EKS-MYL-00239

Eukaryotic Protein Kinase & Protein Phosphatase Database

Tag

Content

EKPD ID

EKS-MYL-00239

Classification

Group/Family	Score	E-Value	Start	End	Domain Length
CAMK/CAMKL	387.5	2.4E-116	60	311	252

Status

Unreviewed

Ensembl Protein

ENSMLUP00000013516

UniProt Accession

G1PQY1;

Protein Name

Protein Synonyms/Alias

Gene Name

MARK1

Gene Synonyms/Alias

MARK1;

Ensembl Information

Ensembl Gene ID	Ensembl Protein ID	Ensembl Transcript ID
ENSMLUG00000014846	ENSMLUP00000013516	ENSMLUT00000014850

Organism

Myotis lucifugus

Functional Description

Protein Length

796

Protein Sequence
(FASTA)

ISDQKFLDKF SSRRQDNHTS VDGYTEPHIQ PTKSSSRQNI PRCRNSITSA ADEQPHIGNY 60

RLQKTIGKGN FAKVKLARHV LTGREVAVKI IDKTQLNPTS LQKLFREVRI MKILNHPNIV 120

KLFEVIETEK TLYLVMEYAS GGEVFDYLVA HGRMKEKEAR AKFRQIVSAV QYCHQKCIVH 180

RDLKAENLLL DADMNIKIAD FGFSNEFTVG NKLDTFCGSP PYAAPELFQG KKYDGPEVDV 240

WSLGVILYTL VSGSLPFDGQ NLKELRERVL RGKYRIPFYM STDCENLLKK LLVLNPIKRG 300

SLEQIMKDRW MNVGHEEEEL KPYTEPEPDF NDTKRIDVMV TMGFARDEIN DALINQKYDE 360

VMATYILLGR KPPEFEGGES LSSGNLSQRS RPSSDLNNST LQSPAHLKVQ RSISANQKQR 420

RFSDHAGPSI SAAVSYTKRP QANSVESEQK DEWDKDGAAR KLGSTTVGSK SEVTTSPLVG 480

PERKKASTIP SNNVYAGGSM ARRNTYVCER TTDRYMALQN GKDSSLTEMS ASSLSSAGSA 540

VAPAVPSARP RHQKSMSASG HPIKVTLPTI KDGSEAYRPG TTQRVPAASP SAHSISASTP 600

DRTRFPRGSS SRSTFHGEQL RERRSAAHAG PPASPSHESG AFAHARRGTS TGLISKITSR 660

FVRRDPSEGE ASGRTDTSRS TSGDPKERDK EEGKDPKPRS LRFTWSMKTT SSMDPNDMMR 720

EIRKVLDANN CDYEQKERFL LFCVHGDARQ DSLVQWEMEV CKLPRLSLNG VRFKRISGTS 780

IAFKNIASKI ANELKL 796

Nucleotide Sequence
(FASTA)

ATTTCTGATC AAAAATTTTT AGACAAGTTT TCATCACGTA GGCAGGACAA CCATACATCT 60

GTGGATGGAT ATACTGAACC ACACATCCAG CCTACCAAAT CGAGTAGCAG ACAGAACATC 120

CCTCGGTGTA GAAACTCCAT TACGTCCGCA GCAGACGAAC AGCCTCACAT TGGGAATTAC 180

CGTTTACAAA AAACAATAGG GAAGGGGAAC TTTGCCAAAG TGAAATTGGC AAGGCATGTT 240

CTAACTGGGA GAGAGGTTGC TGTGAAAATA ATAGATAAAA CTCAGCTAAA TCCTACCAGT 300

CTACAAAAGT TGTTTCGAGA AGTACGAATA ATGAAGATAT TGAATCACCC TAACATAGTA 360

AAATTGTTTG AAGTTATTGA AACAGAGAAG ACCCTCTATC TAGTCATGGA ATACGCAAGT 420

GGGGGTGAAG TATTTGATTA CTTAGTTGCC CATGGAAGAA TGAAAGAAAA AGAGGCCCGT 480

GCAAAATTTA GGCAGATTGT GTCCGCTGTA CAGTATTGTC ATCAAAAGTG CATTGTTCAC 540

CGTGATCTTA AGGCTGAAAA CCTTCTCCTT GATGCTGACA TGAATATTAA AATTGCTGAC 600

TTTGGTTTTA GTAACGAGTT TACAGTCGGG AACAAATTGG ACACATTTTG CGGAAGTCCC 660

CCCTACGCCG CTCCCGAGCT CTTCCAGGGG AAGAAGTACG ACGGGCCCGA GGTGGACGTG 720

TGGAGCCTGG GCGTCATTCT CTACACGCTG GTCAGCGGCT CCCTGCCGTT TGACGGCCAG 780

AATCTGAAGG AACTTCGGGA GCGAGTCTTA CGCGGGAAAT ACCGCATCCC CTTCTATATG 840

TCCACCGACT GTGAAAACCT TCTGAAGAAA TTATTAGTGC TGAATCCCAT TAAAAGAGGC 900

AGCTTGGAAC AAATAATGAA AGATCGGTGG ATGAATGTTG GTCACGAAGA AGAAGAACTA 960

AAGCCATATA CTGAGCCTGA ACCAGATTTC AATGACACAA AAAGGATAGA TGTCATGGTC 1020

ACCATGGGTT TCGCACGAGA TGAGATAAAT GACGCCTTAA TAAATCAGAA ATACGATGAA 1080

GTCATGGCTA CTTACATTCT TCTAGGTAGA AAACCACCTG AATTTGAAGG CGGTGAGTCA 1140

TTATCCAGTG GAAACTTGAG TCAGAGGTCG CGGCCCAGTA GTGACCTAAA CAACAGCACC 1200

CTCCAGTCCC CCGCTCACCT GAAGGTCCAG AGGAGCATCT CGGCCAATCA GAAGCAGCGG 1260

CGCTTTAGCG ATCATGCTGG TCCATCCATC TCCGCGGCCG TATCGTACAC AAAGAGGCCT 1320

CAGGCCAACA GCGTGGAGAG TGAGCAGAAA GACGAGTGGG ACAAGGACGG GGCAGCGCGC 1380

AAACTCGGCA GCACGACCGT GGGATCGAAG AGCGAGGTGA CCACCAGCCC GCTCGTGGGG 1440

CCGGAGAGGA AAAAGGCGTC CACTATCCCG AGCAACAACG TATATGCTGG AGGAAGCATG 1500

GCAAGAAGGA ACACGTATGT CTGTGAAAGG ACCACAGACC GCTACATGGC CCTGCAAAAT 1560

GGAAAAGACA GCAGCCTCAC GGAGATGTCG GCCAGCAGCT TGTCTTCTGC CGGCTCCGCC 1620

GTGGCCCCTG CTGTCCCCTC GGCACGGCCC CGCCACCAGA AGTCCATGTC CGCCTCCGGG 1680

CACCCCATCA AAGTCACACT GCCAACCATT AAAGACGGCT CCGAAGCTTA CCGACCCGGG 1740

ACCACCCAGA GAGTGCCTGC CGCGTCCCCG TCTGCCCACA GTATTAGTGC CAGCACCCCA 1800

GACCGGACCC GCTTTCCCCG CGGCAGCTCC AGCCGCAGCA CCTTCCACGG GGAGCAGCTC 1860

CGGGAGCGGC GCAGCGCCGC CCACGCTGGG CCCCCCGCGT CTCCGTCCCA CGAAAGCGGG 1920

GCCTTTGCCC ACGCCCGGCG GGGCACGTCC ACCGGCCTCA TCAGCAAGAT CACCTCCAGA 1980

TTCGTTCGCA GGGATCCAAG TGAAGGCGAA GCCAGTGGCA GAACAGACAC CTCAAGAAGT 2040

ACATCCGGGG ACCCGAAAGA AAGAGACAAG GAAGAGGGGA AAGACCCCAA GCCACGCTCT 2100

CTGCGCTTCA CCTGGAGCAT GAAGACCACG AGTTCCATGG ACCCCAATGA CATGATGCGA 2160

GAGATCCGGA AAGTGTTAGA TGCAAACAAC TGCGATTACG AACAGAAGGA GAGGTTTTTG 2220

CTCTTCTGCG TCCACGGAGA TGCCCGCCAG GACAGCCTCG TGCAGTGGGA GATGGAAGTG 2280

TGCAAGCTGC CACGGCTGTC GCTGAACGGG GTCCGCTTCA AGCGAATCTC GGGAACGTCG 2340

ATTGCCTTTA AGAACATCGC ATCTAAAATA GCCAATGAGC TCAAACTGTA A 2391

Domain Profile

S: 1     ykllktlGegsfgkVklakhketkekvavKiikkkklseeslekikrEieilkklkhpni  60

         y+l+kt+G+g+f+kVkla+h +t+++vavKii+k++l+ +sl+k++rE++i+k+l+hpni

Q: 60    YRLQKTIGKGNFAKVKLARHVLTGREVAVKIIDKTQLNPTSLQKLFREVRIMKILNHPNI  119

         99**********************************************************

S: 61    ikllevietkkklylvleyasggeLfdyieekgrlkekearklfkqlvsavkYlhskgiv  120

         +kl+eviet+k+lylv+eyasgge+fdy++++gr+kekear+ f+q+vsav+Y+h+k iv

Q: 120   VKLFEVIETEKTLYLVMEYASGGEVFDYLVAHGRMKEKEARAKFRQIVSAVQYCHQKCIV  179

         ************************************************************

S: 121   HrDlKpeNllldkkenikiaDFGlanlfkegklletfcGsppYaaPellkgkkYegpkvD  180

         HrDlK+eNllld+++nikiaDFG++n+f+ g++l+tfcGsppYaaPel++gkkY+gp+vD

Q: 180   HRDLKAENLLLDADMNIKIADFGFSNEFTVGNKLDTFCGSPPYAAPELFQGKKYDGPEVD  239

         ************************************************************

S: 181   vWslGvvLyalvtgklPfdeenlkellekilkgkleipkklskelesLlrklLvvdpekR  240

         vWslGv+Ly+lv+g+lPfd++nlkel+e++l+gk++ip+++s+++e+Ll+klLv +p kR

Q: 240   VWSLGVILYTLVSGSLPFDGQNLKELRERVLRGKYRIPFYMSTDCENLLKKLLVLNPIKR  299

         ************************************************************

S: 241   atieeilkhewl  252

          ++e+i+k++w+

Q: 300   GSLEQIMKDRWM  311

         ***********8

Domain Sequence
(FASTA)

YRLQKTIGKG NFAKVKLARH VLTGREVAVK IIDKTQLNPT SLQKLFREVR IMKILNHPNI 60

VKLFEVIETE KTLYLVMEYA SGGEVFDYLV AHGRMKEKEA RAKFRQIVSA VQYCHQKCIV 120

HRDLKAENLL LDADMNIKIA DFGFSNEFTV GNKLDTFCGS PPYAAPELFQ GKKYDGPEVD 180

VWSLGVILYT LVSGSLPFDG QNLKELRERV LRGKYRIPFY MSTDCENLLK KLLVLNPIKR 240

GSLEQIMKDR WM 252

Keyword

ATP-binding; Complete proteome; Nucleotide-binding; Reference proteome.

Sequence Source

Ensembl

Orthology

Ortholog group

Ailuropoda melanoleuca"; ?>Anolis carolinensis"; ?>Bos taurus"; ?>Callithrix jacchus"; ?>Canis familiaris"; ?>Cavia porcellus"; ?>Equus caballus"; ?>Felis catus"; ?>Gallus gallus"; ?>Gasterosteus aculeatus"; ?>Gorilla gorilla"; ?>Homo sapiens"; ?>Loxodonta africana"; ?>Macaca mulatta"; ?>Meleagris gallopavo"; ?>Monodelphis domestica"; ?>Mus musculus"; ?>Mustela putorius furo"; ?>Nomascus leucogenys"; ?>Oreochromis niloticus"; ?>Ornithorhynchus anatinus"; ?>Oryctolagus cuniculus"; ?>Oryzias latipes"; ?>Otolemur garnettii"; ?>Pan troglodytes"; ?>Pelodiscus sinensis"; ?>Petromyzon marinus"; ?>Pongo abelii"; ?>Pteropus vampyrus"; ?>Rattus norvegicus"; ?>Sarcophilus harrisii"; ?>Sus scrofa"; ?>Taeniopygia guttata"; ?>Tetraodon nigroviridis"; ?>Tupaia belangeri"; ?>Tursiops truncatus"; ?>Vicugna pacos"; ?>Xiphophorus maculatus"; ?>

Gene Ontology

GO:0005524	; F:ATP binding
GO:0004674	; F:protein serine/threonine kinase activity

KEGG

InterPros

IPR001772	; Kinase-assoc_KA1.
IPR011009	; Kinase-like_dom.
IPR000719	; Prot_kinase_cat_dom.
IPR017441	; Protein_kinase_ATP_BS.
IPR002290	; Ser/Thr_dual-sp_kinase_dom.
IPR008271	; Ser/Thr_kinase_AS.
IPR015940	; UBA/transl_elong_EF1B_N_euk.

Pfam

PF02149	; KA1; 1.
PF00069	; Pkinase; 1.

SMARTs

SM00220	; S_TKc; 1.
SM00165	; UBA; 1.

Prosites

PS50032	; KA1; 1.
PS00107	; PROTEIN_KINASE_ATP; 1.
PS50011	; PROTEIN_KINASE_DOM; 1.
PS00108	; PROTEIN_KINASE_ST; 1.
PS50030	; UBA; 1.

Prints

Created Date

20-Feb-2013