EKS-MYL-00124
Eukaryotic Protein Kinase & Protein Phosphatase Database
TagContent
EKPD IDEKS-MYL-00124
Classification
Group/FamilyScoreE-ValueStartEndDomain Length
TK/Tec470.89.0E-142366615250
StatusUnreviewed
Ensembl ProteinENSMLUP00000014409
UniProt AccessionG1PT68;
Protein Name
Protein Synonyms/Alias
Gene NameITK
Gene Synonyms/Alias ITK;
Ensembl Information
Ensembl Gene IDEnsembl Protein IDEnsembl Transcript ID
ENSMLUG00000015811ENSMLUP00000014409ENSMLUT00000015818
OrganismMyotis lucifugus
Functional Description
Protein Length623
Protein Sequence
(FASTA)
SNNSILLEEQ LIKKSQQKRR TSPSNFKVRF FVLTKTSLAY FEDRHGKKRT LKGSIELSRI 60
KCVEIVKSDI SIPCHYKYPF QVVHDNYLLY VFAPDRESRQ RWVLALKEET RNNNSLVSKY 120
HPNFWMDGRW RCCAQLEKLA VGCAQYDPSK NASKKPLPPT PEDNRRSLQE HEETLVIALY 180
DYQTNDPQEL TLQRNDEYYL LDSSEIHWWR VQDKNGHEGY VPSSYLVEKS ANNLETYEWY 240
NKSISRDKAE KLLLDTGKEG AFMVRDSRTP GTYTLSVFTK AIVSESNPCI KHYHIKETND 300
NPKRYYVAEK YVFDSIPLLI NYHQHNGGVN PGLVTRLRYP VCSWRQKAPI TAGLRYGKWV 360
IHPSELTFVQ EIGSGQFGLV HLGYWLNKDK VAIKTIQEGA MSEEDFLEEA EVMMKLSHPK 420
LVQLYGVCLE QAPICLVFEF MEHGCLSDYL RSQRGLLAAE TLLGMCLDVC EGMAYLEEAC 480
VIHRDLAARN CLVGENQVIK VSDFGMTRFV LDDQYTSSTG TKFPVKWASP EVFSFSRYSS 540
KSDVWSFGVL MWEVFSEGKI PYENRSNSEV VEDISTGFRL YKPRLASSHI YQIMNHCWKE 600
KPEDRPPFSR LFSQLGEIAE LGL 623
Nucleotide Sequence
(FASTA)
TCAAACAACT CTATCCTTCT AGAAGAACAG CTCATCAAGA AATCCCAACA AAAGAGAAGA 60
ACTTCTCCCT CGAACTTTAA AGTCCGCTTC TTTGTTTTAA CCAAAACCAG CTTGGCGTAT 120
TTTGAGGACC GTCATGGGAA AAAGCGCACC TTGAAGGGCT CTATTGAACT CTCCAGGATC 180
AAATGTGTCG AGATTGTGAA AAGTGACATC AGCATCCCTT GCCACTACAA GTATCCTTTT 240
CAGGTTGTGC ATGACAACTA CCTCCTGTAT GTGTTTGCTC CAGACCGTGA GAGCCGGCAG 300
CGCTGGGTGT TGGCCCTTAA AGAAGAAACG AGGAATAATA ACAGTTTGGT GTCCAAGTAT 360
CATCCTAATT TCTGGATGGA TGGGAGGTGG AGGTGCTGTG CTCAGCTGGA GAAGCTTGCA 420
GTGGGCTGCG CCCAGTACGA TCCATCCAAA AATGCTTCAA AGAAGCCTCT TCCTCCTACT 480
CCTGAAGACA ACAGGCGATC ACTTCAGGAG CATGAAGAAA CGCTGGTCAT TGCCTTGTAT 540
GACTACCAAA CGAACGATCC TCAGGAACTC ACGCTACAGC GCAATGACGA GTACTACCTG 600
CTGGACAGCT CTGAGATTCA CTGGTGGAGA GTTCAAGACA AGAATGGACA CGAAGGATAC 660
GTACCAAGCA GCTATCTGGT GGAAAAATCT GCAAATAACC TGGAAACCTA CGAGTGGTAC 720
AATAAGAGTA TCAGCCGAGA CAAAGCCGAA AAACTTCTTT TGGACACAGG CAAAGAAGGA 780
GCCTTCATGG TACGGGATTC CAGGACTCCA GGCACATACA CCCTGTCTGT CTTCACCAAG 840
GCCATCGTAA GTGAGAGCAA CCCCTGCATA AAGCACTATC ACATCAAAGA AACAAATGAC 900
AACCCCAAGC GATACTATGT GGCTGAAAAG TATGTGTTCG ATTCCATCCC TCTGCTCATC 960
AACTATCACC AGCACAACGG AGGAGTCAAC CCAGGCCTGG TCACGCGCCT TCGCTATCCT 1020
GTTTGTTCCT GGAGGCAGAA AGCCCCCATC ACAGCTGGGC TGAGATACGG GAAATGGGTG 1080
ATCCATCCCT CGGAGCTCAC TTTCGTGCAG GAGATCGGCA GCGGGCAGTT CGGACTGGTG 1140
CATCTTGGCT ACTGGCTCAA CAAGGACAAG GTGGCCATCA AAACCATTCA GGAAGGAGCT 1200
ATGTCAGAAG AGGACTTCCT AGAGGAGGCT GAAGTCATGA TGAAACTCTC TCACCCCAAA 1260
CTGGTCCAGC TGTACGGGGT GTGCCTGGAG CAGGCCCCCA TCTGCCTCGT GTTCGAGTTC 1320
ATGGAGCATG GCTGCCTGTC GGATTACCTG CGCAGCCAGC GGGGGCTCTT GGCTGCAGAG 1380
ACCCTGCTGG GCATGTGCCT GGACGTGTGT GAGGGCATGG CCTACCTGGA AGAGGCGTGT 1440
GTCATCCACA GAGACCTGGC TGCCAGGAAT TGCCTAGTGG GAGAAAACCA AGTCATCAAG 1500
GTGTCGGACT TTGGGATGAC AAGGTTTGTC CTTGACGATC AGTACACCAG CTCCACGGGC 1560
ACCAAGTTCC CGGTGAAGTG GGCGTCCCCA GAAGTCTTCT CCTTCAGCCG CTACAGCAGC 1620
AAGTCGGATG TGTGGTCATT TGGGGTGCTA ATGTGGGAAG TCTTCAGCGA AGGCAAAATC 1680
CCATATGAAA ACCGAAGCAA CTCAGAGGTG GTGGAAGACA TCAGTACCGG ATTTCGGTTG 1740
TACAAGCCCC GGCTGGCCTC CTCTCATATC TACCAGATCA TGAATCATTG CTGGAAAGAG 1800
AAACCTGAAG ACCGGCCACC TTTCTCCAGA CTCTTCAGTC AACTGGGTGA AATTGCAGAA 1860
TTGGGACTTT AG 1872
Domain Profile
S: 1     ltllkelgsgqfgvvklgkwrakidvaikaikegamseedfieeakvmmklshpklvqly  60
         lt+++e+gsgqfg+v+lg+w +k++vaik+i+egamseedf+eea+vmmklshpklvqly
Q: 366   LTFVQEIGSGQFGLVHLGYWLNKDKVAIKTIQEGAMSEEDFLEEAEVMMKLSHPKLVQLY  425
         79**********************************************************
S: 61    gvclkqkpiyivteylengcllnylrekkkklekelllemckdvcegmeylerksfihrd  120
         gvcl+q+pi++v+e++e+gcl++ylr++++ l++e+ll mc dvcegm+yle++++ihrd
Q: 426   GVCLEQAPICLVFEFMEHGCLSDYLRSQRGLLAAETLLGMCLDVCEGMAYLEEACVIHRD  485
         ************************************************************
S: 121   laarnclvdeelvvkvsdfglaryvlddqyvssvgakfpvkwsppevlsyskyssksdvw  180
         laarnclv+e++v+kvsdfg++r+vlddqy+ss+g+kfpvkw++pev+s+s+yssksdvw
Q: 486   LAARNCLVGENQVIKVSDFGMTRFVLDDQYTSSTGTKFPVKWASPEVFSFSRYSSKSDVW  545
         ************************************************************
S: 181   afgvlmwevfsegklpyekksnsevvekvsrglrlyrpklaskkvyevmkscwkekpeer  240
         +fgvlmwevfsegk+pye++snsevve++s+g+rly+p+las+++y++m++cwkekpe+r
Q: 546   SFGVLMWEVFSEGKIPYENRSNSEVVEDISTGFRLYKPRLASSHIYQIMNHCWKEKPEDR  605
         ************************************************************
S: 241   ptfkellsal  250
         p f++l+s+l
Q: 606   PPFSRLFSQL  615
         *******997
Domain Sequence
(FASTA)
LTFVQEIGSG QFGLVHLGYW LNKDKVAIKT IQEGAMSEED FLEEAEVMMK LSHPKLVQLY 60
GVCLEQAPIC LVFEFMEHGC LSDYLRSQRG LLAAETLLGM CLDVCEGMAY LEEACVIHRD 120
LAARNCLVGE NQVIKVSDFG MTRFVLDDQY TSSTGTKFPV KWASPEVFSF SRYSSKSDVW 180
SFGVLMWEVF SEGKIPYENR SNSEVVEDIS TGFRLYKPRL ASSHIYQIMN HCWKEKPEDR 240
PPFSRLFSQL 250
KeywordATP-binding; Complete proteome; Kinase; Nucleotide-binding; Reference proteome; SH3 domain; Transferase; Tyrosine-protein kinase.
Sequence SourceEnsembl
Orthology
Ortholog group
Ailuropoda melanoleuca"; ?>Anolis carolinensis"; ?>Bos taurus"; ?>Callithrix jacchus"; ?>Canis familiaris"; ?>Cavia porcellus"; ?>Danio rerio"; ?>Equus caballus"; ?>Felis catus"; ?>Gallus gallus"; ?>Gasterosteus aculeatus"; ?>Gorilla gorilla"; ?>Homo sapiens"; ?>Ictidomys tridecemlineatus"; ?>Latimeria chalumnae"; ?>Loxodonta africana"; ?>Macaca mulatta"; ?>Meleagris gallopavo"; ?>Monodelphis domestica"; ?>Mus musculus"; ?>Mustela putorius furo"; ?>Nomascus leucogenys"; ?>Ochotona princeps"; ?>Ornithorhynchus anatinus"; ?>Oryctolagus cuniculus"; ?>Oryzias latipes"; ?>Otolemur garnettii"; ?>Pan troglodytes"; ?>Pelodiscus sinensis"; ?>Pongo abelii"; ?>Rattus norvegicus"; ?>Sarcophilus harrisii"; ?>Taeniopygia guttata"; ?>Takifugu rubripes"; ?>Tetraodon nigroviridis"; ?>Xenopus tropicalis"; ?>
EKS-AIM-00101
EKS-ANC-00099
EKS-BOT-00110
EKS-CAJ-00111
EKS-CAF-00112
EKS-CAP-00105
EKS-DAR-00357
EKS-EQC-00108
EKS-FEC-00105
EKS-GAG-00090
EKS-GAA-00128
EKS-GOG-00111
EKS-HOS-00113
EKS-ICT-00105
EKS-LAC-00114
EKS-LOA-00106
EKS-MAM-00105
EKS-MEG-00085
EKS-MOD-00106
EKS-MUM-00112
EKS-MUP-00113
EKS-NOL-00103
EKS-OCP-00072
EKS-ORA-00089
EKS-ORC-00102
EKS-ORL-00125
EKS-OTG-00112
EKS-PAT-00100
EKS-PES-00093
EKS-POA-00103
EKS-RAN-00108
EKS-SAH-00102
EKS-TAG-00138
EKS-TAR-00137
EKS-TEN-00127
EKS-XET-00091
Gene Ontology
GO:0005622; C:intracellular
GO:0005524; F:ATP binding
GO:0005543; F:phospholipid binding
GO:0004713; F:protein tyrosine kinase activity
GO:0035556; P:intracellular signal transduction
KEGG
InterPros
IPR011009; Kinase-like_dom.
IPR011993; PH_like_dom.
IPR001849; Pleckstrin_homology.
IPR000719; Prot_kinase_cat_dom.
IPR017441; Protein_kinase_ATP_BS.
IPR001245; Ser-Thr/Tyr_kinase_cat_dom.
IPR000980; SH2.
IPR001452; SH3_domain.
IPR013315; Spectrin_alpha_SH3.
IPR008266; Tyr_kinase_AS.
IPR020635; Tyr_kinase_cat_dom.
IPR001562; Znf_Btk_motif.
Pfam
PF00779; BTK; 1.
PF00169; PH; 1.
PF07714; Pkinase_Tyr; 1.
PF00017; SH2; 1.
PF00018; SH3_1; 1.
SMARTs
SM00107; BTK; 1.
SM00233; PH; 1.
SM00252; SH2; 1.
SM00326; SH3; 1.
SM00219; TyrKc; 1.
Prosites
PS50003; PH_DOMAIN; 1.
PS00107; PROTEIN_KINASE_ATP; 1.
PS50011; PROTEIN_KINASE_DOM; 1.
PS00109; PROTEIN_KINASE_TYR; 1.
PS50001; SH2; 1.
PS50002; SH3; 1.
PS51113; ZF_BTK; 1.
Prints
PR00401; SH2DOMAIN.
PR01887; SPECTRNALPHA.
PR00109; TYRKINASE.
Created Date20-Feb-2013