EKS-MYL-00299

Eukaryotic Protein Kinase & Protein Phosphatase Database

Tag

Content

EKPD ID

EKS-MYL-00299

Classification

Group/Family	Score	E-Value	Start	End	Domain Length
TK/EGFR	502.7	1.9E-151	584	841	258

Status

Unreviewed

Ensembl Protein

ENSMLUP00000014680

UniProt Accession

G1PTV5;

Protein Name

Protein Synonyms/Alias

Gene Name

ERBB4

Gene Synonyms/Alias

ERBB4;

Ensembl Information

Ensembl Gene ID	Ensembl Protein ID	Ensembl Transcript ID
ENSMLUG00000016092	ENSMLUP00000014680	ENSMLUT00000016113

Organism

Myotis lucifugus

Functional Description

Protein Length

1174

Protein Sequence
(FASTA)

TEILNGGVYV DQNKFLCYAN TIHWQDIVRN PWPSNLTLVS TNGSSGCGRC HKSCTGRCWG 60

PTENHCQTLT RTVCAEQCDG RCYGPYVSDC CHRECAGGCS GPKDTDCFAC MNFNDSGACV 120

TQCPQTFVYN PTTFQLEHNF NAKYTYGAFC VKKCPHNFVV DSSSCVRACP SSKMEVEENG 180

IKMCKPCTDI CPKACDGIGT GSLLSAQTVD SSNIDKFINC TKINGNLIFL VTGIHGDPYN 240

AIEAIDPEKL NVFRTVREIT GFLNIQSWPP NMTDFSVFSN LVTIGGRVLY SGLSLLILKQ 300

QGITSLQFQS LKEISAGNIY ITDNSNLCYY HTINWTTLFS TINQRIVIRD NRKAENCTAE 360

GMVCNHLCSS DGCWGPGPDQ CLSCRRFSRG RTCIDSCNLY DGQFGIYRKG LDCTLWKSVY 420

DRGEFWRRVC RGKGRYNCIR CSVSSYFYQC SESSPRVLHS QSFYSFCYSA QSKEFHMLKH 480

AHCGPGTKNE TAYICIITYV YPGHISLEPN KHSSRTPLIA AGVIGGLFIL VIMGLTFAVY 540

ARRKSIKKKR ALRRFLETEL VEPLTPSGTA PNQAQLRILK ETELKRVKVL GSGAFGTVYK 600

GIWVPEGETV KIPVAIKILN ETTGPKANVE FMDEALIMAS MDHPHLVRLL GVCLSPTIQL 660

VTQLMPHGCL LDYVHEHKDN IGSQLLLNWC VQIAKGMMYL EERRLVHRDL AARNVLVKSP 720

NHVKITDFGL ARLLEGDEKE YNADGGKMPI KWMALECIHY RKFTHQSDVW SYGVTIWELM 780

TFGGKPYDGI PTREIPDLLE KGERLPQPPI CTIDVYMVMV KCWMIDADSR PKFKELAAEF 840

SRMARDPQRY LVIQGDDRMK LPSPNDSKFF QNLLDEEDLE DMMDAEEYLV PQAFNIPPPI 900

YTSRARIDSN RSEIGHSPPP AYTPMSGNQF VYRDGGFAAE QGVPVPYRAT TSTIPEAPAA 960

QGAAAEMFDD ACCNGTLRKP VAPHVQEDSS TQRYSADPTV FAPERSPRGE LDEEGYMTPM 1020

RDKPKQEYLN PVEENPFVSR RKNGDLQALD NPEYHNASTG PPKAEDEYVN EPLYLNTFAN 1080

TLGNAEYLKN TVLSVPEKAK KAFDNPDYWN HSLPPRSTFQ HPDYLQEYST KYFYKQNGRI 1140

RPIVAENPEY LSEFSLKPGT VLPPPPYRHR NTVV 1174

Nucleotide Sequence
(FASTA)

ACAGAAATCC TAAATGGTGG AGTCTATGTA GACCAGAACA AATTTCTTTG TTATGCAAAC 60

ACAATTCATT GGCAAGATAT TGTTCGGAAT CCATGGCCTT CCAACTTGAC TCTGGTGTCA 120

ACAAATGGTA GCTCAGGATG TGGACGTTGC CATAAGTCCT GTACCGGCCG ATGCTGGGGA 180

CCCACAGAAA ATCATTGCCA GACTTTGACA AGGACGGTGT GTGCAGAACA ATGTGATGGC 240

AGGTGCTACG GACCCTATGT CAGTGACTGC TGTCATCGAG AGTGCGCTGG AGGCTGCTCA 300

GGGCCTAAGG ACACCGACTG CTTTGCCTGC ATGAATTTCA ATGACAGTGG AGCTTGTGTG 360

ACTCAGTGTC CCCAAACTTT TGTCTACAAT CCAACCACCT TTCAACTGGA GCATAACTTC 420

AATGCAAAGT ACACATACGG AGCATTTTGT GTCAAGAAAT GCCCTCATAA CTTTGTGGTC 480

GATTCCAGTT CTTGTGTGCG TGCCTGCCCT AGTTCCAAGA TGGAAGTGGA GGAAAATGGG 540

ATTAAGATGT GCAAACCTTG CACTGATATT TGCCCAAAAG CGTGTGACGG CATCGGCACG 600

GGATCACTGC TGTCCGCACA GACTGTGGAT TCCAGCAACA TCGACAAGTT CATAAACTGC 660

ACCAAGATCA ATGGGAATTT GATCTTCCTT GTCACTGGTA TTCACGGGGA CCCTTACAAT 720

GCGATTGAAG CTATAGACCC AGAGAAACTG AATGTATTTC GGACAGTTCG AGAGATAACA 780

GGTTTCTTGA ACATACAGTC ATGGCCCCCA AACATGACTG ACTTCAGTGT TTTTTCTAAC 840

CTGGTGACCA TTGGTGGAAG AGTACTCTAC AGTGGCCTCT CCTTGCTTAT CCTCAAGCAA 900

CAAGGCATCA CTTCCCTGCA GTTCCAGTCC CTGAAGGAAA TCAGTGCAGG AAACATCTAT 960

ATTACTGACA ACAGCAACCT GTGCTACTAT CACACCATCA ACTGGACGAC GCTCTTCAGC 1020

ACCATCAACC AAAGAATAGT GATTCGAGAC AATAGGAAGG CTGAAAACTG TACTGCTGAA 1080

GGAATGGTGT GTAACCATCT GTGCTCAAGC GATGGCTGTT GGGGACCTGG GCCAGACCAG 1140

TGCCTGTCCT GCCGTCGCTT CAGCAGGGGC AGGACCTGCA TAGACTCTTG TAACCTCTAT 1200

GACGGGCAGT TTGGAATTTA CAGGAAAGGT TTAGATTGTA CACTTTGGAA GAGTGTTTAT 1260

GACCGTGGGG AATTTTGGCG CAGAGTTTGC AGAGGTAAAG GAAGGTATAA CTGTATAAGG 1320

TGTTCAGTAA GCAGTTACTT TTATCAGTGT AGTGAGTCTT CCCCAAGAGT GCTCCACAGT 1380

CAAAGCTTCT ATTCATTCTG CTACTCTGCG CAGAGTAAAG AATTCCATAT GCTTAAACAT 1440

GCGCACTGCG GGCCCGGGAC GAAAAATGAG ACTGCTTACA TCTGTATTAT CACTTACGTA 1500

TATCCTGGTC ATATCTCTTT GGAACCAAAT AAACATTCAA GCAGAACTCC TCTAATTGCA 1560

GCCGGAGTCA TTGGAGGGCT CTTTATCCTG GTCATCATGG GTCTAACGTT CGCAGTTTAT 1620

GCGAGAAGAA AGAGCATCAA GAAGAAAAGA GCCTTGAGAA GATTCCTGGA AACAGAGTTG 1680

GTAGAACCCT TAACTCCAAG TGGCACAGCG CCCAATCAAG CTCAACTTCG TATTTTGAAA 1740

GAAACTGAAC TCAAAAGAGT AAAAGTACTT GGTTCAGGTG CTTTTGGAAC CGTGTATAAA 1800

GGTATCTGGG TACCTGAAGG AGAAACAGTG AAGATTCCCG TGGCTATTAA GATTCTTAAT 1860

GAAACAACTG GTCCCAAAGC CAATGTGGAA TTCATGGACG AAGCTCTGAT CATGGCAAGC 1920

ATGGACCATC CACATTTAGT CCGGTTGTTG GGGGTGTGTC TGAGCCCCAC CATTCAGCTG 1980

GTGACACAGC TTATGCCCCA TGGCTGCCTG TTGGATTACG TCCATGAACA CAAGGATAAC 2040

ATCGGTTCCC AGCTGCTGCT GAACTGGTGT GTCCAGATAG CTAAGGGAAT GATGTATCTG 2100

GAAGAAAGAC GGCTTGTTCA TCGCGATTTG GCAGCCCGTA ATGTCTTAGT GAAATCTCCA 2160

AACCATGTGA AAATCACAGA TTTTGGACTA GCCAGACTCT TGGAAGGAGA TGAAAAGGAG 2220

TATAATGCTG ATGGAGGAAA GATGCCAATT AAATGGATGG CTCTGGAGTG TATACACTAT 2280

AGGAAATTCA CCCATCAGAG TGACGTTTGG AGCTATGGAG TCACCATATG GGAACTGATG 2340

ACATTTGGAG GAAAACCCTA CGATGGAATT CCAACCCGAG AAATCCCTGA TTTATTAGAG 2400

AAAGGAGAAC GTTTGCCCCA GCCACCTATC TGCACTATTG ATGTTTACAT GGTCATGGTC 2460

AAATGTTGGA TGATTGATGC TGACAGTAGA CCAAAATTTA AGGAACTGGC TGCTGAATTT 2520

TCGAGGATGG CTCGGGACCC TCAAAGATAT TTAGTTATTC AGGGTGATGA CCGTATGAAG 2580

CTTCCCAGTC CAAACGACAG CAAGTTCTTT CAGAATCTCT TGGATGAAGA GGATTTGGAA 2640

GATATGATGG ATGCTGAGGA ATACCTGGTT CCTCAGGCTT TCAACATCCC ACCTCCCATC 2700

TATACGTCCA GAGCAAGAAT TGACTCAAAT AGGAGTGAAA TTGGACACAG CCCTCCTCCC 2760

GCCTACACCC CCATGTCAGG AAACCAATTT GTGTACCGAG ATGGGGGTTT TGCCGCAGAA 2820

CAGGGAGTGC CCGTGCCCTA CAGAGCCACG ACCAGCACCA TCCCAGAAGC TCCCGCTGCT 2880

CAGGGGGCCG CAGCCGAGAT GTTTGATGAC GCCTGCTGCA ATGGCACCCT ACGCAAGCCA 2940

GTGGCACCCC ATGTCCAAGA AGATAGCAGC ACCCAGAGGT ACAGTGCCGA CCCCACAGTG 3000

TTTGCCCCGG AACGGAGCCC AAGAGGAGAG CTGGATGAGG AAGGCTACAT GACCCCTATG 3060

CGAGACAAAC CCAAACAAGA ATATCTGAAC CCTGTCGAGG AGAACCCTTT TGTTTCTCGG 3120

AGAAAAAACG GAGACCTTCA AGCTTTGGAT AATCCCGAAT ACCACAATGC TTCCACTGGT 3180

CCACCCAAGG CAGAGGATGA GTATGTGAAT GAGCCACTGT ACCTCAACAC CTTTGCCAAC 3240

ACGCTGGGGA ATGCCGAGTA CCTGAAGAAC ACCGTACTGT CTGTGCCGGA GAAGGCCAAG 3300

AAAGCGTTCG ACAACCCTGA CTACTGGAAC CACAGCCTGC CCCCCCGGAG CACCTTTCAG 3360

CACCCAGACT ACCTGCAGGA GTACAGCACA AAATATTTTT ATAAACAAAA TGGACGGATC 3420

CGGCCTATCG TGGCAGAGAA TCCCGAATAC CTCTCCGAGT TCTCGTTGAA GCCAGGCACT 3480

GTGCTGCCTC CTCCACCCTA CAGACACCGG AATACTGTGG TGTAA 3525

Domain Profile

S: 1     lkklkvlGsGafGtvykGiwipegenvkipvaikvleektgkkankelldealvlasldh  60

         lk++kvlGsGafGtvykGiw+pege+vkipvaik+l+e+tg+kan e++deal++as+dh

Q: 584   LKRVKVLGSGAFGTVYKGIWVPEGETVKIPVAIKILNETTGPKANVEFMDEALIMASMDH  643

         699*********************************************************

S: 61    anlvrllglclsstlqlvtqllplGclldyvrehkdklGsqellnwcvqiakGmsyleek  120

         ++lvrllg+cls t+qlvtql+p+Gclldyv+ehkd++Gsq llnwcvqiakGm+ylee+

Q: 644   PHLVRLLGVCLSPTIQLVTQLMPHGCLLDYVHEHKDNIGSQLLLNWCVQIAKGMMYLEER  703

         ************************************************************

S: 121   rlvhrdlaarnvlvkspnhvkitdfGlaklleadekelkaeggkvpikwlalesilkrky  180

         rlvhrdlaarnvlvkspnhvkitdfGla+lle deke++a+ggk+pikw+ale+i++rk+

Q: 704   RLVHRDLAARNVLVKSPNHVKITDFGLARLLEGDEKEYNADGGKMPIKWMALECIHYRKF  763

         ************************************************************

S: 181   thqsdvwsyGvtvwelltfGakpydgipakeipdllekGerlaqppictidvymvlvkcw  240

         thqsdvwsyGvt+wel+tfG kpydgip++eipdllekGerl+qppictidvymv+vkcw

Q: 764   THQSDVWSYGVTIWELMTFGGKPYDGIPTREIPDLLEKGERLPQPPICTIDVYMVMVKCW  823

         ************************************************************

S: 241   midaesrpkfkelaeefs  258

         mida+srpkfkela+efs

Q: 824   MIDADSRPKFKELAAEFS  841

         ****************96

Domain Sequence
(FASTA)

LKRVKVLGSG AFGTVYKGIW VPEGETVKIP VAIKILNETT GPKANVEFMD EALIMASMDH 60

PHLVRLLGVC LSPTIQLVTQ LMPHGCLLDY VHEHKDNIGS QLLLNWCVQI AKGMMYLEER 120

RLVHRDLAAR NVLVKSPNHV KITDFGLARL LEGDEKEYNA DGGKMPIKWM ALECIHYRKF 180

THQSDVWSYG VTIWELMTFG GKPYDGIPTR EIPDLLEKGE RLPQPPICTI DVYMVMVKCW 240

MIDADSRPKF KELAAEFS 258

Keyword

ATP-binding; Complete proteome; Kinase; Nucleotide-binding; Phosphoprotein; Reference proteome; Transferase; Tyrosine-protein kinase.

Sequence Source

Ensembl

Orthology

Ortholog group

Ailuropoda melanoleuca"; ?>Anolis carolinensis"; ?>Bos taurus"; ?>Caenorhabditis elegans"; ?>Callithrix jacchus"; ?>Canis familiaris"; ?>Cavia porcellus"; ?>Ciona savignyi"; ?>Equus caballus"; ?>Gallus gallus"; ?>Gasterosteus aculeatus"; ?>Gorilla gorilla"; ?>Homo sapiens"; ?>Latimeria chalumnae"; ?>Loxodonta africana"; ?>Macaca mulatta"; ?>Monodelphis domestica"; ?>Mus musculus"; ?>Mustela putorius furo"; ?>Nomascus leucogenys"; ?>Oreochromis niloticus"; ?>Ornithorhynchus anatinus"; ?>Oryctolagus cuniculus"; ?>Oryzias latipes"; ?>Otolemur garnettii"; ?>Pan troglodytes"; ?>Pelodiscus sinensis"; ?>Petromyzon marinus"; ?>Pongo abelii"; ?>Rattus norvegicus"; ?>Sus scrofa"; ?>Taeniopygia guttata"; ?>Takifugu rubripes"; ?>Tetraodon nigroviridis"; ?>Vicugna pacos"; ?>Xenopus tropicalis"; ?>Xiphophorus maculatus"; ?>

Gene Ontology

GO:0016020	; C:membrane
GO:0005524	; F:ATP binding
GO:0004714	; F:transmembrane receptor protein tyrosine kinase activity
GO:0007169	; P:transmembrane receptor protein tyrosine kinase signaling pathway

KEGG

InterPros

IPR000494	; EGF_rcpt_L.
IPR006211	; Furin-like_Cys-rich_dom.
IPR006212	; Furin_repeat.
IPR009030	; Growth_fac_rcpt.
IPR011009	; Kinase-like_dom.
IPR000719	; Prot_kinase_cat_dom.
IPR017441	; Protein_kinase_ATP_BS.
IPR001245	; Ser-Thr/Tyr_kinase_cat_dom.
IPR008266	; Tyr_kinase_AS.
IPR020635	; Tyr_kinase_cat_dom.

Pfam

PF00757	; Furin-like; 1.
PF07714	; Pkinase_Tyr; 1.
PF01030	; Recep_L_domain; 1.

SMARTs

SM00261	; FU; 3.
SM00219	; TyrKc; 1.

Prosites

PS00107	; PROTEIN_KINASE_ATP; 1.
PS50011	; PROTEIN_KINASE_DOM; 1.
PS00109	; PROTEIN_KINASE_TYR; 1.

Prints

PR00109

; TYRKINASE.

Created Date

20-Feb-2013