EKS-MYL-00278

Eukaryotic Protein Kinase & Protein Phosphatase Database

Tag

Content

EKPD ID

EKS-MYL-00278

Classification

Group/Family	Score	E-Value	Start	End	Domain Length
TKL/STKR	467.5	1.6E-140	173	460	288

Status

Unreviewed

Ensembl Protein

ENSMLUP00000013662

UniProt Accession

G1PRA8;

Protein Name

Protein Synonyms/Alias

Gene Name

TGFBR1

Gene Synonyms/Alias

TGFBR1;

Ensembl Information

Ensembl Gene ID	Ensembl Protein ID	Ensembl Transcript ID
ENSMLUG00000015003	ENSMLUP00000013662	ENSMLUT00000015004

Organism

Myotis lucifugus

Functional Description

Protein Length

471

Protein Sequence
(FASTA)

ALQCFCLLCP KDNFTCVTDG LCFVSVTETT DKIIHNSMCI AEIDLIPRDR PFVCAPSSKA 60

GSVTTTYCCN QDHCNKIELP TVGKPSPGLG PVELAAVIAG PVCFVCISLM LMVYICHNRT 120

VIHHRVPNEE DPSLDRPFIS EGTTLKDLIY DMTTSGSGSG LPLLVQRTIA RTIVLQESIG 180

KGRFGEVWRG KWRGEEVAVK IFSSREERSW FREAEIYQTV MLRHENILGF IAADNKDNGT 240

WTQLWLVSDY HEHGSLFDYL NRYTVTVEGM IKLALSTASG LAHLHMEIVG TQGKPAIAHR 300

DLKSKNILVK KNGTCCIADL GLAVRHDSAT DTIDIAPNHR VGTKRYMAPE VLDDSINMKH 360

FESFKRADIY AMGLVFWEIA RRCSIGGIHE DYQLPYYDLV PSDPSVEEMR KVVCEQKLRP 420

NIPNRWQSCE ALRVMAKIMR ECWYANGAAR LTALRIKKTL SQLSQQEGIK M 471

Nucleotide Sequence
(FASTA)

GCATTACAGT GTTTCTGCCT CCTTTGCCCA AAAGACAATT TTACTTGTGT CACAGATGGA 60

CTCTGCTTTG TCTCTGTCAC AGAGACCACA GACAAAATTA TACACAATAG TATGTGTATA 120

GCTGAAATCG ACCTAATTCC TCGAGACAGG CCATTTGTAT GTGCACCATC TTCAAAAGCT 180

GGGTCTGTTA CTACAACATA CTGCTGCAAT CAGGACCACT GCAATAAAAT AGAACTTCCA 240

ACTGTTGGAA AGCCATCACC TGGCCTTGGT CCCGTTGAAC TGGCAGCTGT CATTGCTGGA 300

CCAGTCTGCT TCGTCTGCAT CTCACTCATG TTGATGGTCT ATATCTGCCA TAACCGCACT 360

GTCATTCACC ATCGAGTGCC AAATGAAGAG GACCCTTCAT TAGATCGCCC TTTTATTTCA 420

GAGGGTACTA CATTAAAAGA TTTAATTTAT GATATGACAA CATCAGGGTC TGGATCAGGT 480

TTGCCATTGC TTGTTCAGAG AACAATTGCA AGAACTATTG TGTTACAAGA AAGTATTGGC 540

AAAGGTCGAT TTGGAGAAGT TTGGAGAGGA AAGTGGAGAG GAGAAGAAGT TGCTGTGAAA 600

ATATTCTCTT CTAGAGAAGA ACGTTCATGG TTCCGTGAGG CAGAGATTTA TCAAACTGTA 660

ATGTTACGTC ATGAAAACAT CTTGGGATTT ATAGCAGCAG ACAATAAAGA CAATGGTACA 720

TGGACTCAGC TCTGGCTGGT GTCAGATTAT CATGAGCATG GATCCCTTTT CGATTATTTG 780

AACAGATACA CAGTTACTGT GGAAGGAATG ATAAAACTCG CTCTGTCCAC AGCAAGTGGA 840

CTTGCCCATC TTCATATGGA GATTGTTGGT ACCCAAGGAA AACCAGCCAT TGCTCACAGA 900

GATTTGAAAT CAAAAAATAT CTTGGTAAAG AAGAACGGAA CTTGTTGTAT TGCAGACTTG 960

GGACTGGCAG TAAGGCATGA TTCAGCCACA GATACAATTG ATATTGCTCC AAACCACAGA 1020

GTGGGAACAA AACGGTACAT GGCCCCTGAA GTTCTAGATG ATTCCATAAA TATGAAACAC 1080

TTTGAATCCT TCAAGCGTGC TGACATCTAT GCAATGGGCT TAGTATTCTG GGAAATAGCT 1140

CGAAGATGTT CCATTGGTGG AATTCATGAA GATTACCAGC TGCCTTATTA TGATCTTGTA 1200

CCTTCTGATC CATCAGTTGA AGAAATGAGA AAAGTTGTTT GTGAACAGAA GTTGAGGCCA 1260

AATATTCCAA ACAGATGGCA GAGCTGTGAA GCCTTGAGAG TAATGGCTAA AATTATGAGA 1320

GAATGTTGGT ATGCCAATGG AGCAGCGAGG CTTACAGCTT TGCGGATTAA GAAAACTTTG 1380

TCACAACTCA GTCAACAGGA AGGCATCAAA ATGTAA 1416

Domain Profile

S: 1     lklleligkGrygeVwkaklrgeevAvKifstedeaswkrEkeiyqtvllrhenilqfia  60

         + l+e igkGr+geVw++k+rgeevAvKifs+++e+sw+rE+eiyqtv+lrhenil+fia

Q: 173   IVLQESIGKGRFGEVWRGKWRGEEVAVKIFSSREERSWFREAEIYQTVMLRHENILGFIA  232

         57899*******************************************************

S: 61    adkkeedsltelllvteyhekgsLsdyLkretldveellrlalslasGlahLHeeivgtk  120

         ad+k+++++t+l+lv++yhe+gsL+dyL+r+t++ve +++lals+asGlahLH+eivgt+

Q: 233   ADNKDNGTWTQLWLVSDYHEHGSLFDYLNRYTVTVEGMIKLALSTASGLAHLHMEIVGTQ  292

         ************************************************************

S: 121   gkkKpaiaHRDlkskNilvkkdltcciaDlGLalkleeekeeldlaansqvGtkRYmaPE  180

         g  KpaiaHRDlkskNilvkk++tcciaDlGLa++++++++++d+a n++vGtkRYmaPE

Q: 293   G--KPAIAHRDLKSKNILVKKNGTCCIADLGLAVRHDSATDTIDIAPNHRVGTKRYMAPE  350

         *..*********************************************************

S: 181   vleealnlkdfeafkraDvYslgLvlWEvasRceevdeeveeyklpfeevvgsdPsleem  240

         vl++++n+k+fe+fkraD+Y++gLv+WE+a+Rc+  ++++e+y+lp+++ v+sdPs+eem

Q: 351   VLDDSINMKHFESFKRADIYAMGLVFWEIARRCSI-GGIHEDYQLPYYDLVPSDPSVEEM  409

         ***********************************.************************

S: 241   kevvvekklrPkipeawkkkealkelsklleecWdadpeaRltalrvkkrl  291

         ++vv+e+klrP+ip++w+++eal++++k+++ecW+a+++aRltalr+kk+l

Q: 410   RKVVCEQKLRPNIPNRWQSCEALRVMAKIMRECWYANGAARLTALRIKKTL  460

         *************************************************97

Domain Sequence
(FASTA)

IVLQESIGKG RFGEVWRGKW RGEEVAVKIF SSREERSWFR EAEIYQTVML RHENILGFIA 60

ADNKDNGTWT QLWLVSDYHE HGSLFDYLNR YTVTVEGMIK LALSTASGLA HLHMEIVGTQ 120

GKPAIAHRDL KSKNILVKKN GTCCIADLGL AVRHDSATDT IDIAPNHRVG TKRYMAPEVL 180

DDSINMKHFE SFKRADIYAM GLVFWEIARR CSIGGIHEDY QLPYYDLVPS DPSVEEMRKV 240

VCEQKLRPNI PNRWQSCEAL RVMAKIMREC WYANGAARLT ALRIKKTL 288

Keyword

ATP-binding; Complete proteome; Kinase; Nucleotide-binding; Reference proteome; Serine/threonine-protein kinase; Transferase.

Sequence Source

Ensembl

Orthology

Ortholog group

Ailuropoda melanoleuca"; ?>Anolis carolinensis"; ?>Bos taurus"; ?>Caenorhabditis elegans"; ?>Callithrix jacchus"; ?>Canis familiaris"; ?>Cavia porcellus"; ?>Ciona intestinalis"; ?>Ciona savignyi"; ?>Danio rerio"; ?>Drosophila melanogaster"; ?>Equus caballus"; ?>Felis catus"; ?>Gadus morhua"; ?>Gallus gallus"; ?>Gasterosteus aculeatus"; ?>Gorilla gorilla"; ?>Ictidomys tridecemlineatus"; ?>Latimeria chalumnae"; ?>Loxodonta africana"; ?>Meleagris gallopavo"; ?>Monodelphis domestica"; ?>Mus musculus"; ?>Mustela putorius furo"; ?>Nomascus leucogenys"; ?>Ochotona princeps"; ?>Oreochromis niloticus"; ?>Ornithorhynchus anatinus"; ?>Oryctolagus cuniculus"; ?>Oryzias latipes"; ?>Otolemur garnettii"; ?>Pan troglodytes"; ?>Pelodiscus sinensis"; ?>Pongo abelii"; ?>Pteropus vampyrus"; ?>Rattus norvegicus"; ?>Sarcophilus harrisii"; ?>Sorex araneus"; ?>Sus scrofa"; ?>Taeniopygia guttata"; ?>Takifugu rubripes"; ?>Tarsius syrichta"; ?>Tetraodon nigroviridis"; ?>Tupaia belangeri"; ?>Tursiops truncatus"; ?>Vicugna pacos"; ?>Xenopus tropicalis"; ?>

Gene Ontology

GO:0016020	; C:membrane
GO:0005524	; F:ATP binding
GO:0005024	; F:transforming growth factor beta-activated receptor activity
GO:0007178	; P:transmembrane receptor protein serine/threonine kinase signaling pathway

KEGG

InterPros

IPR000472	; Activin_rcpt.
IPR011009	; Kinase-like_dom.
IPR000719	; Prot_kinase_cat_dom.
IPR017441	; Protein_kinase_ATP_BS.
IPR008271	; Ser/Thr_kinase_AS.
IPR003605	; TGF_beta_rcpt_GS.

Pfam

PF01064	; Activin_recp; 1.
PF00069	; Pkinase; 1.
PF08515	; TGF_beta_GS; 1.

SMARTs

SM00467

; GS; 1.

Prosites

PS51256	; GS; 1.
PS00107	; PROTEIN_KINASE_ATP; 1.
PS50011	; PROTEIN_KINASE_DOM; 1.
PS00108	; PROTEIN_KINASE_ST; 1.

Prints

Created Date

20-Feb-2013