGCCACCC 1380
ACACCGCTGG GGAACAGTTC CGAGGAGGCG AGTCAGCTGG AGACTAACGT GACGTACTGG 1440
GCGGAGGAGC AGCAGTTCGA GGTGGTGAGC ACGCTGCGCC TGCGCCGCGT GGATCAGCCG 1500
CTATCAGTGC GCTGCACGCT GCGAAACCTG CTGGGCGATG ATGTGCAGGA GGTCACCCTG 1560
GTGCCCCAGT CCGTGCCCTT CAAGGTGGTG GTGATCTCGG CCATCCTGGC TTTGGTGGTC 1620
CTCACAATCA TCTCCCTCAT CATCCTCATC ATGCTCTGGC AGAAGAAGCC CCGTTATGAG 1680
ATCCGATGGA AGGTGATTGA ATCTGTGAGC TCCGATGGCC ATGAGTACAT CTACGTGGAC 1740
CCTATGCAGC TGCCCTACGA CTCCACCTGG GAGCTGCCCC GGGACCAGCT TGTGCTTGGA 1800
CGTACCCTCG GCTCTGGGGC CTTTGGGCAG GTGGTGGAGG CCACGGCTCA CGGCCTGAGC 1860
CATTCTCAGG CCACTATGAA AGTGGCCGTC AAGATGCTGA AATCTGAGCG CCCTCTCTCC 1920
CTCAGCCACA GCCCGCAGTC TAGCGAGAAG CAAGCCCTCA TGTCAGAGCT GAAGATCATG 1980
AGTCACCTCG GGCCCCACCT GAACGTGGTC AATCTGCTGG GAGCCTGCAC CAAAGGAGGG 2040
CCCATCTACA TCATCACCGA GTACTGCCGC TACGGGGACC TGGTGGACTA CCTGCACCGC 2100
AACAAGCACA CCTTCCTGCA GCACTGCTCC GACAAGCGCC GCCAGCCCGG CACCGAGCTC 2160
TACAGCAACG CTCTGCCTGT CGGGCTCCCG CTGCCCAGCC ACATGTCTCC CGGGGAGAGT 2220
GACGGTGGCT ACATGGACAT GAGCAAGGAC GAATCGGTGG ACTACGTGCC CATGCTGGAC 2280
ATGAAAGGAG ACATCAAATA TGCAGACATC GAGTCCTCCA ACTACATGGC TCCTTACGAT 2340
AACTACGTGC CCTCTGCTCC CGAGAGGACC TGTCGAGCGA CCCTGATCAA CGAGTCCCCG 2400
GTGCTTAGCT ACACGGATCT TGTGGGCTTC AGCTACCAGG TGGCCAATGG CATGGAGTTC 2460
CTGGCCTCCA AGAATTGTGT CCACCGAGAC CTGGCAGCCA GGAATGTGCT CATCTGTGAG 2520
GGCAAGCTGG TCAAAATCTG TGACTTCGGC CTTGCTCGTG ACATCATGCG GGACTCTAAC 2580
TACATCTCCA AAGGCAGCAC CTTCCTGCCG CTGAAGTGGA TGGCCCCCGA GAGCATCTTC 2640
AACAGCCTCT ACACCACCCT GAGCGACGTG TGGTCCTTTG GGATCCTTCT CTGGGAGATC 2700
TTCACCCTGG GTGGCACCCC TTACCCAGAG CTGCCCATGA ACGAGCAGTT TTACAATGCC 2760
ATCAAGCGGG GCTACCGCAT GGCCCAGCCT GCCCACGCCT CCGACGAGAT CTACGAGATC 2820
ATGCAGAAGT GCTGGGAAGA GAAGTTTGAG ATTCGCCCCC CCTTCTCCCA GCTGGTGCTG 2880
CTTCTGGAGA GGCTGCTGGG CGAGGGTTAC AAAAAGAAGT ACCAGCAGGT GGACGAGGAG 2940
TTTCTGAGGA GCGACCACCC GGCTGTCCTT CGGTCCCAAG CCCGCTTCCC TGGCTTCCAT 3000
GGCCTCCGAT CCCCGCTGGA CACCAGCTCA GTCCTCTATA CTGCTGTGCA GCCCAACGAG 3060
GGTGACAATG ACTATATCAT CCCCCTGCCC GACCCCAAAC CCGAGGTTGC TGATGAGGGC 3120
CCATTGGAGG GCTCCCCCAG CCTTGCCAGC TCCACCCTGA ATGAAGTCAA CACCTCCTCG 3180
ACCATCTCCT GTGACAGCCC CCTGGAGCCC CAAGAGGAAC CAGAACCAGA GCCGAAGCCT 3240
GAGTCCCAGG TGCAGCCAGA GGCAGAGCCG GAGTGGCTGC CGGATTCAAG CTGCCCCGGG 3300
CACCAGGCTG AGGCAGAGGA CAGCTTCCTG TAG 3333
Domain Profile
S: 1     lelGkvlGsGafGkvveatayGlsksdavlkvavkmlks........tarssekealmse  52
         l+lG++lGsGafG+vveata+Gls+s+a++kvavkmlks        + +ssek+almse
Q: 597   LVLGRTLGSGAFGQVVEATAHGLSHSQATMKVAVKMLKSerplslshSPQSSEKQALMSE  656
         78************************************83333322235799********
S: 53    lkilshlGehenivnllGactkgGpiyviteyccyGdllnylrrkresflkkslekkkek  112
         lki+shlG+h+n+vnllGactkgGpiy+iteyc+yGdl++yl+r++++fl++ ++k++++
Q: 657   LKIMSHLGPHLNVVNLLGACTKGGPIYIITEYCRYGDLVDYLHRNKHTFLQHCSDKRRQP  716
         ************************************************************
S: 113   eeeldskalladkslrsksslssesseeyvdlkkd................vsdvssska  156
          +el+s+al+++  l s++s   es++ y+d++kd                ++d++ss++
Q: 717   GTELYSNALPVGLPLPSHMSP-GESDGGYMDMSKDesvdyvpmldmkgdikYADIESSNY  775
         *****************9876.59************************************
S: 157   dklasekkksalerevkaaleeedsevleledllsfsyqvakGmeflaskncvhrdlaar  216
         ++++++++ sa er+++a+l++e s vl+++dl+ fsyqva+Gmeflaskncvhrdlaar
Q: 776   MAPYDNYVPSAPERTCRATLINE-SPVLSYTDLVGFSYQVANGMEFLASKNCVHRDLAAR  834
         **********************9.9***********************************
S: 217   nvllteGkvvkicdfGlardimkdsnyvvkGnarlpvkwmapesifdslytvksdvwsyG  276
         nvl++eGk+vkicdfGlardim+dsny++kG+++lp+kwmapesif+slyt+ sdvws+G
Q: 835   NVLICEGKLVKICDFGLARDIMRDSNYISKGSTFLPLKWMAPESIFNSLYTTLSDVWSFG  894
         ************************************************************
S: 277   illweifslGstpypgllvdskfyklikeGyrmaqpayateeiyeimqkcweaepekrps  336
         illweif+lG+tpyp+l+++++fy++ik+Gyrmaqpa+a++eiyeimqkcwe+++e rp+
Q: 895   ILLWEIFTLGGTPYPELPMNEQFYNAIKRGYRMAQPAHASDEIYEIMQKCWEEKFEIRPP  954
         ************************************************************
S: 337   fkqlvell  344
         f+qlv ll
Q: 955   FSQLVLLL  962
         ****9986
Domain Sequence
(FASTA)
LVLGRTLGSG AFGQVVEATA HGLSHSQATM KVAVKMLKSE RPLSLSHSPQ SSEKQALMSE 60
LKIMSHLGPH LNVVNLLGAC TKGGPIYIIT EYCRYGDLVD YLHRNKHTFL QHCSDKRRQP 120
GTELYSNALP VGLPLPSHMS PGESDGGYMD MSKDESVDYV PMLDMKGDIK YADIESSNYM 180
APYDNYVPSA PERTCRATLI NESPVLSYTD LVGFSYQVAN GMEFLASKNC VHRDLAARNV 240
LICEGKLVKI CDFGLARDIM RDSNYISKGS TFLPLKWMAP ESIFNSLYTT LSDVWSFGIL 300
LWEIFTLGGT PYPELPMNEQ FYNAIKRGYR MAQPAHASDE IYEIMQKCWE EKFEIRPPFS 360
QLVLLL 366
KeywordATP-binding; Complete proteome; Disulfide bond; Immunoglobulin domain; Kinase; Membrane; Nucleotide-binding; Phosphoprotein; Receptor; Reference proteome; Repeat; Transferase; Transmembrane; Transmembrane helix; Tyrosine-protein kinase.
Sequence SourceEnsembl
Orthology
Ortholog group
Ailuropoda melanoleuca"; ?>Anolis carolinensis"; ?>Bos taurus"; ?>Callithrix jacchus"; ?>Canis familiaris"; ?>Cavia porcellus"; ?>Danio rerio"; ?>Equus caballus"; ?>Felis catus"; ?>Gallus gallus"; ?>Gasterosteus aculeatus"; ?>Gorilla gorilla"; ?>Homo sapiens"; ?>Ictidomys tridecemlineatus"; ?>Latimeria chalumnae"; ?>Loxodonta africana"; ?>Macaca mulatta"; ?>Meleagris gallopavo"; ?>Monodelphis domestica"; ?>Mus musculus"; ?>Mustela putorius furo"; ?>Nomascus leucogenys"; ?>Ochotona princeps"; ?>Oreochromis niloticus"; ?>Ornithorhynchus anatinus"; ?>Oryctolagus cuniculus"; ?>Oryzias latipes"; ?>Otolemur garnettii"; ?>Pelodiscus sinensis"; ?>Pongo abelii"; ?>Rattus norvegicus"; ?>Sarcophilus harrisii"; ?>Sus scrofa"; ?>Taeniopygia guttata"; ?>Takifugu rubripes"; ?>Tetraodon nigroviridis"; ?>Xenopus tropicalis"; ?>Xiphophorus maculatus"; ?>
EKS-AIM-00377
EKS-ANC-00390
EKS-BOT-00403
EKS-CAJ-00406
EKS-CAF-00403
EKS-CAP-00431
EKS-DAR-00792
EKS-EQC-00395
EKS-FEC-00387
EKS-GAG-00340
EKS-GAA-00491
EKS-GOG-00395
EKS-HOS-00408
EKS-ICT-00382
EKS-LAC-00418
EKS-LOA-00411
EKS-MAM-00401
EKS-MEG-00334
EKS-MOD-00394
EKS-MUM-00434
EKS-MUP-00396
EKS-NOL-00367
EKS-OCP-00083
EKS-ORN-00513
EKS-ORA-00353
EKS-ORC-00377
EKS-ORL-00471
EKS-OTG-00404
EKS-PES-00358
EKS-POA-00393
EKS-RAN-00417
EKS-SAH-00371
EKS-SUS-00358
EKS-TAG-00472
EKS-TAR-00509
EKS-TEN-00510
EKS-XET-00513
EKS-XIM-00505
Gene Ontology
GO:0005887; C:integral to plasma membrane
GO:0005524; F:ATP binding
GO:0005021; F:vascular endothelial growth factor-activated receptor activity
GO:0048010; P:vascular endothelial growth factor receptor signaling pathway
GO:0038084; P:vascular endothelial growth factor signaling pathway
KEGG
InterPros
IPR007110; Ig-like.
IPR013783; Ig-like_fold.
IPR013098; Ig_I-set.
IPR003599; Ig_sub.
IPR003598; Ig_sub2.
IPR013151; Immunoglobulin.
IPR011009; Kinase-like_dom.
IPR000719; Prot_kinase_cat_dom.
IPR017441; Protein_kinase_ATP_BS.
IPR001245; Ser-Thr/Tyr_kinase_cat_dom.
IPR008266; Tyr_kinase_AS.
IPR020635; Tyr_kinase_cat_dom.
IPR016243; Tyr_kinase_CSF1/PDGF_rcpt.
IPR001824; Tyr_kinase_rcpt_3_CS.
IPR009134; Tyr_kinase_VEGFR_rcpt_N.
Pfam
PF07679; I-set; 1.
PF00047; ig; 1.
PF07714; Pkinase_Tyr; 1.
SMARTs
SM00409; IG; 2.
SM00408; IGc2; 1.
SM00219; TyrKc; 1.
Prosites
PS50835; IG_LIKE; 2.
PS00107; PROTEIN_KINASE_ATP; 1.
PS50011; PROTEIN_KINASE_DOM; 1.
PS00109; PROTEIN_KINASE_TYR; 1.
PS00240; RECEPTOR_TYR_KIN_III; 1.
Prints
PR01832; VEGFRECEPTOR.
Created Date20-Feb-2013