EKS-MYL-00366

Eukaryotic Protein Kinase & Protein Phosphatase Database

Tag

Content

EKPD ID

EKS-MYL-00366

Classification

Group/Family	Score	E-Value	Start	End	Domain Length
TK/Src	444.2	1.2E-133	247	497	251

Status

Unreviewed

Ensembl Protein

ENSMLUP00000013530

UniProt Accession

G1PQZ4;

Protein Name

Protein Synonyms/Alias

Gene Name

LYN

Gene Synonyms/Alias

LYN;

Ensembl Information

Ensembl Gene ID	Ensembl Protein ID	Ensembl Transcript ID
ENSMLUG00000014860	ENSMLUP00000013530	ENSMLUT00000014865

Organism

Myotis lucifugus

Functional Description

Protein Length

512

Protein Sequence
(FASTA)

MGCIKSKRKD HLNDDGVDLK TQPVRNTDRT IYVRDPTSNK QQRPVPESQL LPGQRFQTKD 60

PEEQGDIVVA LYPYDGIHPD DLSFRKGEKM KVLEEHGEWW KAKSLSTKRE GFIPSNYVAK 120

VNTLETEEWF FKDITRKDAE RQLLAPGNGP GAFLIRESET LKGSYSLSVR DYDPLHGDVI 180

KHYKIRSLDN GGYYISPRIT FPCISDMIKH YQKQSDGLCR RLEKVCISPK PQKPWDKDAW 240

EIPRESIKLV KKLGAGQFGE VWMGYYHNST KVAVKTLKPG TMSVQAFLEE ANLMKTLQHD 300

KLVRLYAVVT KEEPIYIITE YMAKGSLLDF LKSDEGGKVQ LPKLIDFSAQ IAEGMAYIER 360

KNYIHRDLRA ANVLVSESLM CKIADFGLAR IIEDNEYTAR EGAKFPIKWT APEAINFGCF 420

TIKSDVWSFG ILLYEIVTYG KIPYPGRTNA DVMTALSQGY RMPRMENCPD ELYEIMKMCW 480

KEKAEERPTF DYLQSVLDDF YTATEGQYQQ QP 512

Nucleotide Sequence
(FASTA)

ATGGGATGTA TAAAATCAAA AAGGAAAGAC CATCTGAATG ACGATGGAGT AGATTTGAAG 60

ACGCAACCAG TACGTAATAC TGACCGAACT ATTTATGTGA GAGATCCAAC GTCCAATAAA 120

CAGCAAAGGC CAGTTCCAGA ATCTCAGCTT TTGCCAGGAC AGAGGTTTCA GACTAAAGAT 180

CCAGAGGAGC AAGGAGACAT CGTGGTAGCC TTGTACCCCT ATGATGGCAT CCACCCAGAC 240

GACTTGTCTT TCAGGAAAGG GGAGAAGATG AAAGTCTTGG AGGAGCACGG AGAATGGTGG 300

AAAGCTAAGT CCCTTTCCAC AAAGAGAGAA GGCTTCATCC CCAGCAACTA CGTAGCCAAA 360

GTCAACACCT TGGAAACGGA AGAGTGGTTT TTCAAGGATA TAACCAGGAA AGATGCCGAA 420

AGACAGCTTT TGGCACCAGG GAACGGCCCG GGGGCCTTTC TCATCAGAGA AAGTGAAACA 480

TTAAAGGGAA GCTACTCTTT GTCTGTCAGA GATTATGACC CTCTGCACGG TGATGTCATT 540

AAGCACTACA AAATTAGAAG TCTGGACAAT GGGGGTTATT ACATCTCTCC AAGAATCACT 600

TTTCCCTGCA TCAGTGACAT GATTAAGCAT TACCAAAAGC AGTCAGATGG CTTGTGCAGA 660

AGATTGGAGA AGGTCTGTAT TAGTCCCAAA CCACAAAAGC CCTGGGATAA AGACGCCTGG 720

GAGATCCCGC GAGAGTCCAT TAAGTTGGTG AAGAAGCTCG GTGCCGGCCA GTTCGGGGAA 780

GTCTGGATGG GTTACTATCA CAATAGCACC AAAGTGGCCG TGAAAACGCT GAAGCCAGGC 840

ACAATGTCTG TGCAAGCTTT CCTGGAAGAA GCCAACCTCA TGAAGACCCT GCAGCACGAC 900

AAGCTGGTGA GGCTGTACGC CGTGGTCACC AAGGAGGAGC CCATCTACAT CATCACGGAG 960

TACATGGCCA AGGGCAGCTT GCTGGATTTC CTGAAGAGTG ATGAAGGGGG CAAAGTGCAG 1020

CTTCCAAAGC TCATTGACTT TTCTGCTCAG ATCGCAGAGG GAATGGCGTA CATCGAGAGG 1080

AAGAACTACA TTCACCGAGA CCTGCGAGCA GCTAATGTCC TGGTCTCTGA GTCACTCATG 1140

TGCAAAATTG CTGACTTTGG CCTTGCTCGA ATAATTGAAG ATAATGAGTA CACAGCAAGG 1200

GAAGGTGCTA AATTCCCCAT CAAGTGGACC GCTCCAGAAG CAATCAACTT TGGATGTTTC 1260

ACTATTAAGT CTGATGTGTG GTCCTTCGGA ATTCTCCTGT ATGAAATCGT CACCTATGGG 1320

AAAATTCCTT ATCCAGGGAG AACGAATGCG GACGTGATGA CCGCGCTGTC ACAGGGCTAC 1380

AGGATGCCCC GCATGGAGAA CTGCCCGGAC GAGCTCTACG AGATCATGAA AATGTGCTGG 1440

AAAGAAAAGG CAGAAGAGAG GCCCACGTTT GATTACTTGC AGAGCGTCCT GGATGACTTC 1500

TACACCGCCA CGGAAGGCCA GTATCAACAG CAGCCTTAG 1539

Domain Profile

S: 1     lklvkklGeGqfGevwlgkwkgsvkvavktlkegtlspeafleeaqilkklrheklvkly  60

         +klvkklG+GqfGevw+g++++s+kvavktlk+gt+s +afleea+++k+l+h+klv+ly

Q: 247   IKLVKKLGAGQFGEVWMGYYHNSTKVAVKTLKPGTMSVQAFLEEANLMKTLQHDKLVRLY  306

         689*********************************************************

S: 61    avvseeePiyivtelmakGslldflkeeegkklklpklvdlaaqvaeGmayleeknlihr  120

         avv++eePiyi+te+makGslldflk++eg k++lpkl+d++aq+aeGmay+e+kn+ihr

Q: 307   AVVTKEEPIYIITEYMAKGSLLDFLKSDEGGKVQLPKLIDFSAQIAEGMAYIERKNYIHR  366

         ************************************************************

S: 121   dlaarnvlvgeslvvkvadfGlarlieddeytakegaklPikWtaPeaiklgkftiksdv  180

         dl+a+nvlv+esl++k+adfGlar+ied+eyta+egak+PikWtaPeai++g+ftiksdv

Q: 367   DLRAANVLVSESLMCKIADFGLARIIEDNEYTAREGAKFPIKWTAPEAINFGCFTIKSDV  426

         ************************************************************

S: 181   WsfGillteivtkGkvPypGmtneevleqvergyrlprpeecpeelyelllecwkkdpee  240

         WsfGill+eivt+Gk+PypG tn++v++++++gyr+pr+e+cp+elye++++cwk+++ee

Q: 427   WSFGILLYEIVTYGKIPYPGRTNADVMTALSQGYRMPRMENCPDELYEIMKMCWKEKAEE  486

         ************************************************************

S: 241   rPtfetlqevl  251

         rPtf++lq+vl

Q: 487   RPTFDYLQSVL  497

         ********986

Domain Sequence
(FASTA)

IKLVKKLGAG QFGEVWMGYY HNSTKVAVKT LKPGTMSVQA FLEEANLMKT LQHDKLVRLY 60

AVVTKEEPIY IITEYMAKGS LLDFLKSDEG GKVQLPKLID FSAQIAEGMA YIERKNYIHR 120

DLRAANVLVS ESLMCKIADF GLARIIEDNE YTAREGAKFP IKWTAPEAIN FGCFTIKSDV 180

WSFGILLYEI VTYGKIPYPG RTNADVMTAL SQGYRMPRME NCPDELYEIM KMCWKEKAEE 240

RPTFDYLQSV L 251

Keyword

ATP-binding; Complete proteome; Kinase; Nucleotide-binding; Reference proteome; SH3 domain; Transferase; Tyrosine-protein kinase.

Sequence Source

Ensembl

Orthology

Ortholog group

Ailuropoda melanoleuca"; ?>Anolis carolinensis"; ?>Bos taurus"; ?>Callithrix jacchus"; ?>Canis familiaris"; ?>Cavia porcellus"; ?>Danio rerio"; ?>Equus caballus"; ?>Gadus morhua"; ?>Gallus gallus"; ?>Gasterosteus aculeatus"; ?>Gorilla gorilla"; ?>Homo sapiens"; ?>Ictidomys tridecemlineatus"; ?>Latimeria chalumnae"; ?>Loxodonta africana"; ?>Macaca mulatta"; ?>Monodelphis domestica"; ?>Mus musculus"; ?>Mustela putorius furo"; ?>Nomascus leucogenys"; ?>Oreochromis niloticus"; ?>Ornithorhynchus anatinus"; ?>Oryctolagus cuniculus"; ?>Oryzias latipes"; ?>Otolemur garnettii"; ?>Pan troglodytes"; ?>Pelodiscus sinensis"; ?>Pongo abelii"; ?>Rattus norvegicus"; ?>Sarcophilus harrisii"; ?>Sus scrofa"; ?>Taeniopygia guttata"; ?>Tarsius syrichta"; ?>Tetraodon nigroviridis"; ?>Tursiops truncatus"; ?>Xenopus tropicalis"; ?>Xiphophorus maculatus"; ?>

Gene Ontology

GO:0005524	; F:ATP binding
GO:0004713	; F:protein tyrosine kinase activity

KEGG

InterPros

IPR011009	; Kinase-like_dom.
IPR000719	; Prot_kinase_cat_dom.
IPR017441	; Protein_kinase_ATP_BS.
IPR001245	; Ser-Thr/Tyr_kinase_cat_dom.
IPR000980	; SH2.
IPR001452	; SH3_domain.
IPR008266	; Tyr_kinase_AS.
IPR020635	; Tyr_kinase_cat_dom.

Pfam

PF07714	; Pkinase_Tyr; 1.
PF00017	; SH2; 1.
PF00018	; SH3_1; 1.

SMARTs

SM00252	; SH2; 1.
SM00326	; SH3; 1.
SM00219	; TyrKc; 1.

Prosites

PS00107	; PROTEIN_KINASE_ATP; 1.
PS50011	; PROTEIN_KINASE_DOM; 1.
PS00109	; PROTEIN_KINASE_TYR; 1.
PS50001	; SH2; 1.
PS50002	; SH3; 1.

Prints

PR00401	; SH2DOMAIN.
PR00452	; SH3DOMAIN.
PR00109	; TYRKINASE.

Created Date

20-Feb-2013