EKS-MYL-00011

Eukaryotic Protein Kinase & Protein Phosphatase Database

Tag

Content

EKPD ID

EKS-MYL-00011

Classification

Group/Family	Score	E-Value	Start	End	Domain Length
TK/Eph	488.6	3.1E-147	613	869	257

Status

Unreviewed

Ensembl Protein

ENSMLUP00000013625

UniProt Accession

G1PR78;

Protein Name

Protein Synonyms/Alias

Gene Name

EPHA2

Gene Synonyms/Alias

EPHA2;

Ensembl Information

Ensembl Gene ID	Ensembl Protein ID	Ensembl Transcript ID
ENSMLUG00000014957	ENSMLUP00000013625	ENSMLUT00000014964

Organism

Myotis lucifugus

Functional Description

Protein Length

974

Protein Sequence
(FASTA)

MERRRPRTCL ALLWGCMLVA TAAQGKEVVL LDFAAANGEL GWLTHPYGKG WDLMQNIMDD 60

TPIYMYSVCN VVAGDQDNWL RTNWVYRGEA ERIFIELKFT VRDCNSFPGG ASSCKETFNL 120

YYAESDVDYG TNFQKRQFKK IDTIAPDEIT VSSDFEARHV KLNVEERSVG PLTHKGFYLA 180

FQDIGACVAL LSVRVYYKKC PELLQGLARF PETIAGSDAP SLATVAGTCV DHAVVPPGGE 240

EPRMHCAVDG EWLVPIGQCL CQEGYEKVED ACQACSSGFF KSEASESACL ECPAHTLPSS 300

EGATFCECEE GYFRAPQDSL SMPCTGPPSA PSSLTAVGMG AKVELRWTAP LDNGGREDIT 360

YRVTCKQCLP ESDECRPCEA SVRYSELPNK LTRTSVIVSD LEPHMNYTFA VEARNGVSDL 420

VASRSFRTAS VSINQTEPPK VKLESRGTTS LSVSWSIPVP QQSRVWKYEV TYRKKGDSNT 480

YNVHQTEDFS VTLDGLAPDT TYLVQVQALT QEGQGASSKV HEFQTLSTEG SGNVAVIGGV 540

AVVIVLLLVL AGIGFLLHRR RKSQRARQSP EDVYFSKSEQ LKPLKTYVDP HTYEDPNQAV 600

LKFTTEIHPS CVTRQKVIGA GEFGEVYKGT LKASGKKEVP VAIKTLKAGY TEKQRVDFLS 660

EASIMGQFSH HNIIRLEGVV SKYKPMMIIT EYMENGALDK FLREKDGEFC VLQLVGMLRG 720

IAAGMKYLAN MNYVHRDLAA RNILVNSNLV CKVSDFGLSR VLEDDPEATY TTSGGKIPIR 780

WTAPEAISYR KFTSASDVWS YGILMWEVMT YGERPYWELS NHEVMKAIND GFRLPTPMEC 840

PSAIYQLMMQ CWQQERARRP KFADIVSILD KLIRAPDSLK TLADFDPRVS IRLPSTSGSE 900

GVPFRTVSEW LESIKMQQYT EHFLAAGYTA IEKVVQMTND DIKKIGVRLP GHQKRIAYSL 960

LGLKEQVNTV GIPI 974

Nucleotide Sequence
(FASTA)

ATGGAGCGTC GGAGGCCCCG TACCTGTCTC GCCCTGCTGT GGGGCTGCAT GCTGGTCGCT 60

ACCGCGGCGC AGGGCAAGGA AGTTGTTTTG CTGGACTTTG CTGCAGCAAA CGGGGAACTC 120

GGCTGGCTCA CGCACCCGTA CGGCAAAGGG TGGGACCTGA TGCAGAACAT CATGGACGAC 180

ACGCCCATCT ACATGTACTC CGTGTGCAAC GTGGTGGCCG GCGACCAGGA TAACTGGCTG 240

CGCACCAACT GGGTGTACCG CGGCGAGGCC GAGCGGATCT TCATCGAGCT CAAGTTCACC 300

GTGCGCGACT GCAACAGCTT CCCGGGGGGC GCCAGCTCCT GCAAGGAGAC CTTCAACCTC 360

TACTACGCCG AGTCGGATGT GGACTACGGC ACCAACTTCC AGAAGCGCCA GTTCAAGAAG 420

ATCGATACCA TCGCGCCCGA CGAGATCACA GTCAGCAGCG ACTTCGAGGC CCGCCACGTG 480

AAGCTGAACG TGGAGGAGCG CTCCGTGGGG CCGCTCACCC ACAAGGGCTT CTACCTGGCC 540

TTCCAGGACA TCGGCGCCTG CGTGGCGCTG CTCTCCGTCC GCGTCTACTA CAAGAAGTGC 600

CCCGAGCTGC TGCAGGGCCT GGCCCGCTTC CCCGAGACCA TCGCCGGCTC CGACGCGCCC 660

TCCCTGGCCA CCGTGGCAGG CACTTGTGTG GACCATGCTG TGGTTCCCCC TGGGGGCGAA 720

GAGCCCCGCA TGCACTGTGC AGTCGACGGC GAGTGGCTGG TGCCCATCGG TCAGTGCCTG 780

TGCCAGGAGG GCTACGAGAA GGTGGAGGAC GCCTGCCAGG CCTGCTCGTC TGGATTCTTC 840

AAATCGGAGG CGTCCGAGAG TGCCTGTTTG GAGTGCCCCG CACACACCCT GCCGTCCTCC 900

GAGGGGGCCA CGTTCTGCGA GTGTGAGGAA GGCTACTTCC GGGCCCCGCA GGACTCGCTG 960

TCGATGCCCT GCACAGGCCC GCCCTCTGCC CCAAGCTCCC TCACGGCCGT GGGCATGGGT 1020

GCCAAAGTGG AGCTGCGCTG GACGGCGCCC CTGGACAACG GGGGCCGTGA AGACATCACC 1080

TACAGGGTCA CCTGCAAACA GTGCCTGCCC GAGTCAGACG AGTGCAGACC CTGCGAGGCC 1140

AGCGTGCGCT ACTCCGAGCT CCCGAACAAG CTGACCCGCA CCAGCGTGAT AGTCAGTGAC 1200

CTGGAGCCCC ACATGAACTA CACCTTCGCC GTGGAGGCCC GCAACGGCGT CTCGGACCTG 1260

GTGGCCAGCC GCAGCTTCCG CACGGCCAGC GTCAGCATCA ACCAGACAGA GCCCCCCAAG 1320

GTGAAGCTGG AGAGCCGGGG CACCACCTCG CTGAGCGTGT CCTGGAGCAT CCCTGTGCCA 1380

CAGCAGAGCC GTGTGTGGAA GTACGAGGTC ACCTACCGCA AGAAGGGGGA CTCCAACACC 1440

TACAACGTGC ACCAAACCGA GGACTTCTCT GTGACCCTGG ACGGCCTGGC TCCGGACACC 1500

ACCTACCTGG TCCAAGTGCA GGCGCTGACA CAGGAGGGCC AGGGGGCCAG CAGCAAGGTG 1560

CACGAGTTCC AGACGCTGTC CACGGAAGGA TCTGGCAACG TGGCGGTGAT TGGCGGAGTG 1620

GCCGTGGTCA TTGTCTTGCT CCTGGTGCTG GCAGGAATCG GCTTCCTCCT CCATCGCAGG 1680

AGGAAGAGCC AGCGGGCCCG CCAGTCCCCG GAGGATGTTT ACTTCTCCAA GTCAGAACAA 1740

CTGAAGCCCT TGAAGACATA TGTAGACCCC CACACTTACG AGGACCCCAA CCAGGCCGTG 1800

CTCAAGTTCA CCACCGAGAT CCACCCGTCC TGTGTCACGC GGCAGAAGGT GATCGGAGCA 1860

GGAGAGTTTG GGGAGGTGTA CAAGGGGACG CTGAAGGCGT CGGGGAAGAA GGAGGTACCT 1920

GTGGCCATCA AGACGCTGAA AGCCGGCTAC ACCGAGAAGC AGCGGGTGGA CTTCCTCAGC 1980

GAGGCCAGCA TCATGGGCCA GTTCAGCCAC CACAACATCA TCCGCCTGGA GGGCGTCGTC 2040

TCCAAATACA AGCCCATGAT GATCATCACT GAATACATGG AGAACGGGGC CCTGGACAAG 2100

TTCCTTCGGG AGAAGGATGG CGAGTTCTGC GTGCTGCAGC TGGTGGGCAT GCTGCGGGGC 2160

ATCGCGGCCG GCATGAAGTA CCTGGCCAAC ATGAACTACG TCCACCGCGA CCTGGCCGCC 2220

CGCAACATCC TCGTCAACAG CAACCTGGTC TGCAAGGTGT CCGACTTCGG CCTGTCCCGT 2280

GTGCTGGAGG ACGACCCCGA GGCCACCTAC ACCACCAGTG GTGGCAAGAT CCCCATCCGC 2340

TGGACAGCCC CGGAGGCCAT TTCCTACCGC AAGTTCACCT CGGCCAGCGA CGTGTGGAGT 2400

TACGGCATCC TCATGTGGGA AGTGATGACG TATGGCGAGC GGCCCTACTG GGAGCTGTCA 2460

AACCACGAGG TGATGAAAGC CATCAACGAC GGCTTCCGGC TGCCCACGCC CATGGAGTGC 2520

CCCTCCGCCA TCTACCAGCT CATGATGCAG TGCTGGCAGC AGGAGCGCGC CCGCCGCCCC 2580

AAGTTCGCCG ACATCGTCAG CATCCTGGAC AAGCTCATCC GTGCTCCCGA CTCCCTCAAG 2640

ACCCTGGCTG ACTTTGATCC CCGAGTGTCC ATCCGGCTGC CCAGCACCAG CGGCTCCGAG 2700

GGGGTGCCCT TCCGCACGGT GTCCGAGTGG CTCGAGTCCA TCAAGATGCA GCAGTACACA 2760

GAGCACTTCC TGGCGGCCGG CTACACGGCC ATCGAGAAGG TGGTACAGAT GACCAACGAT 2820

GACATCAAGA AGATTGGGGT GCGGCTGCCC GGCCACCAGA AGCGCATCGC CTACAGCCTG 2880

CTGGGACTCA AGGAGCAAGT GAACACAGTG GGGATCCCCA TCTGA 2925

Domain Profile

S: 2     kiekviGaGefGevcsGrlklpgkreiavaiktlkagstekqrrdflseasilGqfdhpn  61

         + +kviGaGefGev++G+lk++gk+e++vaiktlkag+tekqr+dflseasi+Gqf+h+n

Q: 613   TRQKVIGAGEFGEVYKGTLKASGKKEVPVAIKTLKAGYTEKQRVDFLSEASIMGQFSHHN  672

         6789********************************************************

S: 62    iirleGvvtkskpvmivteymengaldsflrkkdgqftviqlvgmlrGiasgmkylsdmg  121

         iirleGvv+k kp+mi+teymengald+flr+kdg+f v+qlvgmlrGia+gmkyl++m+

Q: 673   IIRLEGVVSKYKPMMIITEYMENGALDKFLREKDGEFCVLQLVGMLRGIAAGMKYLANMN  732

         ************************************************************

S: 122   yvhrdlaarnilvnsnlvckvsdfGlsrvleddseaayttsggkipirwtapeaiayrkf  181

         yvhrdlaarnilvnsnlvckvsdfGlsrvledd+ea+yttsggkipirwtapeai+yrkf

Q: 733   YVHRDLAARNILVNSNLVCKVSDFGLSRVLEDDPEATYTTSGGKIPIRWTAPEAISYRKF  792

         ************************************************************

S: 182   tsasdvwsyGivlwevlsyGerpywdmsnqdvikaieegyrlpppmdcpaalyqlmldcw  241

         tsasdvwsyGi++wev++yGerpyw++sn++v+kai++g+rlp+pm+cp+a+yqlm++cw

Q: 793   TSASDVWSYGILMWEVMTYGERPYWELSNHEVMKAINDGFRLPTPMECPSAIYQLMMQCW  852

         ************************************************************

S: 242   qkdraerpkfeqivsil  258

         q++ra+rpkf++ivsil

Q: 853   QQERARRPKFADIVSIL  869

         **************985

Domain Sequence
(FASTA)

TRQKVIGAGE FGEVYKGTLK ASGKKEVPVA IKTLKAGYTE KQRVDFLSEA SIMGQFSHHN 60

IIRLEGVVSK YKPMMIITEY MENGALDKFL REKDGEFCVL QLVGMLRGIA AGMKYLANMN 120

YVHRDLAARN ILVNSNLVCK VSDFGLSRVL EDDPEATYTT SGGKIPIRWT APEAISYRKF 180

TSASDVWSYG ILMWEVMTYG ERPYWELSNH EVMKAINDGF RLPTPMECPS AIYQLMMQCW 240

QQERARRPKF ADIVSIL 257

Keyword

ATP-binding; Complete proteome; Kinase; Membrane; Nucleotide-binding; Receptor; Reference proteome; Transferase; Transmembrane; Transmembrane helix; Tyrosine-protein kinase.

Sequence Source

Ensembl

Orthology

Ortholog group

Ailuropoda melanoleuca"; ?>Anolis carolinensis"; ?>Bos taurus"; ?>Callithrix jacchus"; ?>Canis familiaris"; ?>Cavia porcellus"; ?>Danio rerio"; ?>Equus caballus"; ?>Felis catus"; ?>Gadus morhua"; ?>Gasterosteus aculeatus"; ?>Gorilla gorilla"; ?>Homo sapiens"; ?>Ictidomys tridecemlineatus"; ?>Latimeria chalumnae"; ?>Loxodonta africana"; ?>Macaca mulatta"; ?>Macropus eugenii"; ?>Meleagris gallopavo"; ?>Mus musculus"; ?>Mustela putorius furo"; ?>Nomascus leucogenys"; ?>Ochotona princeps"; ?>Oreochromis niloticus"; ?>Ornithorhynchus anatinus"; ?>Oryctolagus cuniculus"; ?>Oryzias latipes"; ?>Otolemur garnettii"; ?>Pan troglodytes"; ?>Pelodiscus sinensis"; ?>Pongo abelii"; ?>Rattus norvegicus"; ?>Sarcophilus harrisii"; ?>Sus scrofa"; ?>Takifugu rubripes"; ?>Tetraodon nigroviridis"; ?>Xiphophorus maculatus"; ?>

Gene Ontology

GO:0005887	; C:integral to plasma membrane
GO:0005524	; F:ATP binding
GO:0005003	; F:ephrin receptor activity

KEGG

InterPros

IPR001090	; Ephrin_rcpt_lig-bd_dom.
IPR003961	; Fibronectin_type3.
IPR008979	; Galactose-bd-like.
IPR009030	; Growth_fac_rcpt.
IPR013783	; Ig-like_fold.
IPR011009	; Kinase-like_dom.
IPR000719	; Prot_kinase_cat_dom.
IPR017441	; Protein_kinase_ATP_BS.
IPR001660	; SAM.
IPR013761	; SAM/pointed.
IPR021129	; SAM_type1.
IPR001245	; Ser-Thr/Tyr_kinase_cat_dom.
IPR011641	; Tyr-kin_ephrin_A/B_rcpt-like.
IPR008266	; Tyr_kinase_AS.
IPR020635	; Tyr_kinase_cat_dom.
IPR016257	; Tyr_kinase_ephrin_rcpt.
IPR001426	; Tyr_kinase_rcpt_V_CS.

Pfam

PF01404	; Ephrin_lbd; 1.
PF00041	; fn3; 2.
PF07699	; GCC2_GCC3; 1.
PF07714	; Pkinase_Tyr; 1.
PF00536	; SAM_1; 1.

SMARTs

SM00615	; EPH_lbd; 1.
SM00060	; FN3; 2.
SM00454	; SAM; 1.
SM00219	; TyrKc; 1.

Prosites

PS51550	; EPH_LBD; 1.
PS50853	; FN3; 2.
PS00107	; PROTEIN_KINASE_ATP; 1.
PS50011	; PROTEIN_KINASE_DOM; 1.
PS00109	; PROTEIN_KINASE_TYR; 1.
PS00790	; RECEPTOR_TYR_KIN_V_1; 1.
PS00791	; RECEPTOR_TYR_KIN_V_2; 1.
PS50105	; SAM_DOMAIN; 1.

Prints

PR00109

; TYRKINASE.

Created Date

20-Feb-2013