EKS-MYL-00388

Eukaryotic Protein Kinase & Protein Phosphatase Database

Tag

Content

EKPD ID

EKS-MYL-00388

Classification

Group/Family	Score	E-Value	Start	End	Domain Length
STE/STE11	344.8	4.0E-103	1281	1539	259

Status

Unreviewed

Ensembl Protein

ENSMLUP00000013189

UniProt Accession

G1PQ59;

Protein Name

Protein Synonyms/Alias

Gene Name

MAP3K4

Gene Synonyms/Alias

MAP3K4;

Ensembl Information

Ensembl Gene ID	Ensembl Protein ID	Ensembl Transcript ID
ENSMLUG00000014478	ENSMLUP00000013189	ENSMLUT00000014500

Organism

Myotis lucifugus

Functional Description

Protein Length

1546

Protein Sequence
(FASTA)

RPECALGDSA SKNSESDVEE FSDETNTENL FGASPPSTPR QMKRLSTKHQ RNNVGRPVSR 60

SNLKEKTNAL NQPPHKDTGK IGEKKIRAAI RTTERDHKKN VQCSFMLDSV SGSLPKKPIP 120

DVDLNKPYLS LGCSNAKLPV SVPMPIARTA RQTSRTDCPA DRLKFFETLR LLLKLTSVSK 180

KKDREQRGQE NTSAFSFNRS NELIWLELQA WHAGRTINDQ DLFLYTARQA IPDIINEILT 240

FKVNYGSVAF VRNGAGCNGA PVEGQCPAPH GTRIVGYPTY HEHLQRQRVS FEQVKRIMEL 300

LEYIEALYPS LQALQKDYEK YAAKDFQDRV QALCLWLNIT KDLNQKLRIM GTVLGIQNLS 360

DIGWPVFEIS SPRSSKGNEP EDEGDDTEGE LRELESSSDE SEEQTSNPRA PKTRQPLDNT 420

FCFPSQDCPA KRLERLESEE DSVGWGAPDC STEAGCSRHC LTSIYRPFVD KALKQMGLRK 480

LILRLHKLMD GSLQRARVAL VKSDRPVEFS EFPDPMWGSD YVQLTRLPAA SEPKCSAVSW 540

AELEAMDLPS FEPAFLVLCR VLLNVIHECL KLRLEQRPAG EPSLLSIKQL VRECKEVLKG 600

GLLMKQYYQF MLHGVRHGLE KADCNMDAFE EDLQEMLMVY FDYMRSWIQM LQQLPQASHS 660

LKNLLEEEWN FTKEITHYIR GGEAQAGKLF CDIAGMLLKS TGSFLEVGLQ ESCAEFWTSA 720

DDSSASDEIR RSVVEISRAL KELFHEARER ASKALGFAKM LRKDLEIAAE FTLSAPIRDL 780

LEVLKSKQYV KVQIPGLENL QVFVPDTVAE QKSFILALLN AAAGGKDCSK DTDYVLLLDA 840

HLLLTKHSDL AGNSWATWEA PPVKIVPQVE TVETLRSMQV DNLLLVVMQS AHLLIQRKAF 900

QQSIEGLLTL RQEQTSSQPI IAKALQQLKN DALELCNRIS DAIDRVDHMF TSEFDAEVDE 960

SESVTLQQYH REAMIQGYNF GFEYHKEVVR LMSGEFRQKI GDKYISFARK WMNYVLTKCE 1020

SGRGTRPRWA TQGFDFLQAI EPAFISALPE DDFLSLQALM NECIGHVIGK PHSPVTAIHR 1080

NSPRPVKVPR CHSDPPNPHL IIPTPEGFST RSVPSDARSH GPAGAGGDSA PPRPNSSAHD 1140

ASPSGGDSCF LHPSLSPPKD HNRGSSVPEN DRLASVAAEL QFRSLSRHSS PTEERDEPAY 1200

PKGDSSGSAR RSWELRTLIS QTKDTASKQG PMEAVQKSVR LFEEKRYREM RRKNIIGQVC 1260

DTPKSYDNVM HVGLRKVTFK WQRGNKIGEG QYGKVYTCIS VDTGELMAMK EIRFQPNDHK 1320

TIKETADELK IFEGIKHPNL VRYFGVELHR EEMYIFMEYC DEGTLEEVSR LGLQEHVIRL 1380

YSKQITVAIN VLHEHGIVHR DIKGANIFLT SSGLIKLGDF GCSVKLKNNA QTMPGEVNST 1440

LGTAAYMAPE VITRAKGEGH GRAADIWSLG CVVIEMVTGK RPWHEYEHNF QIMYKVGMGH 1500

KPPIPERLSL EGKDFLSHCL ESEPRLRWTA SQLLDHSFVK VCTDEE 1546

Nucleotide Sequence
(FASTA)

AGGCCAGAGT GCGCACTGGG AGATTCGGCT AGCAAGAATT CGGAATCTGA CGTGGAGGAG 60

TTTTCAGATG AAACTAATAC AGAGAACCTT TTTGGCGCCT CTCCCCCCAG TACACCTCGG 120

CAGATGAAAC GCCTGTCAAC CAAACACCAG AGGAATAATG TAGGGAGGCC TGTCAGTCGC 180

TCCAATTTGA AAGAAAAAAC AAATGCATTG AACCAGCCTC CACATAAAGA CACTGGGAAA 240

ATCGGGGAGA AAAAGATCCG AGCGGCCATT AGGACGACAG AGCGCGATCA TAAGAAAAAT 300

GTGCAGTGCT CCTTCATGTT GGACTCAGTG AGTGGGTCTC TGCCCAAAAA GCCGATCCCA 360

GATGTGGATC TCAATAAGCC TTACCTCAGT CTCGGCTGCA GCAACGCCAA GCTTCCCGTG 420

TCTGTGCCCA TGCCTATCGC GAGAACTGCA CGCCAGACTT CCAGGACCGA CTGTCCAGCA 480

GATCGCTTGA AGTTTTTTGA AACTTTACGA CTTCTGCTAA AGCTTACCTC AGTCTCAAAG 540

AAGAAGGACA GGGAGCAAAG AGGACAGGAA AATACATCTG CTTTCTCATT CAACCGGTCG 600

AATGAGCTCA TCTGGTTAGA GCTACAAGCC TGGCATGCGG GACGGACCAT TAACGACCAG 660

GACCTCTTTT TATATACAGC CCGTCAAGCC ATACCAGATA TTATCAACGA AATCCTTACT 720

TTCAAAGTCA ATTATGGGAG CGTTGCCTTT GTTAGAAATG GAGCTGGTTG CAATGGTGCC 780

CCGGTGGAAG GACAGTGCCC GGCCCCTCAC GGAACGAGGA TTGTGGGTTA TCCCACGTAT 840

CATGAGCATC TCCAGCGCCA GAGGGTGTCA TTTGAGCAGG TGAAGCGGAT AATGGAGCTG 900

CTAGAGTACA TAGAAGCACT TTATCCATCG CTGCAGGCTC TGCAGAAGGA CTATGAGAAA 960

TATGCTGCCA AGGACTTCCA GGACAGAGTG CAGGCACTCT GCTTGTGGTT AAACATCACA 1020

AAAGACTTAA ATCAGAAACT AAGGATTATG GGCACTGTTT TGGGCATCCA GAACTTATCA 1080

GACATTGGCT GGCCAGTGTT TGAAATCTCT TCCCCTAGAT CGTCCAAAGG CAATGAGCCA 1140

GAAGATGAGG GAGATGACAC AGAAGGAGAA TTGAGAGAGT TGGAAAGTAG CTCGGATGAG 1200

AGTGAAGAAC AGACCTCTAA TCCAAGGGCG CCAAAAACCA GGCAGCCCCT CGACAACACT 1260

TTCTGCTTCC CGTCGCAGGA CTGCCCCGCC AAGCGGCTGG AGAGGCTCGA ATCGGAGGAG 1320

GACTCTGTTG GCTGGGGAGC GCCGGACTGC AGCACCGAGG CCGGCTGTAG CAGACATTGT 1380

CTGACTTCTA TTTATCGACC ATTTGTAGAC AAAGCACTGA AGCAGATGGG GTTGAGAAAG 1440

TTAATTTTGA GACTTCACAA GCTGATGGAT GGTTCCTTGC AAAGGGCCCG GGTAGCGCTG 1500

GTAAAGAGTG ACCGTCCGGT GGAGTTTTCT GAGTTTCCAG ATCCCATGTG GGGCTCCGAT 1560

TATGTGCAGC TGACCCGGTT GCCCGCTGCT TCCGAGCCGA AGTGCAGCGC TGTGTCCTGG 1620

GCCGAGCTCG AGGCCATGGA CTTACCCTCC TTCGAACCTG CCTTCCTGGT CCTCTGCCGG 1680

GTCCTCCTGA ATGTCATCCA CGAATGCCTC AAGCTGAGAT TGGAGCAGAG ACCTGCGGGA 1740

GAGCCGTCTC TCTTGAGTAT TAAGCAGCTG GTCCGAGAGT GTAAGGAGGT GCTGAAGGGC 1800

GGCCTTCTGA TGAAGCAGTA CTACCAGTTC ATGCTGCATG GCGTCCGGCA CGGCCTGGAG 1860

AAGGCCGACT GCAACATGGA CGCCTTCGAG GAGGACCTGC AGGAGATGCT GATGGTATAT 1920

TTTGATTACA TGAGAAGCTG GATCCAAATG CTACAGCAGT TACCTCAAGC ATCCCACAGT 1980

TTAAAAAATC TGTTAGAAGA AGAATGGAAT TTCACCAAAG AAATAACCCA TTACATCCGG 2040

GGAGGAGAGG CCCAGGCTGG GAAACTTTTC TGCGACATTG CAGGGATGCT GCTGAAGTCC 2100

ACGGGCAGCT TCCTGGAGGT CGGCCTGCAG GAGAGCTGTG CGGAGTTCTG GACCAGTGCC 2160

GATGACAGCA GTGCTTCGGA TGAAATCAGG CGGTCTGTGG TGGAGATCAG CCGGGCCCTG 2220

AAGGAGCTCT TCCACGAGGC TCGGGAGCGA GCCTCCAAGG CACTCGGCTT TGCTAAAATG 2280

CTGAGAAAGG ACCTGGAAAT AGCTGCCGAG TTCACCCTTT CAGCCCCCAT TAGAGACCTT 2340

CTGGAGGTCC TGAAATCAAA GCAGTACGTC AAAGTGCAGA TTCCTGGCTT AGAGAACTTG 2400

CAGGTGTTTG TCCCAGACAC TGTCGCCGAG CAGAAGAGTT TTATCCTGGC CTTACTCAAC 2460

GCCGCCGCGG GAGGAAAGGA CTGCTCCAAG GACACGGACT ACGTGCTGTT GCTCGACGCC 2520

CACCTCCTCC TCACCAAGCA CAGCGACCTC GCAGGCAACA GCTGGGCCAC GTGGGAGGCG 2580

CCGCCTGTGA AAATCGTGCC TCAGGTGGAG ACCGTGGAGA CCCTGAGAAG CATGCAGGTG 2640

GACAACCTGC TGCTGGTTGT CATGCAGTCT GCACACCTCC TCATCCAGAG GAAAGCCTTC 2700

CAGCAGTCCA TTGAGGGGCT CCTGACCCTG CGCCAGGAGC AGACGTCCAG CCAGCCCATC 2760

ATCGCCAAGG CTCTGCAGCA GCTCAAGAAT GATGCATTAG AACTTTGCAA CAGAATAAGT 2820

GATGCCATTG ACCGAGTGGA CCACATGTTC ACTTCAGAAT TTGATGCTGA AGTCGACGAA 2880

TCGGAATCTG TCACGCTGCA GCAGTACCAC CGAGAGGCCA TGATTCAGGG CTACAATTTT 2940

GGGTTCGAGT ATCATAAAGA AGTTGTTCGT CTGATGTCTG GAGAATTTAG ACAGAAGATT 3000

GGAGACAAAT ATATAAGCTT TGCCCGGAAA TGGATGAATT ATGTCCTGAC TAAGTGTGAG 3060

AGTGGGAGAG GCACCAGACC CAGGTGGGCA ACTCAAGGTT TTGACTTTCT GCAAGCCATT 3120

GAACCTGCCT TCATTTCAGC TTTACCAGAA GATGACTTCT TGAGTTTACA AGCCTTGATG 3180

AACGAATGCA TTGGCCACGT GATAGGAAAG CCGCACAGTC CTGTTACAGC CATTCATCGG 3240

AACAGCCCCC GTCCTGTGAA GGTGCCGCGA TGCCACAGCG ACCCTCCTAA CCCCCACCTC 3300

ATCATCCCCA CTCCGGAGGG ATTCAGCACT CGGAGCGTGC CTTCGGACGC GCGCAGCCAC 3360

GGCCCCGCCG GTGCAGGCGG CGACTCCGCG CCACCCAGAC CCAACAGCAG TGCCCATGAC 3420

GCCAGTCCTT CAGGTGGTGA CTCGTGTTTT CTACACCCCT CCCTGTCACC CCCTAAAGAC 3480

CACAACAGGG GTTCCAGTGT CCCTGAAAAC GACCGGCTGG CTTCCGTCGC AGCTGAGCTG 3540

CAGTTCAGGT CCCTGAGTCG CCACTCCAGC CCCACCGAGG AGCGAGATGA ACCAGCATAT 3600

CCAAAAGGTG ATTCCAGTGG GTCGGCCCGA AGAAGTTGGG AACTTCGGAC GCTGATCAGC 3660

CAGACGAAAG ACACCGCTTC TAAACAAGGG CCCATGGAAG CCGTCCAGAA GTCCGTCCGG 3720

CTCTTTGAAG AAAAGAGGTA CCGAGAGATG AGGAGGAAGA ACATCATTGG TCAAGTGTGT 3780

GATACCCCCA AATCGTACGA TAACGTCATG CATGTTGGCC TGAGAAAGGT GACCTTCAAG 3840

TGGCAAAGAG GAAACAAAAT TGGAGAAGGG CAGTACGGGA AGGTCTACAC CTGCATCAGC 3900

GTTGACACGG GCGAGCTGAT GGCCATGAAG GAGATCCGGT TTCAGCCCAA CGACCACAAG 3960

ACGATCAAGG AAACCGCGGA CGAGTTGAAG ATATTTGAGG GCATCAAGCA CCCCAACCTG 4020

GTGCGCTACT TTGGAGTGGA GCTGCACAGG GAGGAGATGT ACATCTTCAT GGAGTACTGC 4080

GACGAGGGCA CGCTGGAGGA GGTGTCCCGG CTGGGCCTGC AGGAGCACGT CATCCGGCTC 4140

TACTCCAAGC AGATCACTGT GGCCATCAAC GTGCTGCACG AGCACGGCAT AGTGCACCGC 4200

GACATCAAAG GCGCCAATAT CTTCCTTACC TCCTCGGGGC TGATCAAGCT GGGAGACTTC 4260

GGGTGCTCGG TGAAGCTTAA AAACAACGCC CAGACCATGC CCGGGGAAGT GAACAGCACG 4320

CTGGGGACCG CAGCGTACAT GGCTCCTGAA GTCATCACTC GTGCGAAGGG AGAAGGTCAC 4380

GGGCGTGCGG CCGACATCTG GAGCCTCGGG TGTGTCGTCA TAGAGATGGT GACTGGCAAG 4440

AGGCCTTGGC ATGAATATGA GCACAACTTT CAGATCATGT ATAAAGTGGG CATGGGGCAC 4500

AAGCCCCCGA TCCCTGAGCG GCTGAGCCTG GAGGGAAAGG ACTTCCTCTC CCACTGCCTG 4560

GAGAGCGAGC CGCGGCTGCG CTGGACGGCC AGCCAGCTCC TCGACCACTC CTTCGTCAAG 4620

GTTTGCACCG ATGAGGAATG A 4641

Domain Profile

S: 1     wqkrevigkGsfgsvyaaldvdtgellavKeveikpekksekkevkalkeEikllkelkH  60

         wq+++ ig+G++g+vy++++vdtgel+a+Ke++++p++++   ++k+ ++E+k+++ +kH

Q: 1281  WQRGNKIGEGQYGKVYTCISVDTGELMAMKEIRFQPNDHK---TIKETADELKIFEGIKH  1337

         99********************************999876...799**************

S: 61    enivkyyGveveeeelkiflEyvegGslssllekygkleesvikkytkqileglayLHek  120

         +n+v+y+Gve ++ee++if+Ey+++G+l+++ +    l+e+vi+ y+kqi  ++++LHe+

Q: 1338  PNLVRYFGVELHREEMYIFMEYCDEGTLEEVSRL--GLQEHVIRLYSKQITVAINVLHEH  1395

         *******************************884..7***********************

S: 121   kivHRDiKgaNilldssgvvklsDFGaskrlaelntka.aelesltGtlaymaPEvikk.  178

         +ivHRDiKgaNi+l+ssg++kl+DFG+s +l+++++++ +e++s+ Gt+aymaPEvi++

Q: 1396  GIVHRDIKGANIFLTSSGLIKLGDFGCSVKLKNNAQTMpGEVNSTLGTAAYMAPEVITRa  1455

         *******************************9988776256*****************98

S: 179   kekgygrkaDiWslgcvviemltgkrPfaeldeelaimfkvgakktkPeipeklseegkd  238

         k +g+gr+aDiWslgcvviem+tgkrP++e++++++im+kvg+ + kP+ipe+ls egkd

Q: 1456  KGEGHGRAADIWSLGCVVIEMVTGKRPWHEYEHNFQIMYKVGMGH-KPPIPERLSLEGKD  1514

         899******************************************.**************

S: 239   flekcleldpkkrpsaeeLLkhefl  263

         fl++cle++p+ r++a++LL+h+f+

Q: 1515  FLSHCLESEPRLRWTASQLLDHSFV  1539

         ***********************96

Domain Sequence
(FASTA)

WQRGNKIGEG QYGKVYTCIS VDTGELMAMK EIRFQPNDHK TIKETADELK IFEGIKHPNL 60

VRYFGVELHR EEMYIFMEYC DEGTLEEVSR LGLQEHVIRL YSKQITVAIN VLHEHGIVHR 120

DIKGANIFLT SSGLIKLGDF GCSVKLKNNA QTMPGEVNST LGTAAYMAPE VITRAKGEGH 180

GRAADIWSLG CVVIEMVTGK RPWHEYEHNF QIMYKVGMGH KPPIPERLSL EGKDFLSHCL 240

ESEPRLRWTA SQLLDHSFV 259

Keyword

ATP-binding; Complete proteome; Nucleotide-binding; Reference proteome.

Sequence Source

Ensembl

Orthology

Ortholog group

Ailuropoda melanoleuca"; ?>Anolis carolinensis"; ?>Bos taurus"; ?>Caenorhabditis elegans"; ?>Callithrix jacchus"; ?>Canis familiaris"; ?>Cavia porcellus"; ?>Ciona intestinalis"; ?>Ciona savignyi"; ?>Danio rerio"; ?>Drosophila melanogaster"; ?>Equus caballus"; ?>Felis catus"; ?>Gallus gallus"; ?>Gasterosteus aculeatus"; ?>Gorilla gorilla"; ?>Homo sapiens"; ?>Ictidomys tridecemlineatus"; ?>Latimeria chalumnae"; ?>Loxodonta africana"; ?>Macaca mulatta"; ?>Meleagris gallopavo"; ?>Monodelphis domestica"; ?>Mus musculus"; ?>Mustela putorius furo"; ?>Oreochromis niloticus"; ?>Ornithorhynchus anatinus"; ?>Oryctolagus cuniculus"; ?>Oryzias latipes"; ?>Otolemur garnettii"; ?>Pelodiscus sinensis"; ?>Petromyzon marinus"; ?>Pongo abelii"; ?>Rattus norvegicus"; ?>Sarcophilus harrisii"; ?>Sus scrofa"; ?>Taeniopygia guttata"; ?>Takifugu rubripes"; ?>Tetraodon nigroviridis"; ?>Xiphophorus maculatus"; ?>Saccharomyces cerevisiae"; ?>Schizosaccharomyces pombe"; ?>

Gene Ontology

GO:0005524	; F:ATP binding
GO:0004674	; F:protein serine/threonine kinase activity

KEGG

InterPros

IPR011009	; Kinase-like_dom.
IPR000719	; Prot_kinase_cat_dom.
IPR017441	; Protein_kinase_ATP_BS.
IPR002290	; Ser/Thr_dual-sp_kinase_dom.
IPR008271	; Ser/Thr_kinase_AS.

Pfam

PF00069

; Pkinase; 1.

SMARTs

SM00220

; S_TKc; 1.

Prosites

PS00107	; PROTEIN_KINASE_ATP; 1.
PS50011	; PROTEIN_KINASE_DOM; 1.
PS00108	; PROTEIN_KINASE_ST; 1.

Prints

Created Date

20-Feb-2013