EPS-MYL-00059

Eukaryotic Protein Kinase & Protein Phosphatase Database

Tag

Content

EKPD ID

EPS-MYL-00059

Classification

Group/Family	Score	E-Value	Start	End	Domain Length
DSP/PTEN	147.8	4.3E-43	346	502	157

Status

Unreviewed

Ensembl Protein

ENSMLUP00000013503

UniProt Accession

G1PQW9;

Protein Name

Protein Synonyms/Alias

Gene Name

GAK

Gene Synonyms/Alias

GAK;

Ensembl Information

Ensembl Gene ID	Ensembl Protein ID	Ensembl Transcript ID
ENSMLUG00000014830	ENSMLUP00000013503	ENSMLUT00000014836

Organism

Myotis lucifugus

Functional Description

Protein Length

582

Protein Sequence
(FASTA)

GGFAFVYEAQ DLGSGREYAL KRLLSNEEER SRAIIQEVCF LKKLSGHPNI VQFCSAASIG 60

KEESDTGQAE FLLLTELCRG QLVEFLKKSE TKGPLSCDTV LKIFYQTCRA VQHMHRQKPP 120

IIHRDLKVEN LLLSNQGTIK LCDFGSATTV SHAPDYSWSA QRRALVEEEV TRNTTPMYRT 180

PEIVDLYSNF PISEKQDIWA LGCILYLLCF GQHPFEDGAK LRIVNGKYSI PADDTRYSVF 240

HGLIRATLKV NPEERLSITE LVNQLQEIAA ARSVNPKSPI TELLEQNGGY GNAAPGSAGP 300

GLAVAEYEQS YGGLLDILRG GPGRLLTNLK DTSSKVIQSV ANYAKGDLDI SYITSRIAVM 360

SFPAEGVESA IKNNIEDVRL FLDSKHPGHY AVYNLSSRTY RPAKFHNRVS ECGWAARRAP 420

SLRSLYSICR DMHWWLRQDH KNVCVLHCTD GRAASAVAVC SFLCFCRLFS TAEAAVYMFS 480

MKRCPPGIWP SHKRYIEYMC DMVAEEPITP HSKPILVRAI VMTPVPLFNK QRSGCRPFCE 540

VYVGDERVAT TSQEYDRMRD FRIEDGKAVI PLGTAVQGDV LI 582

Nucleotide Sequence
(FASTA)

GGAGGGTTTG CGTTCGTATA TGAGGCCCAG GATCTGGGAA GTGGCAGAGA GTATGCGCTG 60

AAGAGACTGC TGTCCAACGA GGAGGAGAGG AGCCGAGCCA TCATCCAGGA GGTGTGCTTC 120

TTGAAAAAGC TTTCTGGCCA CCCCAACATT GTCCAGTTTT GCTCTGCAGC GTCGATAGGG 180

AAAGAGGAGT CGGACACGGG GCAGGCCGAG TTCCTGCTGC TCACGGAGCT CTGCAGAGGG 240

CAGCTGGTGG AGTTTCTGAA GAAAAGCGAG ACCAAAGGGC CTCTGTCGTG CGACACCGTC 300

CTGAAGATTT TCTACCAGAC CTGCAGGGCC GTGCAGCACA TGCACCGGCA GAAGCCGCCC 360

ATCATCCACC GGGACCTCAA GGTTGAAAAC TTGTTGCTGA GTAACCAGGG GACCATTAAG 420

CTGTGCGACT TTGGCAGCGC CACGACCGTC TCACACGCCC CTGACTACAG CTGGAGCGCC 480

CAGCGGCGGG CCCTGGTGGA GGAGGAGGTC ACCAGGAACA CAACGCCCAT GTACAGGACG 540

CCTGAGATCG TGGACCTGTA CTCGAACTTC CCCATCAGCG AGAAGCAGGA CATCTGGGCG 600

CTGGGCTGCA TCTTGTACCT GCTGTGCTTC GGGCAGCACC CTTTTGAAGA CGGAGCAAAG 660

CTTCGCATCG TAAACGGGAA ATACTCCATC CCTGCTGACG ACACTCGGTA CTCCGTGTTC 720

CACGGCCTCA TCCGCGCCAC ACTGAAGGTC AACCCGGAGG AGCGGCTGTC CATCACCGAG 780

CTGGTGAACC AGCTGCAGGA GATCGCGGCT GCCCGGAGTG TGAACCCCAA GTCGCCCATC 840

ACTGAGCTCC TGGAGCAGAA TGGAGGCTAC GGGAACGCTG CCCCCGGGAG CGCAGGGCCC 900

GGCCTGGCGG TGGCTGAGTA CGAGCAGTCC TACGGCGGGC TCCTGGACAT CCTGCGGGGG 960

GGCCCTGGGC GCCTGCTCAC CAACCTCAAG GACACCTCCT CCAAGGTCAT CCAGTCCGTC 1020

GCCAATTACG CGAAGGGAGA CCTGGACATT TCCTACATCA CCTCCCGAAT CGCAGTGATG 1080

TCCTTCCCGG CAGAGGGTGT GGAATCCGCC ATCAAAAACA ACATCGAGGA CGTGCGCTTG 1140

TTTCTGGACT CCAAGCACCC GGGACACTAC GCTGTCTACA ACCTGTCCTC CAGGACGTAC 1200

CGGCCCGCCA AGTTTCACAA CCGCGTGTCC GAGTGCGGGT GGGCGGCCCG GCGGGCCCCG 1260

AGCCTGCGCA GCCTGTACAG CATCTGCAGG GACATGCACT GGTGGCTGCG GCAGGACCAC 1320

AAGAACGTGT GCGTGCTGCA CTGCACGGAC GGGAGAGCGG CGTCGGCCGT GGCCGTCTGC 1380

TCCTTCCTGT GCTTCTGCCG GCTCTTCAGC ACCGCCGAGG CCGCCGTGTA CATGTTCAGC 1440

ATGAAGCGCT GCCCGCCGGG CATTTGGCCG TCCCACAAAA GGTACATCGA GTACATGTGT 1500

GACATGGTGG CGGAGGAGCC CATCACGCCC CATAGCAAGC CGATCCTGGT GCGGGCCATC 1560

GTCATGACGC CCGTGCCGCT GTTCAACAAG CAGAGGAGCG GCTGTCGGCC CTTCTGCGAG 1620

GTCTATGTGG GGGACGAGCG CGTGGCCACC ACGTCCCAGG AGTACGACAG GATGCGGGAT 1680

TTCAGGATCG AGGACGGCAA AGCCGTCATC CCCCTGGGCA CGGCCGTCCA AGGGGACGTG 1740

CTCATC 1746

Domain Profile

S: 8     fdldltyvteriiavsfPaeareevyrnnlrevvrlldskhrnkyklynlcserrydltk  67

          dld+ y+t ri  +sfPae+ e+  +nn+++v  +ldskh ++y +ynl s r y ++k

Q: 346   GDLDISYITSRIAVMSFPAEGVESAIKNNIEDVRLFLDSKHPGHYAVYNL-SSRTYRPAK  404

         59************************************************.9********

S: 68    lnakvaefgiedlnaPaleklvsickeldeWlseddenvvvlhckggkgrlGvivcayll  127

         ++++v+e g+   +aP+l  l sic++++ Wl +d++nv vlhc  g+    v vc++l

Q: 405   FHNRVSECGWAARRAPSLRSLYSICRDMHWWLRQDHKNVCVLHCTDGRAASAVAVCSFLC  464

         ************************************************************

S: 128   aseisakadealdtfgerrtredkvagvkqPsqrryvsyfsql  170

         + + +++a+ a+++f+++r           Ps +ry++y + +

Q: 465   FCRLFSTAEAAVYMFSMKRCPPG-----IWPSHKRYIEYMCDM  502

         ******************97654.....59*********9876

Domain Sequence
(FASTA)

GDLDISYITS RIAVMSFPAE GVESAIKNNI EDVRLFLDSK HPGHYAVYNL SSRTYRPAKF 60

HNRVSECGWA ARRAPSLRSL YSICRDMHWW LRQDHKNVCV LHCTDGRAAS AVAVCSFLCF 120

CRLFSTAEAA VYMFSMKRCP PGIWPSHKRY IEYMCDM 157

Keyword

ATP-binding; Complete proteome; Kinase; Nucleotide-binding; Reference proteome; Serine/threonine-protein kinase; Transferase.

Sequence Source

Ensembl

Orthology

Ortholog group

Ailuropoda melanoleuca"; ?>Anolis carolinensis"; ?>Bos taurus"; ?>Callithrix jacchus"; ?>Canis familiaris"; ?>Cavia porcellus"; ?>Ciona savignyi"; ?>Danio rerio"; ?>Equus caballus"; ?>Felis catus"; ?>Gadus morhua"; ?>Gallus gallus"; ?>Gasterosteus aculeatus"; ?>Gorilla gorilla"; ?>Homo sapiens"; ?>Ictidomys tridecemlineatus"; ?>Loxodonta africana"; ?>Macaca mulatta"; ?>Meleagris gallopavo"; ?>Monodelphis domestica"; ?>Mus musculus"; ?>Mustela putorius furo"; ?>Nomascus leucogenys"; ?>Ochotona princeps"; ?>Oreochromis niloticus"; ?>Ornithorhynchus anatinus"; ?>Oryctolagus cuniculus"; ?>Oryzias latipes"; ?>Otolemur garnettii"; ?>Pan troglodytes"; ?>Pelodiscus sinensis"; ?>Pongo abelii"; ?>Rattus norvegicus"; ?>Sarcophilus harrisii"; ?>Sus scrofa"; ?>Taeniopygia guttata"; ?>Takifugu rubripes"; ?>Tetraodon nigroviridis"; ?>Xenopus tropicalis"; ?>Xiphophorus maculatus"; ?>

Gene Ontology

GO:0005524	; F:ATP binding
GO:0004674	; F:protein serine/threonine kinase activity

KEGG

InterPros

IPR008973	; C2_Ca/lipid-bd_dom_CaLB.
IPR011009	; Kinase-like_dom.
IPR014019	; Phosphatase_tensin-typ.
IPR000719	; Prot_kinase_cat_dom.
IPR008271	; Ser/Thr_kinase_AS.
IPR014020	; Tensin_phosphatase_C2-dom.

Pfam

PF00069	; Pkinase; 1.
PF10409	; PTEN_C2; 1.

SMARTs

Prosites

PS51182	; C2_TENSIN; 1.
PS51181	; PPASE_TENSIN; 1.
PS50011	; PROTEIN_KINASE_DOM; 1.
PS00108	; PROTEIN_KINASE_ST; 1.

Prints

Created Date

20-Feb-2013