EKS-MYL-00273

Eukaryotic Protein Kinase & Protein Phosphatase Database

Tag

Content

EKPD ID

EKS-MYL-00273

Classification

Group/Family	Score	E-Value	Start	End	Domain Length
CMGC/DYRK	438.2	1.9E-131	117	437	321

Status

Unreviewed

Ensembl Protein

ENSMLUP00000012233

UniProt Accession

G1PMU2;

Protein Name

Protein Synonyms/Alias

Gene Name

DYRK1B

Gene Synonyms/Alias

DYRK1B;

Ensembl Information

Ensembl Gene ID	Ensembl Protein ID	Ensembl Transcript ID
ENSMLUG00000013441	ENSMLUP00000012233	ENSMLUT00000013446

Organism

Myotis lucifugus

Functional Description

Protein Length

635

Protein Sequence
(FASTA)

MAVPPGHGPF SGFPGPQEHT QVCARYGPNC QLFAEEGVPL GVRGCKPRPR CSKLSVDLIK 60

TYKHINEVYY AKKKRRAQQA PPQDSSTKKE KKVLNHGYDD DNHDYIVRSG ERWLERYEID 120

SLIGKGSFGQ VVKAYDHQTQ ELVAIKIIKN KKAFLNQAQI ELRLLELMNQ HDTEMKYYIV 180

HLKRHFMFRN HLCLVFELLS YNLYDLLRNT HFRGVSLNLT RKLAQQLCTA LLFLATPELS 240

IIHCDLKPEN ILLCNPKRSA IKIVDFGSSC QLGQRIYQYI QSRFYRSPEV LLGTPYDLAI 300

DMWSLGCILV EMHTGEPLFS GSNEVDQMNR IVEVLGIPPA PMLDQAPKAR KYFERLPGGG 360

WTLRRTKELR KDYQGPGTRR LQEVLGVQTG GPGGRRAGEP GHSPADYLRF QDLVLRMLEY 420

EPAARISPLG ALQHGFFRRT ADEATNTGPA GSSASTSPAP LDTCPSSSTA SSISSSGGSS 480

GSSNDNRTYR YSNRYCGGPG PSITDCEMNS PKVPLSQPMR PWAGGDVPHK THQAPASASS 540

LPGAGTQLPP QPRCLGRPPS PTSPPPPELM DVSLVGGPPD CSPLHPAPAP QHSAASALRT 600

RMTGGRPPLP PPDDPATLGP RLGLRGVPQS TAASS 635

Nucleotide Sequence
(FASTA)

ATGGCCGTCC CACCGGGCCA TGGTCCCTTC TCTGGCTTCC CAGGGCCCCA GGAACACACA 60

CAGGTATGTG CAAGGTATGG CCCTAACTGT CAGCTCTTTG CCGAGGAGGG CGTTCCCCTG 120

GGCGTTCGGG GATGCAAACC ACGGCCCCGA TGCAGCAAGC TCTCCGTGGA CCTCATCAAG 180

ACCTACAAGC ACATCAATGA GGTCTACTAT GCAAAGAAGA AGCGGCGGGC CCAGCAGGCT 240

CCTCCTCAGG ACTCAAGCAC CAAGAAGGAG AAGAAGGTCC TGAACCACGG TTATGACGAT 300

GACAACCATG ACTACATAGT GCGCAGTGGC GAGCGCTGGC TGGAGCGTTA TGAGATTGAC 360

TCCCTCATTG GCAAAGGCTC CTTTGGCCAG GTGGTGAAAG CCTATGATCA TCAGACCCAG 420

GAACTGGTGG CCATCAAGAT CATCAAGAAC AAAAAGGCCT TCCTGAACCA GGCCCAGATT 480

GAGCTGCGGC TGCTGGAGTT GATGAACCAG CATGACACGG AGATGAAGTA CTACATCGTG 540

CACCTGAAGC GGCACTTCAT GTTCCGGAAC CACCTGTGCC TGGTGTTCGA GCTGCTTTCC 600

TACAACCTGT ATGACCTCCT GCGCAACACG CATTTCCGGG GTGTCTCGCT GAACCTGACA 660

CGGAAGTTGG CGCAGCAGCT CTGCACGGCG CTTCTCTTCC TGGCCACGCC CGAGCTTAGC 720

ATCATTCACT GCGACCTCAA GCCTGAGAAC ATCCTGCTCT GCAACCCCAA GCGCAGTGCC 780

ATCAAGATCG TGGACTTCGG CAGTTCCTGC CAGCTTGGCC AGCGGATTTA CCAGTACATC 840

CAGAGCCGCT TCTACCGGTC ACCCGAGGTG CTCCTGGGCA CGCCCTATGA CCTGGCCATT 900

GACATGTGGT CCCTGGGCTG CATCCTGGTG GAGATGCACA CCGGAGAGCC CCTTTTTAGT 960

GGCTCCAATG AGGTGGACCA AATGAATCGG ATTGTGGAGG TGTTGGGCAT CCCACCAGCT 1020

CCCATGCTAG ACCAGGCACC CAAGGCTCGC AAGTACTTTG AACGGCTGCC TGGGGGTGGC 1080

TGGACCCTAC GGAGGACAAA GGAACTCAGG AAGGATTACC AGGGCCCTGG GACACGGCGG 1140

CTGCAGGAGG TGCTGGGCGT GCAGACGGGC GGGCCCGGGG GCCGGCGGGC GGGGGAGCCG 1200

GGCCACAGCC CCGCCGACTA CCTCCGCTTC CAGGACCTGG TGCTGCGCAT GCTGGAGTAT 1260

GAGCCCGCCG CCCGCATCAG CCCACTGGGG GCTCTGCAGC ATGGCTTCTT TCGCCGCACG 1320

GCAGATGAAG CCACCAACAC AGGCCCGGCA GGCAGCAGTG CCTCCACCTC GCCCGCCCCC 1380

CTCGACACCT GCCCCTCCTC CAGCACCGCC AGCTCCATCT CCAGCTCTGG AGGCTCCAGT 1440

GGCTCCTCCA ATGACAACCG GACCTACCGC TACAGCAACC GATATTGTGG GGGCCCTGGG 1500

CCCTCCATCA CTGACTGTGA GATGAACAGC CCCAAGGTCC CACTCTCCCA GCCGATGCGC 1560

CCCTGGGCAG GCGGTGATGT GCCCCACAAG ACACATCAAG CCCCCGCCTC TGCATCATCA 1620

CTGCCAGGGG CTGGCACCCA GTTACCCCCC CAACCCCGAT GCCTTGGCCG TCCTCCATCA 1680

CCAACCTCAC CACCACCTCC GGAGCTGATG GATGTGAGCC TGGTGGGCGG CCCTCCTGAC 1740

TGCTCCCCAC TCCATCCAGC GCCTGCCCCC CAGCACTCGG CTGCCTCAGC CCTCCGGACT 1800

CGGATGACAG GAGGTCGTCC ACCCCTCCCA CCCCCTGATG ACCCTGCCAC TCTGGGGCCT 1860

CGCTTGGGCC TTCGTGGTGT ACCCCAGAGT ACGGCAGCCA GCTCATGA 1908

Domain Profile

S: 1     yevlevigkGsfgqVvkaldkktkeivaikiiknkkrfarqaqeEveiLeklnkkdkeek  60

         ye++++igkGsfgqVvka+d++t+e vaikiiknkk+f++qaq+E+++Le +n++d+e+k

Q: 117   YEIDSLIGKGSFGQVVKAYDHQTQELVAIKIIKNKKAFLNQAQIELRLLELMNQHDTEMK  176

         9***********************************************************

S: 61    ynvvrllelfvfrnhlclvfellsqnLyellkknkfsglslklvrklaqqilkaLklLk.  119

         y++v+l+++f+frnhlclvfells+nLy+ll++++f+g+sl+l+rklaqq+++aL +L+

Q: 177   YYIVHLKRHFMFRNHLCLVFELLSYNLYDLLRNTHFRGVSLNLTRKLAQQLCTALLFLAt  236

         **********************************************************99

S: 120   .elkiiHaDlKPeNillvekkrsevkviDFGsssavsqkeiytyiqsrfYraPEiilglk  178

          el+iiH+DlKPeNill+++krs++k++DFGss++  q+ iy+yiqsrfYr+PE++lg++

Q: 237   pELSIIHCDLKPENILLCNPKRSAIKIVDFGSSCQLGQR-IYQYIQSRFYRSPEVLLGTP  295

         99*************************************.********************

S: 179   ydeaiDmWSlGcvlaElftGkpLfpGenevdqlalivevlglppekllekakkakkfftk  238

         yd aiDmWSlGc+l+E++tG+pLf+G+nevdq++ ivevlg+pp+ +l++a ka+k+f++

Q: 296   YDLAIDMWSLGCILVEMHTGEPLFSGSNEVDQMNRIVEVLGIPPAPMLDQAPKARKYFER  355

         ************************************************************

S: 239   keapkyilktk.........ksdrkkklvlnvkkaakkrkaplskelgealkekedkl.f  288

              ++l+++          ++r+ ++vl+v++ +     p+ +++ge+ ++ +d+l f

Q: 356   LPGGGWTLRRTkelrkdyqgPGTRRLQEVLGVQTGG-----PGGRRAGEPGHSPADYLrF  410

         ********9997888888777778888888887777.....99*****************

S: 289   kdllkrmleldpakRitpkealkhpfv  315

         +dl+ rmle++pa+Ri+p  al+h f+

Q: 411   QDLVLRMLEYEPAARISPLGALQHGFF  437

         *************************97

Domain Sequence
(FASTA)

YEIDSLIGKG SFGQVVKAYD HQTQELVAIK IIKNKKAFLN QAQIELRLLE LMNQHDTEMK 60

YYIVHLKRHF MFRNHLCLVF ELLSYNLYDL LRNTHFRGVS LNLTRKLAQQ LCTALLFLAT 120

PELSIIHCDL KPENILLCNP KRSAIKIVDF GSSCQLGQRI YQYIQSRFYR SPEVLLGTPY 180

DLAIDMWSLG CILVEMHTGE PLFSGSNEVD QMNRIVEVLG IPPAPMLDQA PKARKYFERL 240

PGGGWTLRRT KELRKDYQGP GTRRLQEVLG VQTGGPGGRR AGEPGHSPAD YLRFQDLVLR 300

MLEYEPAARI SPLGALQHGF F 321

Keyword

ATP-binding; Complete proteome; Nucleotide-binding; Reference proteome.

Sequence Source

Ensembl

Orthology

Ortholog group

Ailuropoda melanoleuca"; ?>Anolis carolinensis"; ?>Bos taurus"; ?>Callithrix jacchus"; ?>Canis familiaris"; ?>Cavia porcellus"; ?>Dipodomys ordii"; ?>Equus caballus"; ?>Felis catus"; ?>Homo sapiens"; ?>Ictidomys tridecemlineatus"; ?>Loxodonta africana"; ?>Macaca mulatta"; ?>Monodelphis domestica"; ?>Mus musculus"; ?>Mustela putorius furo"; ?>Nomascus leucogenys"; ?>Otolemur garnettii"; ?>Pan troglodytes"; ?>Pongo abelii"; ?>Procavia capensis"; ?>Rattus norvegicus"; ?>Sus scrofa"; ?>Schizosaccharomyces pombe"; ?>

Gene Ontology

GO:0005524	; F:ATP binding
GO:0004674	; F:protein serine/threonine kinase activity

KEGG

InterPros

IPR011009	; Kinase-like_dom.
IPR000719	; Prot_kinase_cat_dom.
IPR017441	; Protein_kinase_ATP_BS.
IPR002290	; Ser/Thr_dual-sp_kinase_dom.
IPR008271	; Ser/Thr_kinase_AS.

Pfam

PF00069

; Pkinase; 1.

SMARTs

SM00220

; S_TKc; 1.

Prosites

PS00107	; PROTEIN_KINASE_ATP; 1.
PS50011	; PROTEIN_KINASE_DOM; 1.
PS00108	; PROTEIN_KINASE_ST; 1.

Prints

Created Date

20-Feb-2013