EKS-MYL-00331
Eukaryotic Protein Kinase & Protein Phosphatase Database
TagContent
EKPD IDEKS-MYL-00331
Classification
Group/FamilyScoreE-ValueStartEndDomain Length
STE/STE20309.42.0E-922239238
StatusUnreviewed
Ensembl ProteinENSMLUP00000013884
UniProt AccessionG1PRV3;
Protein NameMitogen-activated protein kinase kinase kinase kinase
Protein Synonyms/Alias
Gene NameMAP4K2
Gene Synonyms/Alias MAP4K2;
Ensembl Information
Ensembl Gene IDEnsembl Protein IDEnsembl Transcript ID
ENSMLUG00000015233ENSMLUP00000013884ENSMLUT00000015242
OrganismMyotis lucifugus
Functional Description
Protein Length786
Protein Sequence
(FASTA)
RDTVTSELAA VKIVKLDPRD DISSLQQEIT ILRECHHPNV VAYIGSYLRN DRLWICMEFC 60
GGGSLQEIYH ATGPLEERQI AYVCREALKG LHHLHSQGKI HRDIKGANLL LTLQGDVKLA 120
DFGVSGELTA SVAKRRSFIG TPYWMAPEVA AVERKGGYNE LCDVWALGIT AIELGELQPP 180
LFHLHPMRAL MLMSKSSFQP PKLRDKTRWT QNFHHFLKLA LTKNPKKRPT AEKLLQHPFT 240
TQQLPRALLT QLLDKASDPH LGALSPEDCD LETYDMFPDT IHSRGQHGQA ERTPSEIQFH 300
QVKFGAPRRK ETDPLPEPWE EEWTLLGKEE LSGSLLQSVQ EALEERSLTI RPALELQELD 360
SPDDAVGTIK RAPLGPAPHE PPAEDSLSSP AGTPPRPLSG SDSPPPLPTA WATMKHQEDP 420
ERSSCHGLPP TPKVHMGACF SKVFNGCPLR IHAAVTWIHP GTRDQFLVVG AEEGIYTLNL 480
HELHEDTLEK LISHRCAWLY CVNNVLLSLS GKSTHIWSHD LPGLFEQRRL QQQVPLSIPT 540
NRLTQRIIPR RFALSTKIPD TKGCLQCRVV RNPYTSSTFL LAALPASLLL LQWYEPLQKF 600
LLLKNFSSPL PSPAGMLEPL VLDGKELPQV CVGAEGPEGP GCRVLFHVLP LEAGLTPDVL 660
IPPEGLPGSA QQVVQVDRDT VLVCFDRCVR IVNLLGEPTA TLAPVLTFDF PIETVVCLQD 720
SVLAFWSHGM QGRSLDTNEV TQEITDETRV FRVLGAHRDI ILESIPTDNP GAHSNLYILT 780
GHQSSY 786
Nucleotide Sequence
(FASTA)
CGCGACACCG TCACCTCCGA ACTGGCCGCG GTCAAGATAG TCAAGCTGGA CCCCAGGGAC 60
GACATCAGCT CCCTCCAGCA GGAAATCACT ATCCTGCGTG AGTGCCACCA CCCCAACGTG 120
GTGGCCTACA TTGGCAGCTA TCTCAGGAAT GACCGCCTGT GGATCTGCAT GGAGTTCTGC 180
GGAGGGGGCT CCCTGCAGGA GATTTACCAT GCCACTGGGC CCCTGGAGGA ACGGCAGATC 240
GCCTACGTCT GCCGAGAGGC ACTGAAGGGG CTGCACCACT TGCATTCTCA GGGGAAGATC 300
CACAGAGATA TCAAGGGCGC CAACCTGCTC CTCACCCTCC AGGGAGATGT CAAGCTGGCT 360
GACTTTGGGG TGTCGGGCGA GCTGACGGCA TCTGTGGCCA AGAGGAGGTC CTTCATTGGG 420
ACTCCGTACT GGATGGCCCC CGAGGTGGCC GCTGTGGAGC GCAAAGGTGG CTACAACGAG 480
CTGTGTGACG TCTGGGCCCT GGGCATCACA GCCATTGAGC TGGGCGAGCT GCAGCCCCCG 540
CTGTTCCACC TGCACCCCAT GAGGGCCTTG ATGCTCATGT CCAAGAGCAG CTTCCAGCCG 600
CCCAAGCTGA GGGACAAGAC TCGCTGGACC CAGAATTTCC ACCACTTCCT CAAGCTGGCC 660
TTGACCAAGA ACCCCAAGAA GAGGCCGACA GCAGAGAAGC TTCTACAGCA CCCATTCACA 720
ACGCAACAGC TCCCCCGGGC TCTCCTCACC CAGCTGTTGG ACAAGGCCAG TGACCCCCAC 780
CTGGGCGCCC TCTCCCCGGA GGACTGTGAC CTGGAGACGT ACGACATGTT TCCAGACACC 840
ATTCACTCCC GGGGCCAGCA CGGCCAGGCT GAGCGGACCC CCTCAGAGAT CCAGTTTCAC 900
CAGGTGAAGT TTGGCGCCCC ACGCAGGAAG GAAACGGACC CGCTACCTGA GCCGTGGGAA 960
GAGGAGTGGA CCCTGCTGGG CAAGGAGGAG CTGAGCGGGA GCCTGCTGCA GTCGGTCCAG 1020
GAGGCCCTGG AGGAAAGGAG CCTGACCATC CGGCCAGCCT TGGAACTCCA GGAGCTGGAC 1080
TCTCCAGACG ATGCCGTAGG AACCATCAAG CGGGCCCCGT TGGGGCCAGC CCCACATGAG 1140
CCTCCAGCTG AGGACTCTCT GTCCAGCCCC GCAGGAACCC CACCCCGACC TCTCTCGGGC 1200
TCGGACAGCC CCCCGCCTCT CCCCACCGCC TGGGCCACCA TGAAGCACCA GGAGGATCCT 1260
GAGAGATCGT CTTGCCATGG GCTGCCCCCG ACCCCCAAGG TGCACATGGG TGCCTGCTTC 1320
TCCAAGGTCT TCAATGGCTG CCCCCTGCGG ATCCATGCTG CTGTCACCTG GATTCACCCT 1380
GGCACCCGGG ATCAGTTCCT GGTGGTGGGG GCCGAGGAAG GCATCTACAC CCTCAACCTG 1440
CACGAGCTGC ACGAGGACAC CCTGGAGAAG CTGATCTCAC ACCGCTGCGC CTGGCTCTAC 1500
TGTGTGAACA ATGTGCTGCT GTCACTCTCA GGGAAATCCA CGCACATCTG GTCCCACGAC 1560
CTCCCGGGCC TATTTGAGCA GCGGCGACTG CAGCAGCAGG TTCCCCTCTC CATCCCCACC 1620
AACCGCCTCA CCCAGCGCAT CATCCCCAGA CGCTTTGCCC TGTCCACCAA GATTCCTGAC 1680
ACCAAAGGCT GCCTGCAGTG TCGTGTGGTG CGGAACCCCT ACACGAGCAG CACCTTCCTG 1740
CTGGCCGCCC TGCCCGCCAG CCTGCTCCTG CTGCAGTGGT ACGAGCCGCT ACAGAAGTTC 1800
CTGCTGCTGA AGAACTTCTC CAGCCCCTTG CCCAGCCCAG CAGGGATGCT GGAGCCGCTG 1860
GTCCTGGATG GGAAGGAGCT ACCACAGGTG TGTGTGGGGG CCGAGGGCCC TGAGGGGCCT 1920
GGCTGCCGTG TCCTGTTTCA TGTGCTGCCC CTGGAGGCCG GCCTGACACC TGATGTGCTC 1980
ATACCACCCG AGGGGCTCCC AGGATCGGCC CAGCAGGTGG TCCAGGTGGA CAGGGACACA 2040
GTTCTCGTCT GCTTTGACCG CTGCGTGCGG ATTGTCAACC TGCTGGGCGA GCCTACGGCC 2100
ACACTGGCTC CTGTGCTGAC CTTCGACTTC CCCATTGAGA CTGTGGTGTG TCTGCAGGAC 2160
AGCGTGCTGG CCTTCTGGAG CCACGGAATG CAAGGCCGCA GCCTGGACAC CAACGAGGTG 2220
ACCCAGGAGA TCACAGATGA GACGAGGGTC TTCCGAGTGC TTGGGGCCCA CAGAGACATC 2280
ATCCTGGAGA GCATTCCCAC CGACAACCCG GGGGCTCACA GCAACCTCTA CATCCTCACT 2340
GGCCATCAGA GCAGCTAC 2358
Domain Profile
S: 20    ekktgelvaikkinlekqekleelqkeisvlkklkhpniveylesflkeeelwlvmeyla  79
         ++ t+el+a+k+++l+  +++++lq+ei++l++++hpn+v+y++s+l++++lw++me++ 
Q: 2     DTVTSELAAVKIVKLDPRDDISSLQQEITILRECHHPNVVAYIGSYLRNDRLWICMEFCG  61
         567899******************************************************
S: 80    gGslsdlvkeelkselkEeqiayilrevlkaLeylHskkviHrdikakniLlteegeVkL  139
         gGsl+++++   + +l+E+qiay++re+lk+L++lHs+++iHrdik++n+Llt +g+VkL
Q: 62    GGSLQEIYH--ATGPLEERQIAYVCREALKGLHHLHSQGKIHRDIKGANLLLTLQGDVKL  119
         *********..9************************************************
S: 140   sdfgvaaqlektrkkrktvvgtpywmAPEviaqe.ekgYdekaDiwslGItaielaegep  198
         +dfgv+ +l+++++kr++++gtpywmAPEv a+e + gY+e +D+w+lGItaiel e +p
Q: 120   ADFGVSGELTASVAKRRSFIGTPYWMAPEVAAVErKGGYNELCDVWALGITAIELGELQP  179
         *********************************98889**********************
S: 199   Pfkdleplkallkilkne..ppklkskkkfskefkefvekclqknpekRpsasellkhkF  256
         P+++l+p++al++++k++  ppkl++k++++++f++f++ +l+knp+kRp+a++ll+h+F
Q: 180   PLFHLHPMRALMLMSKSSfqPPKLRDKTRWTQNFHHFLKLALTKNPKKRPTAEKLLQHPF  239
         ***************99988***************************************9
Domain Sequence
(FASTA)
DTVTSELAAV KIVKLDPRDD ISSLQQEITI LRECHHPNVV AYIGSYLRND RLWICMEFCG 60
GGSLQEIYHA TGPLEERQIA YVCREALKGL HHLHSQGKIH RDIKGANLLL TLQGDVKLAD 120
FGVSGELTAS VAKRRSFIGT PYWMAPEVAA VERKGGYNEL CDVWALGITA IELGELQPPL 180
FHLHPMRALM LMSKSSFQPP KLRDKTRWTQ NFHHFLKLAL TKNPKKRPTA EKLLQHPF 238
KeywordATP-binding; Complete proteome; Kinase; Nucleotide-binding; Reference proteome; Serine/threonine-protein kinase; Transferase.
Sequence SourceEnsembl
Orthology
Ortholog group
Ailuropoda melanoleuca"; ?>Bos taurus"; ?>Callithrix jacchus"; ?>Canis familiaris"; ?>Cavia porcellus"; ?>Ciona savignyi"; ?>Danio rerio"; ?>Dipodomys ordii"; ?>Equus caballus"; ?>Felis catus"; ?>Gorilla gorilla"; ?>Homo sapiens"; ?>Ictidomys tridecemlineatus"; ?>Latimeria chalumnae"; ?>Macaca mulatta"; ?>Mus musculus"; ?>Otolemur garnettii"; ?>Pan troglodytes"; ?>Pongo abelii"; ?>Pteropus vampyrus"; ?>Rattus norvegicus"; ?>Sus scrofa"; ?>Takifugu rubripes"; ?>Xenopus tropicalis"; ?>
EKS-AIM-00310
EKS-BOT-00321
EKS-CAJ-00329
EKS-CAF-00324
EKS-CAP-00353
EKS-CIS-00081
EKS-DAR-00674
EKS-DIO-00040
EKS-EQC-00329
EKS-FEC-00324
EKS-GOG-00316
EKS-HOS-00329
EKS-ICT-00315
EKS-LAC-00327
EKS-MAM-00340
EKS-MUM-00354
EKS-OTG-00342
EKS-PAT-00304
EKS-POA-00311
EKS-PTV-00073
EKS-RAN-00352
EKS-SUS-00279
EKS-TAR-00416
EKS-XET-00387
Gene Ontology
GO:0005524; F:ATP binding
GO:0004674; F:protein serine/threonine kinase activity
GO:0005083; F:small GTPase regulator activity
KEGG
InterPros
IPR001180; Citron.
IPR011009; Kinase-like_dom.
IPR021160; MAPKKKK.
IPR000719; Prot_kinase_cat_dom.
IPR002290; Ser/Thr_dual-sp_kinase_dom.
Pfam
PF00780; CNH; 1.
PF00069; Pkinase; 1.
SMARTs
SM00036; CNH; 1.
SM00220; S_TKc; 1.
Prosites
PS50219; CNH; 1.
PS50011; PROTEIN_KINASE_DOM; 1.
Prints
Created Date20-Feb-2013