EKS-MYL-00300

Eukaryotic Protein Kinase & Protein Phosphatase Database

Tag

Content

EKPD ID

EKS-MYL-00300

Classification

Group/Family	Score	E-Value	Start	End	Domain Length
TK/EGFR	459.9	2.3E-138	714	956	243

Status

Unreviewed

Ensembl Protein

ENSMLUP00000013673

UniProt Accession

G1PRB8;

Protein Name

Protein Synonyms/Alias

Gene Name

ERBB2

Gene Synonyms/Alias

ERBB2;

Ensembl Information

Ensembl Gene ID	Ensembl Protein ID	Ensembl Transcript ID
ENSMLUG00000015001	ENSMLUP00000013673	ENSMLUT00000015016

Organism

Myotis lucifugus

Functional Description

Protein Length

1244

Protein Sequence
(FASTA)

VRTMELAAWY RWGLLLALLP PGAAGTQVCT GTDMKLQFPA SPETHLDMLR HLYQGCQVVQ 60

GNLELTHLPG NASLSFLQDI QEVQGYVLIA HSQVTQVPLQ RLRIIRGTQL FEDNYALAVL 120

DNGDSATPGG LRELQLRSLT EILKGGVLMQ RNPQLCHQDT VLWKDIFHKN NRLALLQIDT 180

NRSRACKPCY PSCNPSHCWG ESSKDCQILT RTLCASGCAR CKGSLPTDCC HEQCAAGCTG 240

PKHSDCLACL HFNHSGICEL HCPALVTYNT DTFESMPNPE GRYTFGASCV TTCPYNYLST 300

DVGSCTLVCP LNNQEVTAED GTQRCEKCSK PCARVCYGLG MEHLREARAV TSANIQEFAG 360

CKKIFGSLAF LPESFKGNST SNTAPLEPEQ LRVFETLEEI TGYLYISAWP DSMPDLSVFQ 420

NLQVIRGRVL YDGAYSLTLQ GLGIRWLGLR SLRELGSGLA LIHRNAHLCF VHTVPWDQLF 480

RNPHQALLHS ANRPEDECVG EGQACYPLCA HGHCWGPGPT QCVNCSQFLR GQECVEECRV 540

LQGLPREYVK DRYCLPCHPE CQPQNGSATC LGSEADQCVA CAHYKDSPFC VARCPSGVKP 600

DLSFMPIWKF PDEEGTCQPC PINCTHSCVD LDEKGCPAEQ RASPVTSIIA AVVGILLVMV 660

VGVVLGILIR RRRQKIRKYT MRRLLQETEL VEPLTPSGAM PNQAQMRILK ETELRKVKVL 720

GSGAFGTVYK GIWIPDGENV KIPVAIKVLR ENTSPKANKE ILDEAYVMAG VGSPYVSRLL 780

GICLTSTVQL VTQLMPYGCL LDHVREHRGR LGSQDLLNWC VQIAKGMSYL EEVRLVHRDL 840

AARNVLVKSP NHVKITDFGL ARLLDIDETE YHADGGKVPI KWMALESILR RRFTHQSDVW 900

SYGVTVWELM TFGAKPYDGI PAREIPDLLE KGERLPQPPI CTIDVYMIMV KLCWLLGGGW 960

EVLGGGSTGN MEGGQARMHV TQRPRMVPGT STGSRFPFTY QSRDAPGDQL ESDLDAKSKA 1020

SGTSSLPPES FGLSCPQSGG GELTLGLEPP EEEPPKSPLA PSEGAGSDVF ESDLGMGAAK 1080

GLQSLSPHDP SPLQRYSEDP TVPLPPEADG YVAPATCSPQ PEYVNQPEVR PKPPSPLEGP 1140

LPPPRSASAT LEKPKTLSPK TLSPGKNGVV KDVFAFGGAV ENPEYLAPRG RAAPQPHPPP 1200

AFSPAFDNLY YWDQDPSERG SLPSTFEGTP TAENPEYLGL DAPV 1244

Nucleotide Sequence
(FASTA)

GTGAGGACAA TGGAGCTGGC GGCCTGGTAC CGCTGGGGGC TCCTCCTCGC CCTCCTGCCC 60

CCCGGAGCCG CGGGCACCCA AGTGTGCACC GGCACAGACA TGAAGCTGCA GTTCCCAGCC 120

AGTCCTGAGA CCCACCTGGA CATGCTGCGC CACCTCTACC AGGGCTGTCA GGTGGTGCAG 180

GGTAACCTGG AGCTCACCCA CCTGCCTGGC AATGCCAGCC TCTCCTTCCT ACAGGATATC 240

CAGGAGGTGC AGGGCTACGT GCTCATCGCT CACAGCCAAG TGACACAGGT CCCGCTGCAG 300

AGGCTGCGAA TCATCCGAGG CACCCAGCTC TTTGAGGACA ACTATGCCCT GGCCGTGCTG 360

GACAACGGAG ACAGCGCCAC CCCAGGAGGG CTGCGGGAGC TGCAGCTTCG AAGCCTCACA 420

GAGATCCTGA AGGGAGGGGT GTTGATGCAG CGGAACCCAC AGCTCTGCCA CCAGGACACG 480

GTCCTGTGGA AGGACATCTT CCACAAGAAC AACCGGCTGG CCCTCCTGCA GATAGACACC 540

AACCGCTCAC GGGCCTGCAA ACCCTGTTAT CCATCCTGCA ACCCTTCCCA CTGCTGGGGA 600

GAGAGTTCCA AGGACTGTCA GATCTTGACT CGAACTCTGT GTGCCAGCGG CTGTGCCCGC 660

TGCAAGGGCT CACTGCCCAC CGACTGCTGC CACGAGCAGT GTGCTGCCGG CTGCACGGGC 720

CCCAAGCACT CTGACTGCCT GGCCTGCCTC CACTTCAACC ACAGTGGCAT CTGTGAGCTG 780

CACTGCCCAG CCCTGGTCAC CTACAACACG GACACCTTTG AGTCCATGCC CAACCCCGAG 840

GGCCGCTACA CCTTTGGTGC CAGCTGTGTG ACCACCTGTC CCTACAACTA CCTGTCAACG 900

GACGTGGGAT CCTGCACCCT GGTCTGTCCC CTGAACAACC AAGAGGTGAC AGCTGAGGAC 960

GGAACACAGC GGTGTGAGAA GTGCAGCAAG CCCTGTGCCC GAGTGTGCTA TGGGCTGGGC 1020

ATGGAACACC TGCGGGAGGC GAGGGCAGTC ACCAGTGCCA ATATCCAGGA GTTTGCCGGC 1080

TGCAAGAAGA TCTTTGGGAG CCTGGCGTTT CTGCCAGAGA GCTTTAAGGG GAACTCCACC 1140

TCCAACACTG CCCCCCTGGA GCCTGAGCAG CTCAGAGTGT TTGAGACCTT GGAGGAGATC 1200

ACAGGTTACC TGTACATCTC GGCGTGGCCA GACAGCATGC CTGACCTCAG TGTCTTCCAG 1260

AACCTGCAAG TGATCCGGGG ACGCGTTCTA TATGACGGCG CCTACTCGCT GACCCTGCAA 1320

GGACTGGGCA TCCGATGGCT GGGGCTGCGC TCGCTGCGGG AACTGGGCAG TGGGCTGGCC 1380

CTCATCCACC GCAACGCCCA CCTCTGCTTT GTCCACACGG TGCCCTGGGA CCAGCTCTTC 1440

CGGAACCCTC ACCAGGCCCT GCTCCACAGT GCCAACCGGC CAGAGGATGA GTGTGTGGGT 1500

GAGGGCCAGG CCTGCTACCC GCTGTGCGCC CACGGGCACT GCTGGGGTCC GGGGCCCACC 1560

CAGTGTGTCA ACTGCAGCCA GTTCCTTCGG GGCCAGGAGT GCGTGGAGGA GTGCCGAGTA 1620

CTGCAGGGGC TCCCCAGGGA GTACGTGAAG GATAGGTACT GTCTGCCTTG CCACCCCGAG 1680

TGCCAGCCCC AGAATGGCTC AGCGACCTGC TTAGGATCGG AGGCCGACCA GTGTGTGGCC 1740

TGCGCCCACT ACAAGGACTC TCCCTTCTGT GTGGCCCGGT GCCCCAGTGG CGTGAAGCCT 1800

GACCTCTCCT TCATGCCCAT CTGGAAGTTC CCCGACGAGG AGGGCACGTG CCAGCCATGC 1860

CCCATCAACT GCACCCACTC CTGCGTGGAC CTGGATGAGA AGGGCTGCCC CGCCGAGCAG 1920

AGAGCCAGCC CTGTGACGTC CATCATTGCT GCTGTGGTGG GCATTCTGCT GGTCATGGTC 1980

GTGGGGGTAG TCCTCGGCAT CCTAATCAGG AGAAGGCGGC AGAAGATCCG GAAGTACACG 2040

ATGCGGAGGC TGCTGCAGGA AACGGAGCTG GTGGAGCCGC TGACGCCTAG CGGGGCGATG 2100

CCCAACCAGG CTCAGATGCG GATCCTCAAA GAGACGGAGC TGAGGAAGGT GAAGGTGCTC 2160

GGATCCGGAG CTTTTGGCAC CGTCTACAAG GGCATCTGGA TCCCCGATGG GGAGAACGTG 2220

AAGATCCCAG TGGCCATCAA AGTGTTGAGG GAAAACACAT CTCCCAAAGC CAACAAAGAA 2280

ATCTTGGATG AAGCATATGT GATGGCTGGT GTGGGCTCCC CTTATGTGTC GCGCCTCCTG 2340

GGCATCTGCT TGACCTCCAC GGTGCAGCTG GTGACACAGC TCATGCCCTA CGGCTGCCTC 2400

CTGGACCACG TCCGCGAACA CCGCGGGCGC CTGGGCTCCC AGGACCTGCT GAACTGGTGT 2460

GTGCAGATTG CCAAGGGAAT GAGCTACCTG GAGGAAGTGC GGCTTGTGCA CAGGGACCTG 2520

GCTGCCCGGA ACGTACTGGT CAAGAGTCCC AACCACGTCA AGATCACAGA CTTTGGGCTG 2580

GCTCGGCTGC TGGACATCGA CGAGACGGAG TACCATGCAG ATGGGGGCAA GGTGCCCATC 2640

AAGTGGATGG CGCTGGAGTC CATTCTCCGC CGACGGTTCA CCCACCAGAG TGATGTGTGG 2700

AGCTACGGTG TGACTGTGTG GGAGCTGATG ACTTTTGGGG CCAAACCTTA CGATGGGATC 2760

CCAGCCCGGG AGATCCCTGA CCTGCTGGAG AAGGGGGAGC GGCTGCCCCA GCCGCCCATC 2820

TGCACCATCG ATGTCTACAT GATCATGGTC AAATTGTGCT GGCTGCTTGG AGGCGGGTGG 2880

GAGGTTCTGG GTGGAGGGTC TACAGGGAAC ATGGAAGGGG GCCAAGCCAG AATGCATGTG 2940

ACCCAGAGGC CCCGCATGGT ACCAGGAACC TCCACAGGGT CTCGCTTCCC TTTCACATAC 3000

CAGTCCAGGG ACGCTCCAGG GGACCAGCTA GAAAGCGACT TAGATGCAAA ATCAAAAGCT 3060

TCTGGTACCT CGTCTCTACC ACCTGAGAGC TTTGGACTCT CTTGTCCCCA GAGTGGCGGT 3120

GGTGAACTGA CACTGGGGCT GGAGCCCCCA GAGGAGGAGC CCCCGAAATC TCCACTGGCG 3180

CCCTCCGAGG GGGCGGGCTC TGATGTGTTT GAGAGCGACT TGGGAATGGG GGCGGCCAAG 3240

GGGCTGCAGA GCCTCTCCCC ACATGACCCC AGCCCTCTAC AGCGGTACAG TGAGGACCCC 3300

ACAGTGCCCC TGCCCCCTGA GGCTGATGGC TACGTTGCCC CTGCGACCTG CAGTCCCCAG 3360

CCAGAATACG TGAACCAGCC AGAGGTCCGC CCGAAGCCCC CCTCACCCCT AGAGGGCCCC 3420

CTGCCGCCTC CTCGATCTGC CAGTGCCACT CTGGAAAAGC CCAAGACTCT CTCCCCCAAG 3480

ACTCTGTCCC CTGGGAAGAA CGGGGTTGTC AAAGACGTTT TTGCCTTTGG GGGTGCCGTG 3540

GAGAACCCTG AGTACCTGGC ACCCCGCGGC AGGGCTGCCC CTCAGCCCCA CCCTCCTCCT 3600

GCCTTCAGTC CAGCCTTTGA CAACCTCTAT TACTGGGACC AGGACCCATC CGAGCGTGGC 3660

TCTCTGCCCA GCACCTTTGA AGGGACCCCT ACGGCAGAGA ACCCCGAGTA CCTGGGTCTG 3720

GATGCGCCAG TGTGA 3735

Domain Profile

S: 1     lkklkvlGsGafGtvykGiwipegenvkipvaikvleektgkkankelldealvlasldh  60

         l+k+kvlGsGafGtvykGiwip+genvkipvaikvl+e+t++kanke+ldea+v+a + +

Q: 714   LRKVKVLGSGAFGTVYKGIWIPDGENVKIPVAIKVLRENTSPKANKEILDEAYVMAGVGS  773

         69**********************************************************

S: 61    anlvrllglclsstlqlvtqllplGclldyvrehkdklGsqellnwcvqiakGmsyleek  120

         ++++rllg+cl+st+qlvtql+p+Gclld+vreh+++lGsq+llnwcvqiakGmsylee

Q: 774   PYVSRLLGICLTSTVQLVTQLMPYGCLLDHVREHRGRLGSQDLLNWCVQIAKGMSYLEEV  833

         ************************************************************

S: 121   rlvhrdlaarnvlvkspnhvkitdfGlaklleadekelkaeggkvpikwlalesilkrky  180

         rlvhrdlaarnvlvkspnhvkitdfGla+ll+ de+e++a+ggkvpikw+alesil+r++

Q: 834   RLVHRDLAARNVLVKSPNHVKITDFGLARLLDIDETEYHADGGKVPIKWMALESILRRRF  893

         ************************************************************

S: 181   thqsdvwsyGvtvwelltfGakpydgipakeipdllekGerlaqppictidvymvlvk.c  239

         thqsdvwsyGvtvwel+tfGakpydgipa+eipdllekGerl+qppictidvym++vk c

Q: 894   THQSDVWSYGVTVWELMTFGAKPYDGIPAREIPDLLEKGERLPQPPICTIDVYMIMVKlC  953

         *********************************************************989

S: 240   wmi  242

w++

Q: 954   WLL  956

*86

Domain Sequence
(FASTA)

LRKVKVLGSG AFGTVYKGIW IPDGENVKIP VAIKVLRENT SPKANKEILD EAYVMAGVGS 60

PYVSRLLGIC LTSTVQLVTQ LMPYGCLLDH VREHRGRLGS QDLLNWCVQI AKGMSYLEEV 120

RLVHRDLAAR NVLVKSPNHV KITDFGLARL LDIDETEYHA DGGKVPIKWM ALESILRRRF 180

THQSDVWSYG VTVWELMTFG AKPYDGIPAR EIPDLLEKGE RLPQPPICTI DVYMIMVKLC 240

WLL 243

Keyword

ATP-binding; Complete proteome; Kinase; Nucleotide-binding; Phosphoprotein; Reference proteome; Transferase; Tyrosine-protein kinase.

Sequence Source

Ensembl

Orthology

Ortholog group

Ailuropoda melanoleuca"; ?>Anolis carolinensis"; ?>Bos taurus"; ?>Callithrix jacchus"; ?>Canis familiaris"; ?>Cavia porcellus"; ?>Danio rerio"; ?>Equus caballus"; ?>Felis catus"; ?>Gasterosteus aculeatus"; ?>Gorilla gorilla"; ?>Homo sapiens"; ?>Ictidomys tridecemlineatus"; ?>Latimeria chalumnae"; ?>Loxodonta africana"; ?>Macaca mulatta"; ?>Meleagris gallopavo"; ?>Monodelphis domestica"; ?>Mus musculus"; ?>Mustela putorius furo"; ?>Nomascus leucogenys"; ?>Oreochromis niloticus"; ?>Ornithorhynchus anatinus"; ?>Oryctolagus cuniculus"; ?>Oryzias latipes"; ?>Otolemur garnettii"; ?>Pan troglodytes"; ?>Pelodiscus sinensis"; ?>Pongo abelii"; ?>Rattus norvegicus"; ?>Sarcophilus harrisii"; ?>Sus scrofa"; ?>Taeniopygia guttata"; ?>Takifugu rubripes"; ?>Tetraodon nigroviridis"; ?>Xenopus tropicalis"; ?>Xiphophorus maculatus"; ?>

Gene Ontology

GO:0016021	; C:integral to membrane
GO:0005524	; F:ATP binding
GO:0004716	; F:receptor signaling protein tyrosine kinase activity
GO:0004714	; F:transmembrane receptor protein tyrosine kinase activity
GO:0023014	; P:signal transduction by phosphorylation
GO:0007169	; P:transmembrane receptor protein tyrosine kinase signaling pathway

KEGG

InterPros

IPR021157	; Cyt_c1_TM_anchor_C.
IPR000494	; EGF_rcpt_L.
IPR006211	; Furin-like_Cys-rich_dom.
IPR006212	; Furin_repeat.
IPR009030	; Growth_fac_rcpt.
IPR011009	; Kinase-like_dom.
IPR000719	; Prot_kinase_cat_dom.
IPR017441	; Protein_kinase_ATP_BS.
IPR001245	; Ser-Thr/Tyr_kinase_cat_dom.
IPR008266	; Tyr_kinase_AS.
IPR020635	; Tyr_kinase_cat_dom.
IPR016245	; Tyr_kinase_EGF/ERB/XmrK_rcpt.

Pfam

PF00757	; Furin-like; 1.
PF07714	; Pkinase_Tyr; 1.
PF01030	; Recep_L_domain; 2.

SMARTs

SM00261	; FU; 3.
SM00219	; TyrKc; 1.

Prosites

PS00107	; PROTEIN_KINASE_ATP; 1.
PS50011	; PROTEIN_KINASE_DOM; 1.
PS00109	; PROTEIN_KINASE_TYR; 1.

Prints

PR00109

; TYRKINASE.

Created Date

20-Feb-2013