EKS-MYL-00393
Eukaryotic Protein Kinase & Protein Phosphatase Database
TagContent
EKPD IDEKS-MYL-00393
Classification
Group/FamilyScoreE-ValueStartEndDomain Length
TK/Axl548.62.3E-165575840266
StatusUnreviewed
Ensembl ProteinENSMLUP00000014742
UniProt AccessionG1PU03;
Protein Name
Protein Synonyms/Alias
Gene NameTYRO3
Gene Synonyms/Alias TYRO3;
Ensembl Information
Ensembl Gene IDEnsembl Protein IDEnsembl Transcript ID
ENSMLUG00000016172ENSMLUP00000014742ENSMLUT00000016180
OrganismMyotis lucifugus
Functional Description
Protein Length947
Protein Sequence
(FASTA)
KNRPLGIGLG KLPGLHGSPW YPLGLLSPVP SRPPPPPLVQ EVAGRMRGGK AGETGVATRQ 60
VGAPGEPPGA PRGAVPATGL LLAALGILNL CLKTPGGLKL MGAPVKLTVS QGQPVSLNCS 120
VEGMEDPDIL WMKDGAMVQG LNQMYVSVSE QHWIGFLSLK SVERSDAGRY WCEVEDGGKT 180
EISPPVWLTV EGVPFFTVEP KDLAVPPNAS FQLFCEAVGP PEPVTIIWWR GGTKVGGPFP 240
SPSVLNVTGV TQSTVFSCEA HNRKGLASSR PATVRLQALP AAPFNITVTK LSSSNASVAW 300
TPGADGRAVL QSCTVQVTQA PGGWEVLAVV VPVPPFTCLL RDLAPATNYS LRVRCANALG 360
PSPYADWVPF RTKGLGTAPA SAPRNLRATR TDSGLILEWE EVISEGPLES PLGPYTLSWV 420
QDNGTQGELI VERTWANLTV WDPQKDLIVR VCVSNAVGCG PWSQPLVVSS HDHAGQQGPP 480
HSRTSWVPVV LGVLTALVTA AALALILLRK RRKETRFGQA FDSVMAGGEP AVHFRAARSF 540
NRERPERIEA TLDSLGISDE LKDKLEDVLI PEQQFTLGRM LGKGEFGSVR EAQLKQEDGS 600
FVKVAVKMLK ADIIASSDIE EFLREAACMK EFDHPHVAKL VGVSLRSRAK GRLPIPMVIL 660
PFMKHGDLHA FLLASRIGEN PFNLPLQTLI RFMVDIACGM EYLSSRNFIH RDLAARNCML 720
AEDMTVCVAD FGLSRKIYSG DYYRQGCASK LPVKWLALES LADNLYTVHS DVWAFGVTMW 780
EIMTRGQTPY AGIENAEIYN YLIGGNRLKQ PPDCMEDVYE LMYQCWSADP KQRPSFTCLR 840
MELENILGHL SVLSTSRDPL YINLEGAEQP AEEGSLELPG GDQAGSGAEN GSGMGAVGGT 900
PSDYRYILSP GGLAEQPRQE EQQPESPLNE SQRLLLLQQG LLPHSSC 947
Nucleotide Sequence
(FASTA)
AAGAATAGGC CCTTGGGCAT AGGGCTGGGG AAACTACCAG GACTTCATGG CTCACCTTGG 60
TATCCTCTTG GACTACTGTC CCCAGTCCCG TCCCGTCCCC CCCCCCCCCC ACTAGTTCAG 120
GAAGTGGCGG GGAGGATGCG GGGAGGGAAG GCCGGGGAGA CCGGGGTGGC CACCCGGCAG 180
GTTGGCGCTC CCGGCGAGCC GCCCGGGGCC CCGCGGGGGG CGGTCCCAGC CACCGGATTG 240
CTCCTTGCAG CACTCGGGAT CCTCAATCTC TGCTTAAAAA CACCAGGAGG CCTGAAGCTC 300
ATGGGAGCCC CGGTGAAGCT GACAGTGTCT CAGGGGCAGC CGGTGAGTCT CAACTGCAGT 360
GTGGAGGGGA TGGAGGATCC TGACATACTG TGGATGAAGG ACGGGGCTAT GGTCCAGGGC 420
TTGAATCAGA TGTACGTCTC AGTCAGCGAG CAGCACTGGA TCGGCTTCCT CAGCCTGAAG 480
TCAGTGGAGC GTTCTGATGC AGGCCGGTAC TGGTGCGAGG TGGAAGATGG GGGCAAAACC 540
GAGATCTCCC CCCCAGTGTG GCTCACGGTA GAAGGTGTGC CATTTTTCAC CGTGGAGCCG 600
AAAGATCTGG CAGTACCACC CAATGCCTCT TTCCAACTGT TTTGTGAGGC CGTGGGTCCC 660
CCTGAACCTG TTACCATTAT CTGGTGGAGA GGAGGCACAA AGGTCGGGGG ACCTTTTCCC 720
TCTCCTTCTG TTTTAAACGT AACAGGGGTG ACCCAGAGCA CTGTGTTCTC CTGTGAAGCT 780
CACAACCGGA AAGGCCTGGC CTCTTCCCGC CCAGCCACGG TTCGTCTTCA AGCACTGCCC 840
GCAGCCCCCT TCAACATCAC GGTGACAAAG CTCTCCAGCA GCAATGCTAG TGTGGCCTGG 900
ACGCCAGGTG CTGATGGCAG AGCTGTGCTT CAATCCTGTA CAGTCCAGGT GACACAGGCC 960
CCAGGAGGCT GGGAGGTCCT GGCTGTCGTG GTCCCTGTGC CACCTTTTAC CTGCCTTCTC 1020
CGTGACCTGG CACCTGCTAC CAACTACAGC CTCAGGGTGC GCTGTGCCAA TGCCTTGGGG 1080
CCTTCCCCAT ATGCTGACTG GGTGCCCTTT CGGACAAAGG GTCTAGGTAC AGCCCCAGCC 1140
AGCGCTCCCC GGAACCTCCG TGCCACCCGC ACAGACTCAG GTCTCATCCT GGAGTGGGAA 1200
GAAGTGATCT CTGAGGGCCC TTTGGAAAGC CCTCTGGGAC CCTATACACT GTCCTGGGTT 1260
CAAGACAACG GAACCCAGGG TGAACTGATA GTGGAAAGGA CCTGGGCCAA CTTGACAGTC 1320
TGGGATCCTC AGAAGGACCT GATTGTGCGT GTGTGCGTCT CCAATGCAGT TGGCTGTGGG 1380
CCCTGGAGTC AGCCACTGGT GGTCTCTTCT CACGACCATG CAGGCCAGCA AGGCCCTCCG 1440
CACAGCCGTA CATCCTGGGT GCCTGTGGTC CTGGGTGTGC TGACAGCCCT GGTGACGGCT 1500
GCTGCCCTGG CTCTCATCCT GCTTCGAAAG AGGCGGAAGG AGACACGTTT TGGGCAAGCC 1560
TTTGACAGTG TCATGGCCGG AGGGGAGCCA GCAGTTCACT TCCGGGCAGC CCGGTCCTTC 1620
AATCGGGAAA GGCCTGAACG CATTGAGGCC ACATTGGACA GCTTGGGCAT CAGTGACGAA 1680
CTGAAGGACA AACTGGAGGA TGTGCTCATC CCGGAGCAGC AGTTCACCCT GGGCCGGATG 1740
CTGGGCAAAG GAGAGTTTGG TTCCGTGCGG GAGGCCCAGT TGAAGCAGGA GGATGGCTCC 1800
TTTGTGAAAG TGGCTGTAAA GATGCTGAAA GCTGACATCA TTGCCTCGAG CGACATCGAA 1860
GAGTTCCTCA GGGAAGCGGC TTGCATGAAG GAGTTTGACC ACCCACATGT GGCCAAGCTT 1920
GTTGGGGTCA GCCTCCGGAG CAGGGCCAAA GGCCGTCTCC CCATCCCCAT GGTCATCCTG 1980
CCCTTCATGA AGCACGGGGA CCTGCACGCC TTCCTGCTTG CCTCCCGGAT TGGGGAGAAC 2040
CCCTTTAACC TGCCCCTGCA GACCCTGATT CGGTTCATGG TGGACATTGC CTGTGGCATG 2100
GAGTACCTGA GCTCCCGGAA CTTTATTCAC CGAGACCTGG CTGCTCGGAA TTGCATGCTG 2160
GCAGAAGACA TGACCGTGTG TGTGGCCGAC TTTGGACTCT CCCGGAAGAT CTATAGCGGG 2220
GACTATTATC GTCAGGGCTG TGCCTCCAAA TTGCCTGTCA AGTGGCTGGC CCTGGAGAGC 2280
CTGGCCGACA ACCTGTATAC GGTGCACAGT GACGTGTGGG CCTTTGGGGT GACCATGTGG 2340
GAGATCATGA CTCGTGGACA GACGCCATAT GCTGGCATCG AGAACGCTGA GATTTACAAC 2400
TACCTCATCG GCGGGAACCG CCTGAAACAG CCTCCAGACT GTATGGAGGA TGTGTATGAG 2460
CTCATGTATC AGTGCTGGAG TGCCGACCCC AAGCAGCGCC CAAGCTTCAC CTGCCTGCGA 2520
ATGGAGCTGG AAAACATTCT GGGCCACCTG TCTGTGCTAT CCACCAGCCG CGACCCCTTG 2580
TACATCAACC TTGAGGGAGC CGAGCAGCCT GCTGAGGAAG GGAGCCTGGA GCTGCCTGGT 2640
GGGGACCAGG CCGGGAGCGG GGCTGAGAAT GGCAGTGGCA TGGGGGCAGT GGGGGGCACC 2700
CCCAGTGACT ATCGGTACAT CCTCAGCCCT GGAGGGCTAG CTGAGCAGCC CAGGCAGGAG 2760
GAGCAGCAGC CAGAAAGCCC CCTCAACGAG TCCCAGAGGC TACTGCTGCT GCAGCAAGGG 2820
CTACTGCCCC ACAGTAGCTG TTAG 2844
Domain Profile
S: 1     lvlgkvlgegefgsvmegqlkqedgsilkvavktlkldiiarseieeflseaacmkefdh  60
         ++lg++lg+gefgsv+e+qlkqedgs++kvavk+lk+diia+s+ieefl+eaacmkefdh
Q: 575   FTLGRMLGKGEFGSVREAQLKQEDGSFVKVAVKMLKADIIASSDIEEFLREAACMKEFDH  634
         68**********************************************************
S: 61    pnvirlvgvslessekgrlpkpvvilpfmkygdlhafllysrlgenpvylplqtlvkfmv  120
         p+v++lvgvsl+s++kgrlp+p+vilpfmk+gdlhafll+sr+genp++lplqtl++fmv
Q: 635   PHVAKLVGVSLRSRAKGRLPIPMVILPFMKHGDLHAFLLASRIGENPFNLPLQTLIRFMV  694
         ************************************************************
S: 121   diasgmeylssrnfihrdlaarncmlaedmtvcvadfglskkiysgdyyrqgriaklpvk  180
         dia+gmeylssrnfihrdlaarncmlaedmtvcvadfgls+kiysgdyyrqg+++klpvk
Q: 695   DIACGMEYLSSRNFIHRDLAARNCMLAEDMTVCVADFGLSRKIYSGDYYRQGCASKLPVK  754
         ************************************************************
S: 181   wiaiesladrvytsksdvwafgvtmweiatrgqtpyagvenaeiydyllqgnrlkqpedc  240
         w+a+eslad++yt++sdvwafgvtmwei+trgqtpyag+enaeiy+yl++gnrlkqp+dc
Q: 755   WLALESLADNLYTVHSDVWAFGVTMWEIMTRGQTPYAGIENAEIYNYLIGGNRLKQPPDC  814
         ************************************************************
S: 241   ldelydlmyrcweadpkdrpsfsvlr  266
         ++++y+lmy+cw+adpk+rpsf+ lr
Q: 815   MEDVYELMYQCWSADPKQRPSFTCLR  840
         ***********************998
Domain Sequence
(FASTA)
FTLGRMLGKG EFGSVREAQL KQEDGSFVKV AVKMLKADII ASSDIEEFLR EAACMKEFDH 60
PHVAKLVGVS LRSRAKGRLP IPMVILPFMK HGDLHAFLLA SRIGENPFNL PLQTLIRFMV 120
DIACGMEYLS SRNFIHRDLA ARNCMLAEDM TVCVADFGLS RKIYSGDYYR QGCASKLPVK 180
WLALESLADN LYTVHSDVWA FGVTMWEIMT RGQTPYAGIE NAEIYNYLIG GNRLKQPPDC 240
MEDVYELMYQ CWSADPKQRP SFTCLR 266
KeywordATP-binding; Complete proteome; Disulfide bond; Immunoglobulin domain; Kinase; Membrane; Nucleotide-binding; Phosphoprotein; Receptor; Reference proteome; Repeat; Transferase; Transmembrane; Transmembrane helix; Tyrosine-protein kinase.
Sequence SourceEnsembl
Orthology
Ortholog group
Ailuropoda melanoleuca"; ?>Anolis carolinensis"; ?>Bos taurus"; ?>Callithrix jacchus"; ?>Canis familiaris"; ?>Cavia porcellus"; ?>Ciona savignyi"; ?>Danio rerio"; ?>Equus caballus"; ?>Felis catus"; ?>Gallus gallus"; ?>Gasterosteus aculeatus"; ?>Gorilla gorilla"; ?>Homo sapiens"; ?>Ictidomys tridecemlineatus"; ?>Loxodonta africana"; ?>Macaca mulatta"; ?>Meleagris gallopavo"; ?>Monodelphis domestica"; ?>Mus musculus"; ?>Mustela putorius furo"; ?>Nomascus leucogenys"; ?>Oreochromis niloticus"; ?>Ornithorhynchus anatinus"; ?>Oryctolagus cuniculus"; ?>Oryzias latipes"; ?>Otolemur garnettii"; ?>Pan troglodytes"; ?>Pelodiscus sinensis"; ?>Pongo abelii"; ?>Pteropus vampyrus"; ?>Rattus norvegicus"; ?>Sarcophilus harrisii"; ?>Sus scrofa"; ?>Taeniopygia guttata"; ?>Takifugu rubripes"; ?>Tarsius syrichta"; ?>Xenopus tropicalis"; ?>Xiphophorus maculatus"; ?>
EKS-AIM-00372
EKS-ANC-00384
EKS-BOT-00399
EKS-CAJ-00404
EKS-CAF-00400
EKS-CAP-00424
EKS-CIS-00152
EKS-DAR-00777
EKS-EQC-00387
EKS-FEC-00382
EKS-GAG-00338
EKS-GAA-00488
EKS-GOG-00387
EKS-HOS-00403
EKS-ICT-00375
EKS-LOA-00403
EKS-MAM-00399
EKS-MEG-00329
EKS-MOD-00385
EKS-MUM-00432
EKS-MUP-00390
EKS-NOL-00364
EKS-ORN-00511
EKS-ORA-00344
EKS-ORC-00374
EKS-ORL-00465
EKS-OTG-00402
EKS-PAT-00374
EKS-PES-00355
EKS-POA-00391
EKS-PTV-00110
EKS-RAN-00411
EKS-SAH-00365
EKS-SUS-00346
EKS-TAG-00471
EKS-TAR-00502
EKS-TAS-00046
EKS-XET-00511
EKS-XIM-00503
Gene Ontology
GO:0005789; C:endoplasmic reticulum membrane
GO:0016021; C:integral to membrane
GO:0005635; C:nuclear envelope
GO:0005524; F:ATP binding
GO:0043548; F:phosphatidylinositol 3-kinase binding
GO:0004713; F:protein tyrosine kinase activity
GO:0043277; P:apoptotic cell clearance
GO:0021885; P:forebrain cell migration
GO:0050728; P:negative regulation of inflammatory response
GO:0045824; P:negative regulation of innate immune response
GO:0043524; P:negative regulation of neuron apoptotic process
GO:0034122; P:negative regulation of toll-like receptor signaling pathway
GO:0070050; P:neuron homeostasis
GO:0042698; P:ovulation cycle
GO:0070527; P:platelet aggregation
GO:0046777; P:protein autophosphorylation
GO:0043491; P:protein kinase B signaling cascade
GO:0032940; P:secretion by cell
GO:0007283; P:spermatogenesis
GO:0034446; P:substrate adhesion-dependent cell spreading
KEGG
InterPros
IPR003961; Fibronectin_type3.
IPR007110; Ig-like.
IPR013783; Ig-like_fold.
IPR013098; Ig_I-set.
IPR003599; Ig_sub.
IPR003598; Ig_sub2.
IPR011009; Kinase-like_dom.
IPR000719; Prot_kinase_cat_dom.
IPR017441; Protein_kinase_ATP_BS.
IPR001245; Ser-Thr/Tyr_kinase_cat_dom.
IPR008266; Tyr_kinase_AS.
IPR020635; Tyr_kinase_cat_dom.
Pfam
PF00041; fn3; 1.
PF07679; I-set; 1.
PF07714; Pkinase_Tyr; 1.
SMARTs
SM00060; FN3; 2.
SM00409; IG; 1.
SM00408; IGc2; 1.
SM00219; TyrKc; 1.
Prosites
PS50853; FN3; 2.
PS50835; IG_LIKE; 2.
PS00107; PROTEIN_KINASE_ATP; 1.
PS50011; PROTEIN_KINASE_DOM; 1.
PS00109; PROTEIN_KINASE_TYR; 1.
Prints
PR00109; TYRKINASE.
Created Date20-Feb-2013