EKS-MYL-00008

Eukaryotic Protein Kinase & Protein Phosphatase Database

Tag

Content

EKPD ID

EKS-MYL-00008

Classification

Group/Family	Score	E-Value	Start	End	Domain Length
TK/Eph	509.1	1.7E-153	619	878	260

Status

Unreviewed

Ensembl Protein

ENSMLUP00000013401

UniProt Accession

G1PQN2;

Protein Name

Protein Synonyms/Alias

Gene Name

EPHB3

Gene Synonyms/Alias

EPHB3;

Ensembl Information

Ensembl Gene ID	Ensembl Protein ID	Ensembl Transcript ID
ENSMLUG00000014723	ENSMLUP00000013401	ENSMLUT00000014728

Organism

Myotis lucifugus

Functional Description

Protein Length

984

Protein Sequence
(FASTA)

LFLPILSLAP DLFSSVAPPE TLMDTKWVTS ELAWTSHPES GWEEVSGYDE AMNPIRTYQV 60

CNVRESSQNN WLRTGFIWRR DVQRVYVELK FTVRDCNSIP NIPGSCKETF NLFYYEADSD 120

VASASSPFWM ENPYVKVDTI APDESFSRLD AGRVNTKVRS FGPLSKAGFY LAFQDQGACM 180

SLISVRAFYK KCASTTAGFA LFPETLTGAE PTSLVIAPGT CIANAVEVSV PLKLYCNGDG 240

EWMVPVGACT CATGHEPAAK DTQCRPCPPG SYKAKQGEGP CLPCPPNSRT TSPAASICTC 300

HNNFYRADSD SADSACTTVP SPPRGVISNV NETSLILEWS EPRDLGGRDD LLYNVICKKC 360

HGVPGPGGAS ACSRCDDNVE FVPRQLGLTE RRVHISHLLA HTRYTFEVQA VNGVSGKSPL 420

PPRYAAVNIT TNQAAPSEVP TLHLHSSSGS SLTLSWAPPE RPNGVILDYE MKYFEKSEGI 480

ASTVTSQKNS VQLDGLRPEA RYVVQVRART VAGYGQYSRP AEFETTSERA VPSCLQAPVP 540

CSSRAGLVFV VAVVVIAVVL PQKQRHGSDS EYTEKLQQYS NGKGSQVAPG MKVYIDPFTY 600

EDPNEAVREF AKEIDVSCVK IEEVIGAGEF GEVCRGRLKQ PGRREVFVAI KTLKVGYTER 660

QRRDFLSEAS IMGQFDHPNI IRLEGVVTKS RPVMILTEFM ENCALDSFLR LNDGQFTVIQ 720

LVGMLRGIAA GMKYLSEMNY VHRDLAARNI LVNSNLVCKV SDFGLSRFLE DDPSDPTYTS 780

SLGGKIPIRW TAPEAIAYRK FTSASDVWSY GIVMWEVMSY GERPYWDMSN QDVINAVEQD 840

YRLPPPMDCP TALHQLMLDC WVRDRNLRPK FSQIVNTLDK LIRNAASLKV IASAQSGMSQ 900

PLLDRTVPDY TTFTTVGDWL DAIKMGRYKE SFVSAGFASF DLVAQMTAED LLRIGVTLAG 960

HQKKILSSIQ DMRLQMNQTL PVQV 984

Nucleotide Sequence
(FASTA)

CTTTTCCTTC CCATCCTGAG CTTGGCTCCT GACCTGTTTT CTTCGGTTGC TCCCCCAGAG 60

ACCCTCATGG ACACAAAATG GGTGACATCT GAGTTGGCGT GGACATCTCA TCCAGAAAGT 120

GGGTGGGAAG AGGTGAGTGG CTACGACGAG GCCATGAACC CCATCCGCAC GTACCAGGTG 180

TGTAACGTGC GCGAGTCAAG CCAGAACAAC TGGCTTCGCA CGGGGTTCAT CTGGCGGCGA 240

GATGTGCAGC GGGTCTACGT AGAGCTCAAG TTCACGGTGC GTGACTGCAA TAGCATCCCC 300

AACATCCCCG GCTCCTGCAA GGAGACCTTC AACCTCTTCT ACTACGAGGC TGACAGCGAT 360

GTGGCCTCGG CCTCCTCCCC CTTCTGGATG GAGAATCCCT ACGTAAAGGT GGACACCATC 420

GCGCCCGATG AGAGCTTCTC GAGGCTCGAT GCCGGCCGTG TCAACACCAA GGTGCGCAGC 480

TTCGGGCCGC TGTCCAAGGC CGGCTTCTAC TTGGCCTTCC AGGACCAGGG TGCCTGCATG 540

TCACTCATCT CCGTGCGTGC CTTCTATAAG AAGTGTGCAT CCACCACTGC AGGCTTCGCC 600

CTCTTCCCAG AGACCCTCAC TGGGGCCGAG CCCACCTCAC TGGTCATTGC CCCTGGCACC 660

TGTATCGCTA ACGCTGTAGA GGTGTCAGTG CCACTCAAGC TCTACTGCAA CGGTGACGGG 720

GAGTGGATGG TGCCTGTGGG CGCCTGCACC TGTGCCACCG GCCATGAGCC AGCTGCCAAG 780

GACACCCAGT GCCGTCCCTG TCCCCCTGGG AGCTACAAGG CGAAGCAGGG AGAGGGGCCC 840

TGTCTCCCCT GCCCCCCCAA CAGCCGCACC ACCTCGCCAG CCGCCAGCAT CTGCACCTGC 900

CACAATAACT TCTACCGTGC AGATTCGGAC TCCGCCGACA GTGCCTGTAC CACTGTGCCA 960

TCCCCACCTC GGGGTGTGAT CTCCAATGTG AATGAGACCT CGCTGATCCT CGAGTGGAGT 1020

GAGCCCCGGG ACCTGGGCGG CCGGGACGAC CTCCTGTACA ATGTCATCTG CAAGAAGTGC 1080

CACGGGGTCC CTGGGCCCGG GGGTGCCTCG GCCTGCTCAC GCTGTGACGA CAACGTAGAG 1140

TTTGTGCCTC GGCAGCTGGG CCTGACAGAG CGCCGGGTCC ACATCAGCCA CCTGTTGGCC 1200

CACACACGCT ACACCTTTGA GGTGCAGGCA GTCAACGGTG TCTCGGGCAA GAGCCCTCTG 1260

CCGCCCCGCT ACGCGGCTGT GAATATCACC ACCAACCAGG CTGCCCCGTC TGAAGTGCCT 1320

ACACTCCACC TGCACAGCAG CTCAGGCAGC AGCCTGACAC TGTCCTGGGC ACCCCCCGAG 1380

CGGCCCAACG GCGTCATCCT GGACTATGAG ATGAAGTACT TTGAGAAGAG TGAGGGCATC 1440

GCCTCCACGG TGACCAGCCA GAAGAACTCT GTGCAGCTGG ACGGGCTGCG GCCCGAGGCT 1500

CGCTATGTGG TCCAGGTCCG CGCCCGCACC GTCGCTGGCT ATGGGCAGTA CAGCCGCCCG 1560

GCTGAGTTTG AGACCACCAG TGAGAGAGCA GTGCCCTCCT GTCTCCAGGC TCCAGTGCCC 1620

TGCAGCTCCA GGGCTGGGCT TGTCTTCGTG GTGGCTGTGG TGGTCATTGC TGTTGTGCTG 1680

CCTCAGAAAC AGCGCCATGG CTCCGATTCA GAATACACGG AGAAGCTGCA GCAATACAGT 1740

AATGGGAAAG GCTCTCAAGT TGCTCCTGGA ATGAAAGTTT ATATTGACCC TTTTACCTAC 1800

GAGGACCCTA ATGAGGCCGT GCGGGAGTTT GCCAAGGAGA TCGATGTGTC CTGCGTCAAG 1860

ATTGAGGAGG TGATTGGAGC TGGGGAGTTT GGGGAAGTGT GCCGGGGTCG ACTGAAACAG 1920

CCCGGCCGCC GGGAGGTGTT CGTGGCCATC AAGACGCTGA AGGTGGGCTA CACTGAGAGG 1980

CAGCGGCGGG ACTTCCTAAG TGAGGCCTCC ATCATGGGTC AGTTTGACCA CCCCAACATA 2040

ATCCGGCTGG AGGGCGTGGT TACCAAAAGT CGGCCAGTCA TGATCCTCAC CGAGTTCATG 2100

GAGAACTGTG CCCTGGACTC TTTCCTCCGG CTCAACGATG GACAGTTCAC AGTCATCCAG 2160

CTGGTGGGCA TGTTGCGGGG CATTGCTGCC GGCATGAAAT ACCTGTCCGA GATGAACTAT 2220

GTGCACCGTG ACCTGGCTGC CCGCAATATC CTTGTCAACA GCAACCTGGT CTGCAAAGTC 2280

TCAGACTTTG GCCTCTCCCG CTTCCTGGAG GATGACCCCT CTGATCCTAC CTACACCAGC 2340

TCCCTGGGTG GAAAGATCCC CATCCGCTGG ACTGCCCCAG AGGCCATAGC CTATCGGAAG 2400

TTCACCTCTG CTAGTGACGT CTGGAGCTAC GGAATCGTCA TGTGGGAGGT CATGAGCTAT 2460

GGAGAGAGAC CCTACTGGGA CATGAGCAAC CAGGATGTCA TCAATGCCGT GGAGCAGGAT 2520

TACCGGCTGC CCCCACCCAT GGACTGCCCC ACAGCACTGC ACCAGCTCAT GCTGGATTGC 2580

TGGGTGCGGG ACCGGAACCT CAGGCCCAAA TTCTCCCAGA TTGTCAACAC CCTGGACAAG 2640

CTCATCCGCA ATGCTGCCAG TCTGAAGGTC ATTGCCAGCG CCCAGTCTGG CATGTCACAA 2700

CCCCTCCTGG ACCGCACAGT CCCGGATTAC ACAACCTTCA CGACAGTTGG TGACTGGCTG 2760

GACGCCATTA AGATGGGGCG GTACAAGGAG AGCTTCGTCA GCGCGGGGTT TGCATCCTTT 2820

GACCTGGTGG CCCAGATGAC CGCAGAAGAC CTGCTCCGGA TCGGAGTCAC CTTGGCTGGC 2880

CACCAGAAGA AGATCCTTAG CAGTATACAG GACATGCGGC TGCAGATGAA CCAGACGCTG 2940

CCCGTGCAGG TCTGA 2955

Domain Profile

S: 1     vkiekviGaGefGevcsGrlklpgkreiavaiktlkagstekqrrdflseasilGqfdhp  60

         vkie+viGaGefGevc+Grlk+pg+re+ vaiktlk g+te+qrrdflseasi+Gqfdhp

Q: 619   VKIEEVIGAGEFGEVCRGRLKQPGRREVFVAIKTLKVGYTERQRRDFLSEASIMGQFDHP  678

         79**********************************************************

S: 61    niirleGvvtkskpvmivteymengaldsflrkkdgqftviqlvgmlrGiasgmkylsdm  120

         niirleGvvtks+pvmi+te+men+aldsflr +dgqftviqlvgmlrGia+gmkyls+m

Q: 679   NIIRLEGVVTKSRPVMILTEFMENCALDSFLRLNDGQFTVIQLVGMLRGIAAGMKYLSEM  738

         ************************************************************

S: 121   gyvhrdlaarnilvnsnlvckvsdfGlsrvledds.eaaytts.ggkipirwtapeaiay  178

         +yvhrdlaarnilvnsnlvckvsdfGlsr+ledd+ +++yt+s ggkipirwtapeaiay

Q: 739   NYVHRDLAARNILVNSNLVCKVSDFGLSRFLEDDPsDPTYTSSlGGKIPIRWTAPEAIAY  798

         **********************************99*****999****************

S: 179   rkftsasdvwsyGivlwevlsyGerpywdmsnqdvikaieegyrlpppmdcpaalyqlml  238

         rkftsasdvwsyGiv+wev+syGerpywdmsnqdvi+a+e++yrlpppmdcp+al+qlml

Q: 799   RKFTSASDVWSYGIVMWEVMSYGERPYWDMSNQDVINAVEQDYRLPPPMDCPTALHQLML  858

         ************************************************************

S: 239   dcwqkdraerpkfeqivsil  258

         dcw +dr+ rpkf+qiv++l

Q: 859   DCWVRDRNLRPKFSQIVNTL  878

         *****************975

Domain Sequence
(FASTA)

VKIEEVIGAG EFGEVCRGRL KQPGRREVFV AIKTLKVGYT ERQRRDFLSE ASIMGQFDHP 60

NIIRLEGVVT KSRPVMILTE FMENCALDSF LRLNDGQFTV IQLVGMLRGI AAGMKYLSEM 120

NYVHRDLAAR NILVNSNLVC KVSDFGLSRF LEDDPSDPTY TSSLGGKIPI RWTAPEAIAY 180

RKFTSASDVW SYGIVMWEVM SYGERPYWDM SNQDVINAVE QDYRLPPPMD CPTALHQLML 240

DCWVRDRNLR PKFSQIVNTL 260

Keyword

ATP-binding; Complete proteome; Kinase; Membrane; Nucleotide-binding; Receptor; Reference proteome; Transferase; Transmembrane; Transmembrane helix; Tyrosine-protein kinase.

Sequence Source

Ensembl

Orthology

Ortholog group

Ailuropoda melanoleuca"; ?>Anolis carolinensis"; ?>Bos taurus"; ?>Callithrix jacchus"; ?>Canis familiaris"; ?>Cavia porcellus"; ?>Danio rerio"; ?>Dipodomys ordii"; ?>Equus caballus"; ?>Felis catus"; ?>Gadus morhua"; ?>Gallus gallus"; ?>Gasterosteus aculeatus"; ?>Gorilla gorilla"; ?>Homo sapiens"; ?>Ictidomys tridecemlineatus"; ?>Latimeria chalumnae"; ?>Macaca mulatta"; ?>Meleagris gallopavo"; ?>Mus musculus"; ?>Mustela putorius furo"; ?>Nomascus leucogenys"; ?>Oreochromis niloticus"; ?>Ornithorhynchus anatinus"; ?>Oryctolagus cuniculus"; ?>Oryzias latipes"; ?>Otolemur garnettii"; ?>Pan troglodytes"; ?>Pelodiscus sinensis"; ?>Rattus norvegicus"; ?>Sarcophilus harrisii"; ?>Sus scrofa"; ?>Taeniopygia guttata"; ?>Takifugu rubripes"; ?>Tursiops truncatus"; ?>Xenopus tropicalis"; ?>Xiphophorus maculatus"; ?>

Gene Ontology

GO:0005887	; C:integral to plasma membrane
GO:0005524	; F:ATP binding
GO:0005003	; F:ephrin receptor activity

KEGG

InterPros

IPR001090	; Ephrin_rcpt_lig-bd_dom.
IPR003961	; Fibronectin_type3.
IPR008979	; Galactose-bd-like.
IPR013783	; Ig-like_fold.
IPR011009	; Kinase-like_dom.
IPR000719	; Prot_kinase_cat_dom.
IPR017441	; Protein_kinase_ATP_BS.
IPR001660	; SAM.
IPR013761	; SAM/pointed.
IPR021129	; SAM_type1.
IPR001245	; Ser-Thr/Tyr_kinase_cat_dom.
IPR011641	; Tyr-kin_ephrin_A/B_rcpt-like.
IPR008266	; Tyr_kinase_AS.
IPR020635	; Tyr_kinase_cat_dom.
IPR016257	; Tyr_kinase_ephrin_rcpt.
IPR001426	; Tyr_kinase_rcpt_V_CS.

Pfam

PF01404	; Ephrin_lbd; 1.
PF00041	; fn3; 2.
PF07699	; GCC2_GCC3; 1.
PF07714	; Pkinase_Tyr; 1.
PF00536	; SAM_1; 1.

SMARTs

SM00615	; EPH_lbd; 1.
SM00060	; FN3; 2.
SM00454	; SAM; 1.
SM00219	; TyrKc; 1.

Prosites

PS51550	; EPH_LBD; 1.
PS50853	; FN3; 2.
PS00107	; PROTEIN_KINASE_ATP; 1.
PS50011	; PROTEIN_KINASE_DOM; 1.
PS00109	; PROTEIN_KINASE_TYR; 1.
PS00790	; RECEPTOR_TYR_KIN_V_1; 1.
PS00791	; RECEPTOR_TYR_KIN_V_2; 1.
PS50105	; SAM_DOMAIN; 1.

Prints

PR00109

; TYRKINASE.

Created Date

20-Feb-2013