EKS-MYL-00468

Eukaryotic Protein Kinase & Protein Phosphatase Database

Tag

Content

EKPD ID

EKS-MYL-00468

Classification

Group/Family	Score	E-Value	Start	End	Domain Length
CAMK/CAMK2	583.0	6.5E-176	14	272	259

Status

Unreviewed

Ensembl Protein

ENSMLUP00000012058

UniProt Accession

G1PMD4;

Protein Name

Protein Synonyms/Alias

Gene Name

CAMK2A

Gene Synonyms/Alias

CAMK2A;

Ensembl Information

Ensembl Gene ID	Ensembl Protein ID	Ensembl Transcript ID
ENSMLUG00000013250	ENSMLUP00000012058	ENSMLUT00000013255

Organism

Myotis lucifugus

Functional Description

Protein Length

511

Protein Sequence
(FASTA)

RMATITCTRF TEEYQLFEEL GKGAFSVVRR CVKVLAGQEY AAKIINTKKL SARDHQKLER 60

EARICRLLKH PNIVRLHDSI SEEGHHYLIF DLVTGGELFE DIVAREYYSE ADASHCIQQI 120

LEAVLHCHQM GVVHRDLKPE NLLLASKLKG AAVKLADFGL AIEVEGEQQA WFGFAGTPGY 180

LSPEVLRKDP YGKPVDLWAC GVILYILLVG YPPFWDEDQH RLYQQIKAGA YDFPSPEWDT 240

VTPEAKDLIN KMLTINPSKR ITAAEALKHP WISHRSTVAS CMHRQETVDC LKKFNARRKL 300

KGAILTTMLA TRNFSGGKSG GNKKNDGVKT YQQTNKQTKT KQNKPTKPYL ITLPLILVSP 360

FVTQESSEST NTTIEDEDTK VRKQEIIKVT EQLIEAISNG DFESYTKMCD PGMTAFEPEA 420

LGNLVEGLDF HRFYFENLWS RNSKPVHTTI LNPHIHLMGD ESACIAYIRI TQYLDAGGIP 480

RTAQSEETRV WHRRDGKWQI VHFHRSGAPS V 511

Nucleotide Sequence
(FASTA)

AGGATGGCCA CCATCACCTG CACCCGCTTC ACGGAAGAGT ACCAGCTCTT CGAGGAATTG 60

GGAAAGGGAG CCTTCTCGGT GGTGCGCAGG TGTGTGAAGG TGCTGGCTGG CCAGGAGTAT 120

GCTGCCAAGA TCATCAACAC CAAGAAACTC TCGGCCAGAG ACCATCAGAA GCTGGAGCGC 180

GAAGCCCGCA TCTGCCGCCT GCTGAAGCAC CCCAACATCG TCCGGCTCCA CGACAGCATC 240

TCCGAGGAGG GGCACCATTA CCTGATCTTC GACCTGGTCA CCGGCGGGGA GCTGTTCGAG 300

GACATCGTGG CCCGGGAATA TTACAGCGAG GCTGATGCCA GTCACTGTAT CCAGCAGATC 360

CTGGAGGCCG TGCTGCACTG CCACCAGATG GGGGTGGTGC ACCGGGACCT GAAGCCGGAG 420

AATCTGCTGC TGGCCTCCAA GCTCAAGGGC GCTGCGGTGA AACTGGCAGA CTTTGGCCTG 480

GCCATAGAGG TGGAGGGGGA GCAGCAGGCA TGGTTCGGGT TTGCTGGGAC ACCTGGATAC 540

CTCTCTCCAG AAGTGCTGCG GAAGGACCCG TACGGGAAGC CCGTGGACCT GTGGGCCTGC 600

GGAGTGATCC TGTACATCCT GCTCGTGGGC TACCCCCCGT TCTGGGATGA GGACCAGCAC 660

CGCTTGTACC AGCAGATCAA AGCTGGCGCC TATGATTTCC CATCACCAGA ATGGGACACC 720

GTCACCCCAG AAGCCAAGGA TCTCATCAAT AAGATGTTGA CCATCAACCC GTCCAAACGC 780

ATCACGGCCG CCGAGGCCCT CAAGCACCCC TGGATCTCGC ACCGGTCCAC CGTGGCCTCC 840

TGCATGCACA GACAGGAGAC CGTGGACTGC CTGAAGAAGT TCAACGCCAG GAGAAAACTG 900

AAGGGAGCCA TCCTCACCAC GATGCTGGCC ACCAGGAACT TCTCTGGAGG GAAGAGCGGA 960

GGAAACAAGA AGAACGATGG TGTGAAGACA TACCAGCAAA CAAACAAACA AACAAAAACA 1020

AAACAAAACA AACCGACAAA ACCCTATCTA ATCACTCTCC CTCTCATCTT GGTATCACCA 1080

TTTGTGACTC AGGAATCTTC AGAGAGCACC AACACCACCA TTGAGGACGA AGACACCAAA 1140

GTGCGGAAAC AGGAAATTAT AAAAGTGACA GAGCAGCTGA TTGAAGCCAT AAGCAATGGA 1200

GATTTTGAGT CCTACACGAA AATGTGTGAC CCCGGGATGA CAGCCTTCGA ACCCGAGGCC 1260

CTGGGGAACC TGGTCGAGGG CCTGGACTTC CATCGATTCT ATTTTGAAAA CCTGTGGTCC 1320

CGGAACAGCA AGCCTGTGCA CACCACCATT TTGAACCCCC ACATCCATCT GATGGGCGAC 1380

GAGTCAGCCT GCATCGCCTA CATCCGTATC ACTCAGTACC TGGACGCCGG CGGCATCCCC 1440

CGCACGGCCC AGTCGGAGGA GACCCGCGTC TGGCACCGCC GGGACGGCAA ATGGCAGATT 1500

GTCCACTTCC ACAGATCGGG GGCGCCCTCT GTC 1533

Domain Profile

S: 1     yqlfeelgkgafsvvrrcvkvttgqeyaakiintkklsardhqklerearicrllkhpni  60

         yqlfeelgkgafsvvrrcvkv +gqeyaakiintkklsardhqklerearicrllkhpni

Q: 14    YQLFEELGKGAFSVVRRCVKVLAGQEYAAKIINTKKLSARDHQKLEREARICRLLKHPNI  73

         9***********************************************************

S: 61    vrlhdsiseegfhylvfdlvtggelfedivareyyseadashciqqilesvlhihqngvv  120

         vrlhdsiseeg+hyl+fdlvtggelfedivareyyseadashciqqile+vlh+hq+gvv

Q: 74    VRLHDSISEEGHHYLIFDLVTGGELFEDIVAREYYSEADASHCIQQILEAVLHCHQMGVV  133

         ************************************************************

S: 121   hrdlkpenlllaskakgaavkladfglaievqgdqqawfgfagtpgylspevlrkdpygk  180

         hrdlkpenlllask+kgaavkladfglaiev+g+qqawfgfagtpgylspevlrkdpygk

Q: 134   HRDLKPENLLLASKLKGAAVKLADFGLAIEVEGEQQAWFGFAGTPGYLSPEVLRKDPYGK  193

         ************************************************************

S: 181   pvdlwacgvilyillvgyppfwdedqhrlyqqikagaydfpspewdtvtpeakdlinkml  240

         pvdlwacgvilyillvgyppfwdedqhrlyqqikagaydfpspewdtvtpeakdlinkml

Q: 194   PVDLWACGVILYILLVGYPPFWDEDQHRLYQQIKAGAYDFPSPEWDTVTPEAKDLINKML  253

         ************************************************************

S: 241   tinpakritadealkhpwi  259

         tinp+krita+ealkhpwi

Q: 254   TINPSKRITAAEALKHPWI  272

         ******************8

Domain Sequence
(FASTA)

YQLFEELGKG AFSVVRRCVK VLAGQEYAAK IINTKKLSAR DHQKLEREAR ICRLLKHPNI 60

VRLHDSISEE GHHYLIFDLV TGGELFEDIV AREYYSEADA SHCIQQILEA VLHCHQMGVV 120

HRDLKPENLL LASKLKGAAV KLADFGLAIE VEGEQQAWFG FAGTPGYLSP EVLRKDPYGK 180

PVDLWACGVI LYILLVGYPP FWDEDQHRLY QQIKAGAYDF PSPEWDTVTP EAKDLINKML 240

TINPSKRITA AEALKHPWI 259

Keyword

ATP-binding; Complete proteome; Kinase; Nucleotide-binding; Reference proteome; Serine/threonine-protein kinase; Transferase.

Sequence Source

Ensembl

Orthology

Ortholog group

Ailuropoda melanoleuca"; ?>Anolis carolinensis"; ?>Bos taurus"; ?>Caenorhabditis elegans"; ?>Callithrix jacchus"; ?>Canis familiaris"; ?>Cavia porcellus"; ?>Choloepus hoffmanni"; ?>Ciona intestinalis"; ?>Danio rerio"; ?>Dipodomys ordii"; ?>Drosophila melanogaster"; ?>Equus caballus"; ?>Felis catus"; ?>Gallus gallus"; ?>Gasterosteus aculeatus"; ?>Gorilla gorilla"; ?>Homo sapiens"; ?>Ictidomys tridecemlineatus"; ?>Loxodonta africana"; ?>Meleagris gallopavo"; ?>Monodelphis domestica"; ?>Mus musculus"; ?>Mustela putorius furo"; ?>Nomascus leucogenys"; ?>Oreochromis niloticus"; ?>Ornithorhynchus anatinus"; ?>Oryctolagus cuniculus"; ?>Oryzias latipes"; ?>Otolemur garnettii"; ?>Pan troglodytes"; ?>Pelodiscus sinensis"; ?>Petromyzon marinus"; ?>Pongo abelii"; ?>Procavia capensis"; ?>Pteropus vampyrus"; ?>Rattus norvegicus"; ?>Sarcophilus harrisii"; ?>Sus scrofa"; ?>Taeniopygia guttata"; ?>Takifugu rubripes"; ?>Tetraodon nigroviridis"; ?>Tursiops truncatus"; ?>Vicugna pacos"; ?>Xenopus tropicalis"; ?>Xiphophorus maculatus"; ?>

Gene Ontology

GO:0005524	; F:ATP binding
GO:0004683	; F:calmodulin-dependent protein kinase activity

KEGG

InterPros

IPR020636	; Ca/CaM-dep_Ca-dep_prot_Kinase.
IPR013543	; Ca/CaM-dep_prot_kinase-assoc.
IPR011009	; Kinase-like_dom.
IPR000719	; Prot_kinase_cat_dom.
IPR017441	; Protein_kinase_ATP_BS.
IPR002290	; Ser/Thr_dual-sp_kinase_dom.
IPR008271	; Ser/Thr_kinase_AS.

Pfam

PF08332	; CaMKII_AD; 1.
PF00069	; Pkinase; 1.

SMARTs

SM00220

; S_TKc; 1.

Prosites

PS00107	; PROTEIN_KINASE_ATP; 1.
PS50011	; PROTEIN_KINASE_DOM; 1.
PS00108	; PROTEIN_KINASE_ST; 1.

Prints

Created Date

20-Feb-2013