EKS-MYL-00308

Eukaryotic Protein Kinase & Protein Phosphatase Database

Tag

Content

EKPD ID

EKS-MYL-00308

Classification

Group/Family	Score	E-Value	Start	End	Domain Length
STE/STE20	356.2	1.1E-106	27	291	265

Status

Unreviewed

Ensembl Protein

ENSMLUP00000014281

UniProt Accession

G1PSW3;

Protein Name

Protein Synonyms/Alias

Gene Name

MINK1

Gene Synonyms/Alias

MINK1;

Ensembl Information

Ensembl Gene ID	Ensembl Protein ID	Ensembl Transcript ID
ENSMLUG00000015661	ENSMLUP00000014281	ENSMLUT00000015679

Organism

Myotis lucifugus

Functional Description

Protein Length

1335

Protein Sequence
(FASTA)

MNSEPVQSNT LFFLSLSPPL QDPAGIFELV EVVGNGTYGQ VYKGRHVKTG QLAAIKVMDV 60

TEDEEEEIKQ EINMLKKYSH HRNIATYYGA FIKKSPPGND DQLWLVMEFC GAGSVTDLVK 120

NTKGNALKED CIAYICREIL RGLAHLHAHK VIHRDIKGQN VLLTENAEVK LVDFGVSAQL 180

DRTVGRRNTF IGTPYWMAPE VIACDENPDA TYDYRSDIWS LGITAIEMAE GAPPLCDMHP 240

MRALFLIPRN PPPRLKSKKW SKKFIDFIDT CLIKTYLSRP PTEQLLKFPF IRDQPTERQV 300

RIQLKDHIDR SRKKRGEKEE TEYEYSGSEE EDDSHGEEGE PSSIMNVPGE STLRREFLRL 360

QQENKSNSEA LKQQQQLQQQ QQRDPEAHIK HLLHQRQRRI EEQKEERRRV EEQQRREREQ 420

RKLQEKEQQR RLEDMQALRR EEERRQAERE QEYKRKQLEE QRQSERLQRQ LQQEHAYLKS 480

QQQQQQQQLQ KQQQQQQQIL PGDRKPLYHY SRGINPADKP AWAREVEERT RMNKQQNSPL 540

AKTKPSSTGP EPPVPQASPG PPGPLSQTPP MQRPVEPQEG PHKSLVAHRV PLKPYAAPVP 600

RSQSLQDQPT RNLAAFPASH DPDPAAPTPT ATPSARGAVI RQNSDPTSEG PGPSPNPPAW 660

VRQDNEAPPK VPQRTSSIAT ALNTSGAGGA RPAQAVRARP RSNSAWQIYL QRRAERGSPK 720

PPGPPAQPPG PPNASSNPDL RRSDPGWERS DSVLPASHGH LPQAGSLERN RVGASSKLDS 780

SPVLSPGNKA KPDDHRSRPG RPADFVLLKE RTLDEAPRPP KKAMDYSSSS EEVESSEDDE 840

EESNGEPSEG SRDTPGARSD GDTDSVSTMV VHDVEEIAGT QTPYGGGTMV VQRTPEEERS 900

LLHADSNGYT NLPDVVQPSH SPTESSKGQS PPVKDGGSDY QSRGLVKAPG KSSFTMFVDL 960

GIYQSGGSGD TIPITALVGG EASRLDQLQY DVRKGSVVNV NPTNTRAHSE TPEIRKYKKR 1020

FNSEILCAAL WGVNLLVGTE NGLMLLDRSG QGKVYGLIGR RRFQQMDVLE GLNLLITISG 1080

KRNKLRVYYL SWLRNKILHN DPEVEKKQGW TTVGDMEGCG HYRVVKYERI KFLVIALKNS 1140

VEVYAWAPKP YHKFMAFKSF ADLPHRPLLV DLTVEEGQRL KVIYGSSAGF HAVDVDSGNS 1200

YDIYIPVHIQ SQITPHAIIF LPNTDGMEML LCYEDEGVYV NTYGRIIKDV VLQWGEMPTS 1260

VAYICSNQIM GWGEKAIEIR SVETGHLDGV FMHKRAQRLK FLCERNDKVF FASVRSGGSS 1320

QVYFMTLNRN CIMNW 1335

Nucleotide Sequence
(FASTA)

ATGAACTCTG AACCAGTCCA GTCCAACACC TTATTCTTTC TCTCCCTCTC CCCTCCCCTC 60

CAGGACCCTG CTGGAATCTT TGAGCTGGTG GAAGTGGTTG GCAATGGAAC CTATGGACAG 120

GTGTACAAGG GTCGGCACGT CAAGACTGGG CAGCTGGCTG CCATCAAGGT CATGGATGTC 180

ACGGAGGATG AGGAAGAAGA GATCAAGCAG GAGATCAACA TGTTGAAAAA ATACTCTCAC 240

CACCGCAACA TCGCCACCTA CTACGGAGCC TTCATCAAGA AGAGCCCCCC TGGGAACGAC 300

GACCAGCTCT GGCTGGTAAT GGAGTTCTGT GGTGCTGGTT CCGTGACGGA CCTGGTAAAG 360

AATACAAAAG GGAATGCCCT GAAGGAGGAC TGCATCGCCT ACATCTGCAG GGAGATTCTG 420

CGGGGTCTGG CCCATCTCCA CGCCCACAAG GTGATTCACC GAGACATCAA GGGGCAGAAC 480

GTGCTGCTGA CAGAGAATGC CGAGGTCAAG CTAGTGGATT TTGGGGTGAG TGCTCAGCTG 540

GACCGCACCG TGGGCAGGCG AAACACTTTC ATTGGGACCC CCTACTGGAT GGCCCCGGAG 600

GTCATCGCCT GTGATGAGAA CCCCGACGCC ACCTATGATT ACAGGAGTGA CATTTGGTCT 660

CTAGGAATCA CAGCCATTGA GATGGCAGAG GGAGCCCCCC CTCTGTGTGA CATGCATCCC 720

ATGCGAGCCC TCTTCCTCAT CCCTCGGAAC CCACCACCCA GGCTCAAGTC CAAGAAATGG 780

TCTAAGAAGT TCATCGACTT CATTGACACA TGTCTCATCA AGACTTACCT GAGCCGCCCA 840

CCAACAGAGC AGCTGCTAAA GTTCCCCTTC ATCCGCGACC AGCCCACAGA GCGGCAGGTC 900

CGCATCCAGC TCAAGGACCA CATCGACCGG TCTCGGAAGA AGCGGGGAGA GAAAGAGGAG 960

ACAGAGTATG AGTACAGCGG CAGTGAAGAG GAAGATGACA GCCATGGAGA GGAAGGAGAA 1020

CCAAGCTCCA TCATGAACGT GCCCGGCGAG TCCACGCTAC GCCGGGAGTT CCTCCGGCTC 1080

CAGCAGGAGA ATAAGAGCAA CTCGGAGGCT TTAAAGCAGC AGCAGCAGCT GCAGCAGCAA 1140

CAGCAGCGAG ACCCTGAGGC GCACATCAAA CACCTCCTGC ACCAGCGGCA GCGCCGCATC 1200

GAGGAGCAGA AGGAAGAGCG GCGGCGGGTT GAGGAGCAAC AGCGGCGGGA GCGGGAACAG 1260

CGGAAGCTGC AGGAGAAGGA ACAGCAACGG CGTCTGGAGG ACATGCAGGC CCTGCGGCGG 1320

GAGGAGGAGA GGCGGCAAGC AGAGCGGGAG CAGGAATACA AGCGGAAGCA GCTGGAGGAG 1380

CAGCGGCAGT CGGAGCGCCT GCAGAGGCAG CTGCAGCAGG AGCACGCCTA CCTCAAGTCC 1440

CAGCAGCAGC AGCAGCAGCA GCAGCTGCAG AAACAGCAGC AGCAGCAGCA GCAGATCCTT 1500

CCCGGGGACA GGAAGCCCCT GTACCATTAT AGTCGGGGCA TTAACCCCGC CGACAAGCCA 1560

GCCTGGGCCC GAGAGGTAGA AGAGAGAACA AGGATGAACA AGCAGCAGAA CTCTCCCTTG 1620

GCCAAGACCA AGCCAAGCAG CACAGGGCCT GAGCCCCCTG TTCCTCAGGC CTCCCCTGGG 1680

CCCCCAGGAC CACTTTCCCA AACTCCTCCT ATGCAGAGGC CGGTGGAGCC CCAGGAGGGA 1740

CCGCACAAGA GCCTGGTGGC ACACCGGGTC CCACTGAAGC CATATGCAGC GCCTGTACCC 1800

CGATCCCAGT CCCTGCAGGA CCAGCCCACC CGAAACCTGG CTGCCTTCCC AGCCTCTCAT 1860

GACCCTGACC CTGCCGCCCC CACACCCACT GCCACGCCCA GTGCCCGAGG AGCTGTCATC 1920

CGCCAGAATT CAGACCCTAC CTCGGAGGGG CCTGGCCCCA GCCCGAACCC CCCAGCCTGG 1980

GTCCGGCAGG ATAATGAGGC CCCACCCAAG GTGCCTCAGA GGACCTCATC TATTGCCACT 2040

GCCCTTAACA CCAGTGGGGC CGGAGGGGCT CGGCCAGCCC AGGCTGTCCG TGCCAGACCT 2100

CGCAGCAACT CCGCCTGGCA AATCTATCTG CAAAGGAGGG CAGAGCGGGG GAGTCCCAAG 2160

CCTCCAGGGC CCCCTGCTCA GCCCCCTGGT CCGCCCAACG CCAGTAGTAA CCCCGACCTC 2220

AGAAGGAGCG ACCCTGGCTG GGAGCGCTCG GATAGTGTCC TCCCCGCCTC TCACGGGCAC 2280

CTTCCCCAGG CCGGCTCTCT GGAGCGGAAC CGTGTGGGAG CCTCTTCCAA ACTGGACAGC 2340

TCCCCAGTGC TGTCCCCTGG GAACAAAGCC AAGCCTGATG ACCACCGCTC ACGGCCAGGC 2400

CGGCCCGCAG ATTTTGTGTT GCTGAAAGAG CGGACCCTGG ATGAGGCCCC ACGGCCTCCC 2460

AAGAAGGCCA TGGACTACTC ATCGTCCAGT GAGGAGGTGG AGAGCAGTGA GGACGACGAG 2520

GAGGAAAGCA ATGGCGAACC ATCAGAAGGG AGCAGAGACA CCCCTGGGGC CCGCAGCGAT 2580

GGGGATACAG ACAGTGTCAG CACCATGGTG GTCCATGATG TGGAGGAGAT CGCCGGGACC 2640

CAGACCCCCT ATGGGGGTGG CACCATGGTG GTCCAGCGTA CACCTGAAGA GGAGCGAAGC 2700

CTGCTGCATG CCGACAGCAA CGGTTACACA AACCTGCCAG ACGTGGTCCA GCCCAGCCAC 2760

TCGCCCACTG AAAGCAGCAA AGGTCAAAGC CCCCCCGTGA AGGATGGAGG CAGTGATTAC 2820

CAGTCTCGTG GGCTGGTGAA GGCCCCTGGC AAGAGCTCGT TCACGATGTT TGTGGACCTA 2880

GGCATCTACC AGTCCGGAGG CAGCGGGGAC ACCATCCCTA TCACAGCCCT AGTGGGTGGA 2940

GAGGCCAGTC GGCTTGATCA GCTGCAGTAT GACGTGCGGA AAGGCTCTGT GGTCAACGTG 3000

AACCCCACCA ACACACGGGC CCACAGTGAA ACCCCCGAGA TTCGCAAGTA CAAGAAGCGG 3060

TTCAATTCCG AGATCCTCTG CGCGGCCCTG TGGGGCGTCA ACCTGCTGGT GGGCACGGAG 3120

AACGGGCTGA TGTTGCTGGA CCGAAGTGGG CAGGGCAAGG TGTATGGACT CATTGGGCGG 3180

CGGCGCTTCC AGCAAATGGA CGTGCTGGAA GGACTCAACT TGCTCATCAC CATCTCAGGG 3240

AAAAGGAACA AACTGCGCGT GTACTACCTG TCCTGGCTCC GGAACAAGAT TCTGCACAAC 3300

GACCCAGAAG TGGAGAAGAA GCAGGGCTGG ACCACCGTGG GGGACATGGA GGGCTGCGGG 3360

CACTACCGCG TTGTGAAATA CGAACGTATT AAGTTCCTGG TCATCGCCCT GAAGAATTCC 3420

GTAGAGGTGT ATGCCTGGGC CCCCAAACCC TACCACAAAT TCATGGCCTT CAAGTCCTTT 3480

GCTGACCTGC CTCACCGCCC CCTGCTGGTG GACCTGACGG TAGAGGAGGG ACAGCGGCTC 3540

AAAGTCATCT ATGGCTCCAG TGCTGGCTTC CACGCAGTGG ATGTCGACTC GGGGAACAGC 3600

TATGACATCT ACATCCCTGT TCATATCCAG AGCCAGATCA CACCCCACGC CATCATCTTC 3660

CTCCCCAACA CCGATGGCAT GGAGATGCTG CTGTGCTACG AGGACGAGGG CGTCTACGTC 3720

AACACGTACG GGCGGATCAT TAAGGATGTG GTGCTGCAGT GGGGAGAGAT GCCCACGTCC 3780

GTGGCCTACA TCTGCTCCAA CCAGATAATG GGCTGGGGCG AGAAAGCCAT CGAGATCCGC 3840

TCCGTGGAGA CAGGCCACCT GGACGGGGTC TTCATGCACA AACGAGCTCA GAGGCTCAAG 3900

TTCCTGTGTG AGAGGAATGA CAAGGTATTC TTTGCCTCCG TCCGCTCTGG GGGCAGCAGC 3960

CAAGTTTACT TCATGACTCT GAACCGCAAC TGCATCATGA ACTGGTGA 4008

Domain Profile

S: 1     yelleeigkGalgkvylarekktgelvaikkinlekqekleelqkeisvlkklkh.pniv  59

         +el+e++g+G++g+vy++r++ktg+l+aik++++++ +++ee+++ei++lkk++h +ni

Q: 27    FELVEVVGNGTYGQVYKGRHVKTGQLAAIKVMDVTE-DEEEEIKQEINMLKKYSHhRNIA  85

         899********************************8.999*************998****

S: 60    eylesflk......eeelwlvmeylagGslsdlvkeelkselkEeqiayilrevlkaLey  113

         +y+++f+k      +++lwlvme++ +Gs++dlvk+++ + lkE+ iayi+re+l++L++

Q: 86    TYYGAFIKksppgnDDQLWLVMEFCGAGSVTDLVKNTKGNALKEDCIAYICREILRGLAH  145

         *************99*********************************************

S: 114   lHskkviHrdikakniLlteegeVkLsdfgvaaqlektrkkrktvvgtpywmAPEviaqe  173

         lH++kviHrdik++n+Llte++eVkL+dfgv+aql++t+ +r+t++gtpywmAPEvia++

Q: 146   LHAHKVIHRDIKGQNVLLTENAEVKLVDFGVSAQLDRTVGRRNTFIGTPYWMAPEVIACD  205

         ************************************************************

S: 174   ...ekgYdekaDiwslGItaielaegepPfkdleplkallkilkneppklkskkkfskef  230

            + +Yd+++DiwslGItaie+aeg+pP++d++p++al++i++n+pp+lksk k+sk+f

Q: 206   enpDATYDYRSDIWSLGITAIEMAEGAPPLCDMHPMRALFLIPRNPPPRLKSK-KWSKKF  264

         999999********************************************888.******

S: 231   kefvekclqknpekRpsasellkhkFl  257

          +f+++cl k + +Rp +++llk +F+

Q: 265   IDFIDTCLIKTYLSRPPTEQLLKFPFI  291

         *************************97

Domain Sequence
(FASTA)

FELVEVVGNG TYGQVYKGRH VKTGQLAAIK VMDVTEDEEE EIKQEINMLK KYSHHRNIAT 60

YYGAFIKKSP PGNDDQLWLV MEFCGAGSVT DLVKNTKGNA LKEDCIAYIC REILRGLAHL 120

HAHKVIHRDI KGQNVLLTEN AEVKLVDFGV SAQLDRTVGR RNTFIGTPYW MAPEVIACDE 180

NPDATYDYRS DIWSLGITAI EMAEGAPPLC DMHPMRALFL IPRNPPPRLK SKKWSKKFID 240

FIDTCLIKTY LSRPPTEQLL KFPFI 265

Keyword

ATP-binding; Complete proteome; Nucleotide-binding; Reference proteome.

Sequence Source

Ensembl

Orthology

Ortholog group

Anolis carolinensis"; ?>Bos taurus"; ?>Callithrix jacchus"; ?>Cavia porcellus"; ?>Ciona intestinalis"; ?>Ciona savignyi"; ?>Danio rerio"; ?>Dipodomys ordii"; ?>Equus caballus"; ?>Felis catus"; ?>Gasterosteus aculeatus"; ?>Gorilla gorilla"; ?>Homo sapiens"; ?>Ictidomys tridecemlineatus"; ?>Loxodonta africana"; ?>Macaca mulatta"; ?>Monodelphis domestica"; ?>Mus musculus"; ?>Mustela putorius furo"; ?>Oreochromis niloticus"; ?>Oryctolagus cuniculus"; ?>Oryzias latipes"; ?>Otolemur garnettii"; ?>Pan troglodytes"; ?>Petromyzon marinus"; ?>Pteropus vampyrus"; ?>Rattus norvegicus"; ?>Sarcophilus harrisii"; ?>Sus scrofa"; ?>Tetraodon nigroviridis"; ?>Xenopus tropicalis"; ?>

Gene Ontology

GO:0005524	; F:ATP binding
GO:0004674	; F:protein serine/threonine kinase activity
GO:0005083	; F:small GTPase regulator activity

KEGG

InterPros

IPR001180	; Citron.
IPR011009	; Kinase-like_dom.
IPR000719	; Prot_kinase_cat_dom.
IPR017441	; Protein_kinase_ATP_BS.
IPR002290	; Ser/Thr_dual-sp_kinase_dom.
IPR008271	; Ser/Thr_kinase_AS.

Pfam

PF00780	; CNH; 1.
PF00069	; Pkinase; 1.

SMARTs

SM00036	; CNH; 1.
SM00220	; S_TKc; 1.

Prosites

PS50219	; CNH; 1.
PS00107	; PROTEIN_KINASE_ATP; 1.
PS50011	; PROTEIN_KINASE_DOM; 1.
PS00108	; PROTEIN_KINASE_ST; 1.

Prints

Created Date

20-Feb-2013