EKS-MYL-00267

Eukaryotic Protein Kinase & Protein Phosphatase Database

Tag

Content

EKPD ID

EKS-MYL-00267

Classification

Group/Family	Score	E-Value	Start	End	Domain Length
CMGC/DYRK	470.5	2.8E-141	217	530	314

Status

Unreviewed

Ensembl Protein

ENSMLUP00000012118

UniProt Accession

G1PMI8;

Protein Name

Protein Synonyms/Alias

Gene Name

DYRK2

Gene Synonyms/Alias

DYRK2;

Ensembl Information

Ensembl Gene ID	Ensembl Protein ID	Ensembl Transcript ID
ENSMLUG00000013320	ENSMLUP00000012118	ENSMLUT00000013320

Organism

Myotis lucifugus

Functional Description

Protein Length

596

Protein Sequence
(FASTA)

PSFVSSRAWL PGRGGDSAVR QLQASPALGA GPPRSGVGTG PPSPIALPPL RASNAAAAAH 60

TIGGSKHTMN DHLHVGSHSH GQIQVQQLFE DNSNKRTVLT TQPNGLTTVG KAGLPVVPER 120

QLESIHRRQG SSTSLKSMEG MGKVKATPMT PEQAMKQYMQ KLTTFEHHEI FSYPEIYFLG 180

PNAKKRQGMT GGSNNGGYDD DQGSYVQVPH DHVAYRYEVL KVIGKGSFGQ VVKAYDHKVH 240

QHVALKMVRN EKRFHRQAAE EIRILEHLRK QDKDNTMNVI HMLENFTFRN HICMTFELLS 300

MNLYELIKKN KFQGFSLPLV RKFAHSILQC LDALHKNRII HCDLKPENIL LKQQGRSGIK 360

VIDFGSSCYE HQRVYTYIQS RFYRAPEVIL GARYGMPIDM WSLGCILAEL LTGYPLLPGE 420

DEGDQLACMI ELLGMPSQKL LDASKRAKNF VSSKGYPRYC TVTTLSDGSV VLNGGRSRRG 480

KLRGPPESRE WGNALKGCDD PLFLDFLKQC LEWDPVVRMT PGQALRHPWL RRRLPKPPSG 540

EKMAVKRITE TTGAITSISK LPPPSSSASK LRTNLAQMTD ANGNIQQRTV LPKLVS 596

Nucleotide Sequence
(FASTA)

CCCTCTTTTG TCTCCTCCCG CGCGTGGCTC CCAGGCCGAG GAGGGGACAG CGCCGTTCGT 60

CAGCTTCAGG CTTCCCCGGC GCTCGGAGCG GGCCCCCCCC GGAGCGGAGT GGGGACCGGC 120

CCGCCCTCCC CCATCGCCCT GCCGCCCCTC CGGGCCAGCA ACGCTGCGGC TGCAGCCCAC 180

ACGATTGGTG GCAGTAAGCA CACCATGAAT GATCACCTCC ATGTGGGCAG CCACAGCCAC 240

GGACAGATCC AGGTGCAGCA GCTGTTTGAG GATAACAGCA ACAAGCGGAC AGTGCTCACG 300

ACACAACCCA ATGGGCTTAC AACGGTGGGG AAAGCCGGGT TGCCGGTGGT GCCAGAGCGG 360

CAGCTGGAGA GCATCCATCG ACGGCAGGGG AGCTCCACCT CTCTGAAGTC TATGGAAGGC 420

ATGGGGAAGG TGAAAGCCAC CCCCATGACG CCCGAGCAAG CAATGAAGCA ATACATGCAA 480

AAACTAACCA CCTTTGAGCA CCACGAGATC TTCAGCTACC CTGAAATATA CTTCTTGGGT 540

CCAAATGCAA AGAAGCGCCA GGGCATGACA GGCGGGTCCA ACAACGGTGG CTACGACGAT 600

GACCAGGGAT CCTACGTGCA GGTGCCCCAC GATCACGTGG CTTACAGGTA CGAGGTCCTC 660

AAGGTCATTG GGAAGGGAAG CTTTGGGCAG GTGGTCAAGG CCTACGACCA CAAAGTCCAC 720

CAGCACGTGG CCCTGAAGAT GGTGCGGAAT GAGAAGCGCT TCCACCGGCA GGCGGCGGAG 780

GAGATCCGGA TCCTGGAACA CCTGCGGAAG CAGGACAAGG ACAACACCAT GAACGTCATC 840

CACATGCTGG AGAATTTCAC CTTCCGCAAC CACATCTGTA TGACGTTCGA GCTGCTGAGC 900

ATGAACCTCT ACGAGCTCAT CAAGAAGAAT AAATTCCAGG GCTTCAGCCT GCCTTTGGTG 960

CGCAAGTTCG CCCACTCCAT TCTGCAGTGC TTGGATGCTT TGCACAAAAA CAGAATAATT 1020

CACTGTGACC TTAAGCCCGA GAACATTTTG TTGAAGCAGC AGGGTAGAAG CGGTATCAAA 1080

GTGATCGATT TTGGCTCCAG TTGTTACGAG CATCAGCGCG TCTACACGTA CATTCAGTCC 1140

CGTTTTTACC GGGCTCCGGA AGTGATCCTT GGCGCCAGGT ACGGCATGCC CATCGATATG 1200

TGGAGCCTGG GCTGCATCTT AGCGGAGCTC CTGACCGGGT ACCCCCTCTT GCCTGGGGAA 1260

GATGAAGGGG ACCAGCTGGC CTGTATGATC GAACTGTTGG GCATGCCCTC CCAGAAACTG 1320

TTGGATGCAT CTAAACGAGC CAAAAATTTT GTGAGCTCCA AGGGATATCC CCGTTACTGC 1380

ACTGTCACGA CTCTCTCAGA CGGCTCTGTG GTCCTCAACG GAGGCCGCTC CCGGAGGGGG 1440

AAACTGAGGG GCCCACCAGA GAGCAGAGAG TGGGGGAATG CACTGAAGGG GTGTGATGAT 1500

CCCCTCTTCC TGGACTTCTT GAAACAGTGT TTAGAATGGG ATCCTGTGGT CCGCATGACC 1560

CCCGGCCAGG CTTTGCGGCA TCCCTGGCTG AGGAGGCGGC TGCCAAAGCC TCCCTCCGGG 1620

GAGAAGATGG CAGTGAAAAG GATAACTGAG ACCACTGGTG CTATCACTTC CATTTCCAAG 1680

TTACCTCCAC CTTCCAGCTC CGCTTCCAAA CTGAGGACTA ATTTGGCACA GATGACAGAT 1740

GCCAATGGGA ATATTCAGCA GAGGACAGTC TTGCCAAAAC TTGTTAGC 1788

Domain Profile

S: 1     yevlevigkGsfgqVvkaldkktkeivaikiiknkkrfarqaqeEveiLeklnkkdkeek  60

         yevl+vigkGsfgqVvka+d+k +++va+k+++n+krf+rqa+eE++iLe+l+k+dk+++

Q: 217   YEVLKVIGKGSFGQVVKAYDHKVHQHVALKMVRNEKRFHRQAAEEIRILEHLRKQDKDNT  276

         9***********************************************************

S: 61    ynvvrllelfvfrnhlclvfellsqnLyellkknkfsglslklvrklaqqilkaLklLke  120

         +nv+++le f+frnh+c++fells+nLyel+kknkf+g+sl lvrk+a++il++L++L++

Q: 277   MNVIHMLENFTFRNHICMTFELLSMNLYELIKKNKFQGFSLPLVRKFAHSILQCLDALHK  336

         ************************************************************

S: 121   lkiiHaDlKPeNillvekkrsevkviDFGsssavsqkeiytyiqsrfYraPEiilglkyd  180

         ++iiH+DlKPeNill++++rs +kviDFGss++++q+ +ytyiqsrfYraPE+ilg++y

Q: 337   NRIIHCDLKPENILLKQQGRSGIKVIDFGSSCYEHQR-VYTYIQSRFYRAPEVILGARYG  395

         *************************************.**********************

S: 181   eaiDmWSlGcvlaElftGkpLfpGenevdqlalivevlglppekllekakkakkfftkke  240

         + iDmWSlGc+laEl+tG+pL+pGe+e dqla+++e+lg+p++kll+++k+ak+f+++k+

Q: 396   MPIDMWSLGCILAELLTGYPLLPGEDEGDQLACMIELLGMPSQKLLDASKRAKNFVSSKG  455

         ************************************************************

S: 241   apkyilktkksdrkkklvlnvkkaakkrkaplskelgealkekedklfkdllkrmleldp  300

         +p+y+++t+ sd +++l+ ++++++k r +p+s+e+g+alk ++d lf d+lk++le+dp

Q: 456   YPRYCTVTTLSDGSVVLNGGRSRRGKLRGPPESREWGNALKGCDDPLFLDFLKQCLEWDP  515

         ************************************************************

S: 301   akRitpkealkhpfv  315

           R+tp +al+hp++

Q: 516   VVRMTPGQALRHPWL  530

         **************6

Domain Sequence
(FASTA)

YEVLKVIGKG SFGQVVKAYD HKVHQHVALK MVRNEKRFHR QAAEEIRILE HLRKQDKDNT 60

MNVIHMLENF TFRNHICMTF ELLSMNLYEL IKKNKFQGFS LPLVRKFAHS ILQCLDALHK 120

NRIIHCDLKP ENILLKQQGR SGIKVIDFGS SCYEHQRVYT YIQSRFYRAP EVILGARYGM 180

PIDMWSLGCI LAELLTGYPL LPGEDEGDQL ACMIELLGMP SQKLLDASKR AKNFVSSKGY 240

PRYCTVTTLS DGSVVLNGGR SRRGKLRGPP ESREWGNALK GCDDPLFLDF LKQCLEWDPV 300

VRMTPGQALR HPWL 314

Keyword

ATP-binding; Complete proteome; Nucleotide-binding; Reference proteome.

Sequence Source

Ensembl

Orthology

Ortholog group

Anolis carolinensis"; ?>Bos taurus"; ?>Caenorhabditis elegans"; ?>Callithrix jacchus"; ?>Canis familiaris"; ?>Cavia porcellus"; ?>Choloepus hoffmanni"; ?>Ciona intestinalis"; ?>Ciona savignyi"; ?>Danio rerio"; ?>Dasypus novemcinctus"; ?>Drosophila melanogaster"; ?>Echinops telfairi"; ?>Equus caballus"; ?>Erinaceus europaeus"; ?>Felis catus"; ?>Gadus morhua"; ?>Gallus gallus"; ?>Gasterosteus aculeatus"; ?>Gorilla gorilla"; ?>Homo sapiens"; ?>Ictidomys tridecemlineatus"; ?>Latimeria chalumnae"; ?>Loxodonta africana"; ?>Macaca mulatta"; ?>Meleagris gallopavo"; ?>Mus musculus"; ?>Mustela putorius furo"; ?>Nomascus leucogenys"; ?>Ochotona princeps"; ?>Oreochromis niloticus"; ?>Ornithorhynchus anatinus"; ?>Oryctolagus cuniculus"; ?>Oryzias latipes"; ?>Otolemur garnettii"; ?>Pan troglodytes"; ?>Pelodiscus sinensis"; ?>Petromyzon marinus"; ?>Pongo abelii"; ?>Pteropus vampyrus"; ?>Rattus norvegicus"; ?>Sarcophilus harrisii"; ?>Sorex araneus"; ?>Sus scrofa"; ?>Taeniopygia guttata"; ?>Takifugu rubripes"; ?>Tetraodon nigroviridis"; ?>Tupaia belangeri"; ?>Tursiops truncatus"; ?>Xenopus tropicalis"; ?>Xiphophorus maculatus"; ?>

Gene Ontology

GO:0005524	; F:ATP binding
GO:0004674	; F:protein serine/threonine kinase activity

KEGG

InterPros

IPR011009	; Kinase-like_dom.
IPR000719	; Prot_kinase_cat_dom.
IPR017441	; Protein_kinase_ATP_BS.
IPR002290	; Ser/Thr_dual-sp_kinase_dom.
IPR008271	; Ser/Thr_kinase_AS.

Pfam

PF00069

; Pkinase; 1.

SMARTs

SM00220

; S_TKc; 1.

Prosites

PS00107	; PROTEIN_KINASE_ATP; 1.
PS50011	; PROTEIN_KINASE_DOM; 1.
PS00108	; PROTEIN_KINASE_ST; 1.

Prints

Created Date

20-Feb-2013